Detailed information NTG1130690

Bioinformatically predicted

Overview

• Name: mecA
• Type: Regulator
• Locus tag: H0504_RS08050
• Genome accession: NZ_LR822011
• Coordinates: 1571202..1571951 (-)
• Length: 249 a.a.
• NCBI ID: WP_011225365.1
• Uniprot ID: Q5M699
• Organism: Streptococcus thermophilus isolate STH_CIRM_23
• Function: degradation of ComX (predicted from homology) Competence regulation

Genomic Context

Location: 1566202..1576951

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
H0504_RS08030 (STHERMO_1802)	-	1566525..1567757 (-)	1233	WP_011225367.1	cysteine desulfurase	-
H0504_RS08035 (STHERMO_1803)	sufD	1567811..1569073 (-)	1263	WP_002947640.1	Fe-S cluster assembly protein SufD	-
H0504_RS08040 (STHERMO_1804)	sufC	1569110..1569880 (-)	771	WP_002947634.1	Fe-S cluster assembly ATPase SufC	-
H0504_RS08045 (STHERMO_1805)	-	1570041..1571198 (-)	1158	WP_002947632.1	glycosyltransferase family 4 protein	-
H0504_RS08050 (STHERMO_1806)	mecA	1571202..1571951 (-)	750	WP_011225365.1	adaptor protein MecA	Regulator
H0504_RS08055	-	1572235..1572432 (+)	198	WP_232085789.1	DUF3021 family protein	-
H0504_RS08060 (STHERMO_1807)	-	1572578..1573432 (-)	855	WP_041828107.1	undecaprenyl-diphosphate phosphatase	-
H0504_RS08065 (STHERMO_1808)	-	1573635..1575185 (+)	1551	WP_011225362.1	ABC transporter substrate-binding protein/permease	-
H0504_RS08070 (STHERMO_1809)	-	1575185..1575925 (+)	741	WP_002949253.1	amino acid ABC transporter ATP-binding protein	-
H0504_RS10170	-	1576014..1576121 (-)	108	WP_011225361.1	LPXTG cell wall anchor domain-containing protein	-
H0504_RS08080 (STHERMO_1810)	-	1576208..1576378 (-)	171	WP_011225360.1	hypothetical protein	-

Sequence

Protein

• Length: 249 a.a.
• Molecular weight: 29157.70 Da
• Isoelectric Point: 4.0659

>NTDB_id=1130690 H0504_RS08050 WP_011225365.1 1571202..1571951(-) (mecA) [Streptococcus thermophilus isolate STH_CIRM_23]
MEMKQINETTLKIMITMEDLEEHGMELKDFLIPQEKTEEFFYTVMDELDLPDNFKNSGMLSFRVTPRKDRVDVFVTKSDL
KEALDFNDLSDMEDYSGLSPEEFLKALEDNFMDKGDIEAHHKLEEHDKTLKEVDETMTEPAKEVAEETIREDYTHYVLAF
SDFDQVVTFAQGLKNVSVEGSEFYKLGDVYYMTILLYLADEPDYYANNMYARFLEYANVADRTRPYLQEHATILMEEDAL
PVLQATKWS

Nucleotide

• Length: 750 bp

>NTDB_id=1130690 H0504_RS08050 WP_011225365.1 1571202..1571951(-) (mecA) [Streptococcus thermophilus isolate STH_CIRM_23]
ATGGAAATGAAACAAATAAACGAGACAACTCTAAAAATCATGATTACCATGGAAGATCTTGAAGAACATGGTATGGAGCT
GAAAGATTTCTTGATTCCCCAGGAAAAAACAGAGGAATTTTTCTATACTGTCATGGATGAGTTGGACTTGCCTGATAATT
TTAAAAATAGTGGGATGTTGAGCTTCCGTGTCACGCCACGAAAGGATCGTGTGGATGTTTTTGTGACTAAATCAGATCTT
AAGGAAGCCCTTGATTTCAATGATTTGTCAGATATGGAAGACTATTCAGGACTTTCTCCAGAAGAATTCCTCAAAGCTCT
TGAAGATAACTTTATGGATAAGGGAGATATTGAAGCCCACCATAAGCTCGAAGAGCATGATAAGACCTTGAAAGAGGTTG
ATGAGACTATGACAGAGCCGGCTAAGGAAGTGGCTGAGGAAACTATTCGTGAAGATTATACTCACTATGTCTTGGCTTTC
TCTGACTTTGATCAAGTAGTGACCTTTGCGCAAGGTTTGAAGAATGTGTCAGTGGAGGGTTCTGAATTTTATAAACTTGG
TGATGTCTACTATATGACTATCCTTCTTTACTTGGCTGATGAGCCTGATTATTACGCGAACAATATGTATGCGCGTTTTC
TTGAATATGCGAATGTGGCAGACCGAACACGTCCCTATCTACAAGAGCATGCAACAATCTTGATGGAAGAGGACGCCTTA
CCGGTATTACAAGCAACGAAATGGAGCTAG

Domains

Predicted by InterproScan.

• Negative regulator of genetic competence (MecA) (MecA) (1-242)

3D structure

• AlphaFold DB: Q5M699

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
mecA	Streptococcus thermophilus LMG 18311	100	100	1
mecA	Streptococcus thermophilus LMD-9	99.197	100	0.992
mecA	Streptococcus mutans UA159	57.377	97.992	0.562
mecA	Streptococcus pneumoniae Rx1	46.185	100	0.462
mecA	Streptococcus pneumoniae D39	46.185	100	0.462
mecA	Streptococcus pneumoniae R6	46.185	100	0.462
mecA	Streptococcus pneumoniae TIGR4	46.185	100	0.462