Detailed information
Bioinformatically predicted
Overview
| Name | stkP/pknB | Type | Regulator |
| Locus tag | H0502_RS01615 | Genome accession | NZ_LR822013 |
| Coordinates | 328926..330797 (+) | Length | 623 a.a. |
| NCBI ID | WP_014621795.1 | Uniprot ID | A0A3G6JKP3 |
| Organism | Streptococcus thermophilus isolate STH_CIRM_32 | ||
| Function | activate comX expression (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 254831..332562 | 328926..330797 | within | 0 |
Gene organization within MGE regions
Location: 254831..332562
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| H0502_RS01270 (STHERMO_0293) | - | 254929..255669 (-) | 741 | WP_011681459.1 | amino acid ABC transporter ATP-binding protein | - |
| H0502_RS01275 (STHERMO_0294) | - | 255669..257879 (-) | 2211 | WP_179970611.1 | ABC transporter substrate-binding protein/permease | - |
| H0502_RS01280 | - | 258077..259013 (+) | 937 | Protein_254 | CPBP family intramembrane glutamic endopeptidase | - |
| H0502_RS01285 | - | 259337..259588 (-) | 252 | WP_179970612.1 | hypothetical protein | - |
| H0502_RS01290 (STHERMO_0299) | uvrB | 259700..261691 (+) | 1992 | WP_002953358.1 | excinuclease ABC subunit UvrB | - |
| H0502_RS01295 (STHERMO_0300) | - | 261736..262200 (+) | 465 | WP_011681454.1 | 8-oxo-dGTP diphosphatase | - |
| H0502_RS01300 (STHERMO_0301) | - | 262414..263244 (+) | 831 | WP_022097022.1 | transporter substrate-binding domain-containing protein | - |
| H0502_RS01305 (STHERMO_0302) | - | 263241..264038 (+) | 798 | WP_002951495.1 | transporter substrate-binding domain-containing protein | - |
| H0502_RS01310 (STHERMO_0303) | - | 264385..265494 (+) | 1110 | WP_014727642.1 | aminotransferase | - |
| H0502_RS01315 (STHERMO_0304) | - | 265587..266381 (+) | 795 | WP_014621826.1 | ABC transporter substrate-binding protein | - |
| H0502_RS01320 (STHERMO_0305) | rpsU | 266576..266752 (+) | 177 | WP_011226340.1 | 30S ribosomal protein S21 | - |
| H0502_RS01325 (STHERMO_0306) | dnaG | 267123..268934 (+) | 1812 | WP_116920323.1 | DNA primase | - |
| H0502_RS01330 (STHERMO_0307) | rpoD | 268938..270047 (+) | 1110 | WP_179970613.1 | RNA polymerase sigma factor RpoD | - |
| H0502_RS01335 (STHERMO_0308) | - | 270101..270436 (+) | 336 | WP_179970614.1 | metal-sulfur cluster assembly factor | - |
| H0502_RS01340 (STHERMO_0309) | - | 270447..271373 (+) | 927 | WP_179970615.1 | glycosyltransferase family 2 protein | - |
| H0502_RS01345 (STHERMO_0310) | - | 271428..272687 (+) | 1260 | WP_232086458.1 | DUF2142 domain-containing protein | - |
