Detailed information NTG1127932

Bioinformatically predicted

Overview

• Name: pknB
• Type: Regulator
• Locus tag: FGL22_RS08245
• Genome accession: NZ_LR594048
• Coordinates: 1659767..1661662 (-)
• Length: 631 a.a.
• NCBI ID: WP_004230538.1
• Uniprot ID: -
• Organism: Streptococcus dysgalactiae subsp. equisimilis strain NCTC11556
• Function: modulate the activity of ComDE; modulate the activity of VicKR (predicted from homology) Competence regulation

Genomic Context

Location: 1654767..1666662

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
FGL22_RS08220 (NCTC11556_01705)	-	1655517..1655876 (-)	360	WP_003056775.1	S1 RNA-binding domain-containing protein	-
FGL22_RS08225 (NCTC11556_01706)	-	1655876..1657276 (-)	1401	WP_065355408.1	bifunctional Cof-type HAD-IIB family hydrolase/peptidylprolyl isomerase	-
FGL22_RS08230 (NCTC11556_01707)	-	1657313..1657954 (-)	642	WP_014612503.1	response regulator transcription factor	-
FGL22_RS08235 (NCTC11556_01708)	-	1657947..1658951 (-)	1005	WP_003061197.1	sensor histidine kinase	-
FGL22_RS08240 (NCTC11556_01709)	liaF	1658948..1659640 (-)	693	WP_065355409.1	cell wall-active antibiotics response protein LiaF	-
FGL22_RS08245 (NCTC11556_01710)	pknB	1659767..1661662 (-)	1896	WP_004230538.1	Stk1 family PASTA domain-containing Ser/Thr kinase	Regulator
FGL22_RS08250 (NCTC11556_01711)	-	1661659..1662399 (-)	741	WP_014612505.1	Stp1/IreP family PP2C-type Ser/Thr phosphatase	-
FGL22_RS08255 (NCTC11556_01712)	rsmB	1662437..1663759 (-)	1323	WP_003060995.1	16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB	-
FGL22_RS08260 (NCTC11556_01713)	fmt	1663749..1664684 (-)	936	WP_014612506.1	methionyl-tRNA formyltransferase	-

Sequence

Protein

• Length: 631 a.a.
• Molecular weight: 68711.08 Da
• Isoelectric Point: 7.2906

>NTDB_id=1127932 FGL22_RS08245 WP_004230538.1 1659767..1661662(-) (pknB) [Streptococcus dysgalactiae subsp. equisimilis strain NCTC11556]
MIQIGKLFAGRYRILKSIGRGGMADVYLANDLILDNEDVAIKVLRTNYQTDQVAVARFQREARAMAELNHPNIVAIRDIG
EEDGQQFLVMEYVDGADLKKYIQDHAPLSNNEVVRIMEEVLSAMTLAHQKGIVHRDLKPQNILLTKNGVVKVTDFGIAVA
FAETSLTQTNSMLGSVHYLSPEQARGSKATIQSDIYAMGIMLFEMLTGHIPYDGDSAVTIALQHFQKPLPSIIDENHNVP
QALENVVIRATAKKLSDRYGSTFEMSRDLMTALSYNRSRERKVIFDDVESTKPLPKVTPAPVTTPKVAPTPVTSTTESRL
EHTNQMDTLQKPQKKKRNGRFLGTLLKILFSLFIVGVALFTYLVLTKPTSVKVPNVTGVSLKVAKQELQDLGLKVGKVRQ
IESDTVAEGNVVRTDPPTGTAKRKGSAITVYLSIGNKGFEMENYKGIDYQEAMASLMETYGVPKSKIKIERIVTNEYTEN
TVISQSPSAGDKFNPNGKSKITLSVAVSDTVIMPMVTEYTYADAVNTLTALGIEASRIKAYAPSSSSATGFVQVNSPSSK
AIVSGQTPYYGTTLSLSEKGEISLYLYPEETHSSSSSTSSEASSSSSSTNDGTGTSSNTELSPSESAGQTP

