Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   DQL30_RS01495 Genome accession   NZ_LS483333
Coordinates   260253..261014 (+) Length   253 a.a.
NCBI ID   WP_111713597.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain NCTC12048     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Genomic Context

Location: 255253..266014
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQL30_RS01480 (NCTC12048_00295) - 255511..257079 (-) 1569 WP_002991130.1 ABC transporter substrate-binding protein/permease -
  DQL30_RS01485 (NCTC12048_00296) - 257277..259202 (+) 1926 WP_111703126.1 DUF2207 domain-containing protein -
  DQL30_RS01490 (NCTC12048_00297) - 259268..260107 (+) 840 WP_111713596.1 undecaprenyl-diphosphate phosphatase -
  DQL30_RS01495 (NCTC12048_00298) mecA 260253..261014 (+) 762 WP_111713597.1 adaptor protein MecA Regulator
  DQL30_RS01500 (NCTC12048_00299) - 261021..262190 (+) 1170 WP_111713598.1 glycosyltransferase family 4 protein -
  DQL30_RS01505 (NCTC12048_00300) sufC 262312..263082 (+) 771 WP_002986023.1 Fe-S cluster assembly ATPase SufC -
  DQL30_RS01510 (NCTC12048_00301) sufD 263177..264439 (+) 1263 WP_023079318.1 Fe-S cluster assembly protein SufD -
  DQL30_RS01515 (NCTC12048_00302) - 264470..265696 (+) 1227 WP_111713599.1 cysteine desulfurase -

Sequence

Protein


Download         Length: 253 a.a.        Molecular weight: 29067.77 Da        Isoelectric Point: 4.1622

>NTDB_id=1137010 DQL30_RS01495 WP_111713597.1 260253..261014(+) (mecA) [Streptococcus pyogenes strain NCTC12048]
MEMKQISETTLKITISMDDLEERGMELKDFLIPQEKTEEFFYSVMDELDLPDNFKDSGMLSFRVTPRKDRLDVFVTKSEI
NKDINLEDLAEFGDMSQMTPEDFFKSLEQSMREKGDVKAHEKLEKIEEIMEDVVEATLANQSEAADPSTNHESELLDYVH
YVLDFSTITEAVAFAKTIDFSIEASELYKGSNCYHMTILLDVQQQPSYFANVMYARLIEHANPGSKTRAYLQEHGLQLML
DGAVEQLQKIELG

Nucleotide


Download         Length: 762 bp        

>NTDB_id=1137010 DQL30_RS01495 WP_111713597.1 260253..261014(+) (mecA) [Streptococcus pyogenes strain NCTC12048]
ATGGAAATGAAACAAATTAGCGAGACAACGCTAAAAATAACAATTAGTATGGACGATTTAGAAGAAAGAGGAATGGAGTT
GAAAGATTTCTTGATTCCTCAAGAAAAAACAGAAGAGTTTTTCTATTCTGTGATGGACGAACTCGATCTTCCAGATAATT
TTAAAGATAGTGGTATGCTTAGTTTTCGAGTGACTCCACGCAAAGACCGTCTAGATGTTTTTGTTACCAAATCTGAGATA
AATAAAGATATTAATCTTGAAGATTTAGCAGAGTTTGGTGATATGTCCCAAATGACTCCGGAAGATTTTTTCAAGAGCTT
GGAGCAATCCATGCGTGAAAAGGGAGATGTCAAAGCTCATGAAAAATTGGAAAAAATTGAAGAGATAATGGAAGATGTTG
TTGAAGCCACTCTAGCTAATCAGTCTGAGGCGGCTGATCCATCAACTAATCATGAGTCAGAACTTTTAGACTATGTCCAT
TATGTATTGGATTTTTCAACGATTACAGAGGCAGTGGCTTTTGCTAAAACGATTGATTTTTCGATAGAAGCTTCAGAGTT
ATATAAGGGGAGCAACTGCTACCATATGACTATTTTATTAGATGTTCAGCAACAACCATCTTATTTTGCGAATGTCATGT
ATGCGAGATTGATTGAGCATGCAAACCCTGGATCAAAAACAAGAGCTTATTTACAAGAGCATGGCTTACAATTGATGCTT
GATGGTGCTGTTGAGCAATTACAAAAGATTGAGTTGGGATAA

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-247)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus mutans UA159

63.2

98.814

0.625
  mecA Streptococcus thermophilus LMD-9

56.225

98.419

0.553
  mecA Streptococcus thermophilus LMG 18311

55.422

98.419

0.545
  mecA Streptococcus pneumoniae Rx1

47.843

100

0.482
  mecA Streptococcus pneumoniae D39

47.843

100

0.482
  mecA Streptococcus pneumoniae R6

47.843

100

0.482
  mecA Streptococcus pneumoniae TIGR4

47.843

100

0.482

Multiple sequence alignment