| H0502_RS01350 (STHERMO_0311) | rfbD | 272760..273611 (+) | 852 | WP_100284792.1 | dTDP-4-dehydrorhamnose reductase | - |
| H0502_RS01355 (STHERMO_0312) | - | 273949..274707 (+) | 759 | WP_179970616.1 | DUF4422 domain-containing protein | - |
| H0502_RS01360 (STHERMO_0313) | - | 274704..276161 (+) | 1458 | WP_179970617.1 | flippase | - |
| H0502_RS01365 (STHERMO_0314) | glf | 276164..277273 (+) | 1110 | WP_179970618.1 | UDP-galactopyranose mutase | - |
| H0502_RS10515 | - | 277287..277382 (+) | 96 | WP_374110359.1 | glycosyltransferase | - |
| H0502_RS01370 (STHERMO_0316) | - | 278211..279203 (+) | 993 | WP_179970619.1 | glycosyltransferase family 8 protein | - |
| H0502_RS01375 (STHERMO_0317) | - | 279233..279949 (+) | 717 | WP_041827367.1 | glycosyltransferase family 2 protein | - |
| H0502_RS01380 (STHERMO_0318) | - | 279949..280305 (+) | 357 | WP_011681441.1 | DUF2304 domain-containing protein | - |
| H0502_RS01385 (STHERMO_0319) | - | 280295..281071 (+) | 777 | WP_179970620.1 | glycosyltransferase family 2 protein | - |
| H0502_RS01390 (STHERMO_0321) | - | 281542..282744 (+) | 1203 | WP_179970621.1 | hypothetical protein | - |
| H0502_RS01395 (STHERMO_0322) | - | 282955..285969 (+) | 3015 | WP_179970622.1 | rhamnan synthesis F family protein | - |
| H0502_RS01400 (STHERMO_0323) | - | 285956..287263 (+) | 1308 | WP_179970623.1 | DUF2142 domain-containing protein | - |
| H0502_RS01405 (STHERMO_0324) | - | 287267..288514 (+) | 1248 | WP_101415660.1 | glycosyltransferase family 4 protein | - |
| H0502_RS01410 (STHERMO_0325) | - | 288531..290048 (+) | 1518 | WP_179970624.1 | glucosyltransferase domain-containing protein | - |
| H0502_RS01415 (STHERMO_0327) | cps2T | 290248..291396 (+) | 1149 | WP_065972456.1 | beta 1-4 rhamnosyltransferase Cps2T | - |
| H0502_RS01420 (STHERMO_0328) | - | 291393..292331 (+) | 939 | WP_065972455.1 | glycosyltransferase family 2 protein | - |
| H0502_RS01425 (STHERMO_0329) | - | 292332..293138 (+) | 807 | WP_014608560.1 | ABC transporter permease | - |
| H0502_RS01430 (STHERMO_0330) | - | 293138..294340 (+) | 1203 | WP_014608559.1 | ABC transporter ATP-binding protein | - |
| H0502_RS01435 (STHERMO_0331) | - | 294341..295984 (+) | 1644 | WP_095559418.1 | rhamnan synthesis F family protein | - |
| H0502_RS01440 (STHERMO_0332) | radC | 296032..296718 (+) | 687 | WP_011226324.1 | RadC family protein | - |
| H0502_RS01445 (STHERMO_0333) | - | 296771..297466 (-) | 696 | WP_179970625.1 | gamma-glutamyl-gamma-aminobutyrate hydrolase family protein | - |
