Detailed information    

insolico Bioinformatically predicted

Overview

Name   comA/nlmT   Type   Regulator
Locus tag   H1X13_RS08095 Genome accession   NZ_LR822034
Coordinates   1567368..1569521 (-) Length   717 a.a.
NCBI ID   WP_180481101.1    Uniprot ID   -
Organism   Streptococcus thermophilus isolate STH_CIRM_1049     
Function   transport of ComC (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
ICE 1528529..1598505 1567368..1569521 within 0


Gene organization within MGE regions


Location: 1528529..1598505
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  H1X13_RS07895 (STHERMO_1759) - 1528553..1529335 (+) 783 WP_180481091.1 ABC transporter ATP-binding protein -
  H1X13_RS07900 (STHERMO_1761) - 1529954..1532020 (-) 2067 WP_180481092.1 cation:proton antiporter -
  H1X13_RS07905 (STHERMO_1762) - 1532029..1532271 (-) 243 WP_022096501.1 hypothetical protein -
  H1X13_RS07910 (STHERMO_1763) - 1532268..1532816 (-) 549 WP_004197152.1 tRNA (mnm(5)s(2)U34)-methyltransferase -
  H1X13_RS07915 (STHERMO_1764) - 1532813..1533757 (-) 945 WP_022096500.1 TIGR01212 family radical SAM protein -
  H1X13_RS07920 (STHERMO_1765) sepM 1533842..1534918 (-) 1077 WP_022096499.1 SepM family pheromone-processing serine protease Regulator
  H1X13_RS07925 (STHERMO_1766) coaD 1534896..1535393 (-) 498 WP_011226465.1 pantetheine-phosphate adenylyltransferase -
  H1X13_RS07930 (STHERMO_1767) rsmD 1535427..1536026 (-) 600 Protein_1529 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD -
  H1X13_RS07935 (STHERMO_1768) trxB 1536117..1537070 (-) 954 WP_255136104.1 thioredoxin-disulfide reductase -
  H1X13_RS07940 (STHERMO_1769) - 1537103..1537327 (-) 225 WP_002951743.1 DUF4059 family protein -
  H1X13_RS07945 (STHERMO_1770) - 1537542..1538285 (-) 744 WP_011226469.1 amino acid ABC transporter ATP-binding protein -
  H1X13_RS07950 (STHERMO_1771) - 1538285..1539031 (-) 747 WP_180481337.1 amino acid ABC transporter permease -
  H1X13_RS07955 (STHERMO_1772) - 1539428..1540258 (-) 831 WP_041828322.1 transporter substrate-binding domain-containing protein -
  H1X13_RS07960 (STHERMO_1774) - 1540728..1540961 (-) 234 WP_180481093.1 hypothetical protein -
  H1X13_RS07965 (STHERMO_1775) dinB 1541271..1542374 (-) 1104 WP_164178282.1 DNA polymerase IV -
  H1X13_RS07970 (STHERMO_1776) pflB 1542653..1544962 (+) 2310 WP_002947035.1 formate C-acetyltransferase -
  H1X13_RS07975 (STHERMO_1777) - 1545229..1546011 (+) 783 WP_180481094.1 carbonic anhydrase -
  H1X13_RS07980 (STHERMO_1778) - 1546062..1546514 (+) 453 WP_180481095.1 GNAT family N-acetyltransferase -
  H1X13_RS07985 (STHERMO_1779) - 1546866..1547150 (-) 285 WP_232085801.1 restriction endonuclease subunit S -
  H1X13_RS10445 (STHERMO_1781) mobV 1547196..1547704 (-) 509 Protein_1541 MobV family relaxase -
  H1X13_RS07995 - 1548185..1548774 (-) 590 Protein_1542 site-specific integrase -
  H1X13_RS08000 (STHERMO_1784) - 1548862..1549548 (-) 687 WP_180481096.1 hypothetical protein -
  H1X13_RS08005 (STHERMO_1785) - 1549624..1550379 (-) 756 WP_180481097.1 ABC transporter permease -
  H1X13_RS08010 (STHERMO_1786) - 1550376..1551026 (-) 651 WP_180478205.1 ATP-binding cassette domain-containing protein -
  H1X13_RS08015 (STHERMO_1787) - 1551228..1552184 (-) 957 WP_002951776.1 serine hydrolase domain-containing protein -
  H1X13_RS08020 (STHERMO_1788) - 1552184..1552939 (-) 756 WP_011681560.1 CppA family protein -
  H1X13_RS08025 (STHERMO_1789) - 1553222..1553497 (+) 276 WP_224103608.1 CPBP family intramembrane glutamic endopeptidase -
  H1X13_RS08030 (STHERMO_1790) gla 1553671..1554534 (-) 864 WP_002951781.1 aquaglyceroporin Gla -
  H1X13_RS08035 (STHERMO_1791) - 1554655..1556922 (+) 2268 WP_180481098.1 Xaa-Pro dipeptidyl-peptidase -
