Detailed information    

insolico Bioinformatically predicted

Overview

Name   comA/nlmT   Type   Regulator
Locus tag   H1W95_RS08035 Genome accession   NZ_LR822030
Coordinates   1560696..1562849 (-) Length   717 a.a.
NCBI ID   WP_157795756.1    Uniprot ID   -
Organism   Streptococcus thermophilus isolate STH_CIRM_1046     
Function   transport of ComC (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
ICE 1512050..1585921 1560696..1562849 within 0


Gene organization within MGE regions


Location: 1512050..1585921
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  H1W95_RS07775 (STHERMO_1747) - 1512941..1513492 (-) 552 WP_002946999.1 cysteine hydrolase family protein -
  H1W95_RS07780 (STHERMO_1748) codY 1513555..1514340 (-) 786 WP_002951720.1 GTP-sensing pleiotropic transcriptional regulator CodY -
  H1W95_RS07785 (STHERMO_1749) - 1514600..1515814 (-) 1215 WP_011226456.1 pyridoxal phosphate-dependent aminotransferase -
  H1W95_RS07790 (STHERMO_1750) - 1516169..1516621 (+) 453 WP_002946987.1 universal stress protein -
  H1W95_RS10320 - 1516801..1517372 (+) 572 Protein_1500 IS30 family transposase -
  H1W95_RS07795 (STHERMO_1753) - 1517444..1517617 (-) 174 WP_014621904.1 hypothetical protein -
  H1W95_RS07800 (STHERMO_1754) - 1517684..1518052 (-) 369 WP_014621905.1 membrane protein -
  H1W95_RS07805 (STHERMO_1755) pflA 1518264..1519064 (-) 801 WP_002946980.1 pyruvate formate-lyase-activating protein -
  H1W95_RS07810 - 1519252..1519362 (-) 111 WP_014621906.1 LPXTG cell wall anchor domain-containing protein -
  H1W95_RS07815 (STHERMO_1756) - 1520060..1521391 (-) 1332 WP_002951727.1 hemolysin family protein -
  H1W95_RS07820 (STHERMO_1757) - 1521505..1522287 (+) 783 WP_024703988.1 ABC transporter ATP-binding protein -
  H1W95_RS07825 (STHERMO_1759) - 1522906..1524972 (-) 2067 WP_138496610.1 cation:proton antiporter -
  H1W95_RS07830 (STHERMO_1760) - 1524981..1525223 (-) 243 WP_084830769.1 hypothetical protein -
  H1W95_RS07835 (STHERMO_1761) - 1525220..1525768 (-) 549 WP_011226462.1 tRNA (mnm(5)s(2)U34)-methyltransferase -
  H1W95_RS07840 (STHERMO_1762) - 1525765..1526709 (-) 945 WP_011226463.1 TIGR01212 family radical SAM protein -
  H1W95_RS07845 (STHERMO_1763) sepM 1526794..1527870 (-) 1077 WP_011681549.1 SepM family pheromone-processing serine protease Regulator
  H1W95_RS07850 (STHERMO_1764) coaD 1527848..1528345 (-) 498 WP_011681550.1 pantetheine-phosphate adenylyltransferase -
  H1W95_RS07855 (STHERMO_1765) rsmD 1528379..1528978 (-) 600 Protein_1513 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD -
  H1W95_RS07860 (STHERMO_1766) trxB 1529069..1530022 (-) 954 WP_259699870.1 thioredoxin-disulfide reductase -
  H1W95_RS07865 (STHERMO_1767) - 1530055..1530279 (-) 225 WP_180483378.1 DUF4059 family protein -
  H1W95_RS07870 (STHERMO_1768) - 1530494..1531237 (-) 744 WP_011681551.1 amino acid ABC transporter ATP-binding protein -