| H0502_RS01450 (STHERMO_0334) | - | 297459..298118 (-) | 660 | WP_011681430.1 | redox-sensing transcriptional repressor Rex | - |
| H0502_RS01455 (STHERMO_0335) | - | 298262..298609 (-) | 348 | WP_002948028.1 | DUF1831 domain-containing protein | - |
| H0502_RS01460 (STHERMO_0336) | - | 298611..299723 (-) | 1113 | WP_002948029.1 | cysteine desulfurase family protein | - |
| H0502_RS01465 (STHERMO_0337) | - | 299727..300698 (-) | 972 | WP_002951446.1 | ribose-phosphate diphosphokinase | - |
| H0502_RS01470 (STHERMO_0338) | - | 301063..301638 (-) | 576 | WP_002951444.1 | CYTH domain-containing protein | - |
| H0502_RS01475 (STHERMO_0339) | - | 301734..302408 (+) | 675 | WP_002951443.1 | GTP pyrophosphokinase family protein | - |
| H0502_RS01480 (STHERMO_0340) | - | 302380..303216 (+) | 837 | WP_041827075.1 | NAD kinase | - |
| H0502_RS01485 (STHERMO_0341) | - | 303213..304109 (+) | 897 | WP_179970626.1 | RluA family pseudouridine synthase | - |
| H0502_RS01490 (STHERMO_0342) | pta | 304123..305106 (+) | 984 | WP_011227420.1 | phosphate acetyltransferase | - |
| H0502_RS01495 | - | 305231..306544 (+) | 1314 | Protein_298 | IS3 family transposase | - |
| H0502_RS01500 (STHERMO_0347) | - | 306590..307795 (-) | 1206 | WP_011681420.1 | OFA family MFS transporter | - |
| H0502_RS01505 (STHERMO_0348) | - | 308144..308458 (+) | 315 | Protein_300 | TatD family hydrolase | - |
| H0502_RS09760 | - | 308490..308900 (+) | 411 | Protein_301 | ATP-binding cassette domain-containing protein | - |
| H0502_RS01520 | - | 308894..309078 (+) | 185 | Protein_302 | IS3 family transposase | - |
| H0502_RS01530 (STHERMO_0353) | amiA3 | 310569..312536 (+) | 1968 | WP_179970627.1 | peptide ABC transporter substrate-binding protein | Regulator |
| H0502_RS01535 (STHERMO_0354) | amiC | 312597..314090 (+) | 1494 | WP_179970628.1 | ABC transporter permease | Regulator |
| H0502_RS01540 (STHERMO_0355) | amiD | 314090..315016 (+) | 927 | WP_002946409.1 | oligopeptide ABC transporter permease OppC | Regulator |
| H0502_RS01545 (STHERMO_0356) | amiE | 315026..316111 (+) | 1086 | WP_011226304.1 | ABC transporter ATP-binding protein | Regulator |
| H0502_RS01550 (STHERMO_0357) | amiF | 316104..317033 (+) | 930 | WP_011681415.1 | ATP-binding cassette domain-containing protein | Regulator |
| H0502_RS01555 (STHERMO_0358) | - | 317083..317868 (-) | 786 | WP_002951425.1 | hypothetical protein | - |
| H0502_RS01560 (STHERMO_0359) | - | 317880..318578 (-) | 699 | WP_014608540.1 | ABC transporter ATP-binding protein | - |
