Detailed information    

insolico Bioinformatically predicted

Overview


Name   comA/nlmT   Type   Regulator
Locus tag   H0502_RS00370 Genome accession   NZ_LR822013
Coordinates   82726..84879 (+) Length   717 a.a.
NCBI ID   WP_041827378.1    Uniprot ID   A0A811IIL9
Organism   Streptococcus thermophilus isolate STH_CIRM_32     
Function   transport of ComC (predicted from homology)   
Competence regulation

Related MGE


Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
ICE 53534..123048 82726..84879 within 0


Gene organization within MGE regions


Location: 53534..123048
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  H0502_RS00255 (STHERMO_0055) addA 54439..58092 (+) 3654 WP_014608679.1 helicase-exonuclease AddAB subunit AddA -
  H0502_RS00260 (STHERMO_0057) - 58444..59175 (-) 732 WP_014608678.1 DUF554 domain-containing protein -
  H0502_RS00265 (STHERMO_0058) - 59450..60181 (+) 732 WP_002891761.1 ABC transporter ATP-binding protein -
  H0502_RS00270 (STHERMO_0059) - 60184..61773 (+) 1590 WP_014608677.1 ABC transporter permease -
  H0502_RS00275 (STHERMO_0060) proB 61894..62697 (+) 804 WP_014608676.1 glutamate 5-kinase -
  H0502_RS00280 (STHERMO_0061) - 62699..63949 (+) 1251 WP_014608675.1 glutamate-5-semialdehyde dehydrogenase -
  H0502_RS00285 (STHERMO_0062) - 64282..64449 (+) 168 WP_153300736.1 hypothetical protein -
  H0502_RS00290 (STHERMO_0063) - 64798..65154 (+) 357 WP_023909925.1 DUF805 domain-containing protein -
  H0502_RS09710 (STHERMO_0064) - 65428..65571 (+) 144 WP_014608673.1 hypothetical protein -
  H0502_RS00305 (STHERMO_0067) - 66049..66783 (+) 735 WP_224103476.1 hypothetical protein -
  H0502_RS00310 (STHERMO_0068) rsmH 66950..67900 (+) 951 WP_002888254.1 16S rRNA (cytosine(1402)-N(4))-methyltransferase RsmH -
  H0502_RS00315 (STHERMO_0069) ftsL 67903..68223 (+) 321 WP_014608671.1 cell division protein FtsL -
  H0502_RS00320 (STHERMO_0070) pbp2X 68227..70494 (+) 2268 WP_179970579.1 penicillin-binding protein PBP2X -
  H0502_RS00325 (STHERMO_0071) mraY 70496..71518 (+) 1023 WP_011227524.1 phospho-N-acetylmuramoyl-pentapeptide- transferase -
  H0502_RS00330 (STHERMO_0072) - 71593..72936 (+) 1344 WP_014608670.1 DEAD/DEAH box helicase -
  H0502_RS00335 (STHERMO_0075) - 73784..75139 (+) 1356 WP_002948886.1 bifunctional metallophosphatase/5'-nucleotidase -
  H0502_RS00340 (STHERMO_0076) - 75194..75916 (+) 723 WP_011226505.1 YutD family protein -
  H0502_RS00345 (STHERMO_0077) rlmN 75920..77089 (+) 1170 WP_011226504.1 23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN -
  H0502_RS00350 (STHERMO_0078) - 77091..77618 (+) 528 WP_011226503.1 VanZ family protein -
  H0502_RS09715 (STHERMO_0079) - 77823..78029 (+) 207 WP_002948879.1 hypothetical protein -
  H0502_RS00360 (STHERMO_0081) - 78217..79974 (+) 1758 WP_014608668.1 ABC transporter ATP-binding protein -
  H0502_RS00365 (STHERMO_0082) - 79967..81712 (+) 1746 WP_024703994.1 ABC transporter ATP-binding protein -
  H0502_RS00370 (STHERMO_0087) comA/nlmT 82726..84879 (+) 2154 WP_041827378.1 peptide cleavage/export ABC transporter Regulator
  H0502_RS00375 (STHERMO_0088) - 84895..86262 (+) 1368 WP_011681574.1 bacteriocin secretion accessory protein -
  H0502_RS00380 (STHERMO_0089) - 86277..86438 (+) 162 WP_011681573.1 ComC/BlpC family leader-containing pheromone/bacteriocin -
  H0502_RS09720 - 86456..87259 (-) 804 WP_224102945.1 ATP-binding protein -
  H0502_RS00390 (STHERMO_0091) - 87796..88527 (-) 732 WP_002948869.1 LytR/AlgR family response regulator transcription factor -
  H0502_RS00395 (STHERMO_0092) - 88784..88960 (+) 177 WP_011681570.1 Blp family class II bacteriocin -
  H0502_RS00400 (STHERMO_0093) - 88979..89179 (+) 201 WP_011681569.1 hypothetical protein -