  H1W95_RS07875 (STHERMO_1769) - 1531237..1531983 (-) 747 WP_095559509.1 amino acid ABC transporter permease -
  H1W95_RS07880 (STHERMO_1770) - 1532379..1533209 (-) 831 WP_014727671.1 transporter substrate-binding domain-containing protein -
  H1W95_RS07885 (STHERMO_1772) - 1533669..1533902 (-) 234 WP_002947030.1 hypothetical protein -
  H1W95_RS07890 (STHERMO_1773) dinB 1534200..1535303 (-) 1104 WP_014608654.1 DNA polymerase IV -
  H1W95_RS07895 (STHERMO_1774) pflB 1535582..1537891 (+) 2310 WP_011226473.1 formate C-acetyltransferase -
  H1W95_RS07900 (STHERMO_1775) - 1538158..1538940 (+) 783 WP_011681555.1 carbonic anhydrase -
  H1W95_RS07905 (STHERMO_1776) - 1538991..1539443 (+) 453 WP_014608655.1 GNAT family N-acetyltransferase -
  H1W95_RS07910 (STHERMO_1777) - 1539794..1540078 (-) 285 WP_014608656.1 restriction endonuclease subunit S -
  H1W95_RS10630 (STHERMO_1779) mobV 1540124..1540632 (-) 509 Protein_1525 MobV family relaxase -
  H1W95_RS07920 (STHERMO_1781) - 1541077..1541832 (-) 756 WP_011681558.1 ABC transporter permease -
  H1W95_RS07925 (STHERMO_1782) - 1541829..1542479 (-) 651 WP_011681559.1 ATP-binding cassette domain-containing protein -
  H1W95_RS07930 (STHERMO_1784) - 1542682..1543638 (-) 957 WP_002951776.1 serine hydrolase domain-containing protein -
  H1W95_RS07935 (STHERMO_1785) - 1543638..1544393 (-) 756 WP_011681560.1 CppA family protein -
  H1W95_RS07940 (STHERMO_1786) - 1544675..1545037 (+) 363 WP_014608659.1 CPBP family intramembrane glutamic endopeptidase -
  H1W95_RS07945 (STHERMO_1787) gla 1545124..1545987 (-) 864 WP_002951781.1 aquaglyceroporin Gla -
  H1W95_RS07950 (STHERMO_1788) - 1546108..1548375 (+) 2268 WP_011681561.1 Xaa-Pro dipeptidyl-peptidase -
  H1W95_RS07955 (STHERMO_1789) - 1548455..1548835 (-) 381 WP_002951783.1 hypothetical protein -
  H1W95_RS07960 - 1548960..1549223 (-) 264 WP_002945924.1 hypothetical protein -
  H1W95_RS07965 (STHERMO_1792) - 1549545..1549841 (-) 297 WP_004197070.1 bacteriocin immunity protein -
  H1W95_RS07970 (STHERMO_1793) - 1550006..1550932 (-) 927 WP_022096485.1 thioredoxin family protein -
  H1W95_RS07975 (STHERMO_1794) - 1551119..1551298 (-) 180 WP_011681564.1 hypothetical protein -
  H1W95_RS07980 (STHERMO_1795) - 1551327..1551719 (-) 393 WP_003094909.1 hypothetical protein -
  H1W95_RS07985 (STHERMO_1796) - 1551731..1551970 (-) 240 WP_011681565.1 Blp family class II bacteriocin -
  H1W95_RS07990 - 1552187..1553757 (+) 1571 WP_087009847.1 IS3-like element ISSth1b family transposase -
  H1W95_RS07995 (STHERMO_1799) - 1553903..1554157 (-) 255 WP_014608660.1 Blp family class II bacteriocin -
  H1W95_RS10635 (STHERMO_1800) - 1554408..1554809 (-) 402 WP_024703992.1 hypothetical protein -
  H1W95_RS08000 (STHERMO_1805) - 1555814..1556044 (-) 231 WP_014608662.1 bacteriocin class II family protein -
