Detailed information
Bioinformatically predicted
Overview
| Name | stkP/pknB | Type | Regulator |
| Locus tag | H1W81_RS04125 | Genome accession | NZ_LR824002 |
| Coordinates | 778784..780655 (+) | Length | 623 a.a. |
| NCBI ID | WP_011226292.1 | Uniprot ID | Q5M3J0 |
| Organism | Streptococcus thermophilus isolate STH_CIRM_67 | ||
| Function | activate comX expression (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 712336..782419 | 778784..780655 | within | 0 |
Gene organization within MGE regions
Location: 712336..782419
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| H1W81_RS03810 (STHERMO_0827) | - | 712434..713174 (-) | 741 | WP_002945131.1 | amino acid ABC transporter ATP-binding protein | - |
| H1W81_RS03815 (STHERMO_0828) | - | 713174..715384 (-) | 2211 | WP_011226350.1 | ABC transporter substrate-binding protein/permease | - |
| H1W81_RS09870 | - | 715583..716519 (+) | 937 | Protein_700 | CPBP family intramembrane glutamic endopeptidase | - |
| H1W81_RS03825 (STHERMO_0833) | uvrB | 717206..719197 (+) | 1992 | WP_002953358.1 | excinuclease ABC subunit UvrB | - |
| H1W81_RS03830 (STHERMO_0834) | - | 719242..719706 (+) | 465 | WP_011226345.1 | 8-oxo-dGTP diphosphatase | - |
| H1W81_RS03835 (STHERMO_0835) | - | 719919..720749 (+) | 831 | WP_041828297.1 | transporter substrate-binding domain-containing protein | - |
| H1W81_RS03840 (STHERMO_0836) | - | 720746..721543 (+) | 798 | WP_011226343.1 | transporter substrate-binding domain-containing protein | - |
| H1W81_RS03845 (STHERMO_0837) | - | 721890..722999 (+) | 1110 | WP_041828295.1 | aminotransferase | - |
| H1W81_RS03850 (STHERMO_0838) | - | 723092..723886 (+) | 795 | WP_011226341.1 | transporter substrate-binding domain-containing protein | - |
| H1W81_RS03855 (STHERMO_0839) | rpsU | 724081..724257 (+) | 177 | WP_011226340.1 | 30S ribosomal protein S21 | - |
| H1W81_RS03860 (STHERMO_0840) | dnaG | 724628..726439 (+) | 1812 | WP_011226339.1 | DNA primase | - |
| H1W81_RS03865 (STHERMO_0841) | rpoD | 726443..727552 (+) | 1110 | WP_011226338.1 | RNA polymerase sigma factor RpoD | - |
| H1W81_RS03870 (STHERMO_0842) | - | 727606..727941 (+) | 336 | WP_002891474.1 | metal-sulfur cluster assembly factor | - |
| H1W81_RS03875 (STHERMO_0844) | - | 728275..729690 (+) | 1416 | WP_096811580.1 | DUF2142 domain-containing protein | - |
| H1W81_RS03880 (STHERMO_0845) | - | 729753..730670 (+) | 918 | WP_002946425.1 | glycosyltransferase family 2 protein | - |
