Detailed information    

insolico Bioinformatically predicted

Overview

Name   pknB   Type   Regulator
Locus tag   DQL27_RS06465 Genome accession   NZ_LS483329
Coordinates   1255212..1257110 (-) Length   632 a.a.
NCBI ID   WP_076634159.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain NCTC12058     
Function   modulate the activity of ComDE; modulate the activity of VicKR (predicted from homology)   
Competence regulation

Genomic Context

Location: 1250212..1262110
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQL27_RS06440 (NCTC12058_01281) - 1250948..1251325 (-) 378 WP_002983674.1 S1 RNA-binding domain-containing protein -
  DQL27_RS06445 (NCTC12058_01282) - 1251325..1252725 (-) 1401 WP_031488509.1 bifunctional Cof-type HAD-IIB family hydrolase/peptidylprolyl isomerase -
  DQL27_RS06450 (NCTC12058_01283) - 1252762..1253403 (-) 642 WP_002983671.1 response regulator transcription factor -
  DQL27_RS06455 (NCTC12058_01284) - 1253396..1254400 (-) 1005 WP_002991890.1 sensor histidine kinase -
  DQL27_RS06460 (NCTC12058_01285) liaF 1254397..1255089 (-) 693 WP_011054833.1 cell wall-active antibiotics response protein LiaF -
  DQL27_RS06465 (NCTC12058_01286) pknB 1255212..1257110 (-) 1899 WP_076634159.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  DQL27_RS06470 (NCTC12058_01287) - 1257107..1257847 (-) 741 WP_002983660.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -
  DQL27_RS06475 (NCTC12058_01288) rsmB 1257885..1259207 (-) 1323 WP_014407741.1 16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB -
  DQL27_RS06480 (NCTC12058_01289) fmt 1259197..1260132 (-) 936 WP_031488507.1 methionyl-tRNA formyltransferase -

Sequence

Protein


Download         Length: 632 a.a.        Molecular weight: 68776.04 Da        Isoelectric Point: 7.6397

>NTDB_id=1136814 DQL27_RS06465 WP_076634159.1 1255212..1257110(-) (pknB) [Streptococcus pyogenes strain NCTC12058]
MIQIGKLFAGRYRILKSIGRGGMADVYLANDLILDNEDVAIKVLRTNYQTDQVAVARFQREARAMAELNHPNIVAIRDIG
EEDGQQFLVMEYVDGADLKRYIQNHAPLSNNEVVRIMEEVLSAMTLAHQKGIVHRDLKPQNILLTKNGVVKVTDFGIAVA
FAETSLTQTNSMLGSVHYLSPEQARGSKATIQSDIYAMGIMLFEMLTGHIPYDGDSAVTIALQHFQKPLPSIIEENHNVP
QALENVVIRATAKKLSDRYGSTFEMSRDLMTALSYNRSRERKIVFEDVESTKPLPKVASGPTASVKLSPPTPTVLTQESR
LDQTNQTDALQPPTKKKKSGRFLGTLFKILFSFFIVGVALFTYLILTKPTSVKVPNVAGTSLKVAKQELYDVGLKVGKIR
QIESDTVAEGNVVRTDPKAGTAKKQGSSITLYVSIGNKGFDMENYKGLDYQEAMNSLIETYGVPKSKIKIERIVTNEYPE
NTVISQSPSAGDKFNPNGKSKITLSVAVSDTITMPMVTEYSYADAVNTLTALGIDASRIKAYVPSSSSATGFVPIHSPSS
KAIVSGQSPYYGTSLSLSDKGEISLYLYPEETHSSSSSSSSTSSSNSSSTNDSTAPGSNTELSPSETTAQTP

