Detailed information
Bioinformatically predicted
Overview
| Name | comB | Type | Regulator |
| Locus tag | FJH52_RS00490 | Genome accession | NZ_LR595848 |
| Coordinates | 79701..81050 (+) | Length | 449 a.a. |
| NCBI ID | WP_000801611.1 | Uniprot ID | - |
| Organism | Streptococcus pneumoniae strain 4559 isolate 4559 | ||
| Function | transport of ComC (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| Prophage | 12174..91155 | 79701..81050 | within | 0 |
Gene organization within MGE regions
Location: 12174..91155
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FJH52_RS00060 | ftsH | 12174..14132 (+) | 1959 | WP_000744551.1 | ATP-dependent zinc metalloprotease FtsH | - |
| FJH52_RS00065 | comX/comX2 | 14254..14733 (+) | 480 | WP_000588911.1 | sigma-70 family RNA polymerase sigma factor | Regulator |
| FJH52_RS00100 | - | 20224..21070 (+) | 847 | Protein_14 | IS630 family transposase | - |
| FJH52_RS00105 | - | 21105..21889 (-) | 785 | Protein_15 | transposase | - |
| FJH52_RS00110 | comW | 22154..22390 (+) | 237 | WP_000939545.1 | sigma(X)-activator ComW | Regulator |
| FJH52_RS00115 | - | 22621..23907 (+) | 1287 | WP_001813655.1 | adenylosuccinate synthase | - |
| FJH52_RS00120 | - | 24149..25297 (-) | 1149 | WP_000876732.1 | site-specific integrase | - |
| FJH52_RS00125 | - | 25469..26383 (-) | 915 | WP_000690123.1 | HIRAN domain-containing protein | - |
| FJH52_RS00130 | - | 26395..26778 (-) | 384 | WP_000136460.1 | ImmA/IrrE family metallo-endopeptidase | - |
| FJH52_RS00135 | - | 26791..27156 (-) | 366 | WP_000484469.1 | helix-turn-helix domain-containing protein | - |
| FJH52_RS00140 | - | 27442..27588 (+) | 147 | WP_001001334.1 | hypothetical protein | - |
| FJH52_RS00145 | - | 27581..27784 (+) | 204 | WP_061367654.1 | helix-turn-helix transcriptional regulator | - |
| FJH52_RS00150 | - | 27927..28640 (+) | 714 | WP_001002347.1 | ORF6C domain-containing protein | - |
| FJH52_RS00155 | - | 28652..28909 (+) | 258 | WP_000370959.1 | hypothetical protein | - |
| FJH52_RS00160 | - | 28995..29315 (+) | 321 | WP_000462826.1 | hypothetical protein | - |
| FJH52_RS00165 | - | 29331..29630 (+) | 300 | WP_000391810.1 | hypothetical protein | - |
| FJH52_RS00170 | - | 29621..30409 (+) | 789 | WP_050111337.1 | phage replisome organizer N-terminal domain-containing protein | - |
| FJH52_RS00175 | - | 30397..30555 (+) | 159 | WP_000511766.1 | hypothetical protein | - |
| FJH52_RS00180 | - | 30549..31319 (+) | 771 | WP_061367657.1 | ATP-binding protein | - |
| FJH52_RS11340 | - | 31334..31528 (+) | 195 | WP_000470343.1 | hypothetical protein | - |
| FJH52_RS10890 | - | 31528..31755 (+) | 228 | WP_000891972.1 | hypothetical protein | - |
| FJH52_RS00185 | - | 31882..32046 (+) | 165 | WP_000233201.1 | hypothetical protein | - |
| FJH52_RS00190 | - | 32036..32245 (+) | 210 | WP_001105098.1 | hypothetical protein | - |