  H0502_RS00405 (STHERMO_0094) - 89535..89765 (+) 231 WP_014608662.1 bacteriocin class II family protein -
  H0502_RS10335 (STHERMO_0098) - 90770..91171 (+) 402 WP_024703992.1 hypothetical protein -
  H0502_RS00410 (STHERMO_0099) - 91422..91688 (+) 267 WP_179970580.1 bacteriocin -
  H0502_RS00420 (STHERMO_0102) - 93598..94287 (+) 690 WP_011681563.1 thioredoxin family protein -
  H0502_RS00425 (STHERMO_0103) - 94318..94524 (+) 207 WP_011681562.1 hypothetical protein -
  H0502_RS00430 - 94746..94985 (+) 240 WP_224103609.1 bacteriocin immunity protein -
  H0502_RS00435 - 95307..95570 (+) 264 WP_002945924.1 hypothetical protein -
  H0502_RS00440 (STHERMO_0107) - 95695..96075 (+) 381 WP_002951783.1 hypothetical protein -
  H0502_RS00445 (STHERMO_0108) - 96155..98422 (-) 2268 WP_179970581.1 Xaa-Pro dipeptidyl-peptidase -
  H0502_RS00450 (STHERMO_0109) gla 98543..99406 (+) 864 WP_002951781.1 aquaglyceroporin Gla -
  H0502_RS00455 (STHERMO_0110) - 99493..99855 (-) 363 WP_014608659.1 CPBP family intramembrane glutamic endopeptidase -
  H0502_RS00460 (STHERMO_0111) - 100137..100892 (+) 756 WP_011681560.1 CppA family protein -
  H0502_RS00465 (STHERMO_0112) - 100892..101848 (+) 957 WP_002951776.1 serine hydrolase domain-containing protein -
  H0502_RS00470 (STHERMO_0114) - 102051..102701 (+) 651 WP_011681559.1 ATP-binding cassette domain-containing protein -
  H0502_RS00475 (STHERMO_0115) - 102698..103453 (+) 756 WP_011681558.1 ABC transporter permease -
  H0502_RS10340 (STHERMO_0117) mobV 103898..104406 (+) 509 Protein_94 MobV family relaxase -
  H0502_RS00485 (STHERMO_0119) - 104452..104736 (+) 285 WP_014608656.1 restriction endonuclease subunit S -
  H0502_RS00490 (STHERMO_0120) - 105087..105539 (-) 453 WP_179970582.1 GNAT family N-acetyltransferase -
  H0502_RS00495 (STHERMO_0121) - 105590..106372 (-) 783 WP_011681555.1 carbonic anhydrase -
  H0502_RS00500 (STHERMO_0122) pflB 106639..108948 (-) 2310 WP_011226473.1 formate C-acetyltransferase -
  H0502_RS00505 (STHERMO_0123) dinB 109227..110330 (+) 1104 WP_014608654.1 DNA polymerase IV -
  H0502_RS00510 (STHERMO_0124) - 110628..110861 (+) 234 WP_002947030.1 hypothetical protein -
  H0502_RS00515 (STHERMO_0126) - 111320..112150 (+) 831 WP_041828322.1 transporter substrate-binding domain-containing protein -
  H0502_RS00520 (STHERMO_0127) - 112546..113292 (+) 747 WP_179970821.1 amino acid ABC transporter permease -
  H0502_RS00525 (STHERMO_0128) - 113292..114035 (+) 744 WP_084829069.1 amino acid ABC transporter ATP-binding protein -
  H0502_RS00530 (STHERMO_0129) - 114250..114474 (+) 225 WP_087010135.1 DUF4059 family protein -
  H0502_RS00535 (STHERMO_0130) trxB 114507..115460 (+) 954 WP_255136104.1 thioredoxin-disulfide reductase -
  H0502_RS00540 (STHERMO_0131) rsmD 115551..116150 (+) 600 Protein_106 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD -
  H0502_RS00545 (STHERMO_0132) coaD 116184..116681 (+) 498 WP_011681550.1 pantetheine-phosphate adenylyltransferase -
  H0502_RS00550 (STHERMO_0133) sepM 116659..117735 (+) 1077 WP_011681549.1 SepM family pheromone-processing serine protease Regulator
  H0502_RS00555 (STHERMO_0134) - 117820..118764 (+) 945 WP_011226463.1 TIGR01212 family radical SAM protein -
  H0502_RS00560 (STHERMO_0135) - 118761..119309 (+) 549 WP_011226462.1 tRNA (mnm(5)s(2)U34)-methyltransferase -
  H0502_RS00565 (STHERMO_0136) - 119306..119548 (+) 243 WP_011226461.1 hypothetical protein -
  H0502_RS00570 (STHERMO_0137) - 119557..121623 (+) 2067 WP_179970583.1 cation:proton antiporter -
  H0502_RS00575 (STHERMO_0139) - 122242..123024 (-) 783 WP_011226459.1 ABC transporter ATP-binding protein -