Nucleotide


Download         Length: 1899 bp        

>NTDB_id=1136814 DQL27_RS06465 WP_076634159.1 1255212..1257110(-) (pknB) [Streptococcus pyogenes strain NCTC12058]
ATGATTCAGATTGGCAAATTATTTGCTGGTCGTTATCGCATTCTGAAATCTATTGGCCGCGGTGGTATGGCGGATGTTTA
TTTAGCAAATGATCTAATCTTGGATAATGAAGACGTTGCAATCAAGGTCTTGCGTACCAATTATCAAACAGATCAGGTAG
CAGTTGCGCGTTTCCAACGAGAAGCGCGGGCCATGGCTGAATTGAACCATCCCAATATTGTTGCCATCCGGGATATAGGT
GAAGAAGACGGACAGCAATTTTTAGTAATGGAATATGTGGATGGTGCTGACCTAAAGAGATACATTCAAAATCATGCTCC
ATTATCTAATAATGAAGTGGTTAGAATTATGGAAGAAGTCCTTTCTGCTATGACATTAGCTCACCAGAAAGGGATTGTTC
ATAGAGATTTAAAACCTCAAAACATTCTTTTAACTAAAAATGGTGTGGTTAAGGTAACTGACTTTGGGATTGCCGTTGCT
TTTGCGGAAACGAGTTTGACTCAAACCAACTCTATGTTGGGAAGCGTCCATTACCTATCGCCTGAGCAGGCTCGCGGCTC
CAAAGCGACGATTCAAAGTGATATTTATGCGATGGGGATTATGCTCTTTGAGATGTTGACAGGCCATATCCCTTATGATG
GCGATAGTGCTGTTACGATTGCCTTGCAACATTTTCAAAAGCCTCTTCCATCTATTATCGAGGAGAACCACAATGTGCCA
CAAGCTTTGGAGAATGTTGTTATTCGAGCAACAGCCAAGAAATTAAGTGATCGTTACGGGTCAACCTTTGAAATGAGTCG
TGACTTAATGACGGCGCTTAGTTATAATCGTAGTCGGGAGCGTAAGATTGTCTTTGAGGATGTTGAAAGTACCAAACCCC
TCCCCAAAGTGGCCTCAGGTCCCACCGCTTCTGTAAAATTGTCTCCCCCTACCCCAACAGTGTTAACACAGGAAAGTCGA
TTGGATCAAACTAATCAAACAGATGCTTTACAGCCCCCCACCAAAAAGAAAAAAAGTGGTCGTTTTTTAGGTACTTTATT
CAAAATTCTTTTTTCTTTCTTTATTGTAGGTGTAGCACTCTTTACTTATCTTATACTAACTAAACCAACTTCTGTGAAAG
TTCCTAATGTAGCAGGCACTAGTCTTAAAGTTGCCAAACAAGAACTGTATGATGTTGGGCTAAAAGTGGGTAAAATCAGG
CAAATTGAGAGTGATACGGTTGCTGAGGGAAATGTAGTTAGAACAGATCCTAAAGCAGGAACAGCTAAGAAGCAAGGCTC
AAGCATTACGCTTTATGTGTCAATTGGAAACAAAGGTTTTGACATGGAAAACTACAAAGGACTAGATTATCAAGAAGCTA
TGAATAGTTTGATAGAAACTTATGGTGTTCCAAAATCAAAAATCAAAATTGAGCGCATTGTAACTAATGAATATCCTGAA
AATACAGTCATCAGTCAATCGCCAAGTGCGGGTGATAAATTTAATCCAAACGGAAAGTCTAAAATTACGCTCAGTGTTGC
TGTGAGTGATACGATCACTATGCCTATGGTAACAGAATATAGTTATGCAGATGCAGTCAATACCTTAACAGCTTTAGGTA
TAGATGCATCTAGAATAAAAGCTTATGTGCCAAGCTCTAGCTCAGCAACGGGCTTTGTGCCAATTCATTCTCCTAGTTCT
AAAGCTATTGTCAGTGGTCAATCTCCTTACTATGGAACGTCTTTGAGTCTGTCTGATAAAGGAGAGATTAGTCTTTACCT
TTATCCAGAAGAAACACACTCTTCTAGTAGCTCATCGAGTTCAACGTCAAGTTCAAACAGTTCTTCAACAAATGATAGTA
CTGCACCAGGTAGCAACACTGAATTAAGCCCATCAGAAACTACTGCTCAAACACCTTAA

Domains

Predicted by InterproScan.

PASTA domain (PASTA)

(441-506)

PASTA domain (PASTA)

(372-434)

PASTA domain (PASTA)

(512-588)

Protein kinase domain (Pkinase)

(12-242)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  pknB Streptococcus mutans UA159

65.254

93.354

0.609
  stkP/pknB Streptococcus salivarius strain HSISS4

61.681

94.146

0.581
  stkP Streptococcus pneumoniae TIGR4

57.364

81.646

0.468
  stkP Streptococcus pneumoniae D39

57.171

81.646

0.467
  stkP Streptococcus pneumoniae R6

57.171

81.646

0.467
  stkP Streptococcus pneumoniae Rx1

56.977

81.646

0.465

Multiple sequence alignment