Detailed information NTG1136335

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: DQL06_RS00330
• Genome accession: NZ_LS483321
• Coordinates: 53249..54160 (+)
• Length: 303 a.a.
• NCBI ID: WP_020904818.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain NCTC8314
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 48249..59160

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQL06_RS00310 (NCTC8314_00062)	purE	48533..49024 (+)	492	WP_023079042.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
DQL06_RS00315 (NCTC8314_00063)	purK	49011..50084 (+)	1074	WP_168393620.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
DQL06_RS00320 (NCTC8314_00064)	-	50111..51808 (+)	1698	WP_020904816.1	AIPR family protein	-
DQL06_RS00325 (NCTC8314_00065)	purB	51826..53118 (+)	1293	WP_111689440.1	adenylosuccinate lyase	-
DQL06_RS00330 (NCTC8314_00066)	comR	53249..54160 (+)	912	WP_020904818.1	helix-turn-helix domain-containing protein	Regulator
DQL06_RS09715 (NCTC8314_00067)	comS	54251..54349 (+)	99	WP_020833188.1	quorum-sensing system DWW-type pheromone	Regulator
DQL06_RS00335 (NCTC8314_00068)	ruvB	54380..55378 (+)	999	WP_002986679.1	Holliday junction branch migration DNA helicase RuvB	-
DQL06_RS00340 (NCTC8314_00069)	-	55516..55953 (+)	438	WP_111689441.1	low molecular weight protein-tyrosine-phosphatase	-
DQL06_RS00345 (NCTC8314_00070)	-	55976..56377 (+)	402	WP_002986671.1	MORN repeat-containing protein	-
DQL06_RS00350 (NCTC8314_00071)	-	56374..58149 (+)	1776	WP_053308140.1	acyltransferase family protein	-

Sequence

Protein

• Length: 303 a.a.
• Molecular weight: 35887.54 Da
• Isoelectric Point: 4.9349

>NTDB_id=1136335 DQL06_RS00330 WP_020904818.1 53249..54160(+) (comR) [Streptococcus pyogenes strain NCTC8314]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKVAVDIIQAKFEVYQTGDINFGYSILKEFLPQLKRKSIYNLNE
LLLIDLYLIILVVSHFSDDIFDAQFYEEITESMLKQHNNLSLEDLFLLNNILLSCADTYIRLKMFGRLKETLQLSHFIMS
TIQDFQKMPMYCMYEWKLSIFYLKDINRARNYFEQSILFTQMTGDTYLVQKLRGEWNKDIHYI

Nucleotide

• Length: 912 bp

>NTDB_id=1136335 DQL06_RS00330 WP_020904818.1 53249..54160(+) (comR) [Streptococcus pyogenes strain NCTC8314]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAGTTGCTGTTGATATTATCCAAGCAAAATTTGAAGTTTATCAAACCG
GAGATATTAATTTCGGATATAGTATTTTAAAAGAATTTCTACCACAGCTAAAAAGAAAATCTATCTATAATTTAAATGAA
TTATTACTTATAGATTTGTATTTGATTATTCTGGTAGTTTCTCATTTTTCAGATGATATATTTGATGCACAGTTTTATGA
AGAAATAACAGAGAGCATGTTAAAACAACACAATAATTTATCATTGGAAGATTTATTTTTACTGAATAATATCTTATTAT
CTTGTGCGGACACTTATATTCGTTTGAAGATGTTCGGTCGTCTAAAAGAAACATTACAACTTAGCCACTTTATAATGTCA
ACTATTCAAGATTTTCAAAAAATGCCTATGTATTGTATGTATGAATGGAAGCTATCTATTTTTTATTTGAAAGATATTAA
CCGAGCACGGAATTACTTTGAACAGTCTATTTTATTTACTCAAATGACAGGAGATACATATTTAGTTCAAAAATTACGGG
GAGAATGGAATAAAGATATTCATTATATTTAA

Domains

Predicted by InterproScan.

• ComR tetratricopeptide (ComR_TPR) (73-296)

• Helix-turn-helix (HTH_3) (12-64)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS315	99.34	100	0.993
comR	Streptococcus pyogenes MGAS8232	58.472	99.34	0.581
comR	Streptococcus mutans UA159	47.157	98.68	0.465
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	46.441	97.36	0.452
comR	Streptococcus suis P1/7	37.374	98.02	0.366
comR	Streptococcus suis 05ZYH33	37.374	98.02	0.366