Detailed information NTG1131844

Bioinformatically predicted

Overview

• Name: comA/nlmT
• Type: Regulator
• Locus tag: H1W84_RS08000
• Genome accession: NZ_LR822036
• Coordinates: 1532708..1534861 (-)
• Length: 717 a.a.
• NCBI ID: WP_041827378.1
• Uniprot ID: A0A811IIL9
• Organism: Streptococcus thermophilus isolate STH_CIRM_1055
• Function: transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 1527708..1539861

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
H1W84_RS07965 (STHERMO_1765)	-	1527823..1528053 (-)	231	WP_014608662.1	bacteriocin class II family protein	-
H1W84_RS07970 (STHERMO_1766)	-	1528409..1528609 (-)	201	WP_011681569.1	hypothetical protein	-
H1W84_RS07975 (STHERMO_1767)	-	1528628..1528804 (-)	177	WP_011681570.1	Blp family class II bacteriocin	-
H1W84_RS07980 (STHERMO_1768)	-	1529060..1529791 (+)	732	WP_002948869.1	LytR/AlgR family response regulator transcription factor	-
H1W84_RS10120	-	1530328..1531131 (+)	804	WP_224102945.1	ATP-binding protein	-
H1W84_RS07990 (STHERMO_1770)	-	1531149..1531310 (-)	162	WP_011681573.1	ComC/BlpC family leader-containing pheromone/bacteriocin	-
H1W84_RS07995 (STHERMO_1771)	-	1531325..1532692 (-)	1368	WP_011681574.1	bacteriocin secretion accessory protein	-
H1W84_RS08000 (STHERMO_1772)	comA/nlmT	1532708..1534861 (-)	2154	WP_041827378.1	peptide cleavage/export ABC transporter	Regulator
H1W84_RS08005 (STHERMO_1775)	-	1535875..1537620 (-)	1746	WP_014608667.1	ABC transporter ATP-binding protein	-
H1W84_RS08010 (STHERMO_1776)	-	1537613..1539370 (-)	1758	WP_014608668.1	ABC transporter ATP-binding protein	-
H1W84_RS10125 (STHERMO_1778)	-	1539558..1539764 (-)	207	WP_002948879.1	hypothetical protein	-

Sequence

Protein

• Length: 717 a.a.
• Molecular weight: 80644.44 Da
• Isoelectric Point: 6.8843

>NTDB_id=1131844 H1W84_RS08000 WP_041827378.1 1532708..1534861(-) (comA/nlmT) [Streptococcus thermophilus isolate STH_CIRM_1055]
MFRFRRTFVPQIDMRDCGVAALASVAKYYGSDYSLAHLRELAKTNKEGTTALGLVEAAKKIGFETRAIKAEMSLFEMEDV
PYPFIAHVNKDGKLQHYYVIYKSTKDYLIIGDPDPSVKVTKMTKERFEKEWTGVTLFMGPEPSYKPHKDKKNGLWDFLPL
IFKQRSLIANIVFASLLVTLINILGSYYLQGILDEYVPNQMKSTLGIISIGLVVTYVLQQMMTFARDYLLTILSQRFTID
VILSYIRHIFELPMSFFATRRTGEVISRFSDANSIIDALASTILSLFLDFSIVIIVGGVLLIQNSNLFKLVLCSVPIYTL
IVFAFMKPFERMNHDVMQSNAMVNSAIIEDINGIETIKSLTSEEVCYQKIDGEFIDYLDNSFRLSKLSILQTSLKQGAQL
ILNVLILWTGAQLVMGNTISIGQLITFNMLLSYFTNPLENIINLQTKLQSAKVANTRLNEVYLIESEFGQSDDTYQEGIA
DGDITVTDLSYKYGFGRDTLTDVSLTIRQGEKISFVGVSGSGKTTLAKMLVNFYQPYKGHIDFNGQNISRIDKKTLRQHI
NYLPQQSYIFSGSVLENLTLGAARGITQADILKACEIAEIRQDIENMPMGFQTELSDGAGLSGGQKQRIALARALLTKSP
VLILDEATSGLDVLTEKQVIDNLLALKDKTIIFVAHRLSIAERTDRIVVIDHGRVVETGSHQDLMSYPGFYYQLFRK

