Detailed information    

insolico Bioinformatically predicted

Overview

Name   pknB   Type   Regulator
Locus tag   DQM59_RS08105 Genome accession   NZ_LS483349
Coordinates   1599002..1600852 (-) Length   616 a.a.
NCBI ID   WP_002263039.1    Uniprot ID   A0AAX1K050
Organism   Streptococcus mutans strain NCTC10449     
Function   modulate the activity of ComDE; modulate the activity of VicKR (predicted from homology)   
Competence regulation

Genomic Context

Location: 1594002..1605852
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQM59_RS08080 (NCTC10449_01571) - 1594402..1594788 (-) 387 WP_002263034.1 S1 RNA-binding domain-containing protein -
  DQM59_RS08085 (NCTC10449_01572) - 1594772..1596187 (-) 1416 WP_002263035.1 Cof-type HAD-IIB family hydrolase -
  DQM59_RS08090 (NCTC10449_01573) - 1596231..1596872 (-) 642 WP_002263036.1 response regulator transcription factor -
  DQM59_RS08095 (NCTC10449_01574) - 1596865..1597869 (-) 1005 WP_002272573.1 sensor histidine kinase -
  DQM59_RS08100 (NCTC10449_01575) liaF 1597866..1598561 (-) 696 WP_002263038.1 cell wall-active antibiotics response protein LiaF -
  DQM59_RS08105 (NCTC10449_01577) pknB 1599002..1600852 (-) 1851 WP_002263039.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  DQM59_RS08110 (NCTC10449_01578) - 1600849..1601592 (-) 744 WP_002279923.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -
  DQM59_RS08115 (NCTC10449_01579) rsmB 1601631..1602953 (-) 1323 WP_002267946.1 16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB -
  DQM59_RS08120 (NCTC10449_01580) fmt 1602934..1603869 (-) 936 WP_002263042.1 methionyl-tRNA formyltransferase -

Sequence

Protein


Download         Length: 616 a.a.        Molecular weight: 66913.66 Da        Isoelectric Point: 9.4520

>NTDB_id=1137903 DQM59_RS08105 WP_002263039.1 1599002..1600852(-) (pknB) [Streptococcus mutans strain NCTC10449]
MIQIGKLFAGRYRILQSIGRGGMADVYLANDLILDNEEVAIKVLRTNYQTDQVAVTRFQREARAMAELNHPNIVAIRDIG
EEDGQQFLAMEYVDGADLKKYIQDHAPLSNAEVIRIMKEVLSAMTLAHQKGIIHRDLKPQNVLLTKDGTAKVTDFGIAVA
FAETSLTQTNSMLGSVHYLSPEQARGSKATVQSDIYAMGIMLFEMLTGHIPYDGDSAVTIALQHFQKPLPSIIAENKNVP
QALENVVIKATAKRLTDRYHSTQEMLQDLRTSLQPNRSRERKLVFSDASDTKPLPKLEQAAANSLAAQSLKNKTSNQDKV
DHKSKPKTKPQPKPKKKRHFLARFFKIFFILVAIGIAVLTYLVLTKPSTVSVPDVSGDKLSTAKMIIRKSGLKVGDVQKI
EDDNVGAGKVVRTNPSAGSKKREGSSVDIFVASAKGFKMEDYTGQDYKDAIDNLTNNYGVSRDSIVLKEVSSDDYSGGTV
IGQSPKPGKTYHPSSDKKITLKVVKVTMPNLKNSTYEEAVSTLTAMGISSSRIKAYDASDYSSEISSPSSSSLVVGQSPY
YGNTVSLSSNDDIILYVSTSGGSHSGSSSSESSNSEGTTSSEASTDSSSSATTTSH

