Detailed information NTG1131502

Bioinformatically predicted

Overview

• Name: mecA
• Type: Regulator
• Locus tag: H1W74_RS00940
• Genome accession: NZ_LR822031
• Coordinates: 165863..166612 (+)
• Length: 249 a.a.
• NCBI ID: WP_022096529.1
• Uniprot ID: -
• Organism: Streptococcus thermophilus isolate STH_CIRM_1047
• Function: degradation of ComX (predicted from homology) Competence regulation

Genomic Context

Location: 160863..171612

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
H1W74_RS00910 (STHERMO_0177)	-	161437..161607 (+)	171	WP_011680664.1	hypothetical protein	-
H1W74_RS00915	-	161694..161801 (+)	108	WP_084829946.1	LPXTG cell wall anchor domain-containing protein	-
H1W74_RS00920 (STHERMO_0178)	-	161889..162629 (-)	741	WP_002949253.1	amino acid ABC transporter ATP-binding protein	-
H1W74_RS00925 (STHERMO_0179)	-	162629..164179 (-)	1551	WP_022096528.1	ABC transporter substrate-binding protein/permease	-
H1W74_RS00930 (STHERMO_0180)	-	164382..165236 (+)	855	WP_014607892.1	undecaprenyl-diphosphate phosphatase	-
H1W74_RS00935	-	165382..165597 (-)	216	WP_011226805.1	DUF3021 family protein	-
H1W74_RS00940 (STHERMO_0181)	mecA	165863..166612 (+)	750	WP_022096529.1	adaptor protein MecA	Regulator
H1W74_RS00945 (STHERMO_0182)	-	166616..167773 (+)	1158	WP_002947632.1	glycosyltransferase family 4 protein	-
H1W74_RS00950 (STHERMO_0183)	sufC	167934..168704 (+)	771	WP_002947634.1	Fe-S cluster assembly ATPase SufC	-
H1W74_RS00955 (STHERMO_0184)	sufD	168741..170003 (+)	1263	WP_002947640.1	Fe-S cluster assembly protein SufD	-
H1W74_RS00960 (STHERMO_0185)	-	170057..171289 (+)	1233	WP_022096530.1	cysteine desulfurase	-

Sequence

Protein

• Length: 249 a.a.
• Molecular weight: 29156.76 Da
• Isoelectric Point: 4.1121

>NTDB_id=1131502 H1W74_RS00940 WP_022096529.1 165863..166612(+) (mecA) [Streptococcus thermophilus isolate STH_CIRM_1047]
MEMKQINETTLKIMITMEDLEEHGMELKDFLIPQEKTEEFFYTVMDELDLPDNFKNSGMLSFRVTPRKDRVDVFVTKSDL
KEALDFNDLSDMEDYSGLSPEEFLKALEDNFMDKGDIEAHHKLEEHDKTLKEVDETMTEPAKKVAEETIREDYTHYVLAF
SDFDQVVTFAQGLKNVSVEGSEFYKLGDVYYMTILLYLADEPDYYANNMYARFLEYANVADRTRPYLQEHATILMEEDAL
PVLQATKWS

Nucleotide

• Length: 750 bp

>NTDB_id=1131502 H1W74_RS00940 WP_022096529.1 165863..166612(+) (mecA) [Streptococcus thermophilus isolate STH_CIRM_1047]
ATGGAAATGAAACAAATAAACGAGACAACTCTAAAAATCATGATTACCATGGAAGATCTTGAAGAACATGGTATGGAGCT
GAAAGATTTCTTGATTCCCCAGGAAAAAACAGAGGAATTTTTCTATACTGTCATGGATGAGTTGGACTTGCCTGATAATT
TTAAAAATAGTGGGATGTTGAGCTTCCGTGTCACGCCACGAAAGGATCGTGTGGATGTTTTTGTGACTAAATCAGATCTT
AAGGAAGCCCTTGATTTCAATGATTTGTCAGATATGGAAGACTATTCAGGACTTTCTCCAGAAGAATTCCTCAAAGCTCT
TGAAGATAACTTTATGGATAAGGGAGATATTGAAGCCCACCATAAGCTCGAAGAGCATGATAAGACCTTGAAAGAGGTTG
ATGAGACTATGACAGAGCCGGCTAAGAAAGTGGCTGAGGAAACTATTCGTGAAGATTATACTCACTATGTCTTGGCTTTC
TCTGACTTTGATCAAGTAGTGACCTTTGCGCAAGGTTTGAAGAATGTGTCAGTGGAGGGTTCTGAATTTTATAAACTTGG
TGATGTCTACTATATGACTATCCTTCTTTACTTGGCTGATGAGCCTGATTATTACGCGAACAATATGTATGCGCGTTTTC
TTGAATATGCGAATGTGGCAGACCGAACACGTCCCTATCTACAAGAGCATGCAACAATCTTGATGGAAGAGGACGCCTTA
CCGGTATTACAAGCAACGAAATGGAGCTAG

Domains

Predicted by InterproScan.

• Negative regulator of genetic competence (MecA) (MecA) (1-242)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
mecA	Streptococcus thermophilus LMG 18311	99.598	100	0.996
mecA	Streptococcus thermophilus LMD-9	98.795	100	0.988
mecA	Streptococcus mutans UA159	57.787	97.992	0.566
mecA	Streptococcus pneumoniae Rx1	46.586	100	0.466
mecA	Streptococcus pneumoniae D39	46.586	100	0.466
mecA	Streptococcus pneumoniae R6	46.586	100	0.466
mecA	Streptococcus pneumoniae TIGR4	46.586	100	0.466