Detailed information    

insolico Bioinformatically predicted

Overview

Name   pknB   Type   Regulator
Locus tag   DQL35_RS08460 Genome accession   NZ_LS483325
Coordinates   1753936..1755831 (-) Length   631 a.a.
NCBI ID   WP_111678383.1    Uniprot ID   A0AAJ1PMZ4
Organism   Streptococcus equi subsp. zooepidemicus strain NCTC7022     
Function   modulate the activity of ComDE; modulate the activity of VicKR (predicted from homology)   
Competence regulation

Genomic Context

Location: 1748936..1760831
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQL35_RS08435 (NCTC7022_01707) - 1749679..1750041 (-) 363 WP_012516140.1 S1 RNA-binding domain-containing protein -
  DQL35_RS08440 (NCTC7022_01708) - 1750041..1751441 (-) 1401 WP_111678377.1 bifunctional Cof-type HAD-IIB family hydrolase/peptidylprolyl isomerase -
  DQL35_RS08445 (NCTC7022_01709) - 1751475..1752116 (-) 642 WP_021321066.1 response regulator -
  DQL35_RS08450 (NCTC7022_01710) - 1752109..1753113 (-) 1005 WP_111678379.1 sensor histidine kinase -
  DQL35_RS08455 (NCTC7022_01711) liaF 1753110..1753802 (-) 693 WP_111678381.1 cell wall-active antibiotics response protein LiaF -
  DQL35_RS08460 (NCTC7022_01712) pknB 1753936..1755831 (-) 1896 WP_111678383.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  DQL35_RS08465 (NCTC7022_01713) - 1755828..1756568 (-) 741 WP_111678385.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -
  DQL35_RS08470 (NCTC7022_01714) rsmB 1756606..1757928 (-) 1323 WP_111678857.1 16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB -
  DQL35_RS08475 (NCTC7022_01715) fmt 1757918..1758853 (-) 936 WP_111678387.1 methionyl-tRNA formyltransferase -

Sequence

Protein


Download         Length: 631 a.a.        Molecular weight: 68567.75 Da        Isoelectric Point: 6.7876

>NTDB_id=1136586 DQL35_RS08460 WP_111678383.1 1753936..1755831(-) (pknB) [Streptococcus equi subsp. zooepidemicus strain NCTC7022]
MIQIGKLFAGRYRILKSIGRGGMADVYLANDLILDNEDVAIKVLRTNYQTDQVAVARFQREARAMAELNHPNIVAIRDIG
EEDGQQFLVMEYVDGSDLKKYIQDHAPLSNNEVVRIMEEVLSAMTLAHQKGIVHRDLKPQNILLTKSGVVKVTDFGIAVA
FAETSLTQTNSMLGSVHYLSPEQARGSKATIQSDIYAMGIMLFEMLTGHIPYDGDSAVTIALQHFQKPLPSIIDENPNVP
QALENVVIRATAKKLSDRYRSTFEMSRDLMTALSYNRSRERKVVFNDVESTKPLPKVTPTPVTAPKVSNASQASAAADAR
LEQTSQMDTLQKPQKKKKNGRFLGTLLKILFSFFVVGVALFAYLVLTKPTTVKVPDVTGSSLNAAKQVLEEAGLKVGKVH
QIESDTVSEDQVVKTNPQAGSAKRKGSSVDLYLSIGNKGFEMENYKGQDYQDVMTSLTETYGVPKSKIKIERIVTNEYPE
NTVISQSPSAGEKFNPAGKSKITLSVAVGDTVIMPMVTEYSYADAVNTLTALGIDAARIKAYVPSSSSPTGFVQVSSPSS
KAIVSGQTPYYGTQISLSEKGDISLYLYPEETRASSSSSSSDTSAPNPSAGDTTDSSSHTELGQNDAVTTP

