Detailed information    

insolico Bioinformatically predicted

Overview

Name   pknB   Type   Regulator
Locus tag   DQL21_RS02295 Genome accession   NZ_LS483343
Coordinates   425017..426849 (+) Length   610 a.a.
NCBI ID   WP_018030906.1    Uniprot ID   -
Organism   Streptococcus ferus strain NCTC12278     
Function   modulate the activity of ComDE; modulate the activity of VicKR (predicted from homology)   
Competence regulation

Genomic Context

Location: 420017..431849
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQL21_RS02280 (NCTC12278_00440) fmt 421984..422919 (+) 936 WP_018030909.1 methionyl-tRNA formyltransferase -
  DQL21_RS02285 (NCTC12278_00441) rsmB 422909..424237 (+) 1329 WP_018030908.1 16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB -
  DQL21_RS02290 (NCTC12278_00442) - 424277..425020 (+) 744 WP_026161987.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -
  DQL21_RS02295 (NCTC12278_00443) pknB 425017..426849 (+) 1833 WP_018030906.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  DQL21_RS02300 (NCTC12278_00444) liaF 426954..427652 (+) 699 WP_018030905.1 cell wall-active antibiotics response protein LiaF -
  DQL21_RS02305 (NCTC12278_00445) - 427649..428653 (+) 1005 WP_018030904.1 sensor histidine kinase -
  DQL21_RS02310 (NCTC12278_00446) - 428646..429287 (+) 642 WP_018030903.1 response regulator transcription factor -
  DQL21_RS02315 (NCTC12278_00447) - 429322..430719 (+) 1398 WP_018030902.1 Cof-type HAD-IIB family hydrolase -
  DQL21_RS02320 (NCTC12278_00448) - 430719..431075 (+) 357 WP_018030901.1 S1 RNA-binding domain-containing protein -

Sequence

Protein


Download         Length: 610 a.a.        Molecular weight: 65956.01 Da        Isoelectric Point: 9.3793

>NTDB_id=1137583 DQL21_RS02295 WP_018030906.1 425017..426849(+) (pknB) [Streptococcus ferus strain NCTC12278]
MIQIGKLFAGRYRILQSVGRGGMADVYLAQDLIIDNEEVAIKVLRTNYQTDQVAVARFQREARAMAELNHPNIVSIRDIG
EEDGQQFLVMEYVDGADLKKYIQDHAPLSNVEVIRIMGEVLSAMTLAHQKGIIHRDLKPQNVLLTKDGTAKVTDFGIAVA
FAETSLTQTNSMLGSVHYLSPEQARGSKATVQSDIYAMGIMLFEMLTGEIPYDGDSAVTIALQHFQKPLPSIRSINRNVP
QALENVVIRATAKKLSDRYQTTGQMTKDLMSSLQADRANEQKLVFSDPSDTKPLPKITASTAAAAKQAAKTDQKPKEATK
PAAPKPTKKPKKKKRFLSLFLKIFFLLVMLGIGFLAYSILARPGAVSVPDVTGKSLAAAKTTLTDAGLKVGTVTKVEDST
VEVGKVVRTDPSAGSQKREGSKVNIYISKAKSFTMANYVGQDYQTAVDDLVNNYGVSSDMITIKRVESSTYSDGQVISQT
PKSGKTYSLSSNKKITLRVASTESTTMPNLTGLTYREAVATLTNLGVDESRIKAYNVAGTTLISSPSATAILAGQKPYYG
SSLSLTSSDDVILYLETETTSEEGQSSNTTEATTSNPSTETTTSEATSSN

