Detailed information    

insolico Bioinformatically predicted

Overview

Name   stkP/pknB   Type   Regulator
Locus tag   STHERMO_RS06695 Genome accession   NZ_LR822006
Coordinates   1280773..1282644 (-) Length   623 a.a.
NCBI ID   WP_011226292.1    Uniprot ID   Q5M3J0
Organism   Streptococcus thermophilus isolate STH_CIRM_16     
Function   activate comX expression (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
ICE 1279009..1340387 1280773..1282644 within 0


Gene organization within MGE regions


Location: 1279009..1340387
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  STHERMO_RS06685 (STHERMO_1475) liaF 1279017..1279715 (-) 699 WP_011226289.1 cell wall-active antibiotics response protein LiaF -
  STHERMO_RS09815 (STHERMO_1476) - 1279981..1280136 (-) 156 WP_011226290.1 ion channel -
  STHERMO_RS06695 (STHERMO_1479) stkP/pknB 1280773..1282644 (-) 1872 WP_011226292.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  STHERMO_RS06700 (STHERMO_1480) - 1282644..1283381 (-) 738 WP_179970507.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -
  STHERMO_RS06705 (STHERMO_1481) rsmB 1283425..1284747 (-) 1323 WP_014608533.1 16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB -
  STHERMO_RS06710 (STHERMO_1482) fmt 1284737..1285672 (-) 936 WP_002951411.1 methionyl-tRNA formyltransferase -
  STHERMO_RS06715 (STHERMO_1483) - 1285690..1288086 (-) 2397 WP_011227404.1 primosomal protein N' -
  STHERMO_RS06720 (STHERMO_1484) rpoZ 1288228..1288542 (-) 315 WP_002951415.1 DNA-directed RNA polymerase subunit omega -
  STHERMO_RS06725 (STHERMO_1485) gmk 1288564..1289193 (-) 630 WP_011226296.1 guanylate kinase -
  STHERMO_RS06730 (STHERMO_1486) ftsY 1289426..1290817 (-) 1392 WP_011226297.1 signal recognition particle-docking protein FtsY -
  STHERMO_RS06735 (STHERMO_1487) - 1290831..1291646 (-) 816 WP_011227405.1 Cof-type HAD-IIB family hydrolase -
  STHERMO_RS06740 (STHERMO_1488) - 1291639..1292433 (-) 795 WP_059257398.1 HAD hydrolase family protein -
  STHERMO_RS06745 (STHERMO_1489) - 1292616..1292993 (+) 378 WP_011226300.1 GntR family transcriptional regulator -
  STHERMO_RS06750 (STHERMO_1490) - 1292998..1293696 (+) 699 WP_011226301.1 ABC transporter ATP-binding protein -
  STHERMO_RS06755 (STHERMO_1491) - 1293708..1294493 (+) 786 WP_002951425.1 hypothetical protein -
  STHERMO_RS09820 - 1294543..1295028 (-) 486 Protein_1268 ATP-binding cassette domain-containing protein -
  STHERMO_RS06770 (STHERMO_1494) - 1295060..1295374 (-) 315 Protein_1269 TatD family hydrolase -
  STHERMO_RS06775 (STHERMO_1495) - 1295723..1296928 (+) 1206 WP_011227415.1 OFA family MFS transporter -
  STHERMO_RS06780 - 1296974..1298326 (-) 1353 Protein_1271 IS3 family transposase -
  STHERMO_RS06785 (STHERMO_1500) pta 1298412..1299395 (-) 984 WP_011227420.1 phosphate acetyltransferase -
  STHERMO_RS06790 (STHERMO_1501) - 1299409..1300305 (-) 897 WP_011226316.1 RluA family pseudouridine synthase -
  STHERMO_RS06795 (STHERMO_1502) - 1300302..1301138 (-) 837 WP_041827075.1 NAD kinase -
  STHERMO_RS06800 (STHERMO_1503) - 1301110..1301784 (-) 675 WP_002951443.1 GTP pyrophosphokinase family protein -
  STHERMO_RS06805 (STHERMO_1504) - 1301880..1302455 (+) 576 WP_002951444.1 CYTH domain-containing protein -
  STHERMO_RS06810 (STHERMO_1505) - 1302818..1303789 (+) 972 WP_002951446.1 ribose-phosphate diphosphokinase -
  STHERMO_RS06815 (STHERMO_1506) - 1303793..1304905 (+) 1113 WP_002948029.1 cysteine desulfurase family protein -
  STHERMO_RS06820 (STHERMO_1507) - 1304907..1305254 (+) 348 WP_002948028.1 DUF1831 domain-containing protein -
  STHERMO_RS06825 (STHERMO_1508) - 1305398..1306057 (+) 660 WP_041827076.1 redox-sensing transcriptional repressor Rex -
