Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   H1X63_RS01070 Genome accession   NZ_LR822027
Coordinates   187321..188070 (+) Length   249 a.a.
NCBI ID   WP_100273348.1    Uniprot ID   -
Organism   Streptococcus thermophilus isolate STH_CIRM_998     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Genomic Context

Location: 182321..193070
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  H1X63_RS10390 (STHERMO_0180) - 182847..183248 (+) 402 WP_232086870.1 LPXTG cell wall anchor domain-containing protein -
  H1X63_RS01050 (STHERMO_0181) - 183336..184076 (-) 741 WP_179972549.1 amino acid ABC transporter ATP-binding protein -
  H1X63_RS01055 (STHERMO_0182) - 184076..185626 (-) 1551 WP_179972550.1 ABC transporter substrate-binding protein/permease -
  H1X63_RS01060 (STHERMO_0183) - 185830..186684 (+) 855 WP_011680666.1 undecaprenyl-diphosphate phosphatase -
  H1X63_RS01065 - 186736..187044 (-) 309 WP_306496352.1 DUF3021 family protein -
  H1X63_RS01070 (STHERMO_0184) mecA 187321..188070 (+) 750 WP_100273348.1 adaptor protein MecA Regulator
  H1X63_RS01075 (STHERMO_0185) - 188074..189231 (+) 1158 WP_179972551.1 glycosyltransferase family 4 protein -
  H1X63_RS01080 (STHERMO_0186) sufC 189392..190162 (+) 771 WP_179972552.1 Fe-S cluster assembly ATPase SufC -
  H1X63_RS01085 (STHERMO_0187) sufD 190199..191461 (+) 1263 WP_179972553.1 Fe-S cluster assembly protein SufD -
  H1X63_RS01090 (STHERMO_0188) - 191515..192747 (+) 1233 WP_179972554.1 cysteine desulfurase -

Sequence

Protein


Download         Length: 249 a.a.        Molecular weight: 29116.68 Da        Isoelectric Point: 4.0182

>NTDB_id=1131319 H1X63_RS01070 WP_100273348.1 187321..188070(+) (mecA) [Streptococcus thermophilus isolate STH_CIRM_998]
MEMKQISETTLKIMITMEDLEEHGMELKDFLIPQEKTEEFFYTVMDELDLPDNFKNSGMLSFRVTPRKDRVDVFVTKSDL
KEDLDFNDLSDMEDYSGLSPEEFLKALEDNFMDKGDIEAHHKLEELEKTLKEVDETMTDPAKEVAEETIREDYTHYVLAF
SDFDQVVTFAQGLKNVSVEGSELYKLGDVYYMTILLYLADEPDYYANNMYARFLEYANVADRTRPYLQEHATILMEEDAL
PVLQATKWS

Nucleotide


Download         Length: 750 bp        

>NTDB_id=1131319 H1X63_RS01070 WP_100273348.1 187321..188070(+) (mecA) [Streptococcus thermophilus isolate STH_CIRM_998]
ATGGAAATGAAACAAATAAGCGAGACAACTCTAAAAATCATGATTACCATGGAAGATCTTGAAGAACATGGTATGGAGCT
GAAAGATTTCTTGATTCCCCAGGAAAAAACAGAGGAATTTTTCTATACTGTCATGGATGAGTTGGACTTACCTGATAACT
TTAAAAATAGTGGGATGTTGAGCTTCCGTGTCACGCCACGAAAGGATCGTGTGGATGTTTTTGTGACTAAATCAGATCTT
AAGGAAGACCTTGATTTCAATGATTTGTCAGATATGGAAGACTATTCAGGACTTTCTCCAGAAGAATTCCTCAAAGCTCT
TGAAGATAACTTTATGGATAAGGGAGATATTGAAGCCCACCATAAGCTCGAAGAGCTTGAAAAGACCTTGAAAGAGGTTG
ATGAGACTATGACAGATCCGGCTAAGGAAGTGGCTGAGGAAACTATTCGTGAAGATTATACTCACTATGTCTTGGCTTTC
TCTGACTTTGATCAAGTAGTGACCTTTGCGCAAGGTTTGAAGAATGTGTCAGTGGAGGGTTCTGAACTTTATAAACTTGG
TGATGTCTACTATATGACTATCCTTCTTTACTTGGCTGATGAGCCTGATTATTACGCGAACAATATGTATGCGCGTTTTC
TTGAATATGCGAATGTGGCAGACCGAACACGTCCCTATCTACAAGAGCATGCAACAATCTTGATGGAAGAGGACGCCTTA
CCGGTATTACAAGCAACGAAATGGAGCTAG

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-242)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus thermophilus LMD-9

98.394

100

0.984
  mecA Streptococcus thermophilus LMG 18311

97.59

100

0.976
  mecA Streptococcus mutans UA159

59.016

97.992

0.578
  mecA Streptococcus pneumoniae Rx1

46.988

100

0.47
  mecA Streptococcus pneumoniae D39

46.988

100

0.47
  mecA Streptococcus pneumoniae R6

46.988

100

0.47
  mecA Streptococcus pneumoniae TIGR4

46.988

100

0.47

Multiple sequence alignment