Detailed information
Bioinformatically predicted
Overview
| Name | comA/nlmT | Type | Regulator |
| Locus tag | FGL21_RS02980 | Genome accession | NZ_LR594047 |
| Coordinates | 551124..553277 (-) | Length | 717 a.a. |
| NCBI ID | WP_014612084.1 | Uniprot ID | - |
| Organism | Streptococcus dysgalactiae subsp. equisimilis strain NCTC11554 | ||
| Function | transport of ComC (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 512319..557179 | 551124..553277 | within | 0 |
Gene organization within MGE regions
Location: 512319..557179
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FGL21_RS02775 (NCTC11554_00567) | - | 514907..515509 (+) | 603 | WP_111681583.1 | hypothetical protein | - |
| FGL21_RS02780 (NCTC11554_00568) | - | 515532..515804 (+) | 273 | WP_111681584.1 | hypothetical protein | - |
| FGL21_RS02785 (NCTC11554_00569) | - | 515804..516586 (+) | 783 | WP_111681585.1 | hypothetical protein | - |
| FGL21_RS02790 (NCTC11554_00570) | - | 516608..517099 (+) | 492 | WP_111681586.1 | DUF3801 domain-containing protein | - |
| FGL21_RS02795 (NCTC11554_00571) | - | 517099..519144 (+) | 2046 | WP_111681587.1 | type IV secretory system conjugative DNA transfer family protein | - |
| FGL21_RS02800 (NCTC11554_00572) | - | 519186..519551 (+) | 366 | WP_111681588.1 | hypothetical protein | - |
| FGL21_RS02805 (NCTC11554_00573) | - | 519553..522789 (+) | 3237 | WP_138127991.1 | PBECR4 domain-containing protein | - |
| FGL21_RS02810 (NCTC11554_00574) | - | 522841..523140 (+) | 300 | WP_111681590.1 | hypothetical protein | - |
| FGL21_RS02820 (NCTC11554_00575) | mobC | 523482..523865 (+) | 384 | WP_111681591.1 | plasmid mobilization relaxosome protein MobC | - |
| FGL21_RS02825 (NCTC11554_00576) | - | 523828..525471 (+) | 1644 | WP_111681592.1 | relaxase/mobilization nuclease domain-containing protein | - |
| FGL21_RS02830 (NCTC11554_00577) | - | 525483..526733 (+) | 1251 | WP_138127993.1 | site-specific DNA-methyltransferase | - |
| FGL21_RS02835 (NCTC11554_00578) | - | 526745..527044 (+) | 300 | WP_111681594.1 | hypothetical protein | - |
| FGL21_RS02840 (NCTC11554_00579) | - | 527336..528616 (+) | 1281 | WP_111681595.1 | ISLre2 family transposase | - |
| FGL21_RS02845 (NCTC11554_00580) | rplK | 529081..529506 (+) | 426 | WP_003049875.1 | 50S ribosomal protein L11 | - |
| FGL21_RS02850 (NCTC11554_00581) | rplA | 529612..530301 (+) | 690 | WP_003049876.1 | 50S ribosomal protein L1 | - |
| FGL21_RS11220 (NCTC11554_00582) | - | 530759..530926 (-) | 168 | WP_003054374.1 | hypothetical protein | - |
| FGL21_RS02855 (NCTC11554_00583) | pyrH | 531208..531936 (+) | 729 | WP_003049878.1 | UMP kinase | - |
