Detailed information    

insolico Bioinformatically predicted

Overview

Name   covS   Type   Regulator
Locus tag   H0502_RS06685 Genome accession   NZ_LR822013
Coordinates   1327664..1329181 (-) Length   505 a.a.
NCBI ID   WP_014607970.1    Uniprot ID   A0A2H4K9K6
Organism   Streptococcus thermophilus isolate STH_CIRM_32     
Function   repress comR expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 1322664..1334181
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  H0502_RS06660 - 1322837..1323505 (-) 669 Protein_1324 HI_0552 family protein -
  H0502_RS06665 (STHERMO_1530) der 1323569..1324879 (-) 1311 WP_179970760.1 ribosome biogenesis GTPase Der -
  H0502_RS06670 (STHERMO_1531) dnaI 1324985..1325887 (-) 903 WP_002946786.1 primosomal protein DnaI -
  H0502_RS06675 (STHERMO_1532) - 1325891..1327066 (-) 1176 WP_002949643.1 DnaD domain protein -
  H0502_RS06680 (STHERMO_1533) nrdR 1327063..1327542 (-) 480 WP_002949642.1 transcriptional regulator NrdR -
  H0502_RS06685 (STHERMO_1534) covS 1327664..1329181 (-) 1518 WP_014607970.1 HAMP domain-containing histidine kinase Regulator
  H0502_RS06690 (STHERMO_1535) covR 1329178..1329867 (-) 690 WP_002949638.1 response regulator transcription factor Regulator
  H0502_RS06695 (STHERMO_1536) - 1330023..1330559 (-) 537 WP_002946488.1 DUF177 domain-containing protein -
  H0502_RS06700 (STHERMO_1537) rsmG 1330856..1331569 (+) 714 WP_002946490.1 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG -
  H0502_RS06705 (STHERMO_1538) - 1331639..1333003 (+) 1365 WP_269149496.1 TrkH family potassium uptake protein -
  H0502_RS06710 (STHERMO_1539) - 1333043..1333714 (+) 672 WP_002946492.1 potassium channel family protein -
  H0502_RS10085 - 1333731..1333901 (-) 171 Protein_1335 ascorbate 6-phosphate lactonase -

Sequence

Protein


Download         Length: 505 a.a.        Molecular weight: 57550.96 Da        Isoelectric Point: 5.2689

>NTDB_id=1130797 H0502_RS06685 WP_014607970.1 1327664..1329181(-) (covS) [Streptococcus thermophilus isolate STH_CIRM_32]
MSKLFGKVTIRKKLTMTTAVVFFLVLSMFTLVVVFSANTLLLQRERQNVNNTISKVVTYIEKDWDSDEELSPEPLLAALY
SPKNIYPSIINGVLSEKRSLDGQVAVSNRLYSNQSIYVYDKKGTFIFTSEEDTDSPPGMSEVNKLKLVSYKGKRGFLLQV
PIYGKDKKTIVGYAQVFHDLEFYYALKERLIFLLIFLEVGMTVLVIAVTVVVLTSILRPMRQLHETMGIIIDSPSDLELR
SKIESHDEIGALALNFNCMMDKIQENNQMQMRFLSDVSHELRTPIAVIKGHMDLLQRWGKNDPEILEESLEAASHEANRM
TIMINDMLDSIRVKGSFDNHRNDTCDLNSSIRTVIGNFRVLHDDYQFYLNDSEGSDRPAQIYSQHFEQVITILIDNAVKY
SPVNKKIQITIKALEDEMLVQVQDNGEGISKEDIEHIFERFYRSDKARNRTTTQSGVGIGLSILYQIVEAYRCHIDVSSE
LGVGTRFDLYIPFAESETTTPQIEG

Nucleotide


Download         Length: 1518 bp        

>NTDB_id=1130797 H0502_RS06685 WP_014607970.1 1327664..1329181(-) (covS) [Streptococcus thermophilus isolate STH_CIRM_32]
ATGAGTAAATTATTTGGTAAAGTAACCATTAGAAAAAAGTTGACCATGACAACTGCTGTGGTCTTCTTTCTTGTATTGTC
GATGTTCACTCTGGTTGTTGTATTTTCAGCCAATACGCTTCTTTTGCAACGTGAACGTCAAAATGTAAATAATACAATCT
CAAAAGTTGTTACTTATATCGAAAAGGACTGGGACTCTGATGAAGAGTTGAGTCCAGAGCCGCTTTTAGCGGCCCTTTAT
TCACCGAAAAATATCTATCCATCAATCATTAATGGAGTGCTTTCTGAAAAGCGTTCCTTAGATGGTCAAGTTGCGGTTTC
TAATAGATTATATTCCAACCAGTCTATCTATGTTTATGACAAAAAGGGAACTTTTATCTTTACTTCTGAGGAGGATACAG
ACTCACCTCCAGGCATGTCTGAGGTCAATAAACTGAAGTTGGTTTCCTATAAAGGTAAACGTGGTTTCTTACTACAAGTT
CCAATCTATGGCAAGGATAAGAAGACCATTGTTGGGTATGCTCAAGTTTTCCATGATTTGGAATTCTACTATGCGTTAAA
AGAGCGTTTAATTTTCCTATTGATATTCCTTGAAGTAGGAATGACGGTCTTAGTTATTGCAGTAACTGTAGTTGTCTTGA
CATCTATTCTTCGTCCGATGAGGCAGTTACACGAAACGATGGGTATTATTATCGATTCGCCAAGTGATTTGGAGCTTCGA
TCTAAGATTGAGAGTCATGATGAGATTGGTGCTTTGGCACTTAACTTTAACTGTATGATGGATAAAATTCAAGAAAATAA
TCAGATGCAGATGCGTTTCTTGAGTGACGTCAGTCACGAATTACGTACTCCCATTGCAGTTATTAAAGGACATATGGACC
TCTTGCAACGTTGGGGTAAAAATGATCCTGAAATCCTTGAAGAAAGTCTTGAAGCTGCAAGTCACGAAGCCAACCGTATG
ACGATTATGATTAACGATATGTTGGATTCTATTCGTGTTAAAGGGTCATTTGACAATCATAGAAATGATACATGTGATTT
GAATTCTTCAATCCGTACGGTTATTGGGAATTTTCGTGTCCTACATGACGACTACCAATTCTACCTCAATGATTCTGAGG
GTTCAGATCGTCCAGCACAGATTTACAGCCAGCACTTTGAACAGGTTATTACTATTTTGATTGATAATGCGGTCAAGTAT
TCGCCTGTTAATAAGAAAATCCAGATTACTATCAAGGCTCTGGAAGATGAGATGCTGGTACAGGTACAGGATAATGGTGA
GGGTATCTCTAAAGAAGATATTGAACATATATTTGAACGCTTCTATCGTTCAGATAAGGCGCGTAATCGTACGACAACCC
AATCTGGTGTGGGTATTGGTTTATCAATCCTCTATCAAATTGTGGAAGCTTATCGATGCCATATCGATGTCAGTTCAGAA
CTTGGTGTGGGTACACGTTTTGACCTCTACATTCCTTTTGCAGAGTCAGAAACTACGACACCTCAAATTGAAGGTTAA

Domains

Predicted by InterproScan.

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(384-494)

ArlS sensor domain (ArlS_N)

(39-187)

His Kinase A (phospho-acceptor) domain (HisKA)

(270-329)

HAMP domain (HAMP)

(213-265)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A2H4K9K6

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covS Streptococcus salivarius strain HSISS4

94.422

99.406

0.939

Multiple sequence alignment