Nucleotide

• Length: 2154 bp

>NTDB_id=1131844 H1W84_RS08000 WP_041827378.1 1532708..1534861(-) (comA/nlmT) [Streptococcus thermophilus isolate STH_CIRM_1055]
ATGTTTCGTTTTCGTAGGACTTTTGTCCCTCAAATAGATATGAGGGATTGTGGAGTTGCTGCCTTGGCATCAGTGGCCAA
GTACTATGGTTCAGATTATTCATTAGCACATCTGCGTGAGTTGGCGAAGACCAATAAAGAAGGGACAACTGCCTTAGGTC
TTGTAGAGGCTGCTAAAAAAATTGGCTTTGAAACGAGAGCTATAAAGGCTGAAATGTCGCTCTTTGAGATGGAAGATGTT
CCTTATCCTTTTATTGCTCATGTTAATAAAGATGGGAAGCTTCAACATTATTATGTTATTTATAAAAGCACCAAGGATTA
TCTGATAATTGGAGACCCTGATCCAAGTGTAAAAGTAACTAAAATGACTAAAGAGCGTTTTGAGAAAGAGTGGACAGGTG
TTACTCTTTTTATGGGACCGGAACCCAGTTATAAACCACATAAGGATAAGAAAAATGGACTCTGGGACTTTCTCCCTTTG
ATCTTTAAACAAAGGTCCTTGATAGCTAATATTGTCTTTGCCAGTCTCTTGGTTACTTTAATAAATATTTTAGGTTCCTA
TTATTTACAAGGTATTCTAGACGAATATGTCCCTAATCAAATGAAGTCTACCTTAGGAATTATCTCAATTGGATTAGTTG
TGACCTATGTTTTACAACAAATGATGACTTTTGCAAGAGATTATCTCTTAACCATACTGAGTCAGCGATTTACCATTGAC
GTTATCTTGTCCTACATACGACATATCTTTGAACTCCCAATGTCTTTTTTTGCCACAAGACGTACAGGGGAGGTTATCTC
ACGTTTTAGTGATGCTAACTCTATTATCGATGCTCTGGCTTCGACGATATTATCACTTTTCCTTGATTTCTCTATTGTGA
TTATCGTAGGAGGCGTGTTATTGATACAAAATAGCAATCTCTTCAAGCTAGTTCTTTGTTCGGTTCCAATTTATACCCTT
ATCGTCTTTGCCTTTATGAAACCTTTTGAGCGAATGAATCATGACGTCATGCAGAGTAATGCTATGGTTAATTCAGCCAT
CATTGAGGACATTAATGGGATTGAAACCATAAAGTCACTAACCAGCGAAGAAGTATGCTATCAAAAGATTGATGGTGAGT
TTATTGACTATCTAGACAATTCTTTTCGCCTTTCTAAGTTATCTATACTACAAACATCATTGAAACAAGGTGCTCAACTT
ATTTTAAATGTACTTATCCTCTGGACAGGTGCTCAGTTGGTGATGGGAAATACCATTTCGATAGGACAATTGATTACTTT
TAATATGTTGCTTTCTTACTTCACGAATCCTTTGGAAAATATCATTAACCTGCAAACCAAGTTACAGTCTGCTAAGGTAG
CTAATACTAGGCTCAATGAGGTCTATCTGATTGAATCAGAGTTTGGACAAAGTGATGATACCTATCAAGAAGGCATTGCG
GATGGAGATATCACTGTTACGGATTTATCTTATAAATATGGTTTTGGTCGTGATACTTTGACTGATGTCAGTTTGACGAT
TAGACAAGGAGAAAAAATCAGTTTTGTTGGTGTCAGTGGATCTGGTAAGACTACTCTAGCTAAAATGTTGGTCAATTTTT
ATCAACCATATAAGGGGCACATAGATTTTAATGGTCAAAATATTAGTCGCATAGACAAGAAAACTCTTCGTCAACATATT
AACTATCTCCCTCAGCAATCCTATATATTTAGTGGTAGTGTTTTAGAAAATCTTACTTTAGGTGCAGCACGGGGTATTAC
GCAAGCTGATATTTTGAAAGCTTGTGAAATAGCAGAAATTCGTCAAGATATTGAAAACATGCCTATGGGGTTTCAGACAG
AGCTGTCTGATGGAGCAGGTCTGTCTGGAGGGCAAAAGCAACGTATCGCTTTGGCGCGTGCACTACTAACGAAATCTCCT
GTACTAATCTTAGATGAAGCAACTAGCGGATTGGATGTTTTGACAGAAAAGCAGGTTATTGATAACCTCCTAGCACTAAA
AGATAAAACGATCATCTTTGTAGCACACAGGCTTAGTATCGCTGAGCGGACCGACCGTATCGTAGTCATTGATCACGGAC
GCGTAGTGGAGACAGGTTCTCATCAAGACCTAATGTCTTATCCAGGTTTCTATTATCAATTATTTAGAAAGTGA

Domains

Predicted by InterproScan.

• ABC transporter transmembrane region (ABC_membrane) (170-438)

• ABC transporter (ABC_tran) (500-649)

• Peptidase C39 family (Peptidase_C39) (7-142)

3D structure

• AlphaFold DB: A0A811IIL9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA/nlmT	Streptococcus mutans UA159	67.787	99.582	0.675
comA	Streptococcus mitis NCTC 12261	66.104	99.163	0.656
comA	Streptococcus pneumoniae Rx1	65.682	99.163	0.651
comA	Streptococcus pneumoniae D39	65.682	99.163	0.651
comA	Streptococcus pneumoniae R6	65.682	99.163	0.651
comA	Streptococcus mitis SK321	65.401	99.163	0.649
comA	Streptococcus pneumoniae TIGR4	65.26	99.163	0.647
comA	Streptococcus gordonii str. Challis substr. CH1	64.006	99.582	0.637