| H0502_RS01565 (STHERMO_0360) | - | 318583..318960 (-) | 378 | WP_011681413.1 | GntR family transcriptional regulator | - |
| H0502_RS01570 (STHERMO_0361) | - | 319144..319938 (+) | 795 | WP_011681412.1 | HAD-IIB family hydrolase | - |
| H0502_RS01575 (STHERMO_0362) | - | 319931..320746 (+) | 816 | WP_011226298.1 | Cof-type HAD-IIB family hydrolase | - |
| H0502_RS01580 (STHERMO_0363) | ftsY | 320760..322151 (+) | 1392 | WP_014608538.1 | signal recognition particle-docking protein FtsY | - |
| H0502_RS01585 (STHERMO_0364) | gmk | 322377..323006 (+) | 630 | WP_014608537.1 | guanylate kinase | - |
| H0502_RS01590 (STHERMO_0365) | rpoZ | 323028..323342 (+) | 315 | WP_179970629.1 | DNA-directed RNA polymerase subunit omega | - |
| H0502_RS01595 (STHERMO_0366) | - | 323484..325880 (+) | 2397 | WP_014608535.1 | primosomal protein N' | - |
| H0502_RS01600 (STHERMO_0367) | fmt | 325898..326833 (+) | 936 | WP_014608534.1 | methionyl-tRNA formyltransferase | - |
| H0502_RS01605 (STHERMO_0368) | rsmB | 326823..328145 (+) | 1323 | WP_179970630.1 | 16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB | - |
| H0502_RS01610 (STHERMO_0369) | - | 328189..328926 (+) | 738 | WP_002946881.1 | Stp1/IreP family PP2C-type Ser/Thr phosphatase | - |
| H0502_RS01615 (STHERMO_0370) | stkP/pknB | 328926..330797 (+) | 1872 | WP_014621795.1 | Stk1 family PASTA domain-containing Ser/Thr kinase | Regulator |
| H0502_RS09765 (STHERMO_0373) | - | 331434..331601 (+) | 168 | WP_014608530.1 | potassium channel family protein | - |
| H0502_RS01625 (STHERMO_0374) | liaF | 331856..332554 (+) | 699 | WP_011226289.1 | cell wall-active antibiotics response protein LiaF | - |
Sequence
Protein
Download Length: 623 a.a. Molecular weight: 67847.64 Da Isoelectric Point: 6.9480
>NTDB_id=1130776 H0502_RS01615 WP_014621795.1 328926..330797(+) (stkP/pknB) [Streptococcus thermophilus isolate STH_CIRM_32]
MIQVGKLFAGRYRILKSIGRGGMADVYLANDLILDNESVAIKVLRTNYQTDQVAVARFQREARAMTELSHPNIVAIRDIG
EEDGQQFLVMEYVDGSDLKKFIQDHAPLSNQDVVRIMGEVLSAMTLAHQKGIIHRDLKPQNVLLTKDGRAKVTDFGIAVA
FAETSLTQTNSMLGSVHYLSPEQARGSKATIQSDIYAMGIMLFEMLTGHIPFDGDSAVTIALQHFQKPLPSILAENRNVP
QALENVVIRATAKKLENRYNSTLEMSRDLVTSLHPSHSRDSKVVFDDMTDAKTLPKVDSVSSVGPEKKISPKPSEPTPAP
SKQPREKASLSKKKKNLFSTLLKVLLGFVFIGIIIFAYLVFTNPDNVQVPNVVGQELSTAQTKLESAGFKVGDVKEVEND
SVNKGKVIKTDPTAGTMRKEGASIDVYVSSGSKGFTLKNYKGKNYKDAIEDLTSNYGVSEDQIDIQHVEDDNAKEGEILS
QSSEKNKSFNPKDSKAKIKFRVATPKTITMPDVTGLTVSTAVQTLNSKDISSSSIEYHDYNTGVKLDKSKVPSNTEVLYQ
DPQVGTAVDGTVILYVSVVTKSSSIQQSSSASTTQSSSSTSSSSESSTASSTETATEATHTEQ
