Detailed information    

insolico Bioinformatically predicted

Overview

Name   covR   Type   Regulator
Locus tag   H1W86_RS01635 Genome accession   NZ_LR822042
Coordinates   302817..303506 (+) Length   229 a.a.
NCBI ID   WP_084828484.1    Uniprot ID   A0A0E2Q3Q9
Organism   Streptococcus thermophilus isolate STH_CIRM_1358     
Function   repress comR expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 297817..308506
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  H1W86_RS09530 - 298783..298953 (+) 171 Protein_272 ascorbate 6-phosphate lactonase -
  H1W86_RS01615 (STHERMO_0325) - 298970..299641 (-) 672 WP_002946492.1 potassium channel family protein -
  H1W86_RS01620 (STHERMO_0326) - 299681..301045 (-) 1365 WP_269149496.1 TrkH family potassium uptake protein -
  H1W86_RS01625 (STHERMO_0327) rsmG 301115..301828 (-) 714 WP_002946490.1 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG -
  H1W86_RS01630 (STHERMO_0328) - 302125..302661 (+) 537 WP_002946488.1 DUF177 domain-containing protein -
  H1W86_RS01635 (STHERMO_0329) covR 302817..303506 (+) 690 WP_084828484.1 response regulator transcription factor Regulator
  H1W86_RS01640 (STHERMO_0330) covS 303503..305020 (+) 1518 WP_084828485.1 HAMP domain-containing histidine kinase Regulator
  H1W86_RS01645 (STHERMO_0331) nrdR 305143..305622 (+) 480 WP_002949642.1 transcriptional regulator NrdR -
  H1W86_RS01650 (STHERMO_0332) - 305619..306794 (+) 1176 WP_100262514.1 DnaD domain protein -
  H1W86_RS01655 (STHERMO_0333) dnaI 306798..307700 (+) 903 WP_084828487.1 primosomal protein DnaI -

Sequence

Protein


Download         Length: 229 a.a.        Molecular weight: 26683.82 Da        Isoelectric Point: 4.7059

>NTDB_id=1132104 H1W86_RS01635 WP_084828484.1 302817..303506(+) (covR) [Streptococcus thermophilus isolate STH_CIRM_1358]
MSKRILIVEDERNLARFVSLELQHEGYDVVTADNGREGLEMALEKDFDLILLDLMLPEMDGFEVTRRLQQEKDTYIMMMT
ARDSIMDIVAGLDRGADDYIIKPFAIEELLARIRATFRRQDIEATKKVPAKASTYRDLKLDVQNRAVVRGDEVIPLTKRE
FDLLNTLLSNMNQVMTREELLLQVWKYDDVIETNVVDVYIRYLRGKIDIPGKESYIQTVRGMGYVIRER

Nucleotide


Download         Length: 690 bp        

>NTDB_id=1132104 H1W86_RS01635 WP_084828484.1 302817..303506(+) (covR) [Streptococcus thermophilus isolate STH_CIRM_1358]
ATGAGCAAACGCATTTTGATTGTTGAAGATGAGAGAAACCTTGCTCGTTTTGTCTCTCTTGAACTTCAACACGAAGGATA
CGACGTTGTGACAGCGGACAACGGACGCGAAGGACTTGAAATGGCACTTGAGAAAGATTTCGATCTGATTCTCTTGGACC
TTATGTTGCCTGAGATGGACGGTTTCGAAGTGACACGTCGTCTCCAACAAGAAAAAGATACTTATATTATGATGATGACA
GCTCGCGACTCAATCATGGATATTGTTGCTGGTTTGGATCGTGGAGCTGATGACTATATTATAAAACCATTTGCGATTGA
AGAACTGTTGGCACGTATTCGTGCAACCTTCCGTCGTCAAGATATCGAAGCTACTAAGAAGGTACCAGCTAAAGCGTCAA
CCTATCGCGATTTAAAATTGGATGTTCAAAACCGTGCAGTTGTTCGCGGTGATGAGGTAATTCCATTGACAAAACGTGAG
TTTGATTTGTTGAACACACTTTTAAGCAATATGAACCAAGTAATGACCCGTGAGGAACTCTTGCTTCAAGTCTGGAAATA
TGATGACGTAATTGAAACAAACGTTGTAGATGTTTATATTCGTTACTTACGTGGGAAAATCGACATTCCAGGTAAGGAAT
CATACATTCAAACAGTACGAGGGATGGGTTACGTTATCCGTGAAAGATGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-114)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(152-225)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0E2Q3Q9

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covR Streptococcus salivarius strain HSISS4

95.633

100

0.956
  covR Lactococcus lactis subsp. lactis strain DGCC12653

67.544

99.563

0.672
  vicR Streptococcus mutans UA159

44.828

100

0.454
  micA Streptococcus pneumoniae Cp1015

42.083

100

0.441

Multiple sequence alignment