Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   H1W81_RS00325 Genome accession   NZ_LR824002
Coordinates   70063..70812 (-) Length   249 a.a.
NCBI ID   WP_011225365.1    Uniprot ID   Q5M699
Organism   Streptococcus thermophilus isolate STH_CIRM_67     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Genomic Context

Location: 65063..75812
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  H1W81_RS00305 (STHERMO_0073) - 65386..66618 (-) 1233 WP_011225367.1 cysteine desulfurase -
  H1W81_RS00310 (STHERMO_0074) sufD 66672..67934 (-) 1263 WP_002947640.1 Fe-S cluster assembly protein SufD -
  H1W81_RS00315 (STHERMO_0075) sufC 67971..68741 (-) 771 WP_002947634.1 Fe-S cluster assembly ATPase SufC -
  H1W81_RS00320 (STHERMO_0076) - 68902..70059 (-) 1158 WP_002947632.1 glycosyltransferase family 4 protein -
  H1W81_RS00325 (STHERMO_0077) mecA 70063..70812 (-) 750 WP_011225365.1 adaptor protein MecA Regulator
  H1W81_RS00330 - 71096..71293 (+) 198 WP_232085789.1 DUF3021 family protein -
  H1W81_RS00335 (STHERMO_0078) - 71439..72293 (-) 855 WP_041828107.1 undecaprenyl-diphosphate phosphatase -
  H1W81_RS00340 (STHERMO_0079) - 72496..74046 (+) 1551 WP_011225362.1 ABC transporter substrate-binding protein/permease -
  H1W81_RS00345 (STHERMO_0080) - 74046..74786 (+) 741 WP_002949253.1 amino acid ABC transporter ATP-binding protein -
  H1W81_RS09925 - 74875..74982 (-) 108 WP_011225361.1 LPXTG cell wall anchor domain-containing protein -
  H1W81_RS00355 (STHERMO_0081) - 75069..75239 (-) 171 WP_011225360.1 hypothetical protein -

Sequence

Protein


Download         Length: 249 a.a.        Molecular weight: 29157.70 Da        Isoelectric Point: 4.0659

>NTDB_id=1132307 H1W81_RS00325 WP_011225365.1 70063..70812(-) (mecA) [Streptococcus thermophilus isolate STH_CIRM_67]
MEMKQINETTLKIMITMEDLEEHGMELKDFLIPQEKTEEFFYTVMDELDLPDNFKNSGMLSFRVTPRKDRVDVFVTKSDL
KEALDFNDLSDMEDYSGLSPEEFLKALEDNFMDKGDIEAHHKLEEHDKTLKEVDETMTEPAKEVAEETIREDYTHYVLAF
SDFDQVVTFAQGLKNVSVEGSEFYKLGDVYYMTILLYLADEPDYYANNMYARFLEYANVADRTRPYLQEHATILMEEDAL
PVLQATKWS

Nucleotide


Download         Length: 750 bp        

>NTDB_id=1132307 H1W81_RS00325 WP_011225365.1 70063..70812(-) (mecA) [Streptococcus thermophilus isolate STH_CIRM_67]
ATGGAAATGAAACAAATAAACGAGACAACTCTAAAAATCATGATTACCATGGAAGATCTTGAAGAACATGGTATGGAGCT
GAAAGATTTCTTGATTCCCCAGGAAAAAACAGAGGAATTTTTCTATACTGTCATGGATGAGTTGGACTTGCCTGATAATT
TTAAAAATAGTGGGATGTTGAGCTTCCGTGTCACGCCACGAAAGGATCGTGTGGATGTTTTTGTGACTAAATCAGATCTT
AAGGAAGCCCTTGATTTCAATGATTTGTCAGATATGGAAGACTATTCAGGACTTTCTCCAGAAGAATTCCTCAAAGCTCT
TGAAGATAACTTTATGGATAAGGGAGATATTGAAGCCCACCATAAGCTCGAAGAGCATGATAAGACCTTGAAAGAGGTTG
ATGAGACTATGACAGAGCCGGCTAAGGAAGTGGCTGAGGAAACTATTCGTGAAGATTATACTCACTATGTCTTGGCTTTC
TCTGACTTTGATCAAGTAGTGACCTTTGCGCAAGGTTTGAAGAATGTGTCAGTGGAGGGTTCTGAATTTTATAAACTTGG
TGATGTCTACTATATGACTATCCTTCTTTACTTGGCTGATGAGCCTGATTATTACGCGAACAATATGTATGCGCGTTTTC
TTGAATATGCGAATGTGGCAGACCGAACACGTCCCTATCTACAAGAGCATGCAACAATCTTGATGGAAGAGGACGCCTTA
CCGGTATTACAAGCAACGAAATGGAGCTAG

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-242)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q5M699

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus thermophilus LMG 18311

100

100

1
  mecA Streptococcus thermophilus LMD-9

99.197

100

0.992
  mecA Streptococcus mutans UA159

57.377

97.992

0.562
  mecA Streptococcus pneumoniae Rx1

46.185

100

0.462
  mecA Streptococcus pneumoniae D39

46.185

100

0.462
  mecA Streptococcus pneumoniae R6

46.185

100

0.462
  mecA Streptococcus pneumoniae TIGR4

46.185

100

0.462

Multiple sequence alignment