  STHERMO_RS06830 (STHERMO_1509) - 1306050..1306745 (+) 696 WP_011227423.1 gamma-glutamyl-gamma-aminobutyrate hydrolase family protein -
  STHERMO_RS06835 (STHERMO_1510) radC 1306798..1307484 (-) 687 WP_011227424.1 RadC family protein -
  STHERMO_RS06840 (STHERMO_1511) - 1307663..1309003 (-) 1341 WP_231108743.1 DUF2142 domain-containing protein -
  STHERMO_RS06845 (STHERMO_1512) - 1309152..1310897 (-) 1746 WP_011227426.1 rhamnan synthesis F family protein -
  STHERMO_RS06850 (STHERMO_1513) - 1310899..1312599 (-) 1701 WP_041827077.1 glycosyltransferase family 4 protein -
  STHERMO_RS06855 (STHERMO_1514) - 1312617..1313819 (-) 1203 WP_059257395.1 ABC transporter ATP-binding protein -
  STHERMO_RS06860 (STHERMO_1515) - 1313819..1314625 (-) 807 WP_011227429.1 ABC transporter permease -
  STHERMO_RS06865 (STHERMO_1516) - 1314625..1315566 (-) 942 WP_011227430.1 glycosyltransferase family 2 protein -
  STHERMO_RS06870 (STHERMO_1517) cps2T 1315563..1316711 (-) 1149 WP_011227431.1 beta 1-4 rhamnosyltransferase Cps2T -
  STHERMO_RS06875 (STHERMO_1518) - 1316830..1317612 (-) 783 WP_011227432.1 glycosyltransferase family A protein -
  STHERMO_RS06880 (STHERMO_1519) - 1317613..1317945 (-) 333 WP_011227433.1 DUF2304 domain-containing protein -
  STHERMO_RS06885 (STHERMO_1520) - 1317951..1318646 (-) 696 WP_173405413.1 glycosyltransferase family 2 protein -
  STHERMO_RS06890 - 1318730..1319202 (-) 473 Protein_1293 glycosyltransferase family 2 protein -
  STHERMO_RS06895 (STHERMO_1523) - 1319267..1320253 (-) 987 WP_011227437.1 glycosyltransferase family 2 protein -
  STHERMO_RS06900 (STHERMO_1524) - 1320250..1321509 (-) 1260 WP_011227438.1 oligosaccharide flippase family protein -
  STHERMO_RS06905 (STHERMO_1525) rfbD 1321630..1322481 (-) 852 WP_014621820.1 dTDP-4-dehydrorhamnose reductase -
  STHERMO_RS06910 (STHERMO_1526) - 1322599..1323525 (-) 927 WP_011227439.1 glycosyltransferase family 2 protein -
  STHERMO_RS06915 (STHERMO_1527) - 1323535..1323870 (-) 336 WP_002891474.1 metal-sulfur cluster assembly factor -
  STHERMO_RS06920 (STHERMO_1528) rpoD 1323924..1325033 (-) 1110 WP_011227440.1 RNA polymerase sigma factor RpoD -
  STHERMO_RS06925 (STHERMO_1529) dnaG 1325037..1326848 (-) 1812 WP_179970508.1 DNA primase -
  STHERMO_RS06930 (STHERMO_1530) rpsU 1327220..1327396 (-) 177 WP_011226340.1 30S ribosomal protein S21 -
  STHERMO_RS06935 (STHERMO_1531) - 1327777..1328730 (+) 954 WP_041826943.1 IS30 family transposase -
  STHERMO_RS06940 (STHERMO_1532) - 1328836..1329630 (-) 795 WP_011227442.1 ABC transporter substrate-binding protein -
  STHERMO_RS06945 (STHERMO_1533) - 1329723..1330832 (-) 1110 WP_041828295.1 aminotransferase -
  STHERMO_RS06950 (STHERMO_1534) - 1331179..1331976 (-) 798 WP_059257394.1 transporter substrate-binding domain-containing protein -
  STHERMO_RS06955 (STHERMO_1535) - 1331973..1332803 (-) 831 WP_041828297.1 transporter substrate-binding domain-containing protein -
  STHERMO_RS06960 (STHERMO_1536) - 1333017..1333481 (-) 465 WP_011226345.1 8-oxo-dGTP diphosphatase -
  STHERMO_RS06965 (STHERMO_1537) uvrB 1333526..1335517 (-) 1992 WP_002953358.1 excinuclease ABC subunit UvrB -
  STHERMO_RS09825 (STHERMO_1538) - 1335664..1335909 (-) 246 WP_231779859.1 hypothetical protein -
  STHERMO_RS10150 - 1336204..1337140 (-) 937 Protein_1310 CPBP family intramembrane glutamic endopeptidase -
  STHERMO_RS06975 (STHERMO_1542) - 1337339..1339549 (+) 2211 WP_011226350.1 ABC transporter substrate-binding protein/permease -
  STHERMO_RS06980 (STHERMO_1543) - 1339549..1340289 (+) 741 WP_002945131.1 amino acid ABC transporter ATP-binding protein -