Sequence


Protein


Download         Length: 717 a.a.        Molecular weight: 80644.44 Da        Isoelectric Point: 6.8843

>NTDB_id=1130765 H0502_RS00370 WP_041827378.1 82726..84879(+) (comA/nlmT) [Streptococcus thermophilus isolate STH_CIRM_32]
MFRFRRTFVPQIDMRDCGVAALASVAKYYGSDYSLAHLRELAKTNKEGTTALGLVEAAKKIGFETRAIKAEMSLFEMEDV
PYPFIAHVNKDGKLQHYYVIYKSTKDYLIIGDPDPSVKVTKMTKERFEKEWTGVTLFMGPEPSYKPHKDKKNGLWDFLPL
IFKQRSLIANIVFASLLVTLINILGSYYLQGILDEYVPNQMKSTLGIISIGLVVTYVLQQMMTFARDYLLTILSQRFTID
VILSYIRHIFELPMSFFATRRTGEVISRFSDANSIIDALASTILSLFLDFSIVIIVGGVLLIQNSNLFKLVLCSVPIYTL
IVFAFMKPFERMNHDVMQSNAMVNSAIIEDINGIETIKSLTSEEVCYQKIDGEFIDYLDNSFRLSKLSILQTSLKQGAQL
ILNVLILWTGAQLVMGNTISIGQLITFNMLLSYFTNPLENIINLQTKLQSAKVANTRLNEVYLIESEFGQSDDTYQEGIA
DGDITVTDLSYKYGFGRDTLTDVSLTIRQGEKISFVGVSGSGKTTLAKMLVNFYQPYKGHIDFNGQNISRIDKKTLRQHI
NYLPQQSYIFSGSVLENLTLGAARGITQADILKACEIAEIRQDIENMPMGFQTELSDGAGLSGGQKQRIALARALLTKSP
VLILDEATSGLDVLTEKQVIDNLLALKDKTIIFVAHRLSIAERTDRIVVIDHGRVVETGSHQDLMSYPGFYYQLFRK