| H1W81_RS03885 (STHERMO_0846) | - | 730783..732117 (+) | 1335 | WP_041828293.1 | DUF6056 family protein | - |
| H1W81_RS03890 (STHERMO_0847) | rfbD | 732194..733045 (+) | 852 | WP_014621820.1 | dTDP-4-dehydrorhamnose reductase | - |
| H1W81_RS03895 (STHERMO_0848) | - | 733122..733817 (+) | 696 | WP_173940715.1 | glycosyltransferase family 2 protein | - |
| H1W81_RS03900 (STHERMO_0849) | - | 733823..734155 (+) | 333 | WP_011226332.1 | DUF2304 domain-containing protein | - |
| H1W81_RS03905 (STHERMO_0850) | - | 734148..735422 (+) | 1275 | WP_011226331.1 | lipopolysaccharide biosynthesis protein | - |
| H1W81_RS03910 (STHERMO_0851) | - | 735422..736432 (+) | 1011 | WP_011226330.1 | glycosyltransferase family 2 protein | - |
| H1W81_RS03915 (STHERMO_0852) | cps2T | 736541..737689 (+) | 1149 | WP_041828290.1 | beta 1-4 rhamnosyltransferase Cps2T | - |
| H1W81_RS03920 (STHERMO_0853) | - | 737686..738642 (+) | 957 | WP_011226328.1 | glycosyltransferase family 2 protein | - |
| H1W81_RS03925 (STHERMO_0854) | - | 738626..739435 (+) | 810 | WP_002948020.1 | ABC transporter permease | - |
| H1W81_RS03930 (STHERMO_0855) | - | 739435..740640 (+) | 1206 | WP_011226326.1 | ABC transporter ATP-binding protein | - |
| H1W81_RS03935 (STHERMO_0856) | - | 740660..741715 (+) | 1056 | WP_179971680.1 | glycosyltransferase family 2 protein | - |
| H1W81_RS03940 (STHERMO_0857) | - | 741712..743496 (+) | 1785 | WP_011226325.1 | rhamnan synthesis F family protein | - |
| H1W81_RS03945 (STHERMO_0858) | radC | 743545..744231 (+) | 687 | WP_011226324.1 | RadC family protein | - |
| H1W81_RS03950 (STHERMO_0859) | - | 744284..744979 (-) | 696 | WP_011226323.1 | gamma-glutamyl-gamma-aminobutyrate hydrolase family protein | - |
| H1W81_RS03955 (STHERMO_0860) | - | 744972..745631 (-) | 660 | WP_041828288.1 | redox-sensing transcriptional repressor Rex | - |
| H1W81_RS03960 (STHERMO_0861) | - | 745776..746123 (-) | 348 | WP_011226321.1 | DUF1831 domain-containing protein | - |
| H1W81_RS03965 (STHERMO_0862) | - | 746125..747237 (-) | 1113 | WP_002948029.1 | cysteine desulfurase family protein | - |
| H1W81_RS03970 (STHERMO_0863) | - | 747241..748212 (-) | 972 | WP_002951446.1 | ribose-phosphate diphosphokinase | - |
| H1W81_RS03975 (STHERMO_0864) | - | 748577..749152 (-) | 576 | WP_002951444.1 | CYTH domain-containing protein | - |