| FGL21_RS02860 (NCTC11554_00584) | frr | 531965..532522 (+) | 558 | WP_003054381.1 | ribosome recycling factor | - |
| FGL21_RS02865 (NCTC11554_00585) | - | 532631..533488 (+) | 858 | WP_003054345.1 | S1 RNA-binding domain-containing protein | - |
| FGL21_RS02870 (NCTC11554_00586) | msrA | 533561..534070 (+) | 510 | WP_003054395.1 | peptide-methionine (S)-S-oxide reductase MsrA | - |
| FGL21_RS02875 (NCTC11554_00587) | - | 534067..534282 (+) | 216 | WP_003054340.1 | YozE family protein | - |
| FGL21_RS02880 (NCTC11554_00588) | - | 534442..535692 (+) | 1251 | WP_138127995.1 | LysM domain-containing protein | - |
| FGL21_RS02885 (NCTC11554_00589) | - | 536003..537775 (+) | 1773 | WP_014612076.1 | oleate hydratase | - |
| FGL21_RS02895 (NCTC11554_00590) | - | 537936..538997 (+) | 1062 | WP_003054347.1 | PhoH family protein | - |
| FGL21_RS02900 (NCTC11554_00591) | - | 539044..539619 (+) | 576 | WP_003054351.1 | uracil-DNA glycosylase family protein | - |
| FGL21_RS02905 (NCTC11554_00592) | ybeY | 539778..540275 (+) | 498 | WP_003054373.1 | rRNA maturation RNase YbeY | - |
| FGL21_RS02910 (NCTC11554_00593) | - | 540256..540663 (+) | 408 | WP_003054389.1 | diacylglycerol kinase | - |
| FGL21_RS02915 (NCTC11554_00594) | era | 540784..541680 (+) | 897 | WP_003054336.1 | GTPase Era | - |
| FGL21_RS11355 (NCTC11554_00595) | - | 541867..542172 (+) | 306 | Protein_503 | NUDIX domain-containing protein | - |
| FGL21_RS02920 | - | 542159..543852 (-) | 1694 | Protein_504 | ABC transporter transmembrane domain-containing protein | - |
| FGL21_RS02930 (NCTC11554_00598) | - | 544154..544381 (+) | 228 | WP_003054378.1 | bacteriocin-type signal sequence | - |
| FGL21_RS02935 (NCTC11554_00599) | - | 544430..544747 (+) | 318 | WP_002994587.1 | hypothetical protein | - |
| FGL21_RS02940 (NCTC11554_00600) | - | 545155..545394 (+) | 240 | WP_003054359.1 | Blp family class II bacteriocin | - |
| FGL21_RS02945 (NCTC11554_00601) | - | 545408..545593 (+) | 186 | WP_003054392.1 | hypothetical protein | - |
| FGL21_RS11225 (NCTC11554_00602) | - | 545847..546017 (+) | 171 | WP_014612080.1 | hypothetical protein | - |
| FGL21_RS02955 | - | 546036..547141 (-) | 1106 | Protein_510 | IS3 family transposase | - |
| FGL21_RS02960 (NCTC11554_00606) | comE/blpR | 547388..548137 (+) | 750 | WP_046159788.1 | response regulator transcription factor | Regulator |
| FGL21_RS02965 (NCTC11554_00607) | - | 548138..549472 (+) | 1335 | WP_138127997.1 | GHKL domain-containing protein | - |
| FGL21_RS02970 (NCTC11554_00608) | - | 549533..549658 (-) | 126 | WP_011017462.1 | ComC/BlpC family leader-containing pheromone/bacteriocin | - |
