Detailed information    

insolico Bioinformatically predicted

Overview

Name   pknB   Type   Regulator
Locus tag   DQL56_RS08970 Genome accession   NZ_LS483342
Coordinates   1717491..1719446 (-) Length   651 a.a.
NCBI ID   WP_000614568.1    Uniprot ID   A0A076Z512
Organism   Streptococcus agalactiae strain NCTC11930     
Function   modulate the activity of ComDE; modulate the activity of VicKR (predicted from homology)   
Competence regulation

Genomic Context

Location: 1712491..1724446
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQL56_RS08945 (NCTC11930_01769) - 1713185..1713541 (-) 357 WP_000689608.1 S1 RNA-binding domain-containing protein -
  DQL56_RS08950 (NCTC11930_01770) - 1713543..1714943 (-) 1401 WP_000339133.1 bifunctional Cof-type HAD-IIB family hydrolase/peptidylprolyl isomerase -
  DQL56_RS08955 (NCTC11930_01771) - 1714985..1715626 (-) 642 WP_000357892.1 response regulator transcription factor -
  DQL56_RS08960 (NCTC11930_01772) - 1715619..1716638 (-) 1020 WP_000716170.1 sensor histidine kinase -
  DQL56_RS08965 (NCTC11930_01773) liaF 1716635..1717330 (-) 696 WP_000714456.1 cell wall-active antibiotics response protein LiaF -
  DQL56_RS08970 (NCTC11930_01774) pknB 1717491..1719446 (-) 1956 WP_000614568.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  DQL56_RS08975 (NCTC11930_01775) - 1719446..1720183 (-) 738 WP_000406233.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -
  DQL56_RS08980 (NCTC11930_01776) rsmB 1720221..1721543 (-) 1323 WP_001262599.1 16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB -
  DQL56_RS08985 (NCTC11930_01777) fmt 1721533..1722468 (-) 936 WP_000163893.1 methionyl-tRNA formyltransferase -

Sequence

Protein


Download         Length: 651 a.a.        Molecular weight: 70799.56 Da        Isoelectric Point: 9.6759

>NTDB_id=1137548 DQL56_RS08970 WP_000614568.1 1717491..1719446(-) (pknB) [Streptococcus agalactiae strain NCTC11930]
MIQIGKLFAGRYRILKSIGRGGMADVYLARDLILDNEEVAIKVLRTNYQTDQIAVARFQREARAMAELTHPNIVAIRDIG
EEDGQQFLVMEYVDGFDLKKYIQDNAPLSNNEVVRIMNEVLSAMSLAHQKGIVHRDLKPQNILLTKKGTVKVTDFGIAVA
FAETSLTQTNSMLGSVHYLSPEQARGSKATVQSDIYAMGIMLFEMLTGHIPYDGDSAVTIALQHFQKPLPSILAENKSVP
QALENIVIKATAKKLTDRYKTTYEMGRDLSTALSSTRHREPKLVFNDTESTKTLPKVTSTVSSLTTEQLLRNQKQAKTTE
KITPDSASNDKTKSKKKASHRLLGTIMKLFFALCVVGIIVFAYKILVSPTTIRVPDVSNKTVAQAKMTLENSGLKVGAIR
NIESDSVSEGLVVKTDPAAGRSRREGAKVNLYIATPNKSFTLGNYKEHNYKDILKDLQGKGVKKSLIKVKRKINNDYTTG
TILAQSLPEGTSFNPDGNKKLTLTVAVNDPMIMPDVTGMTVGEVIETLTDLGLDADNLVFYQMQNGVYQTVVTPPSSSKI
ASQDPYYGGEVGLRRGDKVKLYLLGSKTTNNSSSTPIDSSASSSTGTTTSDSVSSSTDASTSDSSSTSTSSSTLPSDSTT
NTGTANNPLTQ