  H1W95_RS08005 (STHERMO_1806) - 1556401..1556601 (-) 201 WP_011681569.1 hypothetical protein -
  H1W95_RS08010 (STHERMO_1807) - 1556620..1556796 (-) 177 WP_011681570.1 Blp family class II bacteriocin -
  H1W95_RS08015 (STHERMO_1808) - 1557048..1557785 (+) 738 WP_011681571.1 LytR/AlgR family response regulator transcription factor -
  H1W95_RS10330 - 1558316..1559119 (+) 804 WP_223899638.1 ATP-binding protein -
  H1W95_RS08025 (STHERMO_1810) - 1559137..1559298 (-) 162 WP_011681573.1 ComC/BlpC family leader-containing pheromone/bacteriocin -
  H1W95_RS08030 (STHERMO_1811) - 1559313..1560680 (-) 1368 WP_011681574.1 bacteriocin secretion accessory protein -
  H1W95_RS08035 (STHERMO_1812) comA/nlmT 1560696..1562849 (-) 2154 WP_157795756.1 peptide cleavage/export ABC transporter Regulator
  H1W95_RS08040 (STHERMO_1817) - 1563863..1565608 (-) 1746 WP_100262366.1 ABC transporter ATP-binding protein -
  H1W95_RS08045 (STHERMO_1818) - 1565601..1567238 (-) 1638 WP_232087073.1 ABC transporter ATP-binding protein -
  H1W95_RS10335 (STHERMO_1820) - 1567547..1567753 (-) 207 WP_002948879.1 hypothetical protein -
  H1W95_RS08055 (STHERMO_1821) - 1567958..1568485 (-) 528 WP_011226503.1 VanZ family protein -
  H1W95_RS08060 (STHERMO_1822) rlmN 1568487..1569656 (-) 1170 WP_011227522.1 23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN -
  H1W95_RS08065 (STHERMO_1823) - 1569660..1570382 (-) 723 WP_011226505.1 YutD family protein -
  H1W95_RS08070 (STHERMO_1824) - 1570437..1571792 (-) 1356 WP_002948886.1 bifunctional metallophosphatase/5'-nucleotidase -
  H1W95_RS08075 (STHERMO_1827) - 1572641..1573984 (-) 1344 WP_180483379.1 DEAD/DEAH box helicase -
  H1W95_RS08080 (STHERMO_1828) mraY 1574059..1575081 (-) 1023 WP_011227524.1 phospho-N-acetylmuramoyl-pentapeptide- transferase -
  H1W95_RS08085 (STHERMO_1829) pbp2X 1575083..1577350 (-) 2268 WP_011226508.1 penicillin-binding protein PBP2X -
  H1W95_RS08090 (STHERMO_1830) ftsL 1577354..1577674 (-) 321 WP_014608671.1 cell division protein FtsL -
  H1W95_RS08095 (STHERMO_1831) rsmH 1577677..1578627 (-) 951 WP_002888254.1 16S rRNA (cytosine(1402)-N(4))-methyltransferase RsmH -
  H1W95_RS08100 (STHERMO_1832) - 1578794..1579525 (-) 732 WP_224103288.1 hypothetical protein -
  H1W95_RS08110 (STHERMO_1834) - 1579869..1580117 (+) 249 WP_023909924.1 hypothetical protein -
  H1W95_RS08115 (STHERMO_1836) - 1580423..1580779 (-) 357 WP_023909925.1 DUF805 domain-containing protein -
  H1W95_RS08120 (STHERMO_1838) - 1581128..1581295 (-) 168 WP_153300736.1 hypothetical protein -
  H1W95_RS08125 (STHERMO_1839) - 1581628..1582878 (-) 1251 WP_071417383.1 glutamate-5-semialdehyde dehydrogenase -
  H1W95_RS08130 (STHERMO_1840) proB 1582880..1583683 (-) 804 WP_014608676.1 glutamate 5-kinase -
  H1W95_RS08135 (STHERMO_1841) - 1583804..1585393 (-) 1590 WP_014608677.1 ABC transporter permease -