| FJH52_RS00195 | - | 32217..32534 (+) | 318 | WP_000969662.1 | hypothetical protein | - |
| FJH52_RS00200 | - | 32536..33045 (+) | 510 | WP_001041150.1 | DUF1642 domain-containing protein | - |
| FJH52_RS00205 | - | 33126..33638 (+) | 513 | WP_139665151.1 | DUF1642 domain-containing protein | - |
| FJH52_RS00210 | - | 33638..33925 (+) | 288 | WP_000194861.1 | hypothetical protein | - |
| FJH52_RS00215 | - | 33925..34113 (+) | 189 | WP_001277861.1 | hypothetical protein | - |
| FJH52_RS00220 | - | 34192..34293 (+) | 102 | Protein_40 | DUF3310 domain-containing protein | - |
| FJH52_RS00225 | - | 34286..34465 (+) | 180 | WP_000005958.1 | hypothetical protein | - |
| FJH52_RS00230 | - | 34455..34685 (+) | 231 | WP_000653364.1 | helix-turn-helix domain-containing protein | - |
| FJH52_RS00235 | - | 34757..35185 (+) | 429 | WP_001165368.1 | ArpU family phage packaging/lysis transcriptional regulator | - |
| FJH52_RS00240 | - | 35474..36040 (+) | 567 | WP_000754954.1 | site-specific integrase | - |
| FJH52_RS00245 | - | 36274..36618 (+) | 345 | WP_001095652.1 | HNH endonuclease | - |
| FJH52_RS00250 | - | 36756..38060 (+) | 1305 | WP_000172766.1 | hypothetical protein | - |
| FJH52_RS00255 | - | 38014..39405 (+) | 1392 | WP_000228948.1 | hypothetical protein | - |
| FJH52_RS00260 | - | 39395..39634 (+) | 240 | WP_050149965.1 | hypothetical protein | - |
| FJH52_RS00265 | - | 39687..39917 (+) | 231 | WP_000528517.1 | hypothetical protein | - |
| FJH52_RS00270 | - | 39968..41380 (+) | 1413 | WP_000101485.1 | DEAD/DEAH box helicase family protein | - |
| FJH52_RS00275 | - | 41462..41926 (+) | 465 | WP_001288685.1 | DUF4355 domain-containing protein | - |
| FJH52_RS00280 | - | 41932..42831 (+) | 900 | WP_000774646.1 | phage major capsid protein | - |
| FJH52_RS00285 | - | 42837..43049 (+) | 213 | WP_001240369.1 | HeH/LEM domain-containing protein | - |
| FJH52_RS00290 | - | 43053..43493 (+) | 441 | WP_000526245.1 | phage Gp19/Gp15/Gp42 family protein | - |
| FJH52_RS00295 | - | 43438..43776 (+) | 339 | WP_000221695.1 | hypothetical protein | - |
| FJH52_RS00300 | - | 43778..44005 (+) | 228 | WP_001852278.1 | hypothetical protein | - |
| FJH52_RS00305 | - | 44002..44337 (+) | 336 | WP_000571659.1 | hypothetical protein | - |
| FJH52_RS00310 | - | 44353..44961 (+) | 609 | WP_000205998.1 | hypothetical protein | - |
| FJH52_RS00315 | - | 44967..45242 (+) | 276 | WP_000387407.1 | hypothetical protein | - |
| FJH52_RS00320 | - | 45254..45640 (+) | 387 | WP_000560881.1 | DUF5361 domain-containing protein | - |
| FJH52_RS00325 | - | 45640..48105 (+) | 2466 | WP_000179968.1 | hypothetical protein | - |
| FJH52_RS00330 | - | 48105..48803 (+) | 699 | WP_000499607.1 | adenylosuccinate synthetase | - |
| FJH52_RS00335 | - | 48800..56173 (+) | 7374 | WP_139665152.1 | phage tail spike protein | - |
