Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   DQM59_RS09240 Genome accession   NZ_LS483349
Coordinates   1818877..1819599 (-) Length   240 a.a.
NCBI ID   WP_002263984.1    Uniprot ID   A0AAX1K0W7
Organism   Streptococcus mutans strain NCTC10449     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Genomic Context

Location: 1813877..1824599
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQM59_RS09215 (NCTC10449_01792) sufU 1813912..1814346 (-) 435 WP_002262744.1 Fe-S cluster assembly sulfur transfer protein SufU -
  DQM59_RS09220 (NCTC10449_01793) - 1814333..1815562 (-) 1230 WP_002271229.1 cysteine desulfurase -
  DQM59_RS09225 (NCTC10449_01794) sufD 1815567..1816829 (-) 1263 WP_002263985.1 Fe-S cluster assembly protein SufD -
  DQM59_RS09230 (NCTC10449_01795) sufC 1816867..1817637 (-) 771 WP_002262747.1 Fe-S cluster assembly ATPase SufC -
  DQM59_RS09235 (NCTC10449_01796) rgpG 1817711..1818871 (-) 1161 WP_002262748.1 rhamnose-glucose polysaccharide biosynthesis protein RgpB -
  DQM59_RS09240 (NCTC10449_01797) mecA 1818877..1819599 (-) 723 WP_002263984.1 adaptor protein MecA Regulator
  DQM59_RS09245 (NCTC10449_01798) - 1819689..1820534 (-) 846 WP_002275187.1 undecaprenyl-diphosphate phosphatase -
  DQM59_RS09250 (NCTC10449_01799) - 1820592..1822493 (-) 1902 WP_002280004.1 DUF2207 domain-containing protein -
  DQM59_RS09255 (NCTC10449_01800) - 1822645..1824198 (+) 1554 WP_002280005.1 ABC transporter substrate-binding protein/permease -

Sequence

Protein


Download         Length: 240 a.a.        Molecular weight: 28028.63 Da        Isoelectric Point: 4.2340

>NTDB_id=1137913 DQM59_RS09240 WP_002263984.1 1818877..1819599(-) (mecA) [Streptococcus mutans strain NCTC10449]
MEMKQISETTLKITISMEDLEERGMELKDFLIPQEKTEEFFYTVMDELDLPENFKDSGMLSFRVTPRNDRIDVFVTKSEI
NKNLNLEDLSDFDDISKMSPEDFFNTLEETMREKGDAAALDKLAEIEKREEEKTQQEKGETKEKRDYVHFVLDFPNIQQV
ISFAKTVDYDVEASELFKESDAYHMTVLLNLEDKPDYYADLMFARMLEHAGRGTKTRAYLLEHGVQLIKADALQELQMIG

Nucleotide


Download         Length: 723 bp        

>NTDB_id=1137913 DQM59_RS09240 WP_002263984.1 1818877..1819599(-) (mecA) [Streptococcus mutans strain NCTC10449]
ATGGAAATGAAACAAATCAGCGAAACAACATTAAAAATCACCATCAGTATGGAAGATTTAGAAGAAAGAGGCATGGAATT
AAAAGATTTCTTGATTCCGCAGGAAAAGACGGAAGAATTTTTCTATACTGTTATGGATGAGCTGGACTTGCCTGAAAATT
TCAAGGACAGTGGGATGTTAAGCTTTCGAGTAACACCAAGGAATGATCGCATTGATGTTTTTGTCACTAAGTCAGAAATC
AATAAAAATCTTAATTTGGAGGATTTGTCTGATTTTGATGATATTTCAAAAATGTCCCCGGAGGATTTCTTTAATACCTT
GGAGGAAACCATGCGTGAAAAAGGGGATGCTGCAGCTCTGGATAAATTGGCTGAAATTGAAAAAAGAGAAGAAGAGAAGA
CTCAGCAGGAAAAAGGTGAAACTAAGGAAAAAAGAGATTACGTTCACTTTGTGCTGGATTTTCCTAATATTCAGCAAGTC
ATAAGTTTTGCTAAGACAGTTGACTATGATGTAGAGGCTTCAGAACTTTTTAAGGAGTCTGACGCTTATCACATGACTGT
TCTGCTTAATCTCGAAGATAAACCTGACTATTATGCTGATCTTATGTTTGCAAGAATGTTGGAGCATGCTGGTAGAGGAA
CAAAGACACGTGCTTATCTATTAGAACATGGAGTTCAGCTCATTAAAGCAGATGCTCTGCAAGAATTACAAATGATTGGA
TAA

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-236)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus mutans UA159

99.583

100

0.996
  mecA Streptococcus thermophilus LMD-9

57.787

100

0.588
  mecA Streptococcus thermophilus LMG 18311

57.377

100

0.583
  mecA Streptococcus pneumoniae Rx1

48.571

100

0.496
  mecA Streptococcus pneumoniae D39

48.571

100

0.496
  mecA Streptococcus pneumoniae R6

48.571

100

0.496
  mecA Streptococcus pneumoniae TIGR4

48.571

100

0.496

Multiple sequence alignment