Detailed information NTG1132105

Bioinformatically predicted

Overview

• Name: covS
• Type: Regulator
• Locus tag: H1W86_RS01640
• Genome accession: NZ_LR822042
• Coordinates: 303503..305020 (+)
• Length: 505 a.a.
• NCBI ID: WP_084828485.1
• Uniprot ID: A0A0E2Q5R4
• Organism: Streptococcus thermophilus isolate STH_CIRM_1358
• Function: repress comR expression (predicted from homology) Competence regulation

Genomic Context

Location: 298503..310020

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
H1W86_RS09530	-	298783..298953 (+)	171	Protein_272	ascorbate 6-phosphate lactonase	-
H1W86_RS01615 (STHERMO_0325)	-	298970..299641 (-)	672	WP_002946492.1	potassium channel family protein	-
H1W86_RS01620 (STHERMO_0326)	-	299681..301045 (-)	1365	WP_269149496.1	TrkH family potassium uptake protein	-
H1W86_RS01625 (STHERMO_0327)	rsmG	301115..301828 (-)	714	WP_002946490.1	16S rRNA (guanine(527)-N(7))-methyltransferase RsmG	-
H1W86_RS01630 (STHERMO_0328)	-	302125..302661 (+)	537	WP_002946488.1	DUF177 domain-containing protein	-
H1W86_RS01635 (STHERMO_0329)	covR	302817..303506 (+)	690	WP_084828484.1	response regulator transcription factor	Regulator
H1W86_RS01640 (STHERMO_0330)	covS	303503..305020 (+)	1518	WP_084828485.1	HAMP domain-containing histidine kinase	Regulator
H1W86_RS01645 (STHERMO_0331)	nrdR	305143..305622 (+)	480	WP_002949642.1	transcriptional regulator NrdR	-
H1W86_RS01650 (STHERMO_0332)	-	305619..306794 (+)	1176	WP_100262514.1	DnaD domain protein	-
H1W86_RS01655 (STHERMO_0333)	dnaI	306798..307700 (+)	903	WP_084828487.1	primosomal protein DnaI	-
H1W86_RS01660 (STHERMO_0334)	der	307806..309116 (+)	1311	WP_180479590.1	ribosome biogenesis GTPase Der	-
H1W86_RS10030	-	309180..309839 (+)	660	Protein_283	HI_0552 family protein	-

Sequence

Protein

• Length: 505 a.a.
• Molecular weight: 57568.03 Da
• Isoelectric Point: 5.5179

>NTDB_id=1132105 H1W86_RS01640 WP_084828485.1 303503..305020(+) (covS) [Streptococcus thermophilus isolate STH_CIRM_1358]
MSKLFGKVTIRKKLTMTTAVVFFLVLSMFTLVVVFSANTLLLQRERQNVNNTISKVVTYIEKDWDSDEELSPEPLLAAFY
SPKNIYPSIINGVLSEKRSLDGQVAVSNRLYSNQSVYVYDKKGTFIFTSEEDTDSPPGMSEVNKLKLVSYKGKRGFLLQV
PIYGKDKKTIVGYAQVFHDLKFYYALKERLIFLLIFLEVGMTVLVIAVIVVVLTSILRPMRQLHETMGIIIDSPSDLELR
SKIESHDEIGALALNFNCMMDKIQENNQMQMRFLSDVSHELRTPIAVIKGHMDLLQRWGKNDPEILEESLEAASHEANRM
TIMINDMLDSIRVKGSFDNHRNDTCDLNSSIRTVIGNFRVLHDDYQFYLNDSEGSDRPAQIYSQHFEQVITILIDNAVKY
SPVNKKIQVTIKALEDEMLVQVQDNGEGISKEDIEHIFERFYRSDKARNRTTTQSGVGIGLSILYQIVEAYRCHIDVSSE
LGVGTRFDLYIPFAESETTTPQIEG