MIQVGKLFAGRYRILKSIGRGGMADVYLANDLILDNESVAIKVLRTNYQTDQVAVARFQREARAMTELSHPNIVAIRDIG
EEDGQQFLVMEYVDGSDLKKFIQDHAPLSNQDVVRIMGEVLSAMTLAHQKGIIHRDLKPQNVLLTKDGRAKVTDFGIAVA
FAETSLTQTNSMLGSVHYLSPEQARGSKATIQSDIYAMGIMLFEMLTGHIPFDGDSAVTIALQHFQKPLPSILAENRNVP
QALENVVIRATAKKLENRYNSTLEMSRDLVTSLHPSHSRDSKVVFDDMTDAKTLPKVDSVSSVGPEKKISPKPSEPTPAP
SKQPREKASLSKKKKNLFSTLLKVLLGFVFIGIIIFAYLVFTNPDNVQVPNVVGQELSTAQTKLESAGFKVGDVKEVEND
SVNKGKVIKTDPTAGTMRKEGASIDVYVSSGSKGFTLKNYKGKNYKDAIEDLTSNYGVSEDQIDIQHVEDDNAKEGEILS
QSSEKNKSFNPKDSKAKIKFRVATPKTITMPDVTGLTVSTAVQTLNSKDISSSSIEYHDYNTGVKLDKSKVPSNTEVLYQ
DPQVGTAVDGTVILYVSVVTKSSSIQQSSSASTTQSSSSTSSSSESSTASSTETATEATHTEQ
Nucleotide
Download Length: 1872 bp
>NTDB_id=1130776 H0502_RS01615 WP_014621795.1 328926..330797(+) (stkP/pknB) [Streptococcus thermophilus isolate STH_CIRM_32]
ATGATCCAAGTTGGCAAATTGTTTGCTGGACGTTATCGAATCCTTAAATCTATCGGACGTGGTGGTATGGCGGATGTTTA
TCTGGCTAACGACCTGATTCTGGATAATGAAAGTGTAGCTATTAAGGTACTACGTACCAATTATCAAACTGATCAGGTTG
CTGTGGCGCGTTTCCAGCGTGAAGCACGTGCCATGACTGAGCTTAGCCATCCGAATATCGTTGCGATTAGAGATATTGGT
GAAGAAGACGGTCAGCAGTTCTTGGTGATGGAGTATGTGGATGGTTCAGACTTGAAGAAATTCATTCAAGACCATGCACC
ATTGTCTAACCAAGATGTTGTGCGTATTATGGGGGAAGTCCTTTCCGCCATGACTCTTGCCCACCAAAAGGGTATTATTC
ACCGTGACCTTAAGCCACAGAACGTTCTATTAACTAAGGATGGTAGAGCTAAGGTTACAGACTTTGGTATCGCAGTAGCA
TTTGCTGAAACCAGCCTGACACAAACTAACTCAATGTTGGGGTCAGTCCATTATTTGTCACCAGAACAGGCACGTGGTTC
TAAAGCCACTATCCAAAGTGATATCTATGCTATGGGGATTATGCTCTTTGAAATGTTGACAGGGCATATCCCTTTTGATG
GCGATAGTGCAGTAACCATTGCACTTCAACATTTCCAAAAGCCCCTGCCATCGATTTTGGCTGAGAACCGTAACGTTCCT
CAAGCTTTAGAAAATGTTGTTATTAGAGCAACTGCTAAAAAGCTTGAAAATCGTTACAACAGCACTTTGGAAATGAGTCG
CGACCTAGTAACTAGTTTGCATCCTAGTCATAGTCGTGATTCTAAGGTAGTTTTTGATGACATGACGGATGCTAAGACCC
TGCCAAAGGTTGATTCAGTTTCATCAGTAGGTCCTGAGAAAAAGATTTCTCCTAAACCATCAGAGCCTACACCGGCTCCA
AGCAAACAACCGAGGGAAAAAGCTTCTCTATCTAAAAAAAAGAAAAATCTCTTTTCAACTCTACTCAAGGTTTTACTAGG
CTTCGTCTTTATAGGAATTATCATTTTTGCCTATCTTGTTTTTACCAATCCTGACAATGTCCAAGTACCAAATGTTGTAG
GTCAAGAGTTGTCAACAGCTCAGACGAAACTTGAAAGTGCAGGCTTTAAGGTTGGCGATGTTAAAGAAGTCGAAAATGAT
TCAGTCAATAAGGGCAAAGTTATCAAGACCGACCCTACAGCTGGGACAATGCGTAAAGAGGGAGCAAGCATTGATGTCTA
TGTTTCTTCTGGTAGCAAAGGTTTCACTCTGAAAAATTACAAGGGGAAAAATTATAAGGATGCCATTGAGGATTTAACCT
CGAATTATGGGGTTTCCGAGGATCAGATCGATATTCAACATGTCGAAGACGATAATGCTAAAGAAGGCGAAATTCTATCT
CAAAGTTCGGAGAAAAACAAGTCCTTCAATCCTAAAGATAGTAAGGCAAAAATCAAGTTTCGTGTGGCAACTCCTAAGAC
TATAACTATGCCTGATGTGACTGGTTTAACTGTCTCGACAGCAGTCCAAACCTTGAATAGTAAAGACATTTCAAGCAGCA
GTATTGAGTATCATGACTATAATACTGGTGTTAAGTTGGATAAGAGTAAGGTACCTAGTAATACAGAGGTCCTTTATCAA
