Detailed information    

insolico Bioinformatically predicted

Overview

Name   stkP/pknB   Type   Regulator
Locus tag   H1W98_RS06995 Genome accession   NZ_LR822026
Coordinates   1344594..1346465 (-) Length   623 a.a.
NCBI ID   WP_179972076.1    Uniprot ID   A0A7U7C4S1
Organism   Streptococcus thermophilus isolate STH_CIRM_967     
Function   activate comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 1339594..1351465
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  H1W98_RS06975 (STHERMO_1584) - 1339780..1340424 (-) 645 WP_022496266.1 response regulator transcription factor -
  H1W98_RS06980 (STHERMO_1585) - 1340414..1341424 (-) 1011 WP_011227402.1 sensor histidine kinase -
  H1W98_RS06985 (STHERMO_1586) liaF 1341421..1342119 (-) 699 WP_179972075.1 cell wall-active antibiotics response protein LiaF -
  H1W98_RS06990 (STHERMO_1587) - 1342302..1343551 (-) 1250 Protein_1319 ISL3 family transposase -
  H1W98_RS06995 (STHERMO_1592) stkP/pknB 1344594..1346465 (-) 1872 WP_179972076.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  H1W98_RS07000 (STHERMO_1593) - 1346465..1347202 (-) 738 WP_180482521.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -
  H1W98_RS07005 (STHERMO_1594) rsmB 1347246..1348568 (-) 1323 WP_180482520.1 16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB -
  H1W98_RS07010 (STHERMO_1595) fmt 1348558..1349493 (-) 936 WP_180482519.1 methionyl-tRNA formyltransferase -

Sequence

Protein


Download         Length: 623 a.a.        Molecular weight: 68012.78 Da        Isoelectric Point: 6.5913

>NTDB_id=1131288 H1W98_RS06995 WP_179972076.1 1344594..1346465(-) (stkP/pknB) [Streptococcus thermophilus isolate STH_CIRM_967]
MIQVGKLFAGRYRILKSIGRGGMADVYLANDLILDNENVAIKVLRTNYQTDQVAVARFQREARAMAELSHPNIVAIRDIG
EEDGQQFLVMEYVDGSDLKKFIQDHAPLSNQDVVHIMGEVLSAMTLAHQKGIIHRDLKPQNVLLTKDGRAKVTDFGIAVA
FAETSLTQTNSMLGSVHYLSPEQARGSKATIQSDIYAMGIMLFEMLTGHIPFDGDSAVTIALQHFQKPLPSILAENRNVP
QALENVVIRATAKKLENRYNSTLEMSRDLVTSLYPSHSRDSKVVFDDMTDTKTLPKVDSVPSVGPEKKISPKPSEPKPAP
SKQPREKASLSKKKKKLFSTLLKVFLGFVFIGIIVFAYLVFTNPDNVQVPNVVGQELSTAQTELESAGFKVGDVKEVEND
SVDKGKVIKTDPTAGTTRKEGTSIDVYVSSGSKGFTLKNYTGKNYKDAIEDLTSNYGVSEDQIDIQYIEDDNAKEGEILS
QSPERNKSFNPKDSKAKIKFRVATPKTITMPDVTGLTVSTAVQTLNRKNISSSSIEYHDYNTGVKLDKSKVPSNTGVLYQ
DPQVGTAVDGTVILYVSVVTESSSIQQSSSASTTQSPSSTSSSSESSTASSTETATEATHTEQ