  H1X13_RS08040 (STHERMO_1792) - 1557002..1557382 (-) 381 WP_002951783.1 hypothetical protein -
  H1X13_RS08045 - 1557507..1557770 (-) 264 WP_002945924.1 hypothetical protein -
  H1X13_RS08050 - 1558092..1558331 (-) 240 WP_224103609.1 bacteriocin immunity protein -
  H1X13_RS08055 (STHERMO_1795) - 1558553..1559479 (-) 927 WP_180481338.1 thioredoxin family protein -
  H1X13_RS08060 - 1559673..1561243 (+) 1571 WP_180481099.1 IS3-like element ISSth1b family transposase -
  H1X13_RS08065 (STHERMO_1798) - 1561389..1561643 (-) 255 WP_054571825.1 Blp family class II bacteriocin -
  H1X13_RS10450 (STHERMO_1799) - 1561894..1562295 (-) 402 WP_011226490.1 hypothetical protein -
  H1X13_RS08070 (STHERMO_1802) - 1563263..1563469 (-) 207 WP_084829836.1 bacteriocin class II family protein -
  H1X13_RS08075 (STHERMO_1803) - 1563720..1564451 (+) 732 WP_180481100.1 LytR/AlgR family response regulator transcription factor -
  H1X13_RS10150 - 1564988..1565791 (+) 804 WP_224103634.1 ATP-binding protein -
  H1X13_RS08085 (STHERMO_1805) - 1565809..1565970 (-) 162 WP_011226496.1 ComC/BlpC family leader-containing pheromone/bacteriocin -
  H1X13_RS08090 (STHERMO_1806) - 1565985..1567352 (-) 1368 WP_084829837.1 bacteriocin secretion accessory protein -
  H1X13_RS08095 (STHERMO_1807) comA/nlmT 1567368..1569521 (-) 2154 WP_180481101.1 peptide cleavage/export ABC transporter Regulator
  H1X13_RS08100 (STHERMO_1811) - 1570535..1572280 (-) 1746 WP_180481102.1 ABC transporter ATP-binding protein -
  H1X13_RS08105 (STHERMO_1812) - 1572273..1574030 (-) 1758 WP_011226502.1 ABC transporter ATP-binding protein -
  H1X13_RS10155 (STHERMO_1814) - 1574218..1574424 (-) 207 WP_002948879.1 hypothetical protein -
  H1X13_RS08115 (STHERMO_1815) - 1574629..1575156 (-) 528 WP_180481103.1 VanZ family protein -
  H1X13_RS08120 (STHERMO_1816) rlmN 1575158..1576327 (-) 1170 WP_011226504.1 23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN -
  H1X13_RS08125 (STHERMO_1817) - 1576331..1577053 (-) 723 WP_180481104.1 YutD family protein -
  H1X13_RS08130 (STHERMO_1818) - 1577108..1578463 (-) 1356 WP_059257451.1 bifunctional metallophosphatase/5'-nucleotidase -
  H1X13_RS08135 (STHERMO_1821) - 1579312..1580655 (-) 1344 WP_002948888.1 DEAD/DEAH box helicase -
  H1X13_RS08140 (STHERMO_1822) mraY 1580730..1581752 (-) 1023 WP_011227524.1 phospho-N-acetylmuramoyl-pentapeptide- transferase -
  H1X13_RS08145 (STHERMO_1823) pbp2X 1581754..1584021 (-) 2268 WP_180481105.1 penicillin-binding protein PBP2X -
  H1X13_RS08150 (STHERMO_1824) ftsL 1584025..1584345 (-) 321 WP_002948801.1 cell division protein FtsL -
  H1X13_RS08155 (STHERMO_1825) rsmH 1584348..1585298 (-) 951 WP_002888254.1 16S rRNA (cytosine(1402)-N(4))-methyltransferase RsmH -
  H1X13_RS10160 (STHERMO_1826) - 1585463..1586455 (-) 993 WP_224103635.1 hypothetical protein -
  H1X13_RS08170 (STHERMO_1827) - 1586523..1586786 (+) 264 WP_180481106.1 hypothetical protein -
  H1X13_RS10165 - 1587092..1587447 (-) 356 Protein_1578 DUF805 domain-containing protein -
  H1X13_RS08175 (STHERMO_1830) - 1588292..1589542 (-) 1251 WP_173940648.1 glutamate-5-semialdehyde dehydrogenase -
  H1X13_RS08180 (STHERMO_1831) proB 1589544..1590347 (-) 804 WP_002948808.1 glutamate 5-kinase -
  H1X13_RS08185 (STHERMO_1832) - 1590468..1592057 (-) 1590 WP_180481107.1 ABC transporter permease -
  H1X13_RS08190 (STHERMO_1833) - 1592060..1592632 (-) 573 Protein_1582 ABC transporter ATP-binding protein -
  H1X13_RS08195 (STHERMO_1834) - 1592820..1593553 (+) 734 Protein_1583 DUF554 domain-containing protein -
  H1X13_RS08200 (STHERMO_1836) addA 1593947..1597600 (-) 3654 WP_180481108.1 helicase-exonuclease AddAB subunit AddA -