Nucleotide


Download         Length: 1896 bp        

>NTDB_id=1136586 DQL35_RS08460 WP_111678383.1 1753936..1755831(-) (pknB) [Streptococcus equi subsp. zooepidemicus strain NCTC7022]
ATGATTCAGATTGGCAAGCTATTTGCTGGTCGTTATCGCATTCTAAAATCTATAGGCCGCGGTGGTATGGCGGATGTTTA
TTTAGCAAACGATTTGATTCTGGATAATGAGGACGTTGCCATTAAGGTCTTGCGGACCAATTATCAAACAGATCAGGTTG
CTGTTGCGCGTTTTCAAAGAGAAGCGCGAGCCATGGCTGAATTAAATCACCCCAATATTGTTGCCATTCGGGATATAGGC
GAGGAAGACGGACAGCAATTTTTAGTAATGGAATACGTTGATGGCTCTGACTTGAAAAAATACATTCAGGATCATGCGCC
ATTATCCAACAATGAGGTGGTGAGAATCATGGAGGAGGTTCTTTCTGCCATGACTCTGGCCCATCAAAAAGGAATTGTCC
ACAGGGATTTAAAGCCTCAAAATATTCTTTTAACCAAATCAGGTGTTGTTAAGGTTACAGATTTTGGGATTGCTGTTGCC
TTTGCAGAGACCAGCCTAACCCAGACAAATTCTATGCTAGGAAGTGTGCATTACCTCTCACCTGAGCAAGCGCGTGGTTC
TAAAGCGACAATTCAAAGTGATATTTACGCGATGGGAATCATGCTCTTTGAAATGCTAACAGGGCATATTCCTTATGATG
GCGATAGCGCTGTGACGATTGCTCTGCAGCATTTTCAAAAGCCGCTGCCCTCTATCATTGATGAAAATCCTAATGTGCCT
CAAGCTTTGGAAAATGTTGTTATTCGGGCCACTGCCAAAAAGCTAAGTGACCGTTATCGCTCGACCTTTGAGATGAGCAG
GGATTTGATGACAGCCCTTAGTTATAATCGCAGTCGTGAGCGTAAGGTTGTTTTTAATGATGTCGAAAGCACAAAGCCCT
TGCCAAAGGTAACACCGACTCCTGTAACAGCACCTAAGGTATCAAATGCTAGTCAGGCATCTGCGGCAGCTGATGCTAGA
CTTGAGCAGACTAGCCAGATGGATACTCTGCAAAAGCCTCAAAAAAAGAAAAAAAATGGGCGTTTTCTAGGAACACTCTT
AAAAATCTTGTTTTCCTTTTTTGTTGTTGGTGTGGCTCTTTTTGCTTATTTGGTCTTGACCAAGCCAACTACGGTTAAGG
TTCCTGATGTGACAGGCTCTAGTCTCAATGCTGCCAAGCAGGTCTTGGAGGAGGCGGGACTAAAGGTCGGTAAGGTCCAT
CAGATTGAAAGTGACACAGTTAGTGAGGATCAGGTGGTTAAGACAAATCCTCAAGCTGGCTCAGCTAAGCGAAAAGGCTC
CAGCGTTGACCTTTACCTTTCGATCGGAAATAAAGGCTTTGAGATGGAAAATTATAAGGGACAGGATTATCAAGATGTGA
TGACCAGTCTGACTGAGACCTATGGTGTACCAAAGTCAAAAATCAAGATTGAGCGTATCGTGACAAATGAATACCCTGAA
AACACCGTTATTAGCCAGTCTCCAAGCGCGGGAGAAAAATTTAACCCAGCTGGTAAATCCAAGATTACTCTCAGTGTAGC
AGTGGGTGATACGGTCATCATGCCAATGGTAACTGAGTACAGCTATGCAGACGCAGTCAATACACTAACAGCCCTAGGAA
TTGATGCCGCAAGAATCAAGGCCTATGTACCAAGCTCCAGCTCTCCGACAGGCTTTGTGCAGGTGAGCTCCCCAAGCTCA
AAGGCGATTGTCAGTGGGCAGACACCGTATTATGGTACCCAGATTAGCCTTTCTGAAAAGGGTGATATTAGCCTCTACCT
CTACCCTGAGGAGACACGTGCATCAAGCAGCTCATCGAGCTCTGATACCTCGGCTCCTAATCCATCAGCTGGAGATACAA
CAGACTCAAGCAGTCATACCGAATTAGGTCAAAATGACGCTGTTACAACACCGTAA

Domains

Predicted by InterproScan.

Protein kinase domain (Pkinase)

(12-232)

PASTA domain (PASTA)

(372-434)

PASTA domain (PASTA)

(512-588)

PASTA domain (PASTA)

(441-506)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  pknB Streptococcus mutans UA159

65.714

94.295

0.62
  stkP/pknB Streptococcus salivarius strain HSISS4

62.245

93.185

0.58
  stkP Streptococcus pneumoniae TIGR4

57.364

81.775

0.469
  stkP Streptococcus pneumoniae D39

56.977

81.775

0.466
  stkP Streptococcus pneumoniae R6

56.977

81.775

0.466
  stkP Streptococcus pneumoniae Rx1

56.783

81.775

0.464

Multiple sequence alignment