Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   DQM46_RS01375 Genome accession   NZ_LS483357
Coordinates   247387..248148 (+) Length   253 a.a.
NCBI ID   WP_021299356.1    Uniprot ID   A0A660A601
Organism   Streptococcus pyogenes strain NCTC8326     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Genomic Context

Location: 242387..253148
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQM46_RS01360 (NCTC8326_00273) - 242645..244213 (-) 1569 WP_042769835.1 ABC transporter substrate-binding protein/permease -
  DQM46_RS01365 (NCTC8326_00274) - 244411..246336 (+) 1926 Protein_214 DUF2207 family protein -
  DQM46_RS01370 (NCTC8326_00276) - 246402..247241 (+) 840 WP_011528245.1 undecaprenyl-diphosphate phosphatase -
  DQM46_RS01375 (NCTC8326_00277) mecA 247387..248148 (+) 762 WP_021299356.1 adaptor protein MecA Regulator
  DQM46_RS01380 (NCTC8326_00278) - 248155..249324 (+) 1170 WP_011528247.1 glycosyltransferase family 4 protein -
  DQM46_RS01385 (NCTC8326_00279) sufC 249446..250216 (+) 771 WP_011528248.1 Fe-S cluster assembly ATPase SufC -
  DQM46_RS01390 (NCTC8326_00280) sufD 250311..251573 (+) 1263 WP_011528249.1 Fe-S cluster assembly protein SufD -
  DQM46_RS01395 (NCTC8326_00281) - 251604..252830 (+) 1227 WP_011528250.1 cysteine desulfurase -

Sequence

Protein


Download         Length: 253 a.a.        Molecular weight: 29051.72 Da        Isoelectric Point: 4.1585

>NTDB_id=1138313 DQM46_RS01375 WP_021299356.1 247387..248148(+) (mecA) [Streptococcus pyogenes strain NCTC8326]
MEMKQISETTLKITISMDDLEERGMELKDFLIPQEKTEEFFYSVMDELDLPDNFKDSGMLSFRVTPRKDRLDVFVTKSEI
NKDINLEDLAEFGDMSQMTPEDFFKSLEQSMREKGDVKAHEKLEKIEEIMEDVVEATLANQSEAADPSTNHDSEPLDYIH
YVLDFSTITEAVAFAKTIDFSIEASELYKGSNCYHMTILLDVQQQPSYFANVMYARLIEHANPGSKTRAYLQEHGLQLML
DGAVEQLQKIELG

Nucleotide


Download         Length: 762 bp        

>NTDB_id=1138313 DQM46_RS01375 WP_021299356.1 247387..248148(+) (mecA) [Streptococcus pyogenes strain NCTC8326]
ATGGAAATGAAACAAATTAGCGAGACAACGCTAAAAATAACAATTAGTATGGACGATTTAGAAGAAAGAGGAATGGAGTT
GAAAGATTTCTTGATTCCTCAAGAAAAAACAGAAGAGTTTTTCTATTCTGTGATGGACGAACTCGATCTTCCAGATAATT
TTAAAGATAGTGGTATGCTTAGTTTTCGAGTGACTCCACGCAAGGACCGTCTAGATGTTTTTGTTACCAAATCTGAGATA
AATAAAGATATTAATCTTGAAGATTTAGCAGAGTTTGGTGATATGTCCCAAATGACTCCGGAAGATTTTTTCAAGAGCTT
GGAGCAATCCATGCGTGAAAAGGGAGATGTCAAAGCTCATGAAAAATTGGAAAAAATTGAAGAGATAATGGAAGATGTTG
TTGAAGCCACTCTAGCTAATCAGTCTGAAGCGGCTGATCCATCAACTAATCATGATTCAGAACCTTTAGACTATATCCAT
TATGTATTGGATTTTTCAACGATTACAGAGGCAGTGGCTTTTGCTAAAACGATTGATTTTTCGATAGAAGCTTCAGAGTT
ATATAAGGGGAGCAACTGCTACCATATGACTATTTTATTAGATGTTCAGCAACAACCATCTTATTTTGCGAATGTCATGT
ATGCGAGATTGATTGAGCATGCAAACCCTGGATCAAAAACAAGAGCTTATTTACAAGAGCATGGCTTACAATTGATGCTT
GATGGTGCTGTTGAGCAATTACAAAAGATTGAGTTGGGATAA

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-247)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A660A601

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus mutans UA159

62.8

98.814

0.621
  mecA Streptococcus thermophilus LMD-9

56.225

98.419

0.553
  mecA Streptococcus thermophilus LMG 18311

55.422

98.419

0.545
  mecA Streptococcus pneumoniae Rx1

48.627

100

0.49
  mecA Streptococcus pneumoniae D39

48.627

100

0.49
  mecA Streptococcus pneumoniae R6

48.627

100

0.49
  mecA Streptococcus pneumoniae TIGR4

48.627

100

0.49

Multiple sequence alignment