GATCCTCAAGTTGGTACTGCTGTTGATGGCACAGTGATTCTCTATGTTTCAGTCGTAACTAAGAGTTCAAGTATTCAACA
GTCAAGCTCAGCAAGTACGACACAATCGTCGTCATCTACAAGTTCTAGTTCTGAAAGTAGTACAGCTTCTAGTACCGAAA
CAGCTACAGAAGCTACTCACACAGAGCAATAA
ATGATCCAAGTTGGCAAATTGTTTGCTGGACGTTATCGAATCCTTAAATCTATCGGACGTGGTGGTATGGCGGATGTTTA
TCTGGCTAACGACCTGATTCTGGATAATGAAAGTGTAGCTATTAAGGTACTACGTACCAATTATCAAACTGATCAGGTTG
CTGTGGCGCGTTTCCAGCGTGAAGCACGTGCCATGACTGAGCTTAGCCATCCGAATATCGTTGCGATTAGAGATATTGGT
GAAGAAGACGGTCAGCAGTTCTTGGTGATGGAGTATGTGGATGGTTCAGACTTGAAGAAATTCATTCAAGACCATGCACC
ATTGTCTAACCAAGATGTTGTGCGTATTATGGGGGAAGTCCTTTCCGCCATGACTCTTGCCCACCAAAAGGGTATTATTC
ACCGTGACCTTAAGCCACAGAACGTTCTATTAACTAAGGATGGTAGAGCTAAGGTTACAGACTTTGGTATCGCAGTAGCA
TTTGCTGAAACCAGCCTGACACAAACTAACTCAATGTTGGGGTCAGTCCATTATTTGTCACCAGAACAGGCACGTGGTTC
TAAAGCCACTATCCAAAGTGATATCTATGCTATGGGGATTATGCTCTTTGAAATGTTGACAGGGCATATCCCTTTTGATG
GCGATAGTGCAGTAACCATTGCACTTCAACATTTCCAAAAGCCCCTGCCATCGATTTTGGCTGAGAACCGTAACGTTCCT
CAAGCTTTAGAAAATGTTGTTATTAGAGCAACTGCTAAAAAGCTTGAAAATCGTTACAACAGCACTTTGGAAATGAGTCG
CGACCTAGTAACTAGTTTGCATCCTAGTCATAGTCGTGATTCTAAGGTAGTTTTTGATGACATGACGGATGCTAAGACCC
TGCCAAAGGTTGATTCAGTTTCATCAGTAGGTCCTGAGAAAAAGATTTCTCCTAAACCATCAGAGCCTACACCGGCTCCA
AGCAAACAACCGAGGGAAAAAGCTTCTCTATCTAAAAAAAAGAAAAATCTCTTTTCAACTCTACTCAAGGTTTTACTAGG
CTTCGTCTTTATAGGAATTATCATTTTTGCCTATCTTGTTTTTACCAATCCTGACAATGTCCAAGTACCAAATGTTGTAG
GTCAAGAGTTGTCAACAGCTCAGACGAAACTTGAAAGTGCAGGCTTTAAGGTTGGCGATGTTAAAGAAGTCGAAAATGAT
TCAGTCAATAAGGGCAAAGTTATCAAGACCGACCCTACAGCTGGGACAATGCGTAAAGAGGGAGCAAGCATTGATGTCTA
TGTTTCTTCTGGTAGCAAAGGTTTCACTCTGAAAAATTACAAGGGGAAAAATTATAAGGATGCCATTGAGGATTTAACCT
CGAATTATGGGGTTTCCGAGGATCAGATCGATATTCAACATGTCGAAGACGATAATGCTAAAGAAGGCGAAATTCTATCT
CAAAGTTCGGAGAAAAACAAGTCCTTCAATCCTAAAGATAGTAAGGCAAAAATCAAGTTTCGTGTGGCAACTCCTAAGAC
TATAACTATGCCTGATGTGACTGGTTTAACTGTCTCGACAGCAGTCCAAACCTTGAATAGTAAAGACATTTCAAGCAGCA
GTATTGAGTATCATGACTATAATACTGGTGTTAAGTTGGATAAGAGTAAGGTACCTAGTAATACAGAGGTCCTTTATCAA
GATCCTCAAGTTGGTACTGCTGTTGATGGCACAGTGATTCTCTATGTTTCAGTCGTAACTAAGAGTTCAAGTATTCAACA
GTCAAGCTCAGCAAGTACGACACAATCGTCGTCATCTACAAGTTCTAGTTCTGAAAGTAGTACAGCTTCTAGTACCGAAA
CAGCTACAGAAGCTACTCACACAGAGCAATAA
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| stkP/pknB | Streptococcus salivarius strain HSISS4 |
90.534 |
93.258 |
0.844 |
| pknB | Streptococcus mutans UA159 |
64.522 |
87.319 |
0.563 |
| stkP | Streptococcus pneumoniae TIGR4 |
56.713 |
80.096 |
0.454 |
| stkP | Streptococcus pneumoniae D39 |
56.513 |
80.096 |
0.453 |
| stkP | Streptococcus pneumoniae R6 |
56.513 |
80.096 |
0.453 |
| stkP | Streptococcus pneumoniae Rx1 |
56.313 |
80.096 |
0.451 |