Detailed information NTG1136828

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: DQL25_RS00280
• Genome accession: NZ_LS483330
• Coordinates: 47264..48175 (+)
• Length: 303 a.a.
• NCBI ID: WP_002986681.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain NCTC8328
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 42264..53175

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQL25_RS00250 (NCTC8328_00049)	purE	42433..42924 (+)	492	WP_002986689.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
DQL25_RS00255 (NCTC8328_00050)	purK	42911..43984 (+)	1074	WP_168391422.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
DQL25_RS00260 (NCTC8328_00051)	-	43985..44914 (+)	930	WP_111703086.1	hypothetical protein	-
DQL25_RS00265 (NCTC8328_00052)	-	44917..45486 (+)	570	WP_032460531.1	hypothetical protein	-
DQL25_RS00270	-	45664..45843 (+)	180	WP_032460530.1	hypothetical protein	-
DQL25_RS00275 (NCTC8328_00053)	purB	45840..47132 (+)	1293	WP_111703087.1	adenylosuccinate lyase	-
DQL25_RS00280 (NCTC8328_00054)	comR	47264..48175 (+)	912	WP_002986681.1	transcriptional regulator Rgg4/ComR	Regulator
DQL25_RS09910 (NCTC8328_00055)	comS	48260..48355 (+)	96	WP_198462994.1	quorum-sensing system DWW-type pheromone	Regulator
DQL25_RS00285 (NCTC8328_00056)	ruvB	48402..49400 (+)	999	WP_002986679.1	Holliday junction branch migration DNA helicase RuvB	-
DQL25_RS00290 (NCTC8328_00057)	-	49538..49975 (+)	438	WP_002994668.1	low molecular weight protein-tyrosine-phosphatase	-
DQL25_RS00295 (NCTC8328_00058)	-	49998..50399 (+)	402	WP_011017240.1	MORN repeat-containing protein	-
DQL25_RS00300 (NCTC8328_00059)	-	50396..52171 (+)	1776	WP_002987732.1	acyltransferase family protein	-

Sequence

Protein

• Length: 303 a.a.
• Molecular weight: 35757.27 Da
• Isoelectric Point: 4.4858

>NTDB_id=1136828 DQL25_RS00280 WP_002986681.1 47264..48175(+) (comR) [Streptococcus pyogenes strain NCTC8328]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKIIIDCLQATLDTLLSENTNFGIDLLQEYFNQIKTKVRFRQND
LILLELYLAYLDIEGMDGQYSDKIFYDSLLDNLSEQFEQFELDELFIVNKIIIDISSLSLKNNRLDNLEKAIEMSQKIMA
KIQDWNRMPILKLIEWKYFLIKQKDIIKAEQSFMKACLFAQMTADQYLENKLIQEWEKDVKSY

Nucleotide

• Length: 912 bp

>NTDB_id=1136828 DQL25_RS00280 WP_002986681.1 47264..48175(+) (comR) [Streptococcus pyogenes strain NCTC8328]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAATAATCATTGATTGTTTACAGGCAACTTTAGATACTTTATTGAGTG
AGAATACTAACTTTGGCATTGACTTACTTCAAGAATATTTTAATCAAATAAAGACTAAGGTACGCTTTAGGCAAAATGAT
TTAATACTTCTAGAATTATATTTAGCTTATCTTGATATTGAGGGAATGGATGGACAATATTCAGATAAGATTTTTTATGA
TTCTTTATTAGATAATCTATCAGAACAATTTGAACAATTTGAATTAGATGAATTATTTATAGTTAATAAGATTATCATTG
ATATTTCATCACTAAGCTTAAAAAATAACCGACTTGATAATTTAGAAAAAGCGATTGAAATGAGTCAAAAAATTATGGCG
AAAATTCAAGATTGGAATAGAATGCCTATTTTAAAACTAATAGAATGGAAATATTTTTTAATCAAACAAAAAGATATAAT
AAAAGCAGAACAATCATTTATGAAGGCATGTTTGTTCGCCCAAATGACAGCTGATCAGTATTTGGAAAACAAGTTAATTC
AAGAGTGGGAAAAAGATGTTAAAAGTTATTAA

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (12-64)

• ComR tetratricopeptide (ComR_TPR) (73-296)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS8232	100	100	1
comR	Streptococcus pyogenes MGAS315	58.472	99.34	0.581
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	51.37	96.37	0.495
comR	Streptococcus mutans UA159	46.358	99.67	0.462