Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   H1W89_RS01070 Genome accession   NZ_LR822029
Coordinates   186899..187648 (+) Length   249 a.a.
NCBI ID   WP_014607893.1    Uniprot ID   -
Organism   Streptococcus thermophilus isolate STH_CIRM_1035     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Genomic Context

Location: 181899..192648
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  H1W89_RS01050 (STHERMO_0179) - 182452..182622 (+) 171 WP_180474484.1 hypothetical protein -
  H1W89_RS01055 (STHERMO_0180) - 182902..183642 (-) 741 WP_002949253.1 amino acid ABC transporter ATP-binding protein -
  H1W89_RS01060 (STHERMO_0181) - 183642..185192 (-) 1551 WP_014607891.1 ABC transporter substrate-binding protein/permease -
  H1W89_RS01065 (STHERMO_0182) - 185395..186249 (+) 855 WP_014607892.1 undecaprenyl-diphosphate phosphatase -
  H1W89_RS01070 (STHERMO_0183) mecA 186899..187648 (+) 750 WP_014607893.1 adaptor protein MecA Regulator
  H1W89_RS01075 (STHERMO_0184) - 187652..188809 (+) 1158 WP_014607894.1 glycosyltransferase family 4 protein -
  H1W89_RS01080 (STHERMO_0185) sufC 188969..189739 (+) 771 WP_002947634.1 Fe-S cluster assembly ATPase SufC -
  H1W89_RS01085 (STHERMO_0186) sufD 189776..191038 (+) 1263 WP_002947640.1 Fe-S cluster assembly protein SufD -
  H1W89_RS01090 (STHERMO_0187) - 191092..192324 (+) 1233 WP_011225367.1 cysteine desulfurase -

Sequence

Protein


Download         Length: 249 a.a.        Molecular weight: 29109.65 Da        Isoelectric Point: 4.0624

>NTDB_id=1131383 H1W89_RS01070 WP_014607893.1 186899..187648(+) (mecA) [Streptococcus thermophilus isolate STH_CIRM_1035]
MEMKQINETTLKIMITMEDLEEHGMELKDFLIPQEKTEEFFYTVMDELDLPDNFKNSGMLSFRVTPRKDRVDVFVTKTDL
KEDLDFNDLSDMEDYSGLSPEEFLKALEDNFMDKGDIEAHHKLEEHDKTLKEVDETMTGPAKEVAEETIREDYTHYVLAF
SDFDQVVTFAQGLKNVSVEGSELYKLGDVYYMTILLYLADEPDYYANNMYARFLEYANVADRTRPYLQEHATILMEEDAL
PVLQATKWS

Nucleotide


Download         Length: 750 bp        

>NTDB_id=1131383 H1W89_RS01070 WP_014607893.1 186899..187648(+) (mecA) [Streptococcus thermophilus isolate STH_CIRM_1035]
ATGGAAATGAAACAAATAAACGAGACAACTCTAAAAATCATGATTACCATGGAAGATCTTGAAGAACATGGTATGGAGCT
GAAAGATTTCTTGATTCCCCAGGAAAAAACAGAGGAATTTTTCTATACTGTCATGGATGAGTTGGACTTGCCTGATAACT
TTAAAAATAGTGGGATGTTGAGCTTCCGTGTCACGCCACGAAAGGATCGTGTGGATGTTTTTGTGACTAAAACAGATCTT
AAGGAAGACCTTGATTTCAATGATTTGTCAGATATGGAAGACTATTCAGGACTTTCTCCAGAAGAATTCCTCAAAGCTCT
TGAAGATAACTTTATGGATAAGGGAGATATTGAAGCCCACCATAAGCTCGAAGAGCATGATAAGACCTTGAAAGAGGTTG
ATGAGACTATGACAGGGCCGGCTAAGGAAGTGGCTGAGGAAACTATTCGTGAAGATTATACTCACTATGTCTTGGCTTTC
TCTGACTTTGATCAAGTAGTGACCTTTGCGCAAGGTTTGAAGAATGTGTCAGTGGAGGGTTCTGAACTTTATAAACTTGG
TGATGTCTACTATATGACTATCCTTCTTTACTTGGCTGATGAGCCTGATTATTACGCGAACAATATGTATGCGCGTTTTC
TTGAATATGCGAATGTGGCAGACCGAACACGTCCCTATCTACAAGAGCATGCAACAATCTTGATGGAAGAGGACGCCTTA
CCGGTATTACAAGCAACGAAATGGAGCTAG

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-242)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus thermophilus LMD-9

98.394

100

0.984
  mecA Streptococcus thermophilus LMG 18311

98.394

100

0.984
  mecA Streptococcus mutans UA159

57.787

97.992

0.566
  mecA Streptococcus pneumoniae Rx1

45.783

100

0.458
  mecA Streptococcus pneumoniae D39

45.783

100

0.458
  mecA Streptococcus pneumoniae R6

45.783

100

0.458
  mecA Streptococcus pneumoniae TIGR4

45.783

100

0.458

Multiple sequence alignment