Detailed information    

insolico Bioinformatically predicted

Overview


Name   comA/nlmT   Type   Regulator
Locus tag   H1W89_RS07895 Genome accession   NZ_LR822029
Coordinates   1510005..1512158 (-) Length   717 a.a.
NCBI ID   WP_041827378.1    Uniprot ID   A0A811IIL9
Organism   Streptococcus thermophilus isolate STH_CIRM_1035     
Function   transport of ComC (predicted from homology)   
Competence regulation

Related MGE


Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
ICE 1470534..1541350 1510005..1512158 within 0


Gene organization within MGE regions


Location: 1470534..1541350
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  H1W89_RS07685 (STHERMO_1694) - 1470560..1471342 (+) 783 WP_180474612.1 ABC transporter ATP-binding protein -
  H1W89_RS07690 (STHERMO_1696) - 1471964..1474030 (-) 2067 WP_011681548.1 cation:proton antiporter -
  H1W89_RS07695 (STHERMO_1697) - 1474039..1474281 (-) 243 WP_011226461.1 hypothetical protein -
  H1W89_RS07700 (STHERMO_1698) - 1474278..1474826 (-) 549 WP_011226462.1 tRNA (mnm(5)s(2)U34)-methyltransferase -
  H1W89_RS07705 (STHERMO_1699) - 1474823..1475767 (-) 945 WP_011226463.1 TIGR01212 family radical SAM protein -
  H1W89_RS07710 (STHERMO_1700) sepM 1475852..1476928 (-) 1077 WP_011681549.1 SepM family pheromone-processing serine protease Regulator
  H1W89_RS07715 (STHERMO_1701) coaD 1476906..1477403 (-) 498 WP_011681550.1 pantetheine-phosphate adenylyltransferase -
  H1W89_RS07720 (STHERMO_1702) rsmD 1477437..1478036 (-) 600 Protein_1470 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD -
  H1W89_RS07725 (STHERMO_1703) trxB 1478127..1479080 (-) 954 WP_259699870.1 thioredoxin-disulfide reductase -
  H1W89_RS07730 (STHERMO_1704) - 1479113..1479337 (-) 225 WP_082309114.1 DUF4059 family protein -
  H1W89_RS07735 (STHERMO_1705) - 1479552..1480295 (-) 744 WP_011681551.1 amino acid ABC transporter ATP-binding protein -
  H1W89_RS07740 (STHERMO_1706) - 1480295..1481041 (-) 747 WP_095559509.1 amino acid ABC transporter permease -
  H1W89_RS07745 (STHERMO_1707) - 1481437..1482267 (-) 831 WP_014727671.1 transporter substrate-binding domain-containing protein -
  H1W89_RS07750 (STHERMO_1709) - 1482727..1482960 (-) 234 WP_002947030.1 hypothetical protein -
  H1W89_RS07755 (STHERMO_1710) dinB 1483258..1484361 (-) 1104 WP_014608654.1 DNA polymerase IV -
  H1W89_RS07760 (STHERMO_1711) pflB 1484640..1486949 (+) 2310 WP_011226473.1 formate C-acetyltransferase -
  H1W89_RS07765 (STHERMO_1712) - 1487216..1487998 (+) 783 WP_180474613.1 carbonic anhydrase -
  H1W89_RS07770 (STHERMO_1713) - 1488049..1488501 (+) 453 WP_014608655.1 GNAT family N-acetyltransferase -
  H1W89_RS07775 (STHERMO_1714) - 1488852..1489157 (-) 306 WP_014621914.1 restriction endonuclease subunit S -
  H1W89_RS10325 (STHERMO_1716) mobV 1489182..1489690 (-) 509 Protein_1482 MobV family relaxase -
  H1W89_RS07785 (STHERMO_1718) - 1490135..1490890 (-) 756 WP_011681558.1 ABC transporter permease -
  H1W89_RS07790 (STHERMO_1719) - 1490887..1491537 (-) 651 WP_011681559.1 ATP-binding cassette domain-containing protein -
  H1W89_RS07795 (STHERMO_1721) - 1491740..1492696 (-) 957 WP_002951776.1 serine hydrolase domain-containing protein -
  H1W89_RS07800 (STHERMO_1722) - 1492696..1493451 (-) 756 WP_011681560.1 CppA family protein -
  H1W89_RS07805 (STHERMO_1723) - 1493733..1494095 (+) 363 WP_014608659.1 CPBP family intramembrane glutamic endopeptidase -
  H1W89_RS07810 (STHERMO_1724) gla 1494182..1495045 (-) 864 WP_002951781.1 aquaglyceroporin Gla -
  H1W89_RS07815 (STHERMO_1725) - 1495166..1497433 (+) 2268 WP_011681561.1 Xaa-Pro dipeptidyl-peptidase -
  H1W89_RS07820 (STHERMO_1726) - 1497513..1497893 (-) 381 WP_002951783.1 hypothetical protein -
  H1W89_RS07825 - 1498018..1498281 (-) 264 WP_002945924.1 hypothetical protein -
  H1W89_RS07830 (STHERMO_1730) - 1498458..1499633 (+) 1176 WP_159341049.1 IS256-like element IS1191 family transposase -