| FJH52_RS11345 | - | 56170..56286 (+) | 117 | WP_001063632.1 | hypothetical protein | - |
| FJH52_RS00340 | - | 56267..56470 (+) | 204 | WP_001091112.1 | hypothetical protein | - |
| FJH52_RS00345 | - | 56473..56823 (+) | 351 | WP_000852244.1 | hypothetical protein | - |
| FJH52_RS00350 | - | 56833..57249 (+) | 417 | WP_001165341.1 | phage holin family protein | - |
| FJH52_RS00355 | - | 57253..57585 (+) | 333 | WP_001186228.1 | phage holin | - |
| FJH52_RS00360 | - | 57589..58545 (+) | 957 | WP_050197950.1 | N-acetylmuramoyl-L-alanine amidase | - |
| FJH52_RS00365 | - | 58765..58944 (-) | 180 | WP_001209433.1 | hypothetical protein | - |
| FJH52_RS00370 | - | 59086..59235 (-) | 150 | WP_001030863.1 | hypothetical protein | - |
| FJH52_RS00375 | tadA | 59515..59982 (+) | 468 | WP_000291872.1 | tRNA adenosine(34) deaminase TadA | - |
| FJH52_RS00385 | - | 60168..60611 (+) | 444 | WP_000701992.1 | dUTP diphosphatase | - |
| FJH52_RS00390 | - | 60613..61128 (+) | 516 | WP_001828232.1 | histidine phosphatase family protein | - |
| FJH52_RS00395 | radA | 61142..62503 (+) | 1362 | WP_073176637.1 | DNA repair protein RadA | Machinery gene |
| FJH52_RS00400 | - | 62576..63073 (+) | 498 | WP_001809263.1 | carbonic anhydrase | - |
| FJH52_RS00405 | - | 63094..63381 (+) | 288 | Protein_77 | PrsW family intramembrane metalloprotease | - |
| FJH52_RS00410 | - | 63435..64786 (+) | 1352 | WP_088778796.1 | IS3 family transposase | - |
| FJH52_RS00415 | - | 64816..65352 (+) | 537 | Protein_79 | PrsW family glutamic-type intramembrane protease | - |
| FJH52_RS00420 | - | 65497..66465 (+) | 969 | WP_000010163.1 | ribose-phosphate diphosphokinase | - |
| FJH52_RS10895 | - | 66583..67510 (+) | 928 | Protein_81 | Rpn family recombination-promoting nuclease/putative transposase | - |
| FJH52_RS00435 | polA | 68118..70751 (+) | 2634 | WP_001836998.1 | DNA polymerase I | - |
| FJH52_RS00440 | - | 70836..71273 (+) | 438 | WP_000076479.1 | CoA-binding protein | - |
| FJH52_RS10900 | - | 71314..71709 (+) | 396 | WP_000693125.1 | hypothetical protein | - |
| FJH52_RS00450 | - | 71728..72738 (-) | 1011 | WP_000009180.1 | YeiH family protein | - |
| FJH52_RS00455 | - | 72887..74056 (+) | 1170 | WP_000366348.1 | pyridoxal phosphate-dependent aminotransferase | - |
| FJH52_RS00460 | recO | 74053..74823 (+) | 771 | WP_000616164.1 | DNA repair protein RecO | - |
| FJH52_RS00465 | plsX | 74820..75812 (+) | 993 | WP_000717456.1 | phosphate acyltransferase PlsX | - |
| FJH52_RS00470 | - | 75818..76051 (+) | 234 | WP_000136449.1 | acyl carrier protein | - |
| FJH52_RS00475 | - | 76088..76388 (+) | 301 | Protein_90 | transposase family protein | - |
| FJH52_RS00480 | blpU | 76590..76820 (+) | 231 | WP_001093075.1 | bacteriocin-like peptide BlpU | - |
| FJH52_RS11275 | - | 76823..76948 (+) | 126 | WP_000346297.1 | PncF family bacteriocin immunity protein | - |