| H1W81_RS03980 (STHERMO_0865) | - | 749248..749922 (+) | 675 | WP_002951443.1 | GTP pyrophosphokinase family protein | - |
| H1W81_RS03985 (STHERMO_0866) | - | 749894..750730 (+) | 837 | WP_041827075.1 | NAD kinase | - |
| H1W81_RS03990 (STHERMO_0867) | - | 750727..751623 (+) | 897 | WP_011226316.1 | RluA family pseudouridine synthase | - |
| H1W81_RS03995 (STHERMO_0868) | pta | 751637..752620 (+) | 984 | WP_011226315.1 | phosphate acetyltransferase | - |
| H1W81_RS04000 | - | 752706..754057 (+) | 1352 | Protein_736 | IS3 family transposase | - |
| H1W81_RS04005 (STHERMO_0873) | - | 754103..755308 (-) | 1206 | WP_011227415.1 | OFA family MFS transporter | - |
| H1W81_RS04010 | - | 755658..755972 (+) | 315 | Protein_738 | TatD family hydrolase | - |
| H1W81_RS04015 (STHERMO_0875) | - | 756004..756414 (+) | 411 | Protein_739 | ATP-binding cassette domain-containing protein | - |
| H1W81_RS04020 | - | 756408..756598 (+) | 191 | Protein_740 | IS3 family transposase | - |
| H1W81_RS04025 (STHERMO_0876) | amiA3 | 756802..758769 (+) | 1968 | WP_179971679.1 | peptide ABC transporter substrate-binding protein | Regulator |
| H1W81_RS04030 (STHERMO_0877) | - | 758814..760063 (-) | 1250 | Protein_742 | ISL3 family transposase | - |
| H1W81_RS04040 (STHERMO_0878) | amiA | 760420..762387 (+) | 1968 | WP_011225333.1 | peptide ABC transporter substrate-binding protein | Regulator |
| H1W81_RS04045 (STHERMO_0879) | amiC | 762449..763942 (+) | 1494 | WP_011227407.1 | ABC transporter permease | Regulator |
| H1W81_RS04050 (STHERMO_0880) | amiD | 763942..764868 (+) | 927 | WP_002946409.1 | oligopeptide ABC transporter permease OppC | Regulator |
| H1W81_RS04055 (STHERMO_0881) | amiE | 764878..765963 (+) | 1086 | WP_011226304.1 | ABC transporter ATP-binding protein | Regulator |
| H1W81_RS04060 (STHERMO_0882) | amiF | 765956..766885 (+) | 930 | WP_002951426.1 | ATP-binding cassette domain-containing protein | Regulator |
| H1W81_RS04065 (STHERMO_0883) | - | 766935..767720 (-) | 786 | WP_002951425.1 | hypothetical protein | - |
| H1W81_RS04070 (STHERMO_0884) | - | 767732..768430 (-) | 699 | WP_011226301.1 | ABC transporter ATP-binding protein | - |
| H1W81_RS04075 (STHERMO_0885) | - | 768435..768812 (-) | 378 | WP_011226300.1 | GntR family transcriptional regulator | - |
| H1W81_RS04080 (STHERMO_0886) | - | 768995..769789 (+) | 795 | WP_059257398.1 | HAD hydrolase family protein | - |
