Detailed information    

insolico Bioinformatically predicted

Overview

Name   stkP/pknB   Type   Regulator
Locus tag   H1X08_RS03180 Genome accession   NZ_LR822025
Coordinates   617902..619773 (+) Length   623 a.a.
NCBI ID   WP_179972076.1    Uniprot ID   A0A7U7C4S1
Organism   Streptococcus thermophilus isolate STH_CIRM_961     
Function   activate comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 612902..624773
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  H1X08_RS03165 (STHERMO_0692) fmt 614874..615809 (+) 936 WP_180482519.1 methionyl-tRNA formyltransferase -
  H1X08_RS03170 (STHERMO_0693) rsmB 615799..617121 (+) 1323 WP_180482520.1 16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB -
  H1X08_RS03175 (STHERMO_0694) - 617165..617902 (+) 738 WP_180482521.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -
  H1X08_RS03180 (STHERMO_0695) stkP/pknB 617902..619773 (+) 1872 WP_179972076.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  H1X08_RS03185 (STHERMO_0699) - 620816..622065 (+) 1250 Protein_600 ISL3 family transposase -
  H1X08_RS03190 (STHERMO_0700) liaF 622248..622946 (+) 699 WP_179972075.1 cell wall-active antibiotics response protein LiaF -
  H1X08_RS03195 (STHERMO_0701) - 622943..623953 (+) 1011 WP_011227402.1 sensor histidine kinase -
  H1X08_RS03200 (STHERMO_0702) - 623943..624587 (+) 645 WP_022496266.1 response regulator transcription factor -

Sequence

Protein


Download         Length: 623 a.a.        Molecular weight: 68012.78 Da        Isoelectric Point: 6.5913

>NTDB_id=1131203 H1X08_RS03180 WP_179972076.1 617902..619773(+) (stkP/pknB) [Streptococcus thermophilus isolate STH_CIRM_961]
MIQVGKLFAGRYRILKSIGRGGMADVYLANDLILDNENVAIKVLRTNYQTDQVAVARFQREARAMAELSHPNIVAIRDIG
EEDGQQFLVMEYVDGSDLKKFIQDHAPLSNQDVVHIMGEVLSAMTLAHQKGIIHRDLKPQNVLLTKDGRAKVTDFGIAVA
FAETSLTQTNSMLGSVHYLSPEQARGSKATIQSDIYAMGIMLFEMLTGHIPFDGDSAVTIALQHFQKPLPSILAENRNVP
QALENVVIRATAKKLENRYNSTLEMSRDLVTSLYPSHSRDSKVVFDDMTDTKTLPKVDSVPSVGPEKKISPKPSEPKPAP
SKQPREKASLSKKKKKLFSTLLKVFLGFVFIGIIVFAYLVFTNPDNVQVPNVVGQELSTAQTELESAGFKVGDVKEVEND
SVDKGKVIKTDPTAGTTRKEGTSIDVYVSSGSKGFTLKNYTGKNYKDAIEDLTSNYGVSEDQIDIQYIEDDNAKEGEILS
QSPERNKSFNPKDSKAKIKFRVATPKTITMPDVTGLTVSTAVQTLNRKNISSSSIEYHDYNTGVKLDKSKVPSNTGVLYQ
DPQVGTAVDGTVILYVSVVTESSSIQQSSSASTTQSPSSTSSSSESSTASSTETATEATHTEQ

