Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   H1X08_RS08970 Genome accession   NZ_LR822025
Coordinates   1750726..1751475 (-) Length   249 a.a.
NCBI ID   WP_100273348.1    Uniprot ID   -
Organism   Streptococcus thermophilus isolate STH_CIRM_961     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Genomic Context

Location: 1745726..1756475
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  H1X08_RS08950 (STHERMO_2050) sufD 1745916..1747178 (-) 1263 WP_179972553.1 Fe-S cluster assembly protein SufD -
  H1X08_RS08955 (STHERMO_2051) sufC 1747215..1747985 (-) 771 WP_179972552.1 Fe-S cluster assembly ATPase SufC -
  H1X08_RS08960 (STHERMO_2052) - 1748276..1749525 (+) 1250 Protein_1727 ISL3 family transposase -
  H1X08_RS08965 (STHERMO_2053) - 1749565..1750722 (-) 1158 WP_179972551.1 glycosyltransferase family 4 protein -
  H1X08_RS08970 (STHERMO_2054) mecA 1750726..1751475 (-) 750 WP_100273348.1 adaptor protein MecA Regulator
  H1X08_RS08975 - 1751770..1752060 (+) 291 WP_223899616.1 DUF3021 family protein -
  H1X08_RS08980 (STHERMO_2055) - 1752112..1752966 (-) 855 WP_011680666.1 undecaprenyl-diphosphate phosphatase -
  H1X08_RS08985 (STHERMO_2057) - 1753170..1754720 (+) 1551 WP_179972550.1 ABC transporter substrate-binding protein/permease -
  H1X08_RS08990 (STHERMO_2058) - 1754720..1755460 (+) 741 WP_179972549.1 amino acid ABC transporter ATP-binding protein -
  H1X08_RS10985 (STHERMO_2059) - 1755548..1755928 (-) 381 WP_232086934.1 LPXTG cell wall anchor domain-containing protein -

Sequence

Protein


Download         Length: 249 a.a.        Molecular weight: 29116.68 Da        Isoelectric Point: 4.0182

>NTDB_id=1131236 H1X08_RS08970 WP_100273348.1 1750726..1751475(-) (mecA) [Streptococcus thermophilus isolate STH_CIRM_961]
MEMKQISETTLKIMITMEDLEEHGMELKDFLIPQEKTEEFFYTVMDELDLPDNFKNSGMLSFRVTPRKDRVDVFVTKSDL
KEDLDFNDLSDMEDYSGLSPEEFLKALEDNFMDKGDIEAHHKLEELEKTLKEVDETMTDPAKEVAEETIREDYTHYVLAF
SDFDQVVTFAQGLKNVSVEGSELYKLGDVYYMTILLYLADEPDYYANNMYARFLEYANVADRTRPYLQEHATILMEEDAL
PVLQATKWS

Nucleotide


Download         Length: 750 bp        

>NTDB_id=1131236 H1X08_RS08970 WP_100273348.1 1750726..1751475(-) (mecA) [Streptococcus thermophilus isolate STH_CIRM_961]
ATGGAAATGAAACAAATAAGCGAGACAACTCTAAAAATCATGATTACCATGGAAGATCTTGAAGAACATGGTATGGAGCT
GAAAGATTTCTTGATTCCCCAGGAAAAAACAGAGGAATTTTTCTATACTGTCATGGATGAGTTGGACTTACCTGATAACT
TTAAAAATAGTGGGATGTTGAGCTTCCGTGTCACGCCACGAAAGGATCGTGTGGATGTTTTTGTGACTAAATCAGATCTT
AAGGAAGACCTTGATTTCAATGATTTGTCAGATATGGAAGACTATTCAGGACTTTCTCCAGAAGAATTCCTCAAAGCTCT
TGAAGATAACTTTATGGATAAGGGAGATATTGAAGCCCACCATAAGCTCGAAGAGCTTGAAAAGACCTTGAAAGAGGTTG
ATGAGACTATGACAGATCCGGCTAAGGAAGTGGCTGAGGAAACTATTCGTGAAGATTATACTCACTATGTCTTGGCTTTC
TCTGACTTTGATCAAGTAGTGACCTTTGCGCAAGGTTTGAAGAATGTGTCAGTGGAGGGTTCTGAACTTTATAAACTTGG
TGATGTCTACTATATGACTATCCTTCTTTACTTGGCTGATGAGCCTGATTATTACGCGAACAATATGTATGCGCGTTTTC
TTGAATATGCGAATGTGGCAGACCGAACACGTCCCTATCTACAAGAGCATGCAACAATCTTGATGGAAGAGGACGCCTTA
CCGGTATTACAAGCAACGAAATGGAGCTAG

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-242)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus thermophilus LMD-9

98.394

100

0.984
  mecA Streptococcus thermophilus LMG 18311

97.59

100

0.976
  mecA Streptococcus mutans UA159

59.016

97.992

0.578
  mecA Streptococcus pneumoniae Rx1

46.988

100

0.47
  mecA Streptococcus pneumoniae D39

46.988

100

0.47
  mecA Streptococcus pneumoniae R6

46.988

100

0.47
  mecA Streptococcus pneumoniae TIGR4

46.988

100

0.47

Multiple sequence alignment