  H1W89_RS07835 (STHERMO_1732) - 1499924..1500220 (-) 297 WP_004197070.1 bacteriocin immunity protein -
  H1W89_RS07840 (STHERMO_1733) - 1500385..1500591 (-) 207 WP_011681562.1 hypothetical protein -
  H1W89_RS07845 (STHERMO_1734) - 1500622..1501311 (-) 690 WP_011681563.1 thioredoxin family protein -
  H1W89_RS07850 - 1501505..1503075 (+) 1571 WP_087009847.1 IS3-like element ISSth1b family transposase -
  H1W89_RS07855 (STHERMO_1737) - 1503221..1503475 (-) 255 WP_014608660.1 Blp family class II bacteriocin -
  H1W89_RS10330 (STHERMO_1738) - 1503726..1504127 (-) 402 WP_024703992.1 hypothetical protein -
  H1W89_RS07860 (STHERMO_1743) - 1505132..1505362 (-) 231 WP_014608662.1 bacteriocin class II family protein -
  H1W89_RS07865 (STHERMO_1744) - 1505718..1505918 (-) 201 WP_011681569.1 hypothetical protein -
  H1W89_RS07870 (STHERMO_1745) - 1505937..1506113 (-) 177 WP_011681570.1 Blp family class II bacteriocin -
  H1W89_RS07875 (STHERMO_1746) - 1506369..1507100 (+) 732 WP_002948869.1 LytR/AlgR family response regulator transcription factor -
  H1W89_RS10020 - 1507901..1508428 (+) 528 WP_231107203.1 ATP-binding protein -
  H1W89_RS07885 (STHERMO_1748) - 1508446..1508607 (-) 162 WP_011681573.1 ComC/BlpC family leader-containing pheromone/bacteriocin -
  H1W89_RS07890 (STHERMO_1749) - 1508622..1509989 (-) 1368 WP_011681574.1 bacteriocin secretion accessory protein -
  H1W89_RS07895 (STHERMO_1750) comA/nlmT 1510005..1512158 (-) 2154 WP_041827378.1 peptide cleavage/export ABC transporter Regulator
  H1W89_RS07900 (STHERMO_1754) - 1513172..1514917 (-) 1746 WP_024703994.1 ABC transporter ATP-binding protein -
  H1W89_RS07905 (STHERMO_1755) - 1514910..1516667 (-) 1758 WP_180474614.1 ABC transporter ATP-binding protein -
  H1W89_RS10025 (STHERMO_1757) - 1516855..1517061 (-) 207 WP_002948879.1 hypothetical protein -
  H1W89_RS07915 (STHERMO_1759) - 1517266..1517793 (-) 528 WP_011226503.1 VanZ family protein -
  H1W89_RS07920 (STHERMO_1760) rlmN 1517795..1518964 (-) 1170 WP_011226504.1 23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN -
  H1W89_RS07925 (STHERMO_1761) - 1518968..1519690 (-) 723 WP_011226505.1 YutD family protein -
  H1W89_RS07930 (STHERMO_1762) - 1519745..1521100 (-) 1356 WP_059257451.1 bifunctional metallophosphatase/5'-nucleotidase -
  H1W89_RS07935 (STHERMO_1765) - 1521948..1523291 (-) 1344 WP_014608670.1 DEAD/DEAH box helicase -
  H1W89_RS07940 (STHERMO_1766) mraY 1523366..1524388 (-) 1023 WP_011227524.1 phospho-N-acetylmuramoyl-pentapeptide- transferase -
  H1W89_RS07945 (STHERMO_1767) pbp2X 1524390..1526657 (-) 2268 WP_011226508.1 penicillin-binding protein PBP2X -
  H1W89_RS07950 (STHERMO_1768) ftsL 1526661..1526981 (-) 321 WP_014608671.1 cell division protein FtsL -
  H1W89_RS07955 (STHERMO_1769) rsmH 1526984..1527934 (-) 951 WP_002888254.1 16S rRNA (cytosine(1402)-N(4))-methyltransferase RsmH -
  H1W89_RS07960 (STHERMO_1770) - 1528101..1528832 (-) 732 WP_232085842.1 hypothetical protein -
  H1W89_RS07970 (STHERMO_1772) - 1529161..1529424 (+) 264 WP_162877224.1 hypothetical protein -
  H1W89_RS07975 (STHERMO_1774) - 1529730..1530086 (-) 357 WP_023909925.1 DUF805 domain-containing protein -
  H1W89_RS07980 (STHERMO_1776) - 1530435..1530602 (-) 168 WP_153300736.1 hypothetical protein -
  H1W89_RS07985 (STHERMO_1777) - 1530935..1532185 (-) 1251 WP_071417383.1 glutamate-5-semialdehyde dehydrogenase -
  H1W89_RS07990 (STHERMO_1778) proB 1532187..1532990 (-) 804 WP_014608676.1 glutamate 5-kinase -
  H1W89_RS07995 (STHERMO_1779) - 1533111..1534700 (-) 1590 WP_071417382.1 ABC transporter permease -
  H1W89_RS08000 (STHERMO_1780) - 1534703..1535434 (-) 732 WP_002891761.1 ABC transporter ATP-binding protein -
  H1W89_RS08005 (STHERMO_1781) - 1535709..1536440 (+) 732 WP_014608678.1 DUF554 domain-containing protein -
  H1W89_RS08010 (STHERMO_1782) addA 1536792..1540445 (-) 3654 WP_024010071.1 helicase-exonuclease AddAB subunit AddA -