Sequence

Protein


Download         Length: 623 a.a.        Molecular weight: 67919.80 Da        Isoelectric Point: 7.1310

>NTDB_id=1130451 STHERMO_RS06695 WP_011226292.1 1280773..1282644(-) (stkP/pknB) [Streptococcus thermophilus isolate STH_CIRM_16]
MIQVGKLFAGRYRILKSIGRGGMADVYLANDLILDNESVAIKVLRTNYQTDQVAVARFQREARAMTELSHPNIVAIRDIG
EEDGQQFLVMEYVDGSDLKKFIQDHAPLSNQDVVRIMGEVLSAMTLAHQKGIIHRDLKPQNVLLTKDGRAKVTDFGIAVA
FAETSLTQTNSMLGSVHYLSPEQARGSKATIQSDIYAMGIMLFEMLTGHIPFDGDSAVTIALQHFQKPLPSILAENRNVP
QALENVVIRATAKKLENRYNSTLEMSRDLVTSLHPSHSRDSKVVFDDMTDAKTLPKVDSVSSVGPEKKISPKPSEPTPAP
SKQPREKASLSKKKKNLFSTLLKVLLGFVFIGIIIFAYLVFTNPDNVQVPNVVGQELSTAQTKLESAGFKVGDVKEVEND
SVNKGKVIKTDPTAGTMRKEGASIDVYVSSGSKGFTLKNYKGKNYKDAIEDLTSNYGVSEDQIDIQHVEDDNAKEGEILS
QSSEKNKSFNPKDSKAKIKFRVATPKTITMPDVTGLTVSTAVQTLNSKDISSSSIEYHDYNTGVKLDKSKVPSNTEVLYQ
YPQVGTAVDGTVILYVSVVTKSSSIQQSSTASTTQSPSSTSSSSESSTASSTETATEATHTEQ

