Detailed information NTG1137620

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: DQL21_RS09555
• Genome accession: NZ_LS483343
• Coordinates: 1870072..1871271 (+)
• Length: 399 a.a.
• NCBI ID: WP_018030411.1
• Uniprot ID: A0A2X3W734
• Organism: Streptococcus ferus strain NCTC12278
• Function: require for competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1865072..1876271

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQL21_RS09540 (NCTC12278_01919)	-	1868017..1868649 (-)	633	WP_051048382.1	YoaK family protein	-
DQL21_RS09545 (NCTC12278_01920)	-	1868725..1869399 (-)	675	WP_018030413.1	DNA alkylation repair protein	-
DQL21_RS09550 (NCTC12278_01921)	rlmH	1869408..1869887 (-)	480	WP_018030412.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
DQL21_RS09555 (NCTC12278_01922)	htrA	1870072..1871271 (+)	1200	WP_018030411.1	S1C family serine protease	Regulator
DQL21_RS09560 (NCTC12278_01923)	spo0J	1871343..1872113 (+)	771	WP_018030410.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 399 a.a.
• Molecular weight: 42249.17 Da
• Isoelectric Point: 4.5185

>NTDB_id=1137620 DQL21_RS09555 WP_018030411.1 1870072..1871271(+) (htrA) [Streptococcus ferus strain NCTC12278]
MNNSKPNSFMRWFIPLIIVFASFLLGVGLTSVYHQLVGGSTTSSKTTTVSNTVYNTKSDTTKAVKEVQDAVVSVINYQKN
SGSSYDQYWSNDSNSSDSEMQIYSEGSGVIYKKDGDSAYLVTNNHVIDGAEKLEIMLANGTKVVGELVGADTYSDLAVIK
ISSKNVDTVAEFADSTKLNVGEPAIAIGSPLGSEYANSVTEGIVSSLSRTVTSQNEEGETISTNAIQTDAAINPGNSGGP
LINIKGQVIGINSSKIASSSSSSSGVAVEGMGFAIPSNDVVSIINQLEENGKVIRPALGISMADLSQASTSAINELNLPD
DVTSGIIVLGTQSGMPADGKLKKYDVITEIDGKKIESTSDLQSILYKHKKGDTIEITFYRGKDKKTVKLELDKTTEDLS

Nucleotide

• Length: 1200 bp

>NTDB_id=1137620 DQL21_RS09555 WP_018030411.1 1870072..1871271(+) (htrA) [Streptococcus ferus strain NCTC12278]
GTGAATAATTCAAAACCAAATAGCTTTATGAGGTGGTTTATTCCTCTTATCATTGTTTTTGCTAGTTTTTTACTGGGAGT
AGGACTTACGAGTGTTTACCACCAACTGGTCGGAGGTTCAACAACTAGTTCCAAGACAACTACTGTCAGCAATACTGTTT
ATAATACAAAATCTGATACGACTAAAGCAGTCAAAGAAGTCCAAGATGCTGTTGTATCAGTCATTAATTACCAAAAAAAC
AGCGGCAGTTCCTACGACCAATACTGGTCAAATGACAGCAATTCTTCCGATTCTGAAATGCAAATTTACAGTGAAGGATC
AGGTGTTATCTACAAAAAAGATGGTGACAGTGCCTATCTAGTCACTAACAATCATGTGATTGACGGAGCAGAAAAACTTG
AAATCATGTTAGCCAACGGCACCAAGGTAGTCGGTGAGCTTGTGGGTGCGGACACCTATTCTGATTTGGCTGTGATTAAA
ATTTCATCCAAAAACGTTGATACGGTTGCTGAATTTGCAGATTCGACCAAATTAAATGTTGGTGAACCTGCTATTGCAAT
TGGAAGTCCTTTAGGAAGTGAATACGCTAATTCCGTTACAGAAGGAATTGTTTCCAGCCTCAGTCGTACCGTCACTAGCC
AAAATGAGGAAGGGGAAACCATCTCAACAAATGCCATCCAGACCGATGCAGCAATCAACCCTGGGAATTCTGGGGGACCT
CTAATCAATATCAAAGGTCAGGTTATCGGCATCAATTCAAGTAAAATTGCGTCTAGCAGCAGTTCCAGCAGCGGTGTCGC
AGTAGAAGGAATGGGCTTTGCAATCCCTTCAAACGATGTTGTTTCGATTATCAATCAGTTGGAAGAAAATGGTAAAGTTA
TTCGTCCGGCACTGGGTATTTCTATGGCTGATTTAAGTCAGGCTTCTACAAGTGCCATCAATGAATTAAATCTTCCTGAT
GATGTGACAAGCGGTATTATTGTTCTTGGAACACAATCTGGCATGCCTGCAGACGGCAAACTTAAAAAATACGATGTCAT
TACTGAAATTGATGGTAAGAAAATTGAATCAACCAGCGATCTTCAAAGTATCCTTTATAAACATAAGAAAGGTGATACAA
TTGAAATAACCTTCTATCGCGGTAAGGACAAGAAAACAGTCAAACTTGAGTTAGATAAAACAACTGAAGATCTATCCTAA

Domains

Predicted by InterproScan.

• PDZ domain (PDZ_2) (296-391)

• Peptidase family M50 (Peptidase_M50) (22-395)

• Trypsin-like peptidase domain (Trypsin_2) (106-251)

3D structure

• AlphaFold DB: A0A2X3W734

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus mutans UA159	74	100	0.742
htrA	Streptococcus gordonii str. Challis substr. CH1	56.824	100	0.574
htrA	Streptococcus mitis NCTC 12261	58.163	98.246	0.571
htrA	Streptococcus pneumoniae TIGR4	57.653	98.246	0.566
htrA	Streptococcus pneumoniae D39	57.653	98.246	0.566
htrA	Streptococcus pneumoniae Rx1	57.653	98.246	0.566
htrA	Streptococcus pneumoniae R6	57.653	98.246	0.566