Nucleotide


Download         Length: 1872 bp        

>NTDB_id=1131288 H1W98_RS06995 WP_179972076.1 1344594..1346465(-) (stkP/pknB) [Streptococcus thermophilus isolate STH_CIRM_967]
ATGATCCAAGTTGGCAAATTATTTGCTGGACGTTATCGAATCCTTAAATCTATCGGACGTGGTGGTATGGCGGATGTTTA
TCTGGCTAACGACCTGATTCTGGATAATGAAAATGTAGCTATTAAGGTGCTACGTACCAATTATCAAACTGATCAGGTTG
CTGTGGCGCGTTTCCAGCGTGAAGCGCGTGCCATGGCTGAGCTTAGTCATCCGAATATCGTTGCGATTAGAGATATTGGT
GAAGAAGACGGTCAGCAGTTCTTGGTGATGGAGTATGTGGATGGTTCGGACTTGAAGAAATTCATTCAAGACCATGCACC
ATTGTCAAACCAAGATGTTGTGCATATTATGGGGGAAGTCCTTTCCGCCATGACTCTTGCCCACCAAAAGGGTATTATTC
ACCGTGACCTTAAGCCACAGAACGTTCTATTAACTAAGGATGGTAGAGCTAAGGTTACAGACTTTGGTATCGCAGTAGCA
TTTGCTGAAACCAGCCTGACACAAACTAACTCAATGTTGGGGTCAGTCCATTATTTGTCACCAGAACAGGCACGTGGTTC
TAAAGCCACTATCCAAAGTGATATCTATGCTATGGGGATTATGCTCTTTGAAATGTTGACAGGGCATATCCCTTTTGATG
GCGATAGTGCAGTAACCATTGCACTTCAACATTTCCAAAAGCCCCTGCCATCGATTTTGGCTGAGAATCGTAACGTTCCT
CAAGCTTTAGAAAATGTTGTTATTAGAGCAACTGCTAAAAAGCTTGAAAATCGTTACAACAGCACTTTGGAAATGAGTCG
CGACCTAGTAACTAGTTTGTATCCTAGTCATAGTCGTGATTCTAAGGTAGTTTTTGATGACATGACGGATACTAAGACCC
TGCCAAAGGTTGATTCAGTTCCATCAGTAGGTCCGGAGAAAAAGATTTCTCCTAAACCATCAGAGCCTAAACCGGCTCCA
AGCAAACAACCGAGGGAAAAAGCTTCTCTATCTAAAAAGAAGAAAAAGCTCTTTTCAACTCTACTCAAGGTTTTCCTAGG
CTTCGTCTTTATAGGAATTATCGTCTTTGCCTATCTTGTTTTTACCAATCCTGACAATGTCCAAGTACCAAATGTTGTAG
GTCAAGAATTGTCAACAGCTCAGACGGAACTTGAAAGTGCAGGCTTTAAGGTTGGTGATGTTAAAGAAGTCGAAAATGAT
TCAGTCGATAAGGGCAAAGTTATCAAGACCGACCCTACAGCTGGGACAACGCGTAAAGAGGGAACAAGCATTGATGTCTA
TGTTTCTTCTGGTAGCAAAGGTTTCACTCTGAAAAATTACACAGGGAAAAATTATAAGGATGCCATTGAGGATTTGACCT
CAAATTATGGGGTTTCCGAGGATCAGATTGATATTCAATATATCGAAGACGATAATGCTAAAGAAGGCGAAATCCTATCT
CAAAGTCCGGAGAGAAACAAGTCCTTCAATCCTAAAGATAGTAAGGCAAAAATCAAGTTTCGTGTGGCAACTCCTAAGAC
CATAACTATGCCTGATGTGACTGGTTTAACTGTCTCGACAGCAGTCCAAACCTTGAATCGTAAAAACATTTCAAGTAGTA
GTATTGAGTATCATGACTATAATACTGGTGTTAAGTTGGATAAGAGTAAGGTACCTAGTAATACAGGGGTCCTTTATCAA
GATCCTCAAGTTGGTACTGCTGTTGATGGCACAGTGATTCTCTATGTTTCAGTCGTAACTGAGAGTTCAAGTATTCAACA
GTCAAGCTCAGCAAGTACGACACAATCGCCGTCATCTACAAGTTCTAGTTCTGAAAGTAGTACAGCTTCTAGTACCGAAA
CAGCTACAGAAGCTACTCACACAGAGCAATAA

Domains

Predicted by InterproScan.

PASTA domain (PASTA)

(508-577)

PASTA domain (PASTA)

(367-429)

PASTA domain (PASTA)

(436-502)

Protein kinase domain (Pkinase)

(12-235)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A7U7C4S1

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  stkP/pknB Streptococcus salivarius strain HSISS4

90.189

93.258

0.841
  pknB Streptococcus mutans UA159

65.498

86.998

0.57
  stkP Streptococcus pneumoniae TIGR4

58.3

79.294

0.462
  stkP Streptococcus pneumoniae D39

58.097

79.294

0.461
  stkP Streptococcus pneumoniae R6

58.097

79.294

0.461
  stkP Streptococcus pneumoniae Rx1

57.895

79.294

0.459

Multiple sequence alignment