Nucleotide


Download         Length: 1872 bp        

>NTDB_id=1130451 STHERMO_RS06695 WP_011226292.1 1280773..1282644(-) (stkP/pknB) [Streptococcus thermophilus isolate STH_CIRM_16]
ATGATCCAAGTTGGCAAATTGTTTGCTGGACGTTATCGAATCCTTAAATCTATCGGACGTGGTGGTATGGCGGATGTTTA
TCTGGCTAACGACCTGATTCTGGATAATGAAAGTGTAGCTATTAAGGTGCTACGTACCAATTATCAAACTGATCAGGTTG
CTGTGGCGCGTTTCCAGCGTGAAGCACGTGCCATGACTGAGCTTAGCCATCCGAATATCGTTGCGATTAGAGATATTGGT
GAAGAAGACGGTCAGCAGTTCTTGGTGATGGAGTATGTGGATGGTTCGGACTTGAAGAAATTCATTCAAGACCATGCACC
ATTGTCTAACCAAGATGTTGTGCGTATTATGGGGGAAGTCCTTTCCGCCATGACTCTTGCCCACCAAAAGGGTATTATTC
ACCGTGACCTTAAGCCACAGAACGTTCTATTAACTAAGGATGGTAGAGCTAAGGTTACAGACTTTGGTATCGCAGTAGCA
TTTGCTGAAACCAGCCTGACACAAACTAACTCAATGTTGGGGTCAGTCCATTATTTGTCACCAGAACAGGCACGTGGTTC
TAAAGCCACTATCCAAAGTGATATCTATGCTATGGGGATTATGCTCTTTGAAATGTTGACAGGGCATATCCCTTTTGATG
GCGATAGTGCAGTAACCATTGCACTTCAACATTTCCAAAAGCCCCTGCCATCGATTTTGGCTGAGAACCGTAACGTTCCT
CAAGCTTTAGAAAATGTTGTTATTAGAGCAACTGCTAAAAAGCTTGAAAATCGTTACAACAGCACTTTGGAAATGAGTCG
CGACCTAGTAACTAGTTTGCATCCTAGTCATAGTCGTGATTCTAAGGTAGTTTTTGATGACATGACGGATGCTAAGACCC
TGCCAAAGGTTGATTCAGTTTCATCAGTAGGTCCTGAGAAAAAGATTTCTCCTAAACCATCAGAGCCTACACCGGCTCCA
AGCAAACAACCGAGGGAAAAAGCTTCTCTATCTAAAAAAAAGAAAAATCTCTTTTCAACTCTACTCAAGGTTTTACTAGG
CTTCGTCTTTATAGGAATTATCATTTTTGCCTATCTTGTTTTTACCAATCCTGACAATGTCCAAGTACCAAATGTTGTAG
GTCAAGAGTTGTCAACAGCTCAGACGAAACTTGAAAGTGCAGGCTTTAAGGTTGGCGATGTTAAAGAAGTCGAAAATGAT
TCAGTCAATAAGGGCAAAGTTATCAAGACCGACCCTACAGCTGGGACAATGCGTAAAGAGGGAGCAAGCATTGATGTCTA
TGTTTCTTCTGGTAGCAAAGGTTTCACTCTGAAAAATTACAAGGGGAAAAATTATAAGGATGCCATTGAGGATTTAACCT
CGAATTATGGGGTTTCCGAGGATCAGATCGATATTCAACATGTCGAAGACGATAATGCTAAAGAAGGCGAAATTCTATCT
CAAAGTTCGGAGAAAAACAAGTCCTTCAATCCTAAAGATAGTAAGGCAAAAATCAAGTTTCGTGTGGCAACTCCTAAGAC
TATAACTATGCCTGATGTGACTGGTTTAACTGTCTCGACAGCAGTCCAAACCTTGAATAGTAAAGACATTTCAAGTAGCA
GTATTGAGTATCATGACTATAATACTGGTGTTAAGTTGGATAAGAGTAAGGTACCTAGTAATACCGAGGTCCTTTATCAA
TATCCTCAAGTTGGTACTGCTGTTGATGGCACAGTGATTCTCTATGTTTCAGTCGTAACTAAGAGTTCAAGTATTCAACA
GTCAAGCACAGCAAGTACGACACAATCGCCGTCATCTACAAGTTCTAGTTCTGAAAGTAGTACAGCTTCTAGTACCGAAA
CAGCTACAGAAGCTACTCACACAGAGCAATAA

Domains

Predicted by InterproScan.

Protein kinase domain (Pkinase)

(12-235)

PASTA domain (PASTA)

(508-577)

PASTA domain (PASTA)

(367-429)

PASTA domain (PASTA)

(436-502)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q5M3J0

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  stkP/pknB Streptococcus salivarius strain HSISS4

90.361

93.258

0.843
  pknB Streptococcus mutans UA159

64.522

87.319

0.563
  stkP Streptococcus pneumoniae TIGR4

56.713

80.096

0.454
  stkP Streptococcus pneumoniae D39

56.513

80.096

0.453
  stkP Streptococcus pneumoniae R6

56.513

80.096

0.453
  stkP Streptococcus pneumoniae Rx1

56.313

80.096

0.451

Multiple sequence alignment