Sequence

Protein


Download         Length: 717 a.a.        Molecular weight: 80624.45 Da        Isoelectric Point: 6.8843

>NTDB_id=1131482 H1W95_RS08035 WP_157795756.1 1560696..1562849(-) (comA/nlmT) [Streptococcus thermophilus isolate STH_CIRM_1046]
MFRFRRTFVPQIDMRDCGVAALASVAKYYGSDYSLAHLRELAKTNKEGTTALGLVEAAKKIGFETRAIKAEMSLFEMEDV
PYPFIAHVNKDGKLQHYYVIYKSTKDYLIIGDPDPSVKVTKMTKERFEKEWTGITLFMGPEPSYKPHKDKKNGLWDFLPL
IFKQRSLIANIVFASLLVTLINILGSYYLQGILDEYVPNQMKSTLGIISIGLVVTYVLQQMMTFARDYLLTILSQRLTID
VILSYIRHIFELPMSFFATRRTGEVISRFSDANSIIDALASTILSLFLDFSIVIIVGGVLLIQNSNLFKLVLCSVPIYTL
IVFAFMKPFERMNHDVMQSNAMVNSAIIEDINGIETIKSLTSEEVCYQKIDGEFIDYLDNSFRLSKLSILQTSLKQGAQL
ILNVLILWTGAQLVMGNTISIGQLITFNMLLSYFTNPLENIINLQTKLQSAKVANTRLNEVYLIESEFGQSDDTYQEGIA
DGDITVTDLSYKYGFGRDTLTDVSLTIRQGEKISFVGVSGSGKTTLAKMLVNFYQPYKGHIDFNGQNISRIDKKTLRQHI
NYLPQQSYIFSGSVLENLTLGAARGITQADILKACEIAEIRQDIENMPMGFQTELSDGAGLSGGQKQRIALARALLTKSP
VLILDEATSGLDVLTEKQVIDNLLALKDKTIIFVAHRLSIAERTDRIVVIDHGRVVETGSHQDLMSYPGFYYQLFRK

