Detailed information    

insolico Bioinformatically predicted

Overview

Name   covR   Type   Regulator
Locus tag   H1X63_RS01770 Genome accession   NZ_LR822027
Coordinates   324247..324936 (+) Length   229 a.a.
NCBI ID   WP_002949638.1    Uniprot ID   A0A060BFD8
Organism   Streptococcus thermophilus isolate STH_CIRM_998     
Function   repress comR expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 319247..329936
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  H1X63_RS10430 (STHERMO_0331) - 320211..320362 (+) 152 Protein_291 ascorbate 6-phosphate lactonase -
  H1X63_RS01750 (STHERMO_0332) - 320400..321071 (-) 672 WP_100284858.1 potassium channel family protein -
  H1X63_RS01755 (STHERMO_0333) - 321111..322475 (-) 1365 WP_269473099.1 TrkH family potassium uptake protein -
  H1X63_RS01760 (STHERMO_0334) rsmG 322545..323258 (-) 714 WP_100284860.1 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG -
  H1X63_RS01765 (STHERMO_0335) - 323555..324091 (+) 537 WP_180487782.1 DUF177 domain-containing protein -
  H1X63_RS01770 (STHERMO_0336) covR 324247..324936 (+) 690 WP_002949638.1 response regulator transcription factor Regulator
  H1X63_RS01775 (STHERMO_0337) covS 324933..326450 (+) 1518 WP_180487783.1 HAMP domain-containing histidine kinase Regulator
  H1X63_RS01780 (STHERMO_0338) nrdR 326572..327051 (+) 480 WP_179972620.1 transcriptional regulator NrdR -
  H1X63_RS01785 (STHERMO_0339) - 327048..328223 (+) 1176 WP_179972621.1 DnaD domain protein -
  H1X63_RS01790 (STHERMO_0340) dnaI 328227..329129 (+) 903 WP_100284865.1 primosomal protein DnaI -

Sequence

Protein


Download         Length: 229 a.a.        Molecular weight: 26655.77 Da        Isoelectric Point: 4.7059

>NTDB_id=1131327 H1X63_RS01770 WP_002949638.1 324247..324936(+) (covR) [Streptococcus thermophilus isolate STH_CIRM_998]
MSKRILIVEDERNLARFVSLELQHEGYDVVTADNGREGLEMALEKDFDLILLDLMLPEMDGFEVTRRLQQEKDTYIMMMT
ARDSIMDIVAGLDRGADDYIIKPFAIEELLARIRATFRRQDIEATKKAPAKASTYRDLKLDVQNRAVVRGDEVIPLTKRE
FDLLNTLLSNMNQVMTREELLLQVWKYDDVIETNVVDVYIRYLRGKIDIPGKESYIQTVRGMGYVIRER

Nucleotide


Download         Length: 690 bp        

>NTDB_id=1131327 H1X63_RS01770 WP_002949638.1 324247..324936(+) (covR) [Streptococcus thermophilus isolate STH_CIRM_998]
ATGAGCAAACGCATTTTGATTGTTGAAGATGAGAGAAACCTTGCTCGTTTTGTCTCTCTTGAACTTCAACACGAAGGATA
CGACGTTGTGACAGCGGACAACGGACGCGAAGGACTTGAAATGGCACTTGAGAAAGATTTCGATCTTATTCTCTTGGATC
TTATGTTGCCTGAGATGGACGGTTTCGAAGTGACACGTCGTCTCCAACAAGAAAAAGATACTTATATTATGATGATGACA
GCTCGCGACTCAATCATGGATATTGTTGCTGGTTTGGATCGTGGAGCTGATGACTATATTATAAAACCATTTGCGATTGA
AGAACTGTTGGCACGTATTCGTGCAACCTTCCGTCGTCAAGATATCGAAGCTACTAAGAAGGCACCAGCTAAAGCGTCAA
CCTATCGCGATTTAAAATTGGATGTTCAAAACCGTGCAGTTGTTCGCGGTGATGAGGTAATTCCATTGACAAAACGTGAG
TTTGATTTGTTGAACACACTTTTAAGCAATATGAACCAAGTAATGACCCGTGAGGAACTCTTGCTTCAAGTCTGGAAATA
TGATGACGTAATTGAAACAAACGTTGTAGATGTTTATATTCGTTACTTACGTGGGAAAATCGACATTCCAGGTAAGGAAT
CATACATTCAAACAGTACGAGGGATGGGTTACGTTATCCGTGAAAGATGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-114)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(152-225)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A060BFD8

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covR Streptococcus salivarius strain HSISS4

96.07

100

0.961
  covR Lactococcus lactis subsp. lactis strain DGCC12653

67.544

99.563

0.672
  vicR Streptococcus mutans UA159

45.259

100

0.459
  micA Streptococcus pneumoniae Cp1015

43.913

100

0.441

Multiple sequence alignment