Detailed information NTG1127889

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: FGL22_RS00360
• Genome accession: NZ_LR594048
• Coordinates: 57538..58449 (+)
• Length: 303 a.a.
• NCBI ID: WP_003060893.1
• Uniprot ID: A0AAE9U6L1
• Organism: Streptococcus dysgalactiae subsp. equisimilis strain NCTC11556
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 52538..63449

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
FGL22_RS00335 (NCTC11556_00067)	purE	53038..53526 (+)	489	WP_003062588.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
FGL22_RS00340 (NCTC11556_00068)	purK	53513..54586 (+)	1074	WP_012766418.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
FGL22_RS00345 (NCTC11556_00069)	-	54596..55852 (+)	1257	WP_012766419.1	DUF4041 domain-containing protein	-
FGL22_RS00350	-	55845..56054 (+)	210	WP_014611912.1	hypothetical protein	-
FGL22_RS00355 (NCTC11556_00070)	purB	56103..57395 (+)	1293	WP_003056595.1	adenylosuccinate lyase	-
FGL22_RS00360 (NCTC11556_00071)	comR	57538..58449 (+)	912	WP_003060893.1	XRE family transcriptional regulator	Regulator
FGL22_RS00365 (NCTC11556_00073)	ruvB	58668..59666 (+)	999	WP_015057190.1	Holliday junction branch migration DNA helicase RuvB	-
FGL22_RS00370 (NCTC11556_00074)	-	59801..60232 (+)	432	WP_003059365.1	low molecular weight protein-tyrosine-phosphatase	-
FGL22_RS00375 (NCTC11556_00075)	-	60261..60662 (+)	402	WP_003049089.1	MORN repeat-containing protein	-
FGL22_RS00380 (NCTC11556_00076)	-	60659..62434 (+)	1776	WP_003059359.1	acyltransferase family protein	-

Sequence

Protein

• Length: 303 a.a.
• Molecular weight: 35995.62 Da
• Isoelectric Point: 4.7392

>NTDB_id=1127889 FGL22_RS00360 WP_003060893.1 57538..58449(+) (comR) [Streptococcus dysgalactiae subsp. equisimilis strain NCTC11556]
MLEHFGEKVRGLRLEKGISREELCGDEAELSVRQLARIELGQSIPSLAKVIFIAKALEVSVGYLTDGANLELPKRYKELK
YLILRTPTYMDDRKLQVRESQFDEIFENYYDQLPEEEKIAIDIIQAKFEVYQTGDINFGFNILKEFLPQLKKKTVYNLNE
LLLIDLYLIILVVSNFTNDLFDEEFYKEITERILEQHQYLLLEDLFLLNNILLSCADTSIRLKMFERLKDTLQLSHFIMS
TIQDFQRMPMYCMYEWKLSIFYLKDIKRAETYFSQSLTFTQMTNDSYLAQKLQKEWDKDIHPS

Nucleotide

• Length: 912 bp

>NTDB_id=1127889 FGL22_RS00360 WP_003060893.1 57538..58449(+) (comR) [Streptococcus dysgalactiae subsp. equisimilis strain NCTC11556]
ATGTTAGAGCATTTTGGTGAAAAAGTGAGAGGATTAAGACTTGAGAAAGGGATTAGTCGAGAGGAATTGTGTGGAGATGA
GGCAGAATTGTCTGTTCGCCAGTTGGCGAGGATAGAGCTAGGTCAATCTATACCAAGTTTAGCGAAGGTTATTTTTATTG
CGAAAGCCTTAGAGGTCAGCGTCGGTTATTTGACGGATGGCGCTAACCTAGAACTCCCTAAACGATATAAAGAGTTAAAA
TATCTCATTTTAAGGACTCCGACTTATATGGACGATCGCAAATTACAGGTCCGGGAGTCTCAGTTTGATGAGATATTTGA
AAACTATTATGATCAATTGCCCGAGGAGGAAAAAATAGCGATTGATATTATCCAGGCAAAATTTGAAGTTTATCAGACAG
GTGATATTAATTTTGGTTTTAATATTTTAAAAGAATTTCTACCACAACTAAAAAAGAAAACGGTTTATAACTTAAATGAA
TTATTATTAATTGATTTATATTTAATTATTTTAGTTGTTTCTAACTTTACAAATGACCTATTTGATGAGGAATTTTATAA
AGAAATAACGGAGCGAATCTTAGAACAGCATCAATACCTGTTATTAGAAGATTTATTTCTATTAAATAATATTCTTTTAT
CTTGCGCAGATACTTCTATTCGTTTAAAAATGTTTGAACGACTAAAGGATACGTTACAACTCAGTCATTTTATTATGTCA
ACCATTCAAGATTTTCAGCGAATGCCCATGTATTGCATGTATGAATGGAAATTGTCTATCTTTTATTTAAAAGATATTAA
ACGAGCAGAAACTTATTTTAGTCAATCTCTCACGTTTACTCAAATGACTAATGATAGTTATTTGGCACAAAAGCTTCAAA
AAGAATGGGATAAGGATATTCATCCCTCTTAA

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (12-64)

• ComR tetratricopeptide (ComR_TPR) (73-296)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS315	83.389	99.34	0.828
comR	Streptococcus pyogenes MGAS8232	55.629	99.67	0.554
comR	Streptococcus mutans UA159	46.154	98.68	0.455
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	46.575	96.37	0.449
comR	Streptococcus suis P1/7	37.288	97.36	0.363
comR	Streptococcus suis 05ZYH33	37.288	97.36	0.363