Detailed information NTG1137622

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: DQL69_RS00335
• Genome accession: NZ_LS483345
• Coordinates: 53124..54035 (+)
• Length: 303 a.a.
• NCBI ID: WP_014635220.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain NCTC8231
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 48124..59035

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQL69_RS00315 (NCTC8231_00062)	purE	48462..48953 (+)	492	WP_002987716.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
DQL69_RS00320 (NCTC8231_00063)	purK	48940..50013 (+)	1074	WP_023612871.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
DQL69_RS09330	-	50034..51363 (+)	1330	Protein_30	hypothetical protein	-
DQL69_RS00330 (NCTC8231_00066)	purB	51732..53024 (+)	1293	WP_023612869.1	adenylosuccinate lyase	-
DQL69_RS00335 (NCTC8231_00067)	comR	53124..54035 (+)	912	WP_014635220.1	helix-turn-helix domain-containing protein	Regulator
DQL69_RS09185 (NCTC8231_00068)	comS	54126..54224 (+)	99	WP_020833188.1	quorum-sensing system DWW-type pheromone	Regulator
DQL69_RS00340 (NCTC8231_00069)	ruvB	54255..55253 (+)	999	WP_002986679.1	Holliday junction branch migration DNA helicase RuvB	-
DQL69_RS00345 (NCTC8231_00070)	-	55391..55828 (+)	438	WP_002994668.1	low molecular weight protein-tyrosine-phosphatase	-
DQL69_RS00350 (NCTC8231_00071)	-	55851..56252 (+)	402	WP_011017240.1	MORN repeat-containing protein	-
DQL69_RS00355 (NCTC8231_00072)	-	56249..58024 (+)	1776	WP_002987732.1	acyltransferase family protein	-

Sequence

Protein

• Length: 303 a.a.
• Molecular weight: 35925.63 Da
• Isoelectric Point: 4.9349

>NTDB_id=1137622 DQL69_RS00335 WP_014635220.1 53124..54035(+) (comR) [Streptococcus pyogenes strain NCTC8231]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKVAVDIIQAKFEVYQTGDINFGYSILKEFLPQLKRKSIYNLNE
LLLIDLYLIILVVSHFSDDIFDVQFYEEITESMLKQHNNLPLEDLFLLNNILLSCADTYIRLKMFGRLKETLQLSHFIMS
TIQDFQKMPMYCMYEWKLSIFYLKDINRARNYFEQSILFTQMTGDTYLVQKLRGEWNKDIHYI

Nucleotide

• Length: 912 bp

>NTDB_id=1137622 DQL69_RS00335 WP_014635220.1 53124..54035(+) (comR) [Streptococcus pyogenes strain NCTC8231]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAGTTGCTGTTGATATTATCCAAGCAAAATTTGAAGTTTATCAAACCG
GAGATATTAATTTCGGATATAGTATTTTAAAAGAATTTCTACCACAGCTAAAAAGAAAATCTATCTATAATTTAAATGAA
TTATTACTTATAGATTTGTATTTGATTATTCTGGTAGTTTCTCATTTTTCAGATGATATATTTGATGTACAGTTTTATGA
AGAAATAACAGAGAGCATGTTAAAACAACACAATAATTTACCATTGGAAGATTTATTTTTACTGAATAATATCTTATTAT
CTTGTGCGGACACTTATATTCGTTTGAAGATGTTCGGTCGTCTAAAAGAAACATTACAACTTAGCCACTTTATAATGTCA
ACTATTCAAGATTTTCAAAAAATGCCTATGTATTGTATGTATGAATGGAAGCTATCTATTTTTTATTTGAAAGATATTAA
CCGAGCACGGAATTACTTTGAACAGTCTATTTTATTTACTCAAATGACAGGAGATACATATTTAGTTCAAAAATTACGGG
GAGAATGGAATAAAGATATTCATTATATTTAA

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (12-64)

• ComR tetratricopeptide (ComR_TPR) (73-296)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS315	99.34	100	0.993
comR	Streptococcus pyogenes MGAS8232	58.472	99.34	0.581
comR	Streptococcus mutans UA159	47.492	98.68	0.469
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	46.441	97.36	0.452
comR	Streptococcus suis P1/7	37.374	98.02	0.366
comR	Streptococcus suis 05ZYH33	37.374	98.02	0.366