Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   DQL21_RS01425 Genome accession   NZ_LS483343
Coordinates   253897..254613 (+) Length   238 a.a.
NCBI ID   WP_018030770.1    Uniprot ID   A0A2X3VVN9
Organism   Streptococcus ferus strain NCTC12278     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Genomic Context

Location: 248897..259613
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQL21_RS01410 (NCTC12278_00268) - 249323..250876 (-) 1554 WP_018030773.1 ABC transporter substrate-binding protein/permease -
  DQL21_RS01415 (NCTC12278_00269) - 251012..252901 (+) 1890 WP_018030772.1 DUF2207 domain-containing protein -
  DQL21_RS01420 (NCTC12278_00270) - 252953..253804 (+) 852 WP_018030771.1 undecaprenyl-diphosphate phosphatase -
  DQL21_RS01425 (NCTC12278_00271) mecA 253897..254613 (+) 717 WP_018030770.1 adaptor protein MecA Regulator
  DQL21_RS01430 (NCTC12278_00272) - 254618..255775 (+) 1158 WP_018030769.1 glycosyltransferase family 4 protein -
  DQL21_RS01435 (NCTC12278_00273) sufC 255854..256624 (+) 771 WP_018030768.1 Fe-S cluster assembly ATPase SufC -
  DQL21_RS01440 (NCTC12278_00274) sufD 256662..257924 (+) 1263 WP_018030767.1 Fe-S cluster assembly protein SufD -
  DQL21_RS01445 (NCTC12278_00275) - 257924..259156 (+) 1233 WP_018030766.1 cysteine desulfurase -
  DQL21_RS01450 (NCTC12278_00276) sufU 259143..259586 (+) 444 WP_018030765.1 Fe-S cluster assembly sulfur transfer protein SufU -

Sequence

Protein


Download         Length: 238 a.a.        Molecular weight: 27337.87 Da        Isoelectric Point: 4.0872

>NTDB_id=1137565 DQL21_RS01425 WP_018030770.1 253897..254613(+) (mecA) [Streptococcus ferus strain NCTC12278]
MEMKQISETTLKITISMDDLEERGMELKDFLIPQEKTEEFFYAVMDELDLPENFKDSGMLSFRVTPRKDRIDVFVTKSEI
SKDLNLEDLADMEDIAQMSPEDFFKTLEQNMRDKGDAEALDRLAEAEKAEETAASSEEEPAQEFVHFVLDFDSIEDVVRF
AQAVNFDVEASELFKVGDNYYMTVLLNLIDKPSYYLNLMHARILEYASPGTKTRAYLLEHGVQLLSADTLAHLKMIGQ

Nucleotide


Download         Length: 717 bp        

>NTDB_id=1137565 DQL21_RS01425 WP_018030770.1 253897..254613(+) (mecA) [Streptococcus ferus strain NCTC12278]
ATGGAAATGAAACAGATTAGTGAAACCACACTGAAAATAACAATCAGCATGGATGATCTTGAAGAAAGAGGGATGGAATT
GAAGGATTTCTTGATTCCTCAGGAAAAGACCGAAGAGTTTTTCTATGCTGTCATGGATGAACTGGACTTGCCAGAAAATT
TTAAGGATAGCGGTATGCTGAGTTTTCGTGTCACCCCTCGCAAGGATCGGATTGACGTGTTTGTGACCAAGTCTGAAATC
AGTAAGGACTTAAACTTAGAGGACTTGGCCGACATGGAAGATATTGCGCAGATGTCTCCAGAAGATTTTTTCAAAACCTT
GGAGCAAAATATGAGAGATAAAGGAGATGCTGAGGCTCTAGATAGGCTGGCAGAAGCTGAGAAGGCAGAAGAAACCGCTG
CAAGCTCAGAAGAAGAACCCGCGCAAGAGTTTGTCCATTTTGTTCTGGACTTTGACAGCATTGAGGATGTGGTCCGCTTT
GCTCAGGCGGTCAACTTTGATGTGGAGGCTTCAGAGCTTTTCAAGGTCGGTGACAATTACTACATGACCGTGCTGCTGAA
TCTCATTGATAAACCGAGCTATTATCTTAATCTCATGCACGCACGAATCTTGGAATACGCTTCCCCGGGGACAAAAACAA
GAGCTTATCTGCTGGAACACGGTGTTCAGCTCCTATCAGCTGATACCTTGGCGCACTTGAAAATGATAGGACAATAA

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-233)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A2X3VVN9

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus mutans UA159

74.583

100

0.752
  mecA Streptococcus thermophilus LMD-9

59.426

100

0.609
  mecA Streptococcus thermophilus LMG 18311

58.607

100

0.601
  mecA Streptococcus pneumoniae Rx1

48.79

100

0.508
  mecA Streptococcus pneumoniae D39

48.79

100

0.508
  mecA Streptococcus pneumoniae R6

48.79

100

0.508
  mecA Streptococcus pneumoniae TIGR4

48.79

100

0.508

Multiple sequence alignment