| FGL21_RS02975 (NCTC11554_00609) | - | 549749..551113 (-) | 1365 | WP_012766651.1 | bacteriocin secretion accessory protein | - |
| FGL21_RS02980 (NCTC11554_00610) | comA/nlmT | 551124..553277 (-) | 2154 | WP_014612084.1 | peptide cleavage/export ABC transporter | Regulator |
| FGL21_RS02985 (NCTC11554_00611) | - | 553564..553791 (+) | 228 | WP_002992018.1 | Blp family class II bacteriocin | - |
| FGL21_RS02990 (NCTC11554_00612) | - | 553804..554004 (+) | 201 | WP_003060803.1 | class IIb bacteriocin, lactobin A/cerein 7B family | - |
| FGL21_RS03000 (NCTC11554_00614) | - | 554299..554493 (+) | 195 | WP_002990768.1 | hypothetical protein | - |
| FGL21_RS03010 (NCTC11554_00616) | - | 554659..555093 (+) | 435 | WP_014612086.1 | helix-turn-helix domain-containing protein | - |
| FGL21_RS03020 | - | 556291..556824 (+) | 534 | Protein_521 | IS30 family transposase | - |
| FGL21_RS11550 | - | 556855..557094 (+) | 240 | WP_014612088.1 | hypothetical protein | - |
Sequence
Protein
Download Length: 717 a.a. Molecular weight: 80532.38 Da Isoelectric Point: 6.8704
>NTDB_id=1127851 FGL21_RS02980 WP_014612084.1 551124..553277(-) (comA/nlmT) [Streptococcus dysgalactiae subsp. equisimilis strain NCTC11554]
MISYRKTFVAQIDARDCGVAALASIAKYYGSDYSLAHLRELAKTNKEGTTALGIVKAAKLMGFETRAIQADMTLFDIEDV
PYPFIVHVNKEGKFQHYYVVYQNKKNYLIIGDPDPTVNVTKMTKERFTSEWTGVAIFLAPEPSYKPHKDKKNGLISFLPL
IFKQRSLIFYIILASLLVTLINIVGSYYLQGILDDYIPNQLKSTLGIISIGLIITYILQQMMSFSRDYLLTVLSQRLSID
VILSYIRHIFELPMSFFATRRTGEIISRFTDANAIIDALASTILSLFLDVSILTIVGTVLLVQNTNLFLLSLVSVPLYIV
IIFIFMHPFEKMNNDVMQSNSMVSSAIIEDTNGIETIKSLTSEENRYQKIDSEFVDYLDKSFKLSKYSILQSSLKQGAQL
ILNVIVLWFGAKLVMGGKISVGQLITFNTLLSYFTNPLENIINLQTKLQSAKVANNRLNEVYLVDSEFQEAGTLVNQELL
HGDIQFEELSYKYGFGRDTLSNINLTIKQGDKVSLVGISGSGKTTLAKMIVNFFEPYNGRITINHNDLKMIDKKSLRQHI
NYLPQQAYIFNGSILENLTLGANDCTSHEDILRACEVAEIRQDIEQMPMGYQTELSDGAGLSGGQKQRIALARALLTKAP
VLILDEATSGLDVLTEKRVIDNLLAMTDKTIIFVAHRLSISARTNQVIVLDEGKIIEIGSHQELMTKQGFYHHLFSS
MISYRKTFVAQIDARDCGVAALASIAKYYGSDYSLAHLRELAKTNKEGTTALGIVKAAKLMGFETRAIQADMTLFDIEDV
PYPFIVHVNKEGKFQHYYVVYQNKKNYLIIGDPDPTVNVTKMTKERFTSEWTGVAIFLAPEPSYKPHKDKKNGLISFLPL
IFKQRSLIFYIILASLLVTLINIVGSYYLQGILDDYIPNQLKSTLGIISIGLIITYILQQMMSFSRDYLLTVLSQRLSID
VILSYIRHIFELPMSFFATRRTGEIISRFTDANAIIDALASTILSLFLDVSILTIVGTVLLVQNTNLFLLSLVSVPLYIV
IIFIFMHPFEKMNNDVMQSNSMVSSAIIEDTNGIETIKSLTSEENRYQKIDSEFVDYLDKSFKLSKYSILQSSLKQGAQL
ILNVIVLWFGAKLVMGGKISVGQLITFNTLLSYFTNPLENIINLQTKLQSAKVANNRLNEVYLVDSEFQEAGTLVNQELL
HGDIQFEELSYKYGFGRDTLSNINLTIKQGDKVSLVGISGSGKTTLAKMIVNFFEPYNGRITINHNDLKMIDKKSLRQHI
NYLPQQAYIFNGSILENLTLGANDCTSHEDILRACEVAEIRQDIEQMPMGYQTELSDGAGLSGGQKQRIALARALLTKAP
