Detailed information    

insolico Bioinformatically predicted

Overview

Name   covR   Type   Regulator
Locus tag   H0502_RS06690 Genome accession   NZ_LR822013
Coordinates   1329178..1329867 (-) Length   229 a.a.
NCBI ID   WP_002949638.1    Uniprot ID   A0A060BFD8
Organism   Streptococcus thermophilus isolate STH_CIRM_32     
Function   repress comR expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 1324178..1334867
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  H0502_RS06670 (STHERMO_1531) dnaI 1324985..1325887 (-) 903 WP_002946786.1 primosomal protein DnaI -
  H0502_RS06675 (STHERMO_1532) - 1325891..1327066 (-) 1176 WP_002949643.1 DnaD domain protein -
  H0502_RS06680 (STHERMO_1533) nrdR 1327063..1327542 (-) 480 WP_002949642.1 transcriptional regulator NrdR -
  H0502_RS06685 (STHERMO_1534) covS 1327664..1329181 (-) 1518 WP_014607970.1 HAMP domain-containing histidine kinase Regulator
  H0502_RS06690 (STHERMO_1535) covR 1329178..1329867 (-) 690 WP_002949638.1 response regulator transcription factor Regulator
  H0502_RS06695 (STHERMO_1536) - 1330023..1330559 (-) 537 WP_002946488.1 DUF177 domain-containing protein -
  H0502_RS06700 (STHERMO_1537) rsmG 1330856..1331569 (+) 714 WP_002946490.1 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG -
  H0502_RS06705 (STHERMO_1538) - 1331639..1333003 (+) 1365 WP_269149496.1 TrkH family potassium uptake protein -
  H0502_RS06710 (STHERMO_1539) - 1333043..1333714 (+) 672 WP_002946492.1 potassium channel family protein -
  H0502_RS10085 - 1333731..1333901 (-) 171 Protein_1335 ascorbate 6-phosphate lactonase -

Sequence

Protein


Download         Length: 229 a.a.        Molecular weight: 26655.77 Da        Isoelectric Point: 4.7059

>NTDB_id=1130798 H0502_RS06690 WP_002949638.1 1329178..1329867(-) (covR) [Streptococcus thermophilus isolate STH_CIRM_32]
MSKRILIVEDERNLARFVSLELQHEGYDVVTADNGREGLEMALEKDFDLILLDLMLPEMDGFEVTRRLQQEKDTYIMMMT
ARDSIMDIVAGLDRGADDYIIKPFAIEELLARIRATFRRQDIEATKKAPAKASTYRDLKLDVQNRAVVRGDEVIPLTKRE
FDLLNTLLSNMNQVMTREELLLQVWKYDDVIETNVVDVYIRYLRGKIDIPGKESYIQTVRGMGYVIRER

Nucleotide


Download         Length: 690 bp        

>NTDB_id=1130798 H0502_RS06690 WP_002949638.1 1329178..1329867(-) (covR) [Streptococcus thermophilus isolate STH_CIRM_32]
ATGAGCAAACGCATTTTGATTGTTGAAGATGAGAGAAACCTTGCTCGTTTTGTCTCTCTTGAACTTCAACACGAAGGATA
CGATGTTGTGACAGCGGACAACGGACGCGAAGGACTTGAAATGGCACTTGAGAAAGATTTCGATCTTATTCTCTTGGACC
TTATGTTGCCTGAGATGGACGGTTTCGAAGTGACACGTCGTCTCCAACAAGAAAAAGATACTTATATTATGATGATGACA
GCTCGCGACTCAATCATGGATATTGTTGCTGGTTTGGATCGTGGAGCTGATGACTATATTATAAAACCATTTGCGATTGA
AGAACTGTTGGCACGTATTCGTGCAACCTTCCGTCGTCAAGATATCGAAGCTACTAAGAAGGCACCAGCTAAAGCGTCAA
CCTATCGCGATTTAAAATTGGATGTTCAAAACCGTGCAGTTGTTCGCGGTGATGAGGTAATTCCATTGACAAAACGTGAG
TTTGATTTGTTGAACACACTTTTAAGCAATATGAACCAAGTAATGACCCGTGAGGAACTCTTGCTTCAAGTCTGGAAATA
TGATGACGTAATTGAAACAAACGTTGTAGATGTTTATATTCGTTACTTACGTGGGAAAATCGACATTCCAGGTAAGGAAT
CATACATTCAGACAGTACGAGGGATGGGTTACGTTATCCGTGAAAGATGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-114)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(152-225)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A060BFD8

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covR Streptococcus salivarius strain HSISS4

96.07

100

0.961
  covR Lactococcus lactis subsp. lactis strain DGCC12653

67.544

99.563

0.672
  vicR Streptococcus mutans UA159

45.259

100

0.459
  micA Streptococcus pneumoniae Cp1015

43.913

100

0.441

Multiple sequence alignment