Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   H0505_RS00995 Genome accession   NZ_LR822012
Coordinates   172276..173025 (+) Length   249 a.a.
NCBI ID   WP_179971148.1    Uniprot ID   -
Organism   Streptococcus thermophilus isolate STH_CIRM_30     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Genomic Context

Location: 167276..178025
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  H0505_RS00965 (STHERMO_0173) - 167850..168020 (+) 171 WP_011680664.1 hypothetical protein -
  H0505_RS00970 - 168107..168214 (+) 108 WP_084829946.1 LPXTG cell wall anchor domain-containing protein -
  H0505_RS00975 (STHERMO_0174) - 168302..169042 (-) 741 WP_002949253.1 amino acid ABC transporter ATP-binding protein -
  H0505_RS00980 (STHERMO_0175) - 169042..170592 (-) 1551 WP_179971147.1 ABC transporter substrate-binding protein/permease -
  H0505_RS00985 (STHERMO_0176) - 170795..171649 (+) 855 WP_014607892.1 undecaprenyl-diphosphate phosphatase -
  H0505_RS00990 - 171795..172010 (-) 216 WP_011226805.1 DUF3021 family protein -
  H0505_RS00995 (STHERMO_0177) mecA 172276..173025 (+) 750 WP_179971148.1 adaptor protein MecA Regulator
  H0505_RS01000 (STHERMO_0178) - 173029..174186 (+) 1158 WP_014607894.1 glycosyltransferase family 4 protein -
  H0505_RS01005 (STHERMO_0179) sufC 174347..175117 (+) 771 WP_002947634.1 Fe-S cluster assembly ATPase SufC -
  H0505_RS01010 (STHERMO_0180) sufD 175154..176416 (+) 1263 WP_116920089.1 Fe-S cluster assembly protein SufD -
  H0505_RS01015 (STHERMO_0181) - 176470..177702 (+) 1233 WP_022096530.1 cysteine desulfurase -

Sequence

Protein


Download         Length: 249 a.a.        Molecular weight: 29122.74 Da        Isoelectric Point: 4.1121

>NTDB_id=1130710 H0505_RS00995 WP_179971148.1 172276..173025(+) (mecA) [Streptococcus thermophilus isolate STH_CIRM_30]
MEMKQINETTLKIMITMEDLEEHGMELKDFLIPQEKTEEFFYTVMDELDLPDNFKNSGMLSFRVTPRKDRVDVFVTKSDL
KEALDFNDLSDMEDYSGLSPEEFLKALEDNFMDKGDIEAHHKLEEHDKTLKEVDETMTEPAKKVAEETIREDYTHYVLAF
SDFDQVVTFAQGLKNVSVEGSELYKLGDVYYMTILLYLADEPDYYANNMYARFLEYANVADRTRPYLQEHATILMEEDAL
PVLQATKWS

Nucleotide


Download         Length: 750 bp        

>NTDB_id=1130710 H0505_RS00995 WP_179971148.1 172276..173025(+) (mecA) [Streptococcus thermophilus isolate STH_CIRM_30]
ATGGAAATGAAACAAATAAACGAGACAACTCTAAAAATCATGATTACCATGGAAGATCTTGAAGAACATGGTATGGAGCT
GAAAGATTTCTTGATTCCCCAGGAAAAAACAGAGGAATTTTTCTATACTGTCATGGATGAGTTGGACTTGCCTGATAACT
TTAAAAATAGTGGGATGTTGAGCTTCCGTGTCACGCCACGAAAGGATCGTGTGGATGTTTTTGTGACTAAATCAGATCTT
AAGGAAGCCCTTGATTTCAATGATTTGTCAGATATGGAAGACTATTCAGGACTTTCTCCAGAAGAATTCCTCAAAGCTCT
TGAAGATAACTTTATGGATAAGGGAGATATTGAAGCCCACCATAAGCTCGAAGAGCATGATAAGACCTTGAAAGAGGTTG
ATGAGACTATGACAGAGCCGGCTAAGAAAGTGGCTGAGGAAACTATTCGTGAAGATTATACTCACTATGTCTTGGCTTTC
TCTGACTTTGATCAAGTAGTGACCTTTGCGCAAGGTTTGAAGAATGTGTCAGTGGAGGGTTCTGAACTTTATAAACTTGG
TGATGTCTACTATATGACTATCCTTCTTTACTTGGCTGATGAGCCTGATTATTACGCGAACAATATGTATGCGCGTTTTC
TTGAATATGCGAATGTGGCAGACCGAACACGTCCCTATCTACAAGAGCATGCAACAATCTTGATGGAAGAGGACGCCTTA
CCGGTATTACAAGCAACGAAATGGAGCTAG

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-242)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus thermophilus LMG 18311

99.197

100

0.992
  mecA Streptococcus thermophilus LMD-9

98.394

100

0.984
  mecA Streptococcus mutans UA159

58.197

97.992

0.57
  mecA Streptococcus pneumoniae Rx1

46.988

100

0.47
  mecA Streptococcus pneumoniae D39

46.988

100

0.47
  mecA Streptococcus pneumoniae R6

46.988

100

0.47
  mecA Streptococcus pneumoniae TIGR4

46.988

100

0.47

Multiple sequence alignment