VLILDEATSGLDVLTEKRVIDNLLAMTDKTIIFVAHRLSISARTNQVIVLDEGKIIEIGSHQELMTKQGFYHHLFSS
Nucleotide
Download Length: 2154 bp
>NTDB_id=1127851 FGL21_RS02980 WP_014612084.1 551124..553277(-) (comA/nlmT) [Streptococcus dysgalactiae subsp. equisimilis strain NCTC11554]
ATGATATCCTATCGAAAAACATTTGTTGCTCAGATTGATGCTAGAGACTGTGGTGTGGCTGCTCTTGCTTCCATCGCTAA
ATATTACGGTTCAGACTACTCTTTAGCTCATTTAAGAGAGTTAGCTAAAACAAATAAAGAGGGAACAACAGCGCTTGGCA
TCGTCAAAGCTGCCAAATTAATGGGATTTGAAACAAGAGCTATTCAAGCAGACATGACCCTCTTTGATATAGAAGATGTC
CCTTATCCTTTTATTGTTCATGTTAATAAAGAAGGTAAATTCCAACACTACTATGTCGTCTATCAAAACAAAAAAAATTA
TCTGATAATCGGCGACCCTGACCCGACAGTAAATGTCACTAAGATGACAAAGGAGCGATTTACTTCTGAATGGACGGGTG
TCGCTATTTTTCTAGCACCCGAGCCCAGCTACAAGCCTCATAAGGATAAAAAGAACGGTCTAATAAGCTTTTTACCTCTC
ATTTTTAAACAGCGATCTCTGATTTTCTATATCATATTAGCTAGCCTACTCGTTACTCTGATTAATATTGTAGGTTCTTA
TTACCTACAAGGTATATTAGATGACTATATTCCAAATCAACTGAAATCAACACTCGGCATTATTTCAATTGGTCTTATCA
TTACCTATATCCTCCAACAGATGATGAGTTTTTCGCGAGATTATCTCCTGACTGTACTGAGTCAGCGATTAAGCATTGAT
GTTATTTTATCCTATATTCGTCATATTTTTGAGCTTCCCATGTCTTTCTTTGCAACACGTCGGACAGGAGAAATCATTTC
ACGGTTTACAGATGCTAATGCTATTATTGATGCACTCGCTTCTACTATTTTGTCTCTTTTTCTTGATGTCAGTATTTTAA
CTATCGTAGGGACAGTTCTGTTAGTGCAAAATACCAATCTTTTTCTTCTATCTCTGGTTTCAGTCCCTCTATATATTGTT
ATTATCTTTATATTTATGCACCCATTTGAAAAGATGAATAATGATGTCATGCAGAGTAACTCTATGGTTAGCTCAGCCAT
TATCGAAGATACCAATGGCATTGAAACTATTAAATCACTGACCAGTGAAGAAAATCGTTATCAGAAAATTGATAGTGAAT
TTGTGGACTATCTGGATAAATCTTTCAAGTTAAGTAAGTACTCTATTTTACAAAGCAGTCTCAAACAAGGGGCGCAACTA
ATCCTTAACGTGATAGTCTTATGGTTTGGGGCCAAATTAGTTATGGGAGGAAAAATTTCTGTTGGTCAGTTGATTACGTT
TAATACTCTCTTATCTTATTTTACCAATCCTTTAGAAAATATCATTAATCTTCAAACTAAACTGCAATCAGCCAAGGTAG
CTAATAATCGTCTCAATGAAGTTTACCTAGTCGATTCTGAGTTTCAAGAGGCTGGGACATTAGTCAATCAAGAATTATTA
CACGGAGACATTCAATTTGAAGAGTTATCCTATAAATATGGCTTTGGACGCGATACTCTATCAAATATTAATCTCACTAT
TAAGCAAGGGGACAAAGTTAGCCTTGTTGGTATTAGTGGATCTGGTAAAACGACTCTAGCTAAAATGATTGTTAATTTTT
TTGAGCCTTATAACGGCCGAATTACCATTAATCATAATGACTTAAAAATGATTGATAAAAAAAGTCTTCGCCAACATATT
AATTATCTCCCCCAACAAGCCTATATTTTTAATGGTTCTATTTTAGAAAATTTAACCTTAGGTGCTAATGACTGTACTAG
TCATGAAGATATTCTAAGAGCTTGTGAGGTTGCAGAAATTCGACAAGATATTGAACAAATGCCTATGGGCTATCAAACAG
AGCTTTCTGATGGTGCCGGACTCTCAGGAGGCCAAAAGCAACGAATTGCACTTGCCAGAGCTCTCCTAACCAAGGCGCCT
GTGCTTATTCTAGATGAGGCTACAAGCGGTCTTGACGTACTAACTGAAAAGAGGGTTATTGATAATCTTTTGGCTATGAC
GGATAAAACTATTATTTTCGTAGCTCATCGTCTCAGCATTTCAGCGCGGACCAATCAAGTCATTGTGCTTGATGAGGGTA
AAATTATTGAAATAGGATCTCATCAAGAATTAATGACTAAACAAGGTTTCTATCATCATTTATTTAGTAGTTAA
ATGATATCCTATCGAAAAACATTTGTTGCTCAGATTGATGCTAGAGACTGTGGTGTGGCTGCTCTTGCTTCCATCGCTAA
ATATTACGGTTCAGACTACTCTTTAGCTCATTTAAGAGAGTTAGCTAAAACAAATAAAGAGGGAACAACAGCGCTTGGCA