Nucleotide

• Length: 1896 bp

>NTDB_id=1127932 FGL22_RS08245 WP_004230538.1 1659767..1661662(-) (pknB) [Streptococcus dysgalactiae subsp. equisimilis strain NCTC11556]
ATGATTCAGATTGGCAAGTTATTTGCTGGTCGTTATCGCATTCTAAAATCTATTGGCCGCGGTGGTATGGCGGATGTTTA
TTTAGCAAATGATCTAATCTTGGATAATGAAGACGTTGCAATCAAGGTCTTACGTACCAATTATCAGACAGATCAGGTAG
CGGTTGCCCGTTTCCAACGGGAAGCGCGTGCCATGGCTGAGTTAAACCATCCTAATATTGTTGCCATCCGGGATATAGGT
GAAGAAGACGGACAGCAATTTTTAGTAATGGAATACGTAGATGGCGCTGACTTAAAGAAGTATATTCAAGATCATGCTCC
TCTATCCAATAATGAAGTGGTCAGAATCATGGAAGAGGTGCTTTCTGCCATGACATTAGCTCACCAGAAAGGGATTGTTC
ATAGAGATTTAAAACCTCAAAACATTCTTTTAACTAAAAATGGTGTGGTTAAGGTAACTGACTTTGGGATTGCCGTTGCT
TTTGCGGAAACGAGTTTGACTCAAACCAACTCTATGTTGGGAAGCGTCCATTACCTATCGCCTGAGCAGGCTCGCGGCTC
AAAAGCGACCATTCAAAGTGATATTTATGCGATGGGAATTATGCTCTTTGAAATGTTGACAGGACATATCCCTTATGATG
GCGATAGTGCTGTTACCATTGCTTTGCAACATTTCCAAAAGCCTCTTCCGTCTATTATTGACGAAAACCACAATGTACCG
CAAGCTTTAGAGAATGTGGTTATCCGAGCAACAGCTAAGAAATTAAGCGATCGTTACGGATCAACCTTTGAAATGAGTCG
TGATCTGATGACGGCTCTCAGTTACAACCGGAGTCGTGAACGGAAAGTTATTTTTGATGATGTGGAAAGCACAAAACCTC
TCCCTAAAGTAACACCGGCACCAGTAACGACGCCAAAAGTAGCTCCAACTCCTGTTACGTCCACAACTGAAAGTCGTTTA
GAACACACTAATCAGATGGATACGCTCCAGAAACCACAAAAAAAGAAGCGAAATGGTCGTTTCTTGGGTACTTTGTTAAA
AATCCTCTTTTCTCTTTTTATTGTAGGTGTGGCTCTCTTCACTTACTTGGTGCTAACAAAACCTACCTCAGTAAAAGTTC
CTAACGTGACAGGTGTCAGTCTTAAAGTTGCAAAGCAGGAACTGCAAGATTTAGGCTTGAAAGTTGGTAAGGTGAGACAG
ATTGAAAGTGATACTGTTGCGGAAGGGAATGTTGTCCGAACGGATCCACCAACGGGAACAGCCAAGCGCAAGGGTTCAGC
TATCACAGTTTACTTGTCAATTGGTAATAAAGGGTTTGAGATGGAAAACTACAAAGGGATTGATTATCAAGAAGCCATGG
CTAGCTTGATGGAAACTTACGGTGTTCCTAAATCGAAGATTAAGATTGAACGAATCGTGACCAATGAATACACGGAAAAT
ACTGTTATTAGCCAATCTCCGAGTGCAGGGGATAAATTTAATCCTAATGGGAAATCTAAAATTACTCTTAGTGTTGCCGT
GAGTGACACAGTCATTATGCCTATGGTAACAGAATATACCTATGCTGATGCAGTAAATACTTTGACAGCATTAGGTATTG
AAGCTTCAAGGATTAAAGCTTATGCTCCAAGCTCAAGTTCAGCAACAGGTTTTGTTCAGGTTAATTCTCCAAGTTCAAAA
GCTATTGTCAGTGGTCAAACCCCTTATTACGGTACCACATTGAGCCTCTCTGAAAAAGGTGAGATAAGCCTTTACCTTTA
CCCAGAAGAAACGCATTCTTCAAGTAGTTCAACCAGTTCTGAGGCAAGTTCTAGCAGTTCCTCAACAAATGATGGAACGG
GAACAAGTAGTAATACTGAATTAAGCCCATCGGAATCAGCTGGTCAAACCCCTTAA

Domains

Predicted by InterproScan.

• Protein kinase domain (Pkinase) (12-233)

• PASTA domain (PASTA) (511-587)

• PASTA domain (PASTA) (440-505)

• PASTA domain (PASTA) (371-433)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
pknB	Streptococcus mutans UA159	65.358	92.868	0.607
stkP/pknB	Streptococcus salivarius strain HSISS4	62.017	94.295	0.585
stkP	Streptococcus pneumoniae TIGR4	58.221	81.933	0.477
stkP	Streptococcus pneumoniae D39	58.027	81.933	0.475
stkP	Streptococcus pneumoniae R6	58.027	81.933	0.475
stkP	Streptococcus pneumoniae Rx1	57.834	81.933	0.474