Nucleotide

• Length: 1518 bp

>NTDB_id=1132105 H1W86_RS01640 WP_084828485.1 303503..305020(+) (covS) [Streptococcus thermophilus isolate STH_CIRM_1358]
ATGAGTAAATTATTTGGTAAAGTAACCATTAGAAAAAAGTTGACCATGACAACTGCTGTGGTCTTCTTTCTTGTATTGTC
GATGTTCACTCTGGTTGTTGTATTTTCAGCCAATACGCTTCTTTTGCAACGTGAACGTCAAAATGTAAATAATACAATCT
CAAAAGTTGTTACTTATATCGAAAAGGACTGGGACTCTGATGAAGAGTTGAGTCCAGAGCCGCTTTTAGCGGCCTTTTAT
TCACCGAAAAATATCTATCCATCAATCATTAATGGAGTGCTTTCTGAAAAGCGTTCCTTAGATGGTCAAGTTGCGGTTTC
TAATAGATTATATTCCAACCAGTCTGTCTATGTTTATGACAAAAAGGGAACTTTTATCTTTACTTCTGAGGAGGATACAG
ACTCACCTCCAGGCATGTCTGAGGTCAATAAACTGAAGTTGGTTTCCTATAAAGGTAAACGTGGTTTCTTACTACAAGTT
CCAATCTATGGCAAGGATAAGAAGACCATTGTTGGGTATGCTCAAGTTTTCCATGATTTGAAATTCTACTATGCGTTAAA
AGAGCGTTTAATTTTCCTATTGATATTCCTTGAAGTAGGAATGACGGTCTTAGTTATTGCAGTAATTGTAGTTGTCTTGA
CATCTATTCTTCGTCCGATGAGGCAGTTACACGAAACAATGGGTATTATTATCGATTCGCCAAGTGATTTGGAGCTTCGA
TCTAAGATTGAGAGTCATGATGAGATTGGTGCTTTGGCACTTAACTTTAACTGTATGATGGATAAAATTCAAGAAAATAA
TCAGATGCAGATGCGTTTCTTGAGTGACGTCAGTCACGAATTACGTACTCCCATTGCAGTTATTAAAGGACATATGGACC
TCTTGCAACGTTGGGGTAAAAATGATCCTGAAATCCTTGAAGAAAGTCTTGAAGCTGCAAGTCACGAAGCCAACCGTATG
ACGATTATGATTAACGATATGTTGGATTCTATTCGTGTTAAAGGGTCATTTGACAATCATAGAAATGATACATGTGATTT
GAATTCTTCAATCCGTACGGTTATTGGGAATTTCCGTGTCCTACATGACGACTACCAATTCTACCTCAATGATTCTGAGG
GTTCAGATCGTCCAGCACAGATTTACAGCCAGCACTTTGAACAGGTTATTACTATTTTGATTGATAATGCGGTCAAGTAT
TCGCCTGTTAATAAGAAAATCCAGGTTACTATCAAGGCTCTGGAAGATGAGATGCTGGTACAGGTACAGGATAATGGTGA
GGGTATCTCTAAAGAAGATATTGAACATATATTTGAACGCTTCTATCGTTCAGATAAGGCGCGTAATCGTACGACAACCC
AATCTGGTGTGGGTATTGGTTTATCAATCCTCTATCAAATTGTGGAAGCTTATCGATGCCATATCGATGTCAGTTCAGAA
CTTGGTGTGGGTACACGTTTTGACCTCTACATTCCTTTTGCAGAGTCAGAAACTACGACACCTCAAATTGAAGGTTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (384-494)

• His Kinase A (phospho-acceptor) domain (HisKA) (270-329)

• ArlS sensor domain (ArlS_N) (39-187)

• HAMP domain (HAMP) (213-265)

3D structure

• AlphaFold DB: A0A0E2Q5R4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
covS	Streptococcus salivarius strain HSISS4	94.223	99.406	0.937