TCGTCAAAGCTGCCAAATTAATGGGATTTGAAACAAGAGCTATTCAAGCAGACATGACCCTCTTTGATATAGAAGATGTC
CCTTATCCTTTTATTGTTCATGTTAATAAAGAAGGTAAATTCCAACACTACTATGTCGTCTATCAAAACAAAAAAAATTA
TCTGATAATCGGCGACCCTGACCCGACAGTAAATGTCACTAAGATGACAAAGGAGCGATTTACTTCTGAATGGACGGGTG
TCGCTATTTTTCTAGCACCCGAGCCCAGCTACAAGCCTCATAAGGATAAAAAGAACGGTCTAATAAGCTTTTTACCTCTC
ATTTTTAAACAGCGATCTCTGATTTTCTATATCATATTAGCTAGCCTACTCGTTACTCTGATTAATATTGTAGGTTCTTA
TTACCTACAAGGTATATTAGATGACTATATTCCAAATCAACTGAAATCAACACTCGGCATTATTTCAATTGGTCTTATCA
TTACCTATATCCTCCAACAGATGATGAGTTTTTCGCGAGATTATCTCCTGACTGTACTGAGTCAGCGATTAAGCATTGAT
GTTATTTTATCCTATATTCGTCATATTTTTGAGCTTCCCATGTCTTTCTTTGCAACACGTCGGACAGGAGAAATCATTTC
ACGGTTTACAGATGCTAATGCTATTATTGATGCACTCGCTTCTACTATTTTGTCTCTTTTTCTTGATGTCAGTATTTTAA
CTATCGTAGGGACAGTTCTGTTAGTGCAAAATACCAATCTTTTTCTTCTATCTCTGGTTTCAGTCCCTCTATATATTGTT
ATTATCTTTATATTTATGCACCCATTTGAAAAGATGAATAATGATGTCATGCAGAGTAACTCTATGGTTAGCTCAGCCAT
TATCGAAGATACCAATGGCATTGAAACTATTAAATCACTGACCAGTGAAGAAAATCGTTATCAGAAAATTGATAGTGAAT
TTGTGGACTATCTGGATAAATCTTTCAAGTTAAGTAAGTACTCTATTTTACAAAGCAGTCTCAAACAAGGGGCGCAACTA
ATCCTTAACGTGATAGTCTTATGGTTTGGGGCCAAATTAGTTATGGGAGGAAAAATTTCTGTTGGTCAGTTGATTACGTT
TAATACTCTCTTATCTTATTTTACCAATCCTTTAGAAAATATCATTAATCTTCAAACTAAACTGCAATCAGCCAAGGTAG
CTAATAATCGTCTCAATGAAGTTTACCTAGTCGATTCTGAGTTTCAAGAGGCTGGGACATTAGTCAATCAAGAATTATTA
CACGGAGACATTCAATTTGAAGAGTTATCCTATAAATATGGCTTTGGACGCGATACTCTATCAAATATTAATCTCACTAT
TAAGCAAGGGGACAAAGTTAGCCTTGTTGGTATTAGTGGATCTGGTAAAACGACTCTAGCTAAAATGATTGTTAATTTTT
TTGAGCCTTATAACGGCCGAATTACCATTAATCATAATGACTTAAAAATGATTGATAAAAAAAGTCTTCGCCAACATATT
AATTATCTCCCCCAACAAGCCTATATTTTTAATGGTTCTATTTTAGAAAATTTAACCTTAGGTGCTAATGACTGTACTAG
TCATGAAGATATTCTAAGAGCTTGTGAGGTTGCAGAAATTCGACAAGATATTGAACAAATGCCTATGGGCTATCAAACAG
AGCTTTCTGATGGTGCCGGACTCTCAGGAGGCCAAAAGCAACGAATTGCACTTGCCAGAGCTCTCCTAACCAAGGCGCCT
GTGCTTATTCTAGATGAGGCTACAAGCGGTCTTGACGTACTAACTGAAAAGAGGGTTATTGATAATCTTTTGGCTATGAC
GGATAAAACTATTATTTTCGTAGCTCATCGTCTCAGCATTTCAGCGCGGACCAATCAAGTCATTGTGCTTGATGAGGGTA
AAATTATTGAAATAGGATCTCATCAAGAATTAATGACTAAACAAGGTTTCTATCATCATTTATTTAGTAGTTAA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| comA/nlmT | Streptococcus mutans UA159 |
72.587 |
99.721 |
0.724 |
| comA | Streptococcus mitis NCTC 12261 |
67.367 |
99.582 |
0.671 |
| comA | Streptococcus mitis SK321 |
66.947 |
99.582 |
0.667 |
| comA | Streptococcus pneumoniae Rx1 |
66.947 |
99.582 |
0.667 |
| comA | Streptococcus pneumoniae D39 |
66.947 |
99.582 |
0.667 |
| comA | Streptococcus pneumoniae R6 |
66.947 |
99.582 |
0.667 |
| comA | Streptococcus pneumoniae TIGR4 |
66.667 |
99.582 |
0.664 |
| comA | Streptococcus gordonii str. Challis substr. CH1 |
65.738 |
100 |
0.658 |