Sequence

Protein


Download         Length: 717 a.a.        Molecular weight: 80675.58 Da        Isoelectric Point: 7.0163

>NTDB_id=1131724 H1X13_RS08095 WP_180481101.1 1567368..1569521(-) (comA/nlmT) [Streptococcus thermophilus isolate STH_CIRM_1049]
MFRFRRTFVPQIDMRDCGVAALASVAKYYGSDYSLAHLRELAKTNKEGTTALGLVEAAKKIGFETRAIKAEMSLFEMEDV
PYPFIAHVNKDGKLQHYYVIYKSTKDYLIIGDPDPSVKVTKMTKERFEKEWTGVTLFMGPEPSYKPHKDKKNGLWDFLPL
IFKQRSLIANIVFASLLVTLINILGSYYLQGILDEYVPNQMKSTLGIISIGLVVTYVLQQMMTFARDYLLTILSQRLIID
VILSYIRHIFELPMSFFATRRTGEVISRFSDANSIIDALASTILSLFLDFSIVIIVGGVLLIQNSNLFKLVLCSVPIYTL
IVFAFMKPFERMNHDVMQSNAMVNSAIIEDINGIETIKSLTSEEVCYQKIDGEFVDYLDNSFRLSKLSILQTSLKQGAQL
ILNVLILWTGAQLVMGNTISIGQLITFNMLLSYFTNPLENIINLQTKLQSAKVANTRLNEVYLIESEFGQSDDTYQEGIA
DGDITVTDLSYKYGFGRDTLTDVSLTIRQGEKISFVGVSGSGKTTLAKMLVNFYQPYKGHIDFNGQNISRIDKKTLRQHI
NYLPQQSYIFSGSVLENLTLGAARGITQADILKACEIAEIRQDIENMPMGFQTELSDGAGLSGGQKQRIALVRALLTKSP
VLILDEATSGLDVLTEKQVIDNLLALKDKTIIFVAHRLSIAERTDRIVVIYQGRVVETGSHQDLMSYPGFYYQLFRK