Nucleotide


Download         Length: 2154 bp        

>NTDB_id=1131482 H1W95_RS08035 WP_157795756.1 1560696..1562849(-) (comA/nlmT) [Streptococcus thermophilus isolate STH_CIRM_1046]
ATGTTTCGTTTTCGTAGGACTTTTGTCCCTCAAATAGACATGAGGGATTGTGGAGTTGCTGCCTTGGCATCAGTGGCCAA
GTACTATGGTTCAGATTATTCATTAGCACATCTGCGTGAGTTGGCGAAGACCAATAAAGAAGGGACAACTGCCTTAGGTC
TTGTAGAGGCTGCTAAAAAAATTGGCTTTGAAACGAGAGCTATAAAGGCTGAAATGTCGCTCTTTGAGATGGAAGATGTT
CCTTATCCTTTTATTGCTCATGTTAATAAAGATGGGAAGCTTCAACATTATTATGTTATTTATAAAAGCACCAAGGATTA
TCTGATAATTGGAGACCCTGATCCAAGTGTAAAAGTAACTAAAATGACTAAAGAGCGTTTTGAGAAAGAGTGGACAGGTA
TTACTCTTTTTATGGGACCGGAACCCAGTTATAAACCACATAAGGATAAGAAAAATGGACTCTGGGACTTTCTCCCTTTG
ATCTTTAAACAAAGGTCCTTGATAGCTAATATTGTCTTTGCCAGTCTCTTGGTTACTTTAATAAATATTTTAGGTTCCTA
TTATTTACAAGGTATTCTAGACGAATATGTCCCTAATCAAATGAAGTCTACCTTAGGAATTATCTCAATTGGATTAGTTG
TGACCTATGTTTTACAACAAATGATGACTTTTGCAAGAGATTATCTCTTAACCATACTGAGTCAGCGATTGACCATTGAC
GTTATCTTGTCCTACATACGACATATCTTTGAACTCCCAATGTCTTTTTTTGCCACAAGACGTACAGGGGAGGTTATCTC
ACGTTTTAGTGATGCTAACTCTATTATCGATGCTCTGGCTTCGACGATATTATCACTTTTCCTTGATTTCTCTATTGTGA
TTATCGTAGGAGGCGTGTTATTGATACAAAATAGCAATCTCTTCAAGCTAGTTCTTTGTTCGGTTCCAATTTATACCCTT
ATCGTCTTTGCCTTTATGAAACCTTTTGAGCGAATGAATCATGACGTCATGCAGAGTAATGCTATGGTTAATTCAGCCAT
CATTGAGGACATTAATGGGATTGAAACCATAAAGTCACTAACCAGCGAAGAAGTATGCTATCAAAAGATTGATGGTGAGT
TTATTGACTATCTAGACAATTCTTTTCGCCTTTCTAAGTTATCTATACTACAAACATCATTGAAACAAGGTGCTCAACTT
ATTTTAAATGTACTTATCCTCTGGACAGGTGCTCAGTTGGTGATGGGAAATACCATTTCGATAGGACAATTGATTACTTT
TAATATGTTGCTTTCTTACTTCACGAATCCTTTGGAAAATATCATTAACCTGCAAACCAAGTTACAGTCTGCTAAGGTAG
CTAATACTAGGCTCAATGAGGTCTATCTGATTGAATCAGAGTTTGGACAAAGTGATGATACCTATCAAGAAGGCATTGCG
GATGGAGATATCACTGTTACGGATTTATCTTATAAATATGGTTTTGGTCGTGATACTTTGACTGATGTCAGTTTGACGAT
TAGACAAGGAGAAAAAATCAGTTTTGTTGGTGTCAGTGGATCTGGTAAGACTACTCTAGCTAAAATGTTGGTCAATTTTT
ATCAACCATATAAGGGGCACATAGATTTTAATGGTCAAAATATTAGTCGCATAGACAAGAAAACTCTTCGTCAACATATT
AACTATCTCCCTCAGCAATCCTATATATTTAGTGGTAGTGTTTTAGAAAATCTTACTTTAGGTGCAGCACGGGGTATTAC
GCAAGCTGATATTTTGAAAGCTTGTGAAATAGCAGAAATTCGTCAAGATATTGAAAACATGCCTATGGGGTTTCAGACAG
AGCTGTCTGATGGAGCAGGTCTGTCTGGAGGGCAAAAGCAACGTATCGCTTTGGCGCGTGCACTACTAACGAAATCTCCT
GTACTAATCTTAGATGAAGCAACTAGCGGATTGGATGTTTTGACAGAAAAGCAGGTTATTGATAACCTCCTAGCACTAAA
AGATAAAACGATCATCTTTGTAGCACACAGGCTTAGTATCGCTGAGCGGACCGACCGTATCGTAGTCATTGATCACGGAC
GCGTAGTGGAGACAGGTTCTCATCAAGACCTAATGTCTTATCCAGGTTTCTATTATCAATTATTTAGAAAGTGA

Domains

Predicted by InterproScan.

ABC transporter transmembrane region (ABC_membrane)

(170-438)

ABC transporter (ABC_tran)

(500-649)

Peptidase C39 family (Peptidase_C39)

(7-142)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comA/nlmT Streptococcus mutans UA159

67.927

99.582

0.676
  comA Streptococcus mitis NCTC 12261

66.104

99.163

0.656
  comA Streptococcus pneumoniae Rx1

65.682

99.163

0.651
  comA Streptococcus pneumoniae D39

65.682

99.163

0.651
  comA Streptococcus pneumoniae R6

65.682

99.163

0.651
  comA Streptococcus mitis SK321

65.401

99.163

0.649
  comA Streptococcus pneumoniae TIGR4

65.26

99.163

0.647
  comA Streptococcus gordonii str. Challis substr. CH1

64.286

99.582

0.64

Multiple sequence alignment