Sequence


Protein


Download         Length: 717 a.a.        Molecular weight: 80644.44 Da        Isoelectric Point: 6.8843

>NTDB_id=1131422 H1W89_RS07895 WP_041827378.1 1510005..1512158(-) (comA/nlmT) [Streptococcus thermophilus isolate STH_CIRM_1035]
MFRFRRTFVPQIDMRDCGVAALASVAKYYGSDYSLAHLRELAKTNKEGTTALGLVEAAKKIGFETRAIKAEMSLFEMEDV
PYPFIAHVNKDGKLQHYYVIYKSTKDYLIIGDPDPSVKVTKMTKERFEKEWTGVTLFMGPEPSYKPHKDKKNGLWDFLPL
IFKQRSLIANIVFASLLVTLINILGSYYLQGILDEYVPNQMKSTLGIISIGLVVTYVLQQMMTFARDYLLTILSQRFTID
VILSYIRHIFELPMSFFATRRTGEVISRFSDANSIIDALASTILSLFLDFSIVIIVGGVLLIQNSNLFKLVLCSVPIYTL
IVFAFMKPFERMNHDVMQSNAMVNSAIIEDINGIETIKSLTSEEVCYQKIDGEFIDYLDNSFRLSKLSILQTSLKQGAQL
ILNVLILWTGAQLVMGNTISIGQLITFNMLLSYFTNPLENIINLQTKLQSAKVANTRLNEVYLIESEFGQSDDTYQEGIA
DGDITVTDLSYKYGFGRDTLTDVSLTIRQGEKISFVGVSGSGKTTLAKMLVNFYQPYKGHIDFNGQNISRIDKKTLRQHI
NYLPQQSYIFSGSVLENLTLGAARGITQADILKACEIAEIRQDIENMPMGFQTELSDGAGLSGGQKQRIALARALLTKSP
VLILDEATSGLDVLTEKQVIDNLLALKDKTIIFVAHRLSIAERTDRIVVIDHGRVVETGSHQDLMSYPGFYYQLFRK