Nucleotide


Download         Length: 1872 bp        

>NTDB_id=1131203 H1X08_RS03180 WP_179972076.1 617902..619773(+) (stkP/pknB) [Streptococcus thermophilus isolate STH_CIRM_961]
ATGATCCAAGTTGGCAAATTATTTGCTGGACGTTATCGAATCCTTAAATCTATCGGACGTGGTGGTATGGCGGATGTTTA
TCTGGCTAACGACCTGATTCTGGATAATGAAAATGTAGCTATTAAGGTGCTACGTACCAATTATCAAACTGATCAGGTTG
CTGTGGCGCGTTTCCAGCGTGAAGCGCGTGCCATGGCTGAGCTTAGTCATCCGAATATCGTTGCGATTAGAGATATTGGT
GAAGAAGACGGTCAGCAGTTCTTGGTGATGGAGTATGTGGATGGTTCGGACTTGAAGAAATTCATTCAAGACCATGCACC
ATTGTCAAACCAAGATGTTGTGCATATTATGGGGGAAGTCCTTTCCGCCATGACTCTTGCCCACCAAAAGGGTATTATTC
ACCGTGACCTTAAGCCACAGAACGTTCTATTAACTAAGGATGGTAGAGCTAAGGTTACAGACTTTGGTATCGCAGTAGCA
TTTGCTGAAACCAGCCTGACACAAACTAACTCAATGTTGGGGTCAGTCCATTATTTGTCACCAGAACAGGCACGTGGTTC
TAAAGCCACTATCCAAAGTGATATCTATGCTATGGGGATTATGCTCTTTGAAATGTTGACAGGGCATATCCCTTTTGATG
GCGATAGTGCAGTAACCATTGCACTTCAACATTTCCAAAAGCCCCTGCCATCGATTTTGGCTGAGAATCGTAACGTTCCT
CAAGCTTTAGAAAATGTTGTTATTAGAGCAACTGCTAAAAAGCTTGAAAATCGTTACAACAGCACTTTGGAAATGAGTCG
CGACCTAGTAACTAGTTTGTATCCTAGTCATAGTCGTGATTCTAAGGTAGTTTTTGATGACATGACGGATACTAAGACCC
TGCCAAAGGTTGATTCAGTTCCATCAGTAGGTCCGGAGAAAAAGATTTCTCCTAAACCATCAGAGCCTAAACCGGCTCCA
AGCAAACAACCGAGGGAAAAAGCTTCTCTATCTAAAAAGAAGAAAAAGCTCTTTTCAACTCTACTCAAGGTTTTCCTAGG
CTTCGTCTTTATAGGAATTATCGTCTTTGCCTATCTTGTTTTTACCAATCCTGACAATGTCCAAGTACCAAATGTTGTAG
GTCAAGAATTGTCAACAGCTCAGACGGAACTTGAAAGTGCAGGCTTTAAGGTTGGTGATGTTAAAGAAGTCGAAAATGAT
TCAGTCGATAAGGGCAAAGTTATCAAGACCGACCCTACAGCTGGGACAACGCGTAAAGAGGGAACAAGCATTGATGTCTA
TGTTTCTTCTGGTAGCAAAGGTTTCACTCTGAAAAATTACACAGGGAAAAATTATAAGGATGCCATTGAGGATTTGACCT
CAAATTATGGGGTTTCCGAGGATCAGATTGATATTCAATATATCGAAGACGATAATGCTAAAGAAGGCGAAATCCTATCT
CAAAGTCCGGAGAGAAACAAGTCCTTCAATCCTAAAGATAGTAAGGCAAAAATCAAGTTTCGTGTGGCAACTCCTAAGAC
CATAACTATGCCTGATGTGACTGGTTTAACTGTCTCGACAGCAGTCCAAACCTTGAATCGTAAAAACATTTCAAGTAGTA
GTATTGAGTATCATGACTATAATACTGGTGTTAAGTTGGATAAGAGTAAGGTACCTAGTAATACAGGGGTCCTTTATCAA
GATCCTCAAGTTGGTACTGCTGTTGATGGCACAGTGATTCTCTATGTTTCAGTCGTAACTGAGAGTTCAAGTATTCAACA
GTCAAGCTCAGCAAGTACGACACAATCGCCGTCATCTACAAGTTCTAGTTCTGAAAGTAGTACAGCTTCTAGTACCGAAA
CAGCTACAGAAGCTACTCACACAGAGCAATAA

Domains

Predicted by InterproScan.

PASTA domain (PASTA)

(508-577)

PASTA domain (PASTA)

(367-429)

PASTA domain (PASTA)

(436-502)

Protein kinase domain (Pkinase)

(12-235)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A7U7C4S1

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  stkP/pknB Streptococcus salivarius strain HSISS4

90.189

93.258

0.841
  pknB Streptococcus mutans UA159

65.498

86.998

0.57
  stkP Streptococcus pneumoniae TIGR4

58.3

79.294

0.462
  stkP Streptococcus pneumoniae D39

58.097

79.294

0.461
  stkP Streptococcus pneumoniae R6

58.097

79.294

0.461
  stkP Streptococcus pneumoniae Rx1

57.895

79.294

0.459

Multiple sequence alignment