| FJH52_RS00485 | comA | 77535..79688 (+) | 2154 | WP_000668272.1 | peptide cleavage/export ABC transporter ComA | Regulator |
| FJH52_RS00490 | comB | 79701..81050 (+) | 1350 | WP_000801611.1 | competence pheromone export protein ComB | Regulator |
| FJH52_RS00495 | purC | 81220..81927 (+) | 708 | WP_000043309.1 | phosphoribosylaminoimidazolesuccinocarboxamide synthase | - |
| FJH52_RS11350 | - | 81929..82072 (+) | 144 | WP_050167432.1 | hypothetical protein | - |
| FJH52_RS00505 | - | 82129..85854 (+) | 3726 | WP_000361173.1 | phosphoribosylformylglycinamidine synthase | - |
| FJH52_RS00510 | purF | 85947..87389 (+) | 1443 | WP_000220633.1 | amidophosphoribosyltransferase | - |
| FJH52_RS00515 | purM | 87426..88448 (+) | 1023 | WP_001284588.1 | phosphoribosylformylglycinamidine cyclo-ligase | - |
| FJH52_RS00520 | purN | 88445..88990 (+) | 546 | WP_000717505.1 | phosphoribosylglycinamide formyltransferase | - |
| FJH52_RS00525 | - | 89074..89583 (+) | 510 | WP_000894018.1 | VanZ family protein | - |
| FJH52_RS00530 | purH | 89608..91155 (+) | 1548 | WP_000167081.1 | bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase | - |
Sequence
Protein
Download Length: 449 a.a. Molecular weight: 49601.49 Da Isoelectric Point: 5.5642
>NTDB_id=1128304 FJH52_RS00490 WP_000801611.1 79701..81050(+) (comB) [Streptococcus pneumoniae strain 4559 isolate 4559]
MKPEFLESAEFYNRRYHNFSSSVIVPMALLLVFLLGFATVAEKEMSLSTRATVEPSRILANIQSTSNNRILVNHLEENKL
VKKGDLLVQYQEGAEGVQAESYASQLDMLKDQKKQLEYLQKSLQEGENHFPEEDKFGYQATFRDYISQAGSLRASTSQQN
ETIASQNAAASQTQAEIGNLISQTEAKIRDYQTAKSAIETGASLAGQNLAYSLYQSYKSQGEENPQTKVQAVAQVEAQIS
QLESSLATYRVQYAGSGTQQAYASGLSSQLESLKSQHLAKVGQELTLLAQKILEAESGKKVQGNLLDKGKVTASEDGVLH
LNPETSDSSMVAEGALLAQLYPSLEREGKAKLTAYLSSKYVARIKVGDSVRYTTTHDAGNQLFLDSTITSIDATATKTEK
GNFFKIEAETNLTSEQAEKLRYGVEGRLQMITGKKSYLRYYLDQFLNKE
MKPEFLESAEFYNRRYHNFSSSVIVPMALLLVFLLGFATVAEKEMSLSTRATVEPSRILANIQSTSNNRILVNHLEENKL
VKKGDLLVQYQEGAEGVQAESYASQLDMLKDQKKQLEYLQKSLQEGENHFPEEDKFGYQATFRDYISQAGSLRASTSQQN
ETIASQNAAASQTQAEIGNLISQTEAKIRDYQTAKSAIETGASLAGQNLAYSLYQSYKSQGEENPQTKVQAVAQVEAQIS
QLESSLATYRVQYAGSGTQQAYASGLSSQLESLKSQHLAKVGQELTLLAQKILEAESGKKVQGNLLDKGKVTASEDGVLH
LNPETSDSSMVAEGALLAQLYPSLEREGKAKLTAYLSSKYVARIKVGDSVRYTTTHDAGNQLFLDSTITSIDATATKTEK
GNFFKIEAETNLTSEQAEKLRYGVEGRLQMITGKKSYLRYYLDQFLNKE
Nucleotide
Download Length: 1350 bp
>NTDB_id=1128304 FJH52_RS00490 WP_000801611.1 79701..81050(+) (comB) [Streptococcus pneumoniae strain 4559 isolate 4559]
ATGAAACCAGAATTTTTAGAAAGTGCGGAGTTTTATAATCGTCGTTACCATAATTTTTCCAGTAGTGTGATTGTACCCAT
GGCCCTTCTGCTTGTGTTTTTACTTGGCTTTGCAACTGTTGCAGAGAAGGAGATGAGTTTGTCCACTAGAGCTACTGTCG
AACCTAGTCGTATCCTTGCAAATATCCAGTCAACTAGCAACAATCGTATTCTTGTCAATCATTTGGAAGAAAATAAGCTG
GTTAAGAAGGGGGATCTTTTGGTTCAATACCAAGAAGGGGCAGAGGGTGTCCAAGCGGAGTCCTATGCCAGTCAGTTGGA
CATGCTAAAGGATCAAAAAAAGCAATTGGAGTATCTGCAAAAGAGCCTGCAAGAAGGGGAGAACCACTTTCCAGAGGAGG
