Detailed information    

insolico Bioinformatically predicted

Overview

Name   covR   Type   Regulator
Locus tag   H0504_RS07390 Genome accession   NZ_LR822011
Coordinates   1438775..1439464 (-) Length   229 a.a.
NCBI ID   WP_002949638.1    Uniprot ID   A0A060BFD8
Organism   Streptococcus thermophilus isolate STH_CIRM_23     
Function   repress comR expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 1433775..1444464
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  H0504_RS07370 (STHERMO_1646) dnaI 1434582..1435484 (-) 903 WP_002946786.1 primosomal protein DnaI -
  H0504_RS07375 (STHERMO_1647) - 1435488..1436663 (-) 1176 WP_002949643.1 DnaD domain protein -
  H0504_RS07380 (STHERMO_1648) nrdR 1436660..1437139 (-) 480 WP_002949642.1 transcriptional regulator NrdR -
  H0504_RS07385 (STHERMO_1649) covS 1437261..1438778 (-) 1518 WP_179971748.1 HAMP domain-containing histidine kinase Regulator
  H0504_RS07390 (STHERMO_1650) covR 1438775..1439464 (-) 690 WP_002949638.1 response regulator transcription factor Regulator
  H0504_RS07395 (STHERMO_1651) - 1439620..1440156 (-) 537 WP_041826965.1 DUF177 domain-containing protein -
  H0504_RS07400 (STHERMO_1652) rsmG 1440453..1441166 (+) 714 WP_002946490.1 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG -
  H0504_RS07405 (STHERMO_1653) - 1441236..1442600 (+) 1365 WP_269473675.1 TrkH family potassium uptake protein -
  H0504_RS07410 (STHERMO_1654) - 1442640..1443311 (+) 672 WP_002946492.1 potassium channel family protein -
  H0504_RS09780 - 1443328..1443498 (-) 171 Protein_1428 ascorbate 6-phosphate lactonase -

Sequence

Protein


Download         Length: 229 a.a.        Molecular weight: 26655.77 Da        Isoelectric Point: 4.7059

>NTDB_id=1130683 H0504_RS07390 WP_002949638.1 1438775..1439464(-) (covR) [Streptococcus thermophilus isolate STH_CIRM_23]
MSKRILIVEDERNLARFVSLELQHEGYDVVTADNGREGLEMALEKDFDLILLDLMLPEMDGFEVTRRLQQEKDTYIMMMT
ARDSIMDIVAGLDRGADDYIIKPFAIEELLARIRATFRRQDIEATKKAPAKASTYRDLKLDVQNRAVVRGDEVIPLTKRE
FDLLNTLLSNMNQVMTREELLLQVWKYDDVIETNVVDVYIRYLRGKIDIPGKESYIQTVRGMGYVIRER

Nucleotide


Download         Length: 690 bp        

>NTDB_id=1130683 H0504_RS07390 WP_002949638.1 1438775..1439464(-) (covR) [Streptococcus thermophilus isolate STH_CIRM_23]
ATGAGCAAACGCATTTTGATTGTTGAAGATGAGAGAAACCTTGCTCGTTTTGTCTCTCTTGAACTTCAACACGAAGGATA
CGACGTTGTGACAGCGGACAACGGACGCGAAGGACTTGAAATGGCACTTGAGAAAGATTTCGATCTTATTCTCTTGGACC
TTATGTTGCCTGAGATGGACGGTTTCGAAGTGACACGTCGTCTCCAACAAGAAAAAGATACTTATATTATGATGATGACA
GCTCGCGACTCAATCATGGATATTGTTGCTGGTTTGGATCGTGGAGCTGATGACTATATTATAAAACCATTTGCGATTGA
AGAACTGTTGGCACGTATTCGTGCAACCTTCCGTCGTCAAGATATCGAAGCTACTAAGAAGGCACCAGCTAAAGCGTCAA
CCTATCGCGATTTAAAATTAGATGTTCAAAACCGTGCAGTTGTTCGCGGTGATGAGGTAATTCCATTGACAAAACGTGAG
TTTGATTTGTTGAACACACTTTTAAGCAATATGAACCAAGTAATGACCCGTGAGGAACTCTTGCTTCAAGTCTGGAAATA
TGATGACGTAATTGAAACAAACGTTGTAGATGTTTATATTCGTTACTTACGTGGGAAAATCGACATTCCAGGTAAGGAAT
CATACATTCAAACAGTACGAGGGATGGGTTACGTTATCCGTGAAAGATGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-114)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(152-225)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A060BFD8

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covR Streptococcus salivarius strain HSISS4

96.07

100

0.961
  covR Lactococcus lactis subsp. lactis strain DGCC12653

67.544

99.563

0.672
  vicR Streptococcus mutans UA159

45.259

100

0.459
  micA Streptococcus pneumoniae Cp1015

43.913

100

0.441

Multiple sequence alignment