Nucleotide


Download         Length: 1851 bp        

>NTDB_id=1137903 DQM59_RS08105 WP_002263039.1 1599002..1600852(-) (pknB) [Streptococcus mutans strain NCTC10449]
ATGATTCAGATTGGCAAATTATTTGCTGGTCGTTATCGGATTCTCCAGTCTATCGGACGAGGTGGGATGGCGGATGTTTA
TTTAGCTAATGATTTGATTTTAGATAATGAGGAAGTGGCCATTAAGGTTCTACGTACGAATTATCAGACAGATCAGGTTG
CTGTGACACGTTTTCAGCGGGAAGCACGTGCCATGGCAGAACTTAATCATCCTAATATTGTAGCCATTCGTGACATTGGA
GAAGAAGACGGTCAGCAATTCCTTGCAATGGAATATGTTGATGGCGCCGACTTGAAGAAATACATTCAAGATCACGCTCC
TTTATCAAATGCTGAAGTCATTAGAATCATGAAAGAGGTTCTTTCTGCTATGACTCTTGCCCACCAAAAGGGTATTATTC
ATCGGGATTTAAAACCTCAAAATGTTTTACTGACCAAAGATGGAACGGCTAAAGTAACAGACTTTGGTATTGCTGTGGCT
TTTGCTGAAACGAGTTTGACCCAAACCAATTCAATGCTGGGTTCAGTACATTACTTATCTCCTGAACAGGCGCGTGGTTC
TAAGGCTACTGTTCAAAGTGATATCTATGCAATGGGGATTATGCTTTTTGAAATGCTGACAGGGCATATTCCCTATGATG
GCGATAGTGCTGTTACAATTGCTTTGCAGCATTTTCAAAAGCCTTTACCATCTATTATTGCTGAGAATAAAAATGTCCCT
CAAGCTCTTGAAAATGTTGTTATTAAAGCAACAGCTAAACGATTAACGGACCGCTATCATTCAACGCAGGAGATGTTGCA
GGATTTAAGAACGTCTCTGCAGCCGAATCGCAGCCGTGAAAGAAAGCTTGTTTTCAGTGATGCTTCAGATACAAAACCAC
TACCAAAACTGGAACAGGCAGCAGCAAACTCTTTAGCTGCTCAGTCCTTAAAAAATAAAACTTCCAATCAGGATAAAGTA
GATCATAAATCTAAGCCTAAAACCAAACCACAACCTAAGCCTAAGAAAAAAAGACATTTTTTAGCTCGTTTCTTTAAAAT
CTTCTTTATATTAGTTGCCATTGGTATTGCTGTTTTGACCTACCTGGTTCTGACAAAACCGAGTACTGTTTCAGTTCCTG
ACGTTTCAGGAGATAAATTATCAACGGCCAAGATGATTATTAGAAAATCGGGTCTTAAGGTGGGTGACGTTCAAAAAATT
GAGGATGATAACGTTGGTGCTGGAAAGGTCGTAAGAACTAATCCAAGTGCAGGCAGTAAAAAACGTGAAGGTTCTAGTGT
TGATATTTTTGTAGCTAGTGCTAAGGGATTTAAGATGGAGGACTATACCGGTCAAGACTACAAGGATGCTATTGATAATT
TGACTAATAATTATGGTGTTTCTAGGGACAGTATTGTTCTTAAGGAAGTTTCATCTGATGACTACAGTGGTGGAACTGTT
ATCGGTCAATCACCAAAACCCGGAAAGACCTATCATCCTAGCAGTGATAAAAAAATAACTCTCAAGGTTGTCAAAGTCAC
TATGCCAAATCTTAAAAATTCTACTTATGAAGAGGCTGTCAGTACTTTAACAGCTATGGGGATTTCTTCAAGCCGTATAA
AAGCTTATGATGCCAGCGATTACTCATCAGAAATTTCATCACCATCATCTTCGTCACTCGTTGTCGGTCAAAGTCCTTAT
TATGGTAATACTGTCAGTCTGTCATCTAATGATGATATTATCTTGTATGTTTCAACATCAGGTGGCTCTCATTCTGGTTC
GTCGTCGTCTGAATCTTCGAACAGTGAAGGAACAACATCAAGCGAAGCCTCGACAGACTCTAGTTCAAGTGCGACGACAA
CTTCACATTAA

Domains

Predicted by InterproScan.

Protein kinase domain (Pkinase)

(12-258)

PASTA domain (PASTA)

(370-432)

PASTA domain (PASTA)

(506-579)

PASTA domain (PASTA)

(438-505)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  pknB Streptococcus mutans UA159

100

100

1
  stkP/pknB Streptococcus salivarius strain HSISS4

62.919

96.753

0.609
  stkP Streptococcus pneumoniae TIGR4

52.381

98.864

0.518
  stkP Streptococcus pneumoniae D39

52.217

98.864

0.516
  stkP Streptococcus pneumoniae R6

52.217

98.864

0.516
  stkP Streptococcus pneumoniae Rx1

52.053

98.864

0.515

Multiple sequence alignment