ATAAGTTTGGCTACCAAGCCACCTTTCGCGACTACATCAGTCAAGCAGGCAGTCTTAGGGCTAGTACATCGCAACAAAAT
GAGACCATCGCGTCCCAGAATGCAGCAGCTAGCCAAACCCAAGCCGAAATCGGCAACCTCATCAGTCAAACAGAGGCTAA
AATTCGCGATTACCAGACAGCTAAGTCAGCTATTGAAACAGGTGCTTCCTTGGCCGGTCAGAATCTAGCCTACTCTCTTT
ACCAGTCCTACAAGTCTCAGGGCGAGGAAAATCCCCAAACTAAGGTTCAGGCAGTTGCACAGGTTGAAGCACAGATTTCT
CAGTTAGAATCTAGTCTTGCTACTTACCGTGTCCAGTATGCAGGTTCAGGTACCCAGCAAGCCTATGCGTCAGGGTTAAG
CAGTCAATTGGAATCCCTTAAATCCCAACACTTGGCAAAGGTTGGTCAGGAATTGACCCTTCTAGCCCAGAAAATTTTGG
AGGCAGAGTCAGGTAAGAAGGTACAGGGAAATCTTTTAGACAAGGGGAAAGTTACGGCGAGTGAGGATGGGGTGCTTCAT
CTTAATCCTGAGACCAGTGATTCTAGCATGGTTGCAGAAGGTGCCCTACTAGCCCAACTTTATCCATCTTTGGAAAGAGA
AGGGAAAGCCAAACTCACAGCTTATCTAAGTTCAAAATATGTAGCAAGAATCAAGGTCGGTGATTCTGTTCGCTATACTA
CGACTCATGATGCCGGGAATCAACTTTTCCTAGATTCTACTATTACAAGTATTGATGCGACAGCTACTAAGACTGAGAAA
GGGAATTTCTTTAAAATCGAGGCGGAGACTAATCTAACTTCGGAGCAGGCTGAAAAACTTAGGTACGGGGTGGAAGGCCG
CTTGCAGATGATTACGGGCAAGAAAAGTTACCTACGTTATTATTTGGATCAATTTTTGAACAAAGAGTAA
ATGAAACCAGAATTTTTAGAAAGTGCGGAGTTTTATAATCGTCGTTACCATAATTTTTCCAGTAGTGTGATTGTACCCAT
GGCCCTTCTGCTTGTGTTTTTACTTGGCTTTGCAACTGTTGCAGAGAAGGAGATGAGTTTGTCCACTAGAGCTACTGTCG
AACCTAGTCGTATCCTTGCAAATATCCAGTCAACTAGCAACAATCGTATTCTTGTCAATCATTTGGAAGAAAATAAGCTG
GTTAAGAAGGGGGATCTTTTGGTTCAATACCAAGAAGGGGCAGAGGGTGTCCAAGCGGAGTCCTATGCCAGTCAGTTGGA
CATGCTAAAGGATCAAAAAAAGCAATTGGAGTATCTGCAAAAGAGCCTGCAAGAAGGGGAGAACCACTTTCCAGAGGAGG
ATAAGTTTGGCTACCAAGCCACCTTTCGCGACTACATCAGTCAAGCAGGCAGTCTTAGGGCTAGTACATCGCAACAAAAT
GAGACCATCGCGTCCCAGAATGCAGCAGCTAGCCAAACCCAAGCCGAAATCGGCAACCTCATCAGTCAAACAGAGGCTAA
AATTCGCGATTACCAGACAGCTAAGTCAGCTATTGAAACAGGTGCTTCCTTGGCCGGTCAGAATCTAGCCTACTCTCTTT
ACCAGTCCTACAAGTCTCAGGGCGAGGAAAATCCCCAAACTAAGGTTCAGGCAGTTGCACAGGTTGAAGCACAGATTTCT
CAGTTAGAATCTAGTCTTGCTACTTACCGTGTCCAGTATGCAGGTTCAGGTACCCAGCAAGCCTATGCGTCAGGGTTAAG
CAGTCAATTGGAATCCCTTAAATCCCAACACTTGGCAAAGGTTGGTCAGGAATTGACCCTTCTAGCCCAGAAAATTTTGG
AGGCAGAGTCAGGTAAGAAGGTACAGGGAAATCTTTTAGACAAGGGGAAAGTTACGGCGAGTGAGGATGGGGTGCTTCAT
CTTAATCCTGAGACCAGTGATTCTAGCATGGTTGCAGAAGGTGCCCTACTAGCCCAACTTTATCCATCTTTGGAAAGAGA
AGGGAAAGCCAAACTCACAGCTTATCTAAGTTCAAAATATGTAGCAAGAATCAAGGTCGGTGATTCTGTTCGCTATACTA
CGACTCATGATGCCGGGAATCAACTTTTCCTAGATTCTACTATTACAAGTATTGATGCGACAGCTACTAAGACTGAGAAA
GGGAATTTCTTTAAAATCGAGGCGGAGACTAATCTAACTTCGGAGCAGGCTGAAAAACTTAGGTACGGGGTGGAAGGCCG
CTTGCAGATGATTACGGGCAAGAAAAGTTACCTACGTTATTATTTGGATCAATTTTTGAACAAAGAGTAA
Domains
No domain identified.
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| comB | Streptococcus pneumoniae TIGR4 |
100 |
100 |
1 |
| comB | Streptococcus pneumoniae Rx1 |
98.886 |
100 |
0.989 |
| comB | Streptococcus pneumoniae D39 |
98.886 |
100 |
0.989 |
| comB | Streptococcus pneumoniae R6 |
98.886 |
100 |
0.989 |
| comB | Streptococcus mitis SK321 |
94.655 |
100 |
0.947 |
| comB | Streptococcus mitis NCTC 12261 |
94.209 |
100 |
0.942 |
| comB | Streptococcus gordonii str. Challis substr. CH1 |
55.111 |
100 |
0.552 |