| H1W81_RS04085 (STHERMO_0887) | - | 769782..770597 (+) | 816 | WP_011227405.1 | Cof-type HAD-IIB family hydrolase | - |
| H1W81_RS04090 (STHERMO_0888) | ftsY | 770611..772002 (+) | 1392 | WP_011226297.1 | signal recognition particle-docking protein FtsY | - |
| H1W81_RS04095 (STHERMO_0889) | gmk | 772235..772864 (+) | 630 | WP_011226296.1 | guanylate kinase | - |
| H1W81_RS04100 (STHERMO_0890) | rpoZ | 772886..773200 (+) | 315 | WP_002951415.1 | DNA-directed RNA polymerase subunit omega | - |
| H1W81_RS04105 (STHERMO_0891) | - | 773342..775738 (+) | 2397 | WP_011226295.1 | primosomal protein N' | - |
| H1W81_RS04110 (STHERMO_0892) | fmt | 775756..776691 (+) | 936 | WP_002951411.1 | methionyl-tRNA formyltransferase | - |
| H1W81_RS04115 (STHERMO_0893) | rsmB | 776681..778003 (+) | 1323 | WP_014608533.1 | 16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB | - |
| H1W81_RS04120 (STHERMO_0894) | - | 778047..778784 (+) | 738 | WP_002946881.1 | Stp1/IreP family PP2C-type Ser/Thr phosphatase | - |
| H1W81_RS04125 (STHERMO_0895) | stkP/pknB | 778784..780655 (+) | 1872 | WP_011226292.1 | Stk1 family PASTA domain-containing Ser/Thr kinase | Regulator |
| H1W81_RS09475 (STHERMO_0898) | - | 781292..781447 (+) | 156 | WP_011226290.1 | ion channel | - |
| H1W81_RS04135 (STHERMO_0899) | liaF | 781713..782411 (+) | 699 | WP_011226289.1 | cell wall-active antibiotics response protein LiaF | - |
Sequence
Protein
Download Length: 623 a.a. Molecular weight: 67919.80 Da Isoelectric Point: 7.1310
>NTDB_id=1132338 H1W81_RS04125 WP_011226292.1 778784..780655(+) (stkP/pknB) [Streptococcus thermophilus isolate STH_CIRM_67]
MIQVGKLFAGRYRILKSIGRGGMADVYLANDLILDNESVAIKVLRTNYQTDQVAVARFQREARAMTELSHPNIVAIRDIG
EEDGQQFLVMEYVDGSDLKKFIQDHAPLSNQDVVRIMGEVLSAMTLAHQKGIIHRDLKPQNVLLTKDGRAKVTDFGIAVA
FAETSLTQTNSMLGSVHYLSPEQARGSKATIQSDIYAMGIMLFEMLTGHIPFDGDSAVTIALQHFQKPLPSILAENRNVP
QALENVVIRATAKKLENRYNSTLEMSRDLVTSLHPSHSRDSKVVFDDMTDAKTLPKVDSVSSVGPEKKISPKPSEPTPAP
SKQPREKASLSKKKKNLFSTLLKVLLGFVFIGIIIFAYLVFTNPDNVQVPNVVGQELSTAQTKLESAGFKVGDVKEVEND
SVNKGKVIKTDPTAGTMRKEGASIDVYVSSGSKGFTLKNYKGKNYKDAIEDLTSNYGVSEDQIDIQHVEDDNAKEGEILS
QSSEKNKSFNPKDSKAKIKFRVATPKTITMPDVTGLTVSTAVQTLNSKDISSSSIEYHDYNTGVKLDKSKVPSNTEVLYQ
YPQVGTAVDGTVILYVSVVTKSSSIQQSSTASTTQSPSSTSSSSESSTASSTETATEATHTEQ
MIQVGKLFAGRYRILKSIGRGGMADVYLANDLILDNESVAIKVLRTNYQTDQVAVARFQREARAMTELSHPNIVAIRDIG
EEDGQQFLVMEYVDGSDLKKFIQDHAPLSNQDVVRIMGEVLSAMTLAHQKGIIHRDLKPQNVLLTKDGRAKVTDFGIAVA
FAETSLTQTNSMLGSVHYLSPEQARGSKATIQSDIYAMGIMLFEMLTGHIPFDGDSAVTIALQHFQKPLPSILAENRNVP