Nucleotide


Download         Length: 2154 bp        

>NTDB_id=1131724 H1X13_RS08095 WP_180481101.1 1567368..1569521(-) (comA/nlmT) [Streptococcus thermophilus isolate STH_CIRM_1049]
ATGTTTCGTTTTCGTAGGACTTTTGTCCCTCAAATAGACATGAGGGATTGTGGAGTTGCTGCCTTGGCATCAGTGGCCAA
GTACTATGGTTCAGATTATTCATTAGCACATCTGCGTGAGTTGGCGAAGACCAATAAAGAAGGGACAACTGCCTTAGGTC
TTGTAGAGGCTGCTAAAAAAATTGGCTTTGAAACGAGAGCTATAAAGGCTGAAATGTCGCTCTTTGAGATGGAAGATGTT
CCTTATCCTTTTATTGCTCATGTTAATAAAGATGGGAAGCTTCAACATTATTATGTTATTTATAAAAGCACCAAGGATTA
TCTGATAATTGGAGACCCTGATCCAAGTGTAAAAGTAACTAAAATGACTAAAGAGCGTTTTGAGAAAGAGTGGACAGGTG
TTACTCTTTTTATGGGACCGGAACCCAGTTATAAACCACATAAGGATAAGAAAAATGGACTCTGGGACTTTCTCCCTTTG
ATCTTTAAACAAAGGTCCTTGATAGCTAATATTGTCTTTGCCAGTCTCTTGGTTACTTTAATAAATATTTTAGGTTCCTA
TTATTTACAAGGTATTCTAGACGAATATGTCCCTAATCAAATGAAGTCTACCTTAGGAATTATCTCAATTGGATTAGTTG
TGACCTATGTTTTACAACAAATGATGACTTTTGCAAGAGACTATCTCTTAACCATACTGAGTCAGCGATTGATCATTGAC
GTTATCTTGTCCTACATACGACATATCTTTGAACTCCCAATGTCTTTTTTTGCCACAAGACGTACAGGGGAGGTTATCTC
ACGTTTTAGTGATGCTAACTCTATTATCGATGCTCTGGCTTCGACGATATTATCACTTTTCCTTGATTTCTCTATTGTGA
TTATCGTAGGAGGCGTGTTATTGATACAAAATAGCAATCTCTTCAAGCTAGTTCTTTGTTCGGTTCCAATTTATACCCTT
ATCGTCTTTGCCTTTATGAAACCTTTTGAGCGAATGAATCATGACGTCATGCAGAGTAATGCTATGGTTAATTCAGCCAT
CATTGAGGACATTAATGGGATTGAAACCATAAAGTCACTAACCAGCGAAGAAGTATGCTATCAAAAGATTGATGGTGAGT
TTGTTGACTATCTAGACAATTCTTTTCGCCTTTCTAAGTTATCTATACTACAAACATCATTGAAACAAGGTGCTCAACTT
ATTTTAAATGTACTTATCCTCTGGACAGGTGCTCAGTTGGTGATGGGAAATACCATTTCGATAGGACAATTGATTACTTT
TAATATGTTGCTTTCCTACTTCACGAATCCTTTGGAAAATATCATTAACCTGCAAACCAAGTTACAGTCTGCTAAGGTAG
CTAATACTAGGCTCAATGAGGTCTATCTGATTGAATCAGAGTTTGGACAAAGTGATGATACCTATCAAGAAGGCATTGCG
GATGGAGATATCACTGTTACGGATTTATCTTATAAATATGGTTTTGGTCGTGATACTTTGACTGATGTCAGTTTGACGAT
TAGACAAGGAGAAAAAATCAGTTTTGTTGGTGTCAGTGGATCTGGTAAGACTACTCTAGCTAAAATGTTGGTCAATTTTT
ATCAACCATATAAGGGGCACATAGATTTTAATGGTCAAAATATTAGTCGCATAGACAAGAAAACTCTTCGTCAACATATT
AACTATCTCCCTCAGCAATCCTATATATTTAGTGGTAGTGTTTTAGAAAATCTTACTTTAGGTGCAGCACGGGGTATTAC
GCAAGCTGATATTTTGAAAGCTTGTGAAATAGCAGAAATTCGTCAAGATATTGAAAACATGCCTATGGGGTTTCAGACAG
AGCTGTCTGATGGAGCAGGTCTGTCTGGAGGGCAAAAGCAACGTATCGCTTTGGTGCGTGCACTACTAACGAAATCTCCT
GTACTAATCTTAGATGAAGCAACTAGCGGATTGGATGTTTTGACAGAAAAGCAGGTTATTGATAACCTCCTAGCACTAAA
AGATAAAACGATCATCTTTGTAGCACACAGGCTTAGTATCGCTGAGCGGACCGACCGTATCGTAGTCATTTATCAGGGAC
GCGTAGTGGAGACAGGTTCTCATCAAGACCTGATGTCTTATCCAGGTTTCTATTATCAATTATTTAGAAAGTGA

Domains

Predicted by InterproScan.

ABC transporter (ABC_tran)

(500-649)

Peptidase C39 family (Peptidase_C39)

(7-142)

ABC transporter transmembrane region (ABC_membrane)

(170-438)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comA/nlmT Streptococcus mutans UA159

67.927

99.582

0.676
  comA Streptococcus mitis NCTC 12261

66.245

99.163

0.657
  comA Streptococcus pneumoniae Rx1

65.823

99.163

0.653
  comA Streptococcus pneumoniae D39

65.823

99.163

0.653
  comA Streptococcus pneumoniae R6

65.823

99.163

0.653
  comA Streptococcus mitis SK321

65.682

99.163

0.651
  comA Streptococcus pneumoniae TIGR4

65.401

99.163

0.649
  comA Streptococcus gordonii str. Challis substr. CH1

64.146

99.582

0.639

Multiple sequence alignment