Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   DQM73_RS02210 Genome accession   NZ_LS483346
Coordinates   420783..421535 (+) Length   250 a.a.
NCBI ID   WP_002925907.1    Uniprot ID   A0A2X3VSQ6
Organism   Streptococcus sanguinis strain NCTC11085     
Function   degradation of ComW (predicted from homology)   
Competence regulation

Genomic Context

Location: 415783..426535
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQM73_RS02195 (NCTC11085_00428) - 416034..417599 (-) 1566 WP_002925912.1 ABC transporter substrate-binding protein/permease -
  DQM73_RS02200 (NCTC11085_00429) - 417731..419626 (+) 1896 WP_002925910.1 DUF2207 domain-containing protein -
  DQM73_RS02205 (NCTC11085_00430) - 419766..420608 (+) 843 WP_002898872.1 undecaprenyl-diphosphate phosphatase -
  DQM73_RS02210 (NCTC11085_00431) mecA 420783..421535 (+) 753 WP_002925907.1 adaptor protein MecA Regulator
  DQM73_RS02215 (NCTC11085_00432) - 421526..422692 (+) 1167 WP_002908072.1 glycosyltransferase family 4 protein -
  DQM73_RS02220 (NCTC11085_00433) sufC 422782..423552 (+) 771 WP_002893635.1 Fe-S cluster assembly ATPase SufC -
  DQM73_RS02225 (NCTC11085_00434) sufD 423594..424856 (+) 1263 WP_002925897.1 Fe-S cluster assembly protein SufD -
  DQM73_RS02230 (NCTC11085_00435) - 424897..426129 (+) 1233 WP_002925896.1 cysteine desulfurase -

Sequence

Protein


Download         Length: 250 a.a.        Molecular weight: 28869.46 Da        Isoelectric Point: 3.9920

>NTDB_id=1137680 DQM73_RS02210 WP_002925907.1 420783..421535(+) (mecA) [Streptococcus sanguinis strain NCTC11085]
MEMKQISDSTIKITIQLEDLEERGMEMADFLVPQEKTEEFFYTILDELEMPDNFLDSGMLSFRVTPKPDKVDVFVTKSKL
DKNLSFEDLADLPDMDELSHMSPDEFLKTLEKSIFEKSKEDIEAVQSLETAEAEEREQLSQEAADEQSAENAERYIYYIL
RFEDIKAAAAFAQTVDYKIDLSELYKYDSAYYLTILVDVEGFPERYPSWLLAKMREFADDSDITRAVLQEHGHLLLVTDA
VSGLQKVECL

Nucleotide


Download         Length: 753 bp        

>NTDB_id=1137680 DQM73_RS02210 WP_002925907.1 420783..421535(+) (mecA) [Streptococcus sanguinis strain NCTC11085]
ATGGAAATGAAACAGATTAGTGATTCGACCATAAAAATCACGATTCAGCTGGAAGATTTGGAAGAGCGCGGAATGGAAAT
GGCCGATTTCTTGGTCCCCCAAGAAAAGACGGAAGAGTTTTTCTATACTATCTTAGATGAGTTGGAAATGCCGGATAATT
TTTTGGACAGCGGTATGCTGAGTTTCCGTGTGACGCCTAAGCCAGATAAGGTGGATGTTTTTGTTACCAAGTCTAAGTTG
GATAAGAATCTGAGTTTTGAGGATTTGGCAGATTTGCCAGACATGGATGAGCTGTCTCATATGTCTCCAGATGAATTCCT
CAAGACACTGGAAAAGAGCATTTTTGAAAAGAGCAAGGAAGATATAGAAGCGGTCCAATCTTTGGAAACAGCCGAAGCAG
AGGAAAGAGAGCAGCTTTCTCAGGAGGCGGCGGATGAGCAGTCGGCGGAAAATGCAGAGCGCTATATATACTATATCCTG
CGTTTTGAAGATATTAAGGCTGCGGCGGCTTTTGCCCAGACGGTGGACTATAAGATTGACTTATCAGAGCTTTATAAGTA
TGATTCAGCTTATTATTTGACGATTTTGGTGGATGTTGAAGGCTTCCCAGAACGCTACCCATCTTGGCTTTTGGCCAAGA
TGCGTGAGTTCGCAGATGATTCAGATATCACTCGGGCAGTGCTGCAGGAGCACGGTCATCTGCTTTTGGTGACAGATGCG
GTCTCCGGCCTGCAGAAGGTTGAATGCCTATGA

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-242)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A2X3VSQ6

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus pneumoniae Rx1

68.421

98.8

0.676
  mecA Streptococcus pneumoniae D39

68.421

98.8

0.676
  mecA Streptococcus pneumoniae R6

68.421

98.8

0.676
  mecA Streptococcus pneumoniae TIGR4

68.016

98.8

0.672
  mecA Streptococcus mutans UA159

49.798

98.8

0.492
  mecA Streptococcus thermophilus LMD-9

48.996

99.6

0.488
  mecA Streptococcus thermophilus LMG 18311

48.594

99.6

0.484

Multiple sequence alignment