QALENVVIRATAKKLENRYNSTLEMSRDLVTSLHPSHSRDSKVVFDDMTDAKTLPKVDSVSSVGPEKKISPKPSEPTPAP
SKQPREKASLSKKKKNLFSTLLKVLLGFVFIGIIIFAYLVFTNPDNVQVPNVVGQELSTAQTKLESAGFKVGDVKEVEND
SVNKGKVIKTDPTAGTMRKEGASIDVYVSSGSKGFTLKNYKGKNYKDAIEDLTSNYGVSEDQIDIQHVEDDNAKEGEILS
QSSEKNKSFNPKDSKAKIKFRVATPKTITMPDVTGLTVSTAVQTLNSKDISSSSIEYHDYNTGVKLDKSKVPSNTEVLYQ
YPQVGTAVDGTVILYVSVVTKSSSIQQSSTASTTQSPSSTSSSSESSTASSTETATEATHTEQ
Nucleotide
Download Length: 1872 bp
>NTDB_id=1132338 H1W81_RS04125 WP_011226292.1 778784..780655(+) (stkP/pknB) [Streptococcus thermophilus isolate STH_CIRM_67]
ATGATCCAAGTTGGCAAATTGTTTGCTGGACGTTATCGAATCCTTAAATCTATCGGACGTGGTGGTATGGCGGATGTTTA
TCTGGCTAACGACCTGATTCTGGATAATGAAAGTGTAGCTATTAAGGTGCTACGTACCAATTATCAAACTGATCAGGTTG
CTGTGGCGCGTTTCCAGCGTGAAGCACGTGCCATGACTGAGCTTAGCCATCCGAATATCGTTGCGATTAGAGATATTGGT
GAAGAAGACGGTCAGCAGTTCTTGGTGATGGAGTATGTGGATGGTTCGGACTTGAAGAAATTCATTCAAGACCATGCACC
ATTGTCTAACCAAGATGTTGTGCGTATTATGGGGGAAGTCCTTTCCGCCATGACTCTTGCCCACCAAAAGGGTATTATTC
ACCGTGACCTTAAGCCACAGAACGTTCTATTAACTAAGGATGGTAGAGCTAAGGTTACAGACTTTGGTATCGCAGTAGCA
TTTGCTGAAACCAGCCTGACACAAACTAACTCAATGTTGGGGTCAGTCCATTATTTGTCACCAGAACAGGCACGTGGTTC
TAAAGCCACTATCCAAAGTGATATCTATGCTATGGGGATTATGCTCTTTGAAATGTTGACAGGGCATATCCCTTTTGATG
GCGATAGTGCAGTAACCATTGCACTTCAACATTTCCAAAAGCCCCTGCCATCGATTTTGGCTGAGAACCGTAACGTTCCT
CAAGCTTTAGAAAATGTTGTTATTAGAGCAACTGCTAAAAAGCTTGAAAATCGTTACAACAGCACTTTGGAAATGAGTCG
CGACCTAGTAACTAGTTTGCATCCTAGTCATAGTCGTGATTCTAAGGTAGTTTTTGATGACATGACGGATGCTAAGACCC
TGCCAAAGGTTGATTCAGTTTCATCAGTAGGTCCTGAGAAAAAGATTTCTCCTAAACCATCAGAGCCTACACCGGCTCCA
AGCAAACAACCGAGGGAAAAAGCTTCTCTATCTAAAAAAAAGAAAAATCTCTTTTCAACTCTACTCAAGGTTTTACTAGG
CTTCGTCTTTATAGGAATTATCATTTTTGCCTATCTTGTTTTTACCAATCCTGACAATGTCCAAGTACCAAATGTTGTAG
GTCAAGAGTTGTCAACAGCTCAGACGAAACTTGAAAGTGCAGGCTTTAAGGTTGGCGATGTTAAAGAAGTCGAAAATGAT
TCAGTCAATAAGGGCAAAGTTATCAAGACCGACCCTACAGCTGGGACAATGCGTAAAGAGGGAGCAAGCATTGATGTCTA
TGTTTCTTCTGGTAGCAAAGGTTTCACTCTGAAAAATTACAAGGGGAAAAATTATAAGGATGCCATTGAGGATTTAACCT
CGAATTATGGGGTTTCCGAGGATCAGATCGATATTCAACATGTCGAAGACGATAATGCTAAAGAAGGCGAAATTCTATCT
CAAAGTTCGGAGAAAAACAAGTCCTTCAATCCTAAAGATAGTAAGGCAAAAATCAAGTTTCGTGTGGCAACTCCTAAGAC
TATAACTATGCCTGATGTGACTGGTTTAACTGTCTCGACAGCAGTCCAAACCTTGAATAGTAAAGACATTTCAAGTAGCA
GTATTGAGTATCATGACTATAATACTGGTGTTAAGTTGGATAAGAGTAAGGTACCTAGTAATACCGAGGTCCTTTATCAA
TATCCTCAAGTTGGTACTGCTGTTGATGGCACAGTGATTCTCTATGTTTCAGTCGTAACTAAGAGTTCAAGTATTCAACA
GTCAAGCACAGCAAGTACGACACAATCGCCGTCATCTACAAGTTCTAGTTCTGAAAGTAGTACAGCTTCTAGTACCGAAA
