Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   H1W95_RS00995 Genome accession   NZ_LR822030
Coordinates   177887..178636 (+) Length   249 a.a.
NCBI ID   WP_180483455.1    Uniprot ID   -
Organism   Streptococcus thermophilus isolate STH_CIRM_1046     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Genomic Context

Location: 172887..183636
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  H1W95_RS00970 (STHERMO_0188) - 173462..173632 (+) 171 WP_023909348.1 hypothetical protein -
  H1W95_RS00975 (STHERMO_0190) - 173913..174653 (-) 741 WP_002949253.1 amino acid ABC transporter ATP-binding protein -
  H1W95_RS00980 (STHERMO_0191) - 174653..176203 (-) 1551 WP_014607891.1 ABC transporter substrate-binding protein/permease -
  H1W95_RS00985 (STHERMO_0192) - 176406..177260 (+) 855 WP_014607892.1 undecaprenyl-diphosphate phosphatase -
  H1W95_RS00990 - 177406..177621 (-) 216 WP_011226805.1 DUF3021 family protein -
  H1W95_RS00995 (STHERMO_0193) mecA 177887..178636 (+) 750 WP_180483455.1 adaptor protein MecA Regulator
  H1W95_RS01000 (STHERMO_0194) - 178640..179797 (+) 1158 WP_014607894.1 glycosyltransferase family 4 protein -
  H1W95_RS01005 (STHERMO_0195) sufC 179957..180727 (+) 771 WP_002947634.1 Fe-S cluster assembly ATPase SufC -
  H1W95_RS01010 (STHERMO_0196) sufD 180764..182026 (+) 1263 WP_002947640.1 Fe-S cluster assembly protein SufD -
  H1W95_RS01015 (STHERMO_0197) - 182080..183312 (+) 1233 WP_002949261.1 cysteine desulfurase -

Sequence

Protein


Download         Length: 249 a.a.        Molecular weight: 29129.64 Da        Isoelectric Point: 4.0624

>NTDB_id=1131442 H1W95_RS00995 WP_180483455.1 177887..178636(+) (mecA) [Streptococcus thermophilus isolate STH_CIRM_1046]
MEMKQINETTLKIMITMEDLEEHGMELKDFLIPQEKTEEFFYTVMDELDLPDNFKNSGMLSFRVTPRKDRVDVFVTKSDL
KEDLDFNDLSDMEDYSGLSPEEFLKALEDNFMDKGDIEAHHKLEEHDKTLKEVDETMTGPAKEVAEETIREDYTHYVLAF
SDFDQVVTFAQGLKNVSVEGSEFYKLGDVYYMTILLYLADEPDYYANNMYARFLEYANVADRTRPYLQEHATILMEEDAL
PVLQATKWS

Nucleotide


Download         Length: 750 bp        

>NTDB_id=1131442 H1W95_RS00995 WP_180483455.1 177887..178636(+) (mecA) [Streptococcus thermophilus isolate STH_CIRM_1046]
ATGGAAATGAAACAAATAAACGAGACAACTCTAAAAATCATGATTACCATGGAAGATCTTGAAGAACATGGTATGGAGCT
GAAAGATTTCTTGATTCCCCAGGAAAAAACAGAGGAATTTTTCTATACTGTCATGGATGAGTTGGACTTGCCTGATAACT
TTAAAAATAGTGGGATGTTGAGCTTCCGTGTCACGCCACGAAAGGATCGTGTGGATGTTTTTGTGACTAAATCAGATCTT
AAGGAAGACCTTGATTTCAATGATTTGTCAGATATGGAAGACTATTCAGGACTTTCTCCAGAAGAATTCCTCAAAGCTCT
TGAAGATAACTTTATGGATAAGGGAGATATTGAAGCCCACCATAAGCTCGAAGAGCATGATAAGACCTTGAAAGAGGTTG
ATGAGACTATGACAGGGCCGGCTAAGGAAGTGGCTGAGGAAACTATTCGTGAAGATTATACTCACTATGTCTTGGCTTTC
TCTGACTTTGATCAAGTAGTGACCTTTGCGCAAGGTTTGAAGAATGTGTCAGTGGAGGGTTCTGAATTTTATAAACTTGG
TGATGTCTACTATATGACTATCCTTCTTTACTTGGCTGATGAGCCTGATTATTACGCGAACAATATGTATGCGCGTTTTC
TTGAATATGCGAATGTGGCAGACCGAACACGTCCCTATCTACAAGAGCATGCAACAATCTTGATGGAAGAGGACGCCTTA
CCGGTATTACAAGCAACGAAATGGAGCTAG

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-242)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus thermophilus LMD-9

99.197

100

0.992
  mecA Streptococcus thermophilus LMG 18311

99.197

100

0.992
  mecA Streptococcus mutans UA159

57.787

97.992

0.566
  mecA Streptococcus pneumoniae Rx1

45.783

100

0.458
  mecA Streptococcus pneumoniae D39

45.783

100

0.458
  mecA Streptococcus pneumoniae R6

45.783

100

0.458
  mecA Streptococcus pneumoniae TIGR4

45.783

100

0.458

Multiple sequence alignment