Nucleotide


Download         Length: 2154 bp        

>NTDB_id=1130765 H0502_RS00370 WP_041827378.1 82726..84879(+) (comA/nlmT) [Streptococcus thermophilus isolate STH_CIRM_32]
ATGTTTCGTTTTCGTAGGACTTTTGTCCCTCAAATAGATATGAGGGATTGTGGAGTTGCTGCCTTGGCATCAGTGGCCAA
GTACTATGGTTCAGATTATTCATTAGCACATCTGCGTGAGTTGGCGAAGACCAATAAAGAAGGGACAACTGCCTTAGGTC
TTGTAGAGGCTGCTAAAAAAATTGGCTTTGAAACGAGAGCTATAAAGGCTGAAATGTCGCTCTTTGAGATGGAAGATGTT
CCTTATCCTTTTATTGCTCATGTTAATAAAGATGGGAAGCTTCAACATTATTATGTTATTTATAAAAGCACCAAGGATTA
TCTGATAATTGGAGACCCTGATCCAAGTGTAAAAGTAACTAAAATGACTAAAGAGCGTTTTGAGAAAGAGTGGACAGGTG
TTACTCTTTTTATGGGACCGGAACCCAGTTATAAACCACATAAGGATAAGAAAAATGGACTCTGGGACTTTCTCCCTTTG
ATCTTTAAACAAAGGTCCTTGATAGCTAATATTGTCTTTGCCAGTCTCTTGGTTACTTTAATAAATATTTTAGGTTCCTA
TTATTTACAAGGTATTCTAGACGAATATGTCCCTAATCAAATGAAGTCTACCTTAGGAATTATCTCAATTGGATTAGTTG
TGACCTATGTTTTACAACAAATGATGACTTTTGCAAGAGATTATCTCTTAACCATACTGAGTCAGCGATTTACCATTGAC
GTTATCTTGTCCTACATACGACATATCTTTGAACTCCCAATGTCTTTTTTTGCCACAAGACGTACAGGGGAGGTTATCTC
ACGTTTTAGTGATGCTAACTCTATTATCGATGCTCTGGCTTCGACGATATTATCACTTTTCCTTGATTTCTCTATTGTGA
TTATCGTAGGAGGCGTGTTATTGATACAAAATAGCAATCTCTTCAAGCTAGTTCTTTGTTCGGTTCCAATTTATACCCTT
ATCGTCTTTGCCTTTATGAAACCTTTTGAGCGAATGAATCATGACGTCATGCAGAGTAATGCTATGGTTAATTCAGCCAT
CATTGAGGACATTAATGGGATTGAAACCATAAAGTCACTAACCAGCGAAGAAGTATGCTATCAAAAGATTGATGGTGAGT
TTATTGACTATCTAGACAATTCTTTTCGCCTTTCTAAGTTATCTATACTACAAACATCATTGAAACAAGGTGCTCAACTT
ATTTTAAATGTACTTATCCTCTGGACAGGTGCTCAGTTGGTGATGGGAAATACCATTTCGATAGGACAATTGATTACTTT
TAATATGTTGCTTTCTTACTTCACGAATCCTTTGGAAAATATCATTAACCTGCAAACCAAGTTACAGTCTGCTAAGGTAG
CTAATACTAGGCTCAATGAGGTCTATCTGATTGAATCAGAGTTTGGACAAAGTGATGATACCTATCAAGAAGGCATTGCG
GATGGAGATATCACTGTTACGGATTTATCTTATAAATATGGTTTTGGTCGTGATACTTTGACTGATGTCAGTTTGACGAT
TAGACAAGGAGAAAAAATCAGTTTTGTTGGTGTCAGTGGATCTGGTAAGACTACTCTAGCTAAAATGTTGGTCAATTTTT
ATCAACCATATAAGGGGCACATAGATTTTAATGGTCAAAATATTAGTCGCATAGACAAGAAAACTCTTCGTCAACATATT
AACTATCTCCCTCAGCAATCCTATATATTTAGTGGTAGTGTTTTAGAAAATCTTACTTTAGGTGCAGCACGGGGTATTAC
GCAAGCTGATATTTTGAAAGCTTGTGAAATAGCAGAAATTCGTCAAGATATTGAAAACATGCCTATGGGGTTTCAGACAG
AGCTGTCTGATGGAGCAGGTCTGTCTGGAGGGCAAAAGCAACGTATCGCTTTGGCGCGTGCACTACTAACGAAATCTCCT
GTACTAATCTTAGATGAAGCAACTAGCGGATTGGATGTTTTGACAGAAAAGCAGGTTATTGATAACCTCCTAGCACTAAA
AGATAAAACGATCATCTTTGTAGCACACAGGCTTAGTATCGCTGAGCGGACCGACCGTATCGTAGTCATTGATCACGGAC
GCGTAGTGGAGACAGGTTCTCATCAAGACCTAATGTCTTATCCAGGTTTCTATTATCAATTATTTAGAAAGTGA


Secondary structure


Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure


Source ID Structure
  AlphaFold DB A0A811IIL9

Transmembrane helices


Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.



Visualization of predicted probability:


Similar proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comA/nlmT Streptococcus mutans UA159

67.787

99.582

0.675

  comA Streptococcus mitis NCTC 12261

66.104

99.163

0.656

  comA Streptococcus pneumoniae Rx1

65.682

99.163

0.651

  comA Streptococcus pneumoniae D39

65.682

99.163

0.651

  comA Streptococcus pneumoniae R6

65.682

99.163

0.651

  comA Streptococcus mitis SK321

65.401

99.163

0.649

  comA Streptococcus pneumoniae TIGR4

65.26

99.163

0.647

  comA Streptococcus gordonii str. Challis substr. CH1

64.006

99.582

0.637


Multiple sequence alignment