Nucleotide


Download         Length: 1956 bp        

>NTDB_id=1137548 DQL56_RS08970 WP_000614568.1 1717491..1719446(-) (pknB) [Streptococcus agalactiae strain NCTC11930]
ATGATTCAGATTGGCAAATTATTTGCTGGTCGTTATCGGATCCTTAAATCAATCGGACGAGGTGGAATGGCGGATGTTTA
TCTAGCTCGAGATCTAATTTTAGATAATGAAGAGGTCGCAATAAAAGTATTGCGAACCAATTATCAAACAGATCAGATTG
CGGTTGCTCGCTTCCAGAGAGAAGCACGAGCAATGGCTGAGCTGACACATCCTAATATTGTCGCTATTCGTGATATAGGT
GAAGAAGACGGACAGCAGTTCTTAGTAATGGAATATGTTGATGGATTCGATTTAAAAAAGTATATTCAAGACAATGCACC
CCTATCAAATAATGAAGTTGTTCGAATCATGAATGAAGTCCTTTCAGCCATGTCACTGGCACATCAGAAAGGTATCGTAC
ACCGTGATTTAAAACCTCAAAATATTTTATTAACTAAAAAAGGGACTGTAAAAGTTACAGATTTCGGTATTGCGGTAGCG
TTTGCTGAAACTAGTTTAACGCAAACGAATTCTATGTTAGGTAGTGTTCATTATTTATCGCCAGAGCAGGCGCGTGGTTC
AAAAGCGACTGTTCAGAGTGATATTTATGCCATGGGAATCATGCTTTTTGAAATGTTAACTGGCCATATTCCTTATGATG
GGGATAGTGCAGTTACTATTGCCCTACAGCACTTCCAAAAACCACTACCATCAATCCTTGCAGAAAATAAAAGCGTTCCA
CAAGCTTTGGAAAACATTGTCATTAAAGCAACAGCTAAAAAGCTAACAGATCGCTATAAGACAACTTATGAGATGGGACG
TGATTTATCAACTGCTCTAAGCTCGACACGTCACCGTGAACCAAAACTTGTTTTTAATGATACTGAGAGTACTAAGACAC
TACCCAAAGTAACATCTACAGTATCATCTCTAACGACAGAACAACTGTTGCGTAATCAAAAACAGGCCAAAACAACAGAA
AAAATAACTCCTGATTCTGCGAGTAACGATAAAACGAAGTCTAAAAAGAAGGCTTCTCATCGACTTCTTGGTACAATCAT
GAAATTATTCTTTGCACTCTGTGTTGTAGGAATAATTGTATTTGCTTATAAAATTTTAGTAAGTCCTACGACTATTCGTG
TTCCAGATGTTAGCAACAAAACAGTAGCTCAAGCAAAAATGACATTGGAAAATTCTGGATTGAAAGTAGGAGCTATTCGT
AATATTGAGAGTGATAGTGTTTCAGAAGGACTTGTCGTAAAAACAGACCCTGCTGCAGGACGTTCTCGCAGAGAAGGGGC
TAAAGTTAATCTTTATATTGCCACTCCAAACAAGAGTTTCACTCTAGGTAATTATAAGGAACATAATTACAAAGATATCC
TCAAAGATCTTCAAGGCAAAGGTGTTAAAAAATCTTTAATCAAGGTTAAGCGTAAAATTAATAATGATTATACTACTGGT
ACAATCTTAGCACAGTCGCTTCCAGAAGGAACATCTTTTAATCCTGATGGTAATAAGAAATTAACACTTACGGTTGCTGT
TAATGATCCAATGATTATGCCTGATGTAACAGGTATGACTGTTGGAGAAGTAATAGAAACCTTGACAGACCTCGGATTAG
ATGCAGATAATCTTGTCTTCTATCAAATGCAAAATGGCGTTTATCAAACAGTAGTAACACCTCCATCTTCAAGTAAGATA
GCAAGTCAGGATCCTTATTACGGAGGAGAAGTTGGATTAAGGAGAGGAGATAAAGTTAAGCTGTATCTTCTTGGTTCTAA
AACAACGAATAACTCATCATCTACGCCAATAGATTCTTCGGCTTCAAGCTCAACAGGAACAACTACCTCGGATTCTGTAA
GCTCATCAACGGATGCTAGCACTTCTGATAGTAGTAGCACTTCTACAAGTAGTTCAACACTACCAAGTGATAGTACAACT
AATACAGGAACAGCTAACAATCCATTAACTCAATAA

Domains

Predicted by InterproScan.

PASTA domain (PASTA)

(511-583)

PASTA domain (PASTA)

(373-434)

PASTA domain (PASTA)

(441-506)

Protein kinase domain (Pkinase)

(12-254)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A076Z512

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  pknB Streptococcus mutans UA159

60.959

89.708

0.547
  stkP/pknB Streptococcus salivarius strain HSISS4

60.9

88.786

0.541
  stkP Streptococcus pneumoniae TIGR4

59.612

79.109

0.472
  stkP Streptococcus pneumoniae D39

59.417

79.109

0.47
  stkP Streptococcus pneumoniae R6

59.417

79.109

0.47
  stkP Streptococcus pneumoniae Rx1

59.223

79.109

0.469

Multiple sequence alignment