Nucleotide


Download         Length: 1833 bp        

>NTDB_id=1137583 DQL21_RS02295 WP_018030906.1 425017..426849(+) (pknB) [Streptococcus ferus strain NCTC12278]
ATGATTCAGATTGGCAAGTTATTTGCTGGTCGTTATCGCATTCTCCAATCGGTCGGACGGGGTGGTATGGCGGATGTTTA
TTTAGCTCAGGACTTGATTATTGATAATGAAGAAGTGGCCATTAAGGTTCTGCGGACCAATTATCAGACGGATCAGGTGG
CTGTCGCACGTTTTCAGAGAGAAGCGCGTGCGATGGCAGAGCTGAACCATCCTAATATTGTCTCTATCCGAGACATTGGA
GAAGAGGACGGACAGCAATTCCTAGTGATGGAATACGTTGACGGTGCGGATTTGAAGAAGTACATTCAGGATCACGCTCC
TCTATCAAATGTTGAAGTCATCAGAATTATGGGTGAGGTTTTGTCGGCGATGACTTTAGCTCATCAAAAAGGCATTATTC
ATCGCGATTTAAAACCTCAAAATGTCCTGCTAACCAAGGATGGGACAGCTAAAGTGACAGACTTTGGTATTGCTGTTGCT
TTTGCGGAGACCAGTCTGACACAGACGAACTCCATGTTAGGTTCCGTTCATTATTTATCACCAGAGCAGGCCAGAGGCTC
TAAGGCAACCGTTCAAAGTGACATCTATGCCATGGGGATTATGCTCTTTGAGATGCTGACAGGAGAAATTCCTTATGATG
GTGATAGTGCGGTCACGATTGCTTTACAGCACTTTCAAAAGCCGCTCCCATCAATTAGGAGTATTAATCGGAATGTGCCT
CAGGCTCTGGAGAATGTTGTCATCAGAGCGACAGCTAAAAAACTGAGCGATCGTTATCAGACGACGGGTCAGATGACTAA
AGATTTGATGTCATCTCTTCAAGCCGATCGTGCCAATGAACAAAAACTGGTCTTTAGTGATCCTTCGGATACTAAACCTC
TTCCGAAAATCACAGCTTCGACAGCTGCAGCGGCTAAACAGGCCGCTAAAACAGATCAGAAGCCTAAGGAAGCCACAAAA
CCGGCTGCACCAAAGCCAACTAAAAAACCGAAGAAGAAAAAGCGGTTCTTATCACTCTTCCTGAAAATCTTCTTCTTATT
GGTGATGCTAGGCATCGGTTTTCTGGCTTACTCTATCTTAGCTAGGCCGGGAGCTGTGTCTGTTCCTGATGTGACAGGAA
AAAGCCTTGCGGCAGCTAAAACCACGCTTACAGATGCTGGGCTGAAGGTTGGTACAGTCACTAAGGTTGAAGACAGCACC
GTAGAGGTGGGCAAGGTGGTTAGAACAGATCCAAGTGCTGGCAGCCAAAAACGTGAAGGATCCAAAGTTAATATCTATAT
CTCCAAGGCCAAAAGCTTTACGATGGCTAATTACGTTGGTCAGGATTATCAGACGGCGGTTGATGATCTTGTTAACAATT
ACGGTGTTTCATCAGATATGATTACCATCAAGCGTGTTGAATCGTCTACATACAGTGACGGTCAGGTTATCAGTCAGACA
CCTAAGTCTGGTAAGACCTACAGTTTAAGCAGTAATAAGAAAATAACGTTGCGTGTTGCCTCAACAGAGTCAACGACGAT
GCCAAACTTGACAGGTTTAACCTACAGAGAAGCGGTTGCTACCCTGACGAACTTAGGTGTCGATGAGTCTCGAATTAAGG
CTTACAATGTTGCGGGAACAACTCTTATTTCATCGCCATCAGCAACCGCTATTTTGGCAGGGCAAAAGCCTTATTATGGC
TCTAGTCTTAGCCTGACTTCGAGTGATGATGTCATTCTCTACTTGGAAACAGAAACCACTTCAGAGGAGGGGCAGTCCTC
TAATACAACAGAAGCGACAACTTCCAATCCATCAACAGAAACAACGACAAGTGAAGCGACATCGTCTAACTGA

Domains

Predicted by InterproScan.

PASTA domain (PASTA)

(434-500)

PASTA domain (PASTA)

(366-429)

PASTA domain (PASTA)

(506-575)

Protein kinase domain (Pkinase)

(12-241)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  pknB Streptococcus mutans UA159

71.379

95.082

0.679
  stkP/pknB Streptococcus salivarius strain HSISS4

62.649

96.557

0.605
  stkP Streptococcus pneumoniae TIGR4

53.245

98.525

0.525
  stkP Streptococcus pneumoniae D39

53.078

98.525

0.523
  stkP Streptococcus pneumoniae R6

53.078

98.525

0.523
  stkP Streptococcus pneumoniae Rx1

52.912

98.525

0.521

Multiple sequence alignment