Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   DQL04_RS01405 Genome accession   NZ_LS483340
Coordinates   253127..253888 (+) Length   253 a.a.
NCBI ID   WP_047235655.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain NCTC12062     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Genomic Context

Location: 248127..258888
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQL04_RS01390 (NCTC12062_00279) - 248385..249953 (-) 1569 WP_002991130.1 ABC transporter substrate-binding protein/permease -
  DQL04_RS01395 (NCTC12062_00280) - 250151..252076 (+) 1926 WP_047235654.1 DUF2207 domain-containing protein -
  DQL04_RS01400 (NCTC12062_00281) - 252142..252981 (+) 840 WP_002991126.1 undecaprenyl-diphosphate phosphatase -
  DQL04_RS01405 (NCTC12062_00282) mecA 253127..253888 (+) 762 WP_047235655.1 adaptor protein MecA Regulator
  DQL04_RS01410 (NCTC12062_00283) - 253895..255064 (+) 1170 WP_014407298.1 glycosyltransferase family 4 protein -
  DQL04_RS01415 (NCTC12062_00284) sufC 255186..255956 (+) 771 WP_002986023.1 Fe-S cluster assembly ATPase SufC -
  DQL04_RS01420 (NCTC12062_00285) sufD 256051..257313 (+) 1263 WP_047235656.1 Fe-S cluster assembly protein SufD -
  DQL04_RS01425 (NCTC12062_00286) - 257344..258570 (+) 1227 WP_011054183.1 cysteine desulfurase -

Sequence

Protein


Download         Length: 253 a.a.        Molecular weight: 29079.78 Da        Isoelectric Point: 4.1622

>NTDB_id=1137407 DQL04_RS01405 WP_047235655.1 253127..253888(+) (mecA) [Streptococcus pyogenes strain NCTC12062]
MEMKQISETTLKITISMDDLEERGMELKDFLIPQEKTEEFFYSVMDELDLPDNFKDSGMLSFRVTPRKDRLDVFVTKSEI
NKDINLEDLAEFGDMSQMTPEDFFKSLEQSMREKGDVKAHEKLEKIEEIMEDVVEATLANQSEAVDPSTNHESEPLDYVH
YVLDFSTITEAVAFAKTIDFSIEASELYKGSNCYHMTILLDVQQQPSYFANVMYARLIEHANPGSKTRAYLQEHGLQLML
DGAVEQLQKIELG

Nucleotide


Download         Length: 762 bp        

>NTDB_id=1137407 DQL04_RS01405 WP_047235655.1 253127..253888(+) (mecA) [Streptococcus pyogenes strain NCTC12062]
ATGGAAATGAAACAAATTAGCGAGACAACGCTAAAAATAACAATTAGTATGGACGATTTAGAAGAAAGAGGAATGGAGTT
GAAAGATTTCTTGATTCCTCAAGAAAAAACAGAAGAGTTTTTCTATTCTGTGATGGACGAACTCGATCTTCCAGATAATT
TTAAAGATAGTGGTATGCTTAGTTTTCGAGTGACTCCACGCAAGGACCGTCTAGATGTTTTTGTTACCAAATCTGAGATA
AATAAAGATATTAATCTTGAAGATTTAGCAGAGTTTGGTGATATGTCCCAAATGACTCCGGAAGATTTTTTCAAGAGCTT
GGAGCAATCCATGCGTGAAAAGGGAGATGTCAAAGCTCATGAAAAATTGGAAAAAATTGAAGAGATAATGGAAGATGTTG
TTGAAGCCACTCTAGCTAATCAGTCTGAAGCGGTTGATCCATCAACTAATCATGAGTCAGAACCTTTAGACTATGTCCAT
TATGTATTGGATTTTTCAACGATTACAGAGGCAGTGGCTTTTGCTAAAACGATTGATTTTTCGATAGAAGCTTCAGAGTT
ATATAAGGGGAGCAACTGCTACCATATGACTATTTTATTAGATGTTCAGCAACAACCATCTTATTTTGCGAATGTCATGT
ATGCGAGATTGATTGAGCATGCAAACCCTGGATCAAAAACAAGAGCTTATTTACAAGAGCATGGCTTACAATTGATGCTT
GATGGTGCTGTTGAGCAATTACAAAAGATTGAGTTGGGATAA

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-247)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus mutans UA159

63.2

98.814

0.625
  mecA Streptococcus thermophilus LMD-9

57.028

98.419

0.561
  mecA Streptococcus thermophilus LMG 18311

56.225

98.419

0.553
  mecA Streptococcus pneumoniae Rx1

48.235

100

0.486
  mecA Streptococcus pneumoniae D39

48.235

100

0.486
  mecA Streptococcus pneumoniae R6

48.235

100

0.486
  mecA Streptococcus pneumoniae TIGR4

48.235

100

0.486

Multiple sequence alignment