Nucleotide


Download         Length: 2154 bp        

>NTDB_id=1131422 H1W89_RS07895 WP_041827378.1 1510005..1512158(-) (comA/nlmT) [Streptococcus thermophilus isolate STH_CIRM_1035]
ATGTTTCGTTTTCGTAGGACTTTTGTCCCTCAAATAGACATGAGGGATTGTGGAGTTGCTGCCTTGGCATCAGTGGCCAA
GTACTATGGTTCAGATTATTCATTAGCACATCTGCGTGAGTTGGCGAAGACCAATAAAGAAGGGACAACTGCCTTAGGTC
TTGTAGAGGCTGCTAAAAAAATTGGCTTTGAAACGAGAGCTATAAAGGCTGAAATGTCGCTCTTTGAGATGGAAGATGTT
CCTTATCCTTTTATTGCTCATGTTAATAAAGATGGGAAGCTTCAACATTATTATGTTATTTATAAAAGCACCAAGGATTA
TCTGATAATTGGAGACCCTGATCCAAGTGTAAAAGTAACTAAAATGACTAAAGAGCGTTTTGAGAAAGAGTGGACAGGTG
TTACTCTTTTTATGGGACCGGAACCCAGTTATAAACCACATAAGGATAAGAAAAATGGACTCTGGGACTTTCTCCCTTTG
ATCTTTAAACAAAGGTCCTTGATAGCTAATATTGTCTTTGCCAGTCTCTTGGTTACTTTAATAAATATTTTAGGTTCCTA
TTATTTACAAGGTATTCTAGACGAATATGTCCCTAATCAAATGAAGTCTACCTTAGGAATTATCTCAATTGGATTAGTTG
TGACCTATGTTTTACAACAAATGATGACTTTTGCAAGAGATTATCTCTTAACCATACTGAGTCAGCGATTTACCATTGAC
GTTATCTTGTCCTACATACGACATATCTTTGAACTCCCAATGTCTTTTTTTGCCACAAGACGTACAGGGGAGGTTATCTC
ACGTTTTAGTGATGCTAACTCTATTATCGATGCTCTGGCTTCGACGATATTATCACTTTTCCTTGATTTCTCTATTGTGA
TTATCGTAGGAGGCGTGTTATTGATACAAAATAGCAATCTCTTCAAGCTAGTTCTTTGTTCGGTTCCAATTTATACCCTT
ATCGTCTTTGCCTTTATGAAACCTTTTGAGCGAATGAATCATGACGTCATGCAGAGTAATGCTATGGTTAATTCAGCCAT
CATTGAGGACATTAATGGGATTGAAACCATAAAGTCACTAACCAGCGAAGAAGTATGCTATCAAAAGATTGATGGTGAGT
TTATTGACTATCTAGACAATTCTTTTCGCCTTTCTAAGTTATCTATACTACAAACATCATTGAAACAAGGTGCTCAACTT
ATTTTAAATGTACTTATCCTCTGGACAGGTGCTCAGTTGGTGATGGGAAACACCATTTCGATAGGACAATTGATTACTTT
TAATATGTTGCTTTCTTACTTCACGAATCCTTTGGAAAATATCATTAACCTGCAAACCAAGTTACAGTCTGCTAAGGTAG
CTAATACTAGGCTCAATGAGGTCTATCTGATTGAATCAGAGTTTGGACAAAGTGATGATACCTATCAAGAAGGCATTGCG
GATGGAGATATCACTGTTACGGATTTATCTTATAAATATGGTTTTGGTCGTGATACTTTGACTGATGTCAGTTTGACGAT
TAGACAAGGAGAAAAAATCAGTTTTGTTGGTGTCAGTGGATCTGGTAAGACTACTCTAGCTAAAATGTTGGTCAATTTTT
ATCAACCATATAAGGGGCACATAGATTTTAATGGTCAAAATATTAGTCGCATAGACAAGAAAACTCTTCGTCAACATATT
AACTATCTCCCTCAGCAATCCTATATATTTAGTGGTAGTGTTTTAGAAAATCTTACTTTAGGTGCAGCACGGGGTATTAC
GCAAGCTGATATTTTGAAAGCTTGTGAAATAGCAGAAATTCGTCAAGATATTGAAAACATGCCTATGGGGTTTCAGACAG
AGCTGTCTGATGGAGCAGGTCTGTCTGGAGGGCAAAAGCAACGTATCGCTTTGGCGCGTGCACTACTAACGAAATCTCCT
GTACTAATCTTAGATGAAGCAACTAGCGGATTGGATGTTTTGACAGAAAAGCAGGTTATTGATAACCTCCTAGCACTAAA
AGATAAAACGATCATCTTTGTAGCACACAGGCTTAGTATCGCTGAGCGGACCGACCGTATCGTAGTCATTGATCACGGAC
GCGTAGTGGAGACAGGTTCTCATCAAGACCTAATGTCTTATCCAGGTTTCTATTATCAATTATTTAGAAAGTGA


Secondary structure


Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure


Source ID Structure
  AlphaFold DB A0A811IIL9

Transmembrane helices


Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.



Visualization of predicted probability:


Similar proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comA/nlmT Streptococcus mutans UA159

67.787

99.582

0.675

  comA Streptococcus mitis NCTC 12261

66.104

99.163

0.656

  comA Streptococcus pneumoniae Rx1

65.682

99.163

0.651

  comA Streptococcus pneumoniae D39

65.682

99.163

0.651

  comA Streptococcus pneumoniae R6

65.682

99.163

0.651

  comA Streptococcus mitis SK321

65.401

99.163

0.649

  comA Streptococcus pneumoniae TIGR4

65.26

99.163

0.647

  comA Streptococcus gordonii str. Challis substr. CH1

64.006

99.582

0.637


Multiple sequence alignment