CAGCTACAGAAGCTACTCACACAGAGCAATAA
ATGATCCAAGTTGGCAAATTGTTTGCTGGACGTTATCGAATCCTTAAATCTATCGGACGTGGTGGTATGGCGGATGTTTA
TCTGGCTAACGACCTGATTCTGGATAATGAAAGTGTAGCTATTAAGGTGCTACGTACCAATTATCAAACTGATCAGGTTG
CTGTGGCGCGTTTCCAGCGTGAAGCACGTGCCATGACTGAGCTTAGCCATCCGAATATCGTTGCGATTAGAGATATTGGT
GAAGAAGACGGTCAGCAGTTCTTGGTGATGGAGTATGTGGATGGTTCGGACTTGAAGAAATTCATTCAAGACCATGCACC
ATTGTCTAACCAAGATGTTGTGCGTATTATGGGGGAAGTCCTTTCCGCCATGACTCTTGCCCACCAAAAGGGTATTATTC
ACCGTGACCTTAAGCCACAGAACGTTCTATTAACTAAGGATGGTAGAGCTAAGGTTACAGACTTTGGTATCGCAGTAGCA
TTTGCTGAAACCAGCCTGACACAAACTAACTCAATGTTGGGGTCAGTCCATTATTTGTCACCAGAACAGGCACGTGGTTC
TAAAGCCACTATCCAAAGTGATATCTATGCTATGGGGATTATGCTCTTTGAAATGTTGACAGGGCATATCCCTTTTGATG
GCGATAGTGCAGTAACCATTGCACTTCAACATTTCCAAAAGCCCCTGCCATCGATTTTGGCTGAGAACCGTAACGTTCCT
CAAGCTTTAGAAAATGTTGTTATTAGAGCAACTGCTAAAAAGCTTGAAAATCGTTACAACAGCACTTTGGAAATGAGTCG
CGACCTAGTAACTAGTTTGCATCCTAGTCATAGTCGTGATTCTAAGGTAGTTTTTGATGACATGACGGATGCTAAGACCC
TGCCAAAGGTTGATTCAGTTTCATCAGTAGGTCCTGAGAAAAAGATTTCTCCTAAACCATCAGAGCCTACACCGGCTCCA
AGCAAACAACCGAGGGAAAAAGCTTCTCTATCTAAAAAAAAGAAAAATCTCTTTTCAACTCTACTCAAGGTTTTACTAGG
CTTCGTCTTTATAGGAATTATCATTTTTGCCTATCTTGTTTTTACCAATCCTGACAATGTCCAAGTACCAAATGTTGTAG
GTCAAGAGTTGTCAACAGCTCAGACGAAACTTGAAAGTGCAGGCTTTAAGGTTGGCGATGTTAAAGAAGTCGAAAATGAT
TCAGTCAATAAGGGCAAAGTTATCAAGACCGACCCTACAGCTGGGACAATGCGTAAAGAGGGAGCAAGCATTGATGTCTA
TGTTTCTTCTGGTAGCAAAGGTTTCACTCTGAAAAATTACAAGGGGAAAAATTATAAGGATGCCATTGAGGATTTAACCT
CGAATTATGGGGTTTCCGAGGATCAGATCGATATTCAACATGTCGAAGACGATAATGCTAAAGAAGGCGAAATTCTATCT
CAAAGTTCGGAGAAAAACAAGTCCTTCAATCCTAAAGATAGTAAGGCAAAAATCAAGTTTCGTGTGGCAACTCCTAAGAC
TATAACTATGCCTGATGTGACTGGTTTAACTGTCTCGACAGCAGTCCAAACCTTGAATAGTAAAGACATTTCAAGTAGCA
GTATTGAGTATCATGACTATAATACTGGTGTTAAGTTGGATAAGAGTAAGGTACCTAGTAATACCGAGGTCCTTTATCAA
TATCCTCAAGTTGGTACTGCTGTTGATGGCACAGTGATTCTCTATGTTTCAGTCGTAACTAAGAGTTCAAGTATTCAACA
GTCAAGCACAGCAAGTACGACACAATCGCCGTCATCTACAAGTTCTAGTTCTGAAAGTAGTACAGCTTCTAGTACCGAAA
CAGCTACAGAAGCTACTCACACAGAGCAATAA
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| stkP/pknB | Streptococcus salivarius strain HSISS4 |
90.361 |
93.258 |
0.843 |
| pknB | Streptococcus mutans UA159 |
64.522 |
87.319 |
0.563 |
| stkP | Streptococcus pneumoniae TIGR4 |
56.713 |
80.096 |
0.454 |
| stkP | Streptococcus pneumoniae D39 |
56.513 |
80.096 |
0.453 |
| stkP | Streptococcus pneumoniae R6 |
56.513 |
80.096 |
0.453 |
| stkP | Streptococcus pneumoniae Rx1 |
56.313 |
80.096 |
0.451 |