Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   DQL11_RS01395 Genome accession   NZ_LS483315
Coordinates   251940..252701 (+) Length   253 a.a.
NCBI ID   WP_002991124.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain NCTC12059     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Genomic Context

Location: 246940..257701
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQL11_RS01380 (NCTC12059_00276) - 247198..248766 (-) 1569 WP_021340818.1 ABC transporter substrate-binding protein/permease -
  DQL11_RS01385 (NCTC12059_00277) - 248964..250889 (+) 1926 WP_111704519.1 DUF2207 domain-containing protein -
  DQL11_RS01390 (NCTC12059_00278) - 250955..251794 (+) 840 WP_002986031.1 undecaprenyl-diphosphate phosphatase -
  DQL11_RS01395 (NCTC12059_00279) mecA 251940..252701 (+) 762 WP_002991124.1 adaptor protein MecA Regulator
  DQL11_RS01400 (NCTC12059_00280) - 252708..253877 (+) 1170 WP_002991122.1 glycosyltransferase family 4 protein -
  DQL11_RS01405 (NCTC12059_00281) sufC 253999..254769 (+) 771 WP_031488668.1 Fe-S cluster assembly ATPase SufC -
  DQL11_RS01410 (NCTC12059_00282) sufD 254864..256126 (+) 1263 WP_047235146.1 Fe-S cluster assembly protein SufD -
  DQL11_RS01415 (NCTC12059_00283) - 256157..257383 (+) 1227 WP_111704520.1 cysteine desulfurase -

Sequence

Protein


Download         Length: 253 a.a.        Molecular weight: 29033.69 Da        Isoelectric Point: 4.1622

>NTDB_id=1136048 DQL11_RS01395 WP_002991124.1 251940..252701(+) (mecA) [Streptococcus pyogenes strain NCTC12059]
MEMKQISETTLKITISMDDLEERGMELKDFLIPQEKTEEFFYSVMDELDLPDNFKDSGMLSFRVTPRKDRLDVFVTKSEI
NKDINLEDLAEFGDMSQMTPEDFFKSLEQSMREKGDVKAHEKLEKIEEIMEDVVEATLANQSEAADPSTNHESEPLDYVH
YVLDFSTITEAVAFAKTIDFSIEASELYKGSNCYHITILLDVQQQPSYFANVMYARLIEHANPGSKTRAYLQEHGLQLML
DGAVEQLQKIELG

Nucleotide


Download         Length: 762 bp        

>NTDB_id=1136048 DQL11_RS01395 WP_002991124.1 251940..252701(+) (mecA) [Streptococcus pyogenes strain NCTC12059]
ATGGAAATGAAACAAATTAGCGAGACAACGCTAAAAATAACAATTAGTATGGACGATTTAGAAGAAAGAGGAATGGAGTT
GAAAGATTTCTTGATTCCTCAAGAAAAAACAGAAGAGTTTTTCTATTCTGTGATGGACGAACTCGATCTTCCAGATAATT
TTAAAGATAGTGGTATGCTTAGTTTTCGAGTGACTCCACGCAAGGACCGTCTAGATGTTTTTGTTACCAAATCTGAGATA
AATAAAGATATTAATCTTGAAGATTTAGCAGAGTTTGGTGATATGTCCCAAATGACTCCGGAAGATTTTTTCAAGAGCTT
GGAGCAATCCATGCGTGAAAAGGGAGATGTCAAAGCTCATGAAAAATTGGAAAAAATTGAAGAGATAATGGAAGATGTTG
TTGAAGCTACTCTAGCTAATCAGTCTGAGGCGGCTGATCCATCAACTAATCATGAGTCAGAACCTTTAGACTATGTCCAT
TATGTATTGGATTTTTCAACGATTACAGAGGCAGTGGCTTTTGCTAAAACGATTGATTTTTCGATAGAAGCTTCAGAGTT
ATATAAGGGGAGCAACTGCTACCATATAACTATTTTATTAGATGTTCAGCAACAACCATCTTATTTTGCGAATGTCATGT
ATGCGAGATTGATTGAGCATGCAAACCCTGGATCAAAAACAAGAGCTTATTTACAAGAGCATGGCTTACAATTGATGCTT
GATGGTGCTGTTGAGCAATTACAAAAGATTGAGTTGGGATAA

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-247)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus mutans UA159

62.8

98.814

0.621
  mecA Streptococcus thermophilus LMD-9

55.823

98.419

0.549
  mecA Streptococcus thermophilus LMG 18311

55.02

98.419

0.542
  mecA Streptococcus pneumoniae Rx1

48.235

100

0.486
  mecA Streptococcus pneumoniae D39

48.235

100

0.486
  mecA Streptococcus pneumoniae R6

48.235

100

0.486
  mecA Streptococcus pneumoniae TIGR4

48.235

100

0.486

Multiple sequence alignment