Detailed information    

insolico Bioinformatically predicted

Overview

Name   pknB   Type   Regulator
Locus tag   FGL18_RS07905 Genome accession   NZ_LR594046
Coordinates   1638975..1640870 (-) Length   631 a.a.
NCBI ID   WP_138126240.1    Uniprot ID   -
Organism   Streptococcus dysgalactiae strain NCTC6403     
Function   modulate the activity of ComDE; modulate the activity of VicKR (predicted from homology)   
Competence regulation

Genomic Context

Location: 1633975..1645870
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  FGL18_RS07880 (NCTC6403_01623) - 1634725..1635084 (-) 360 WP_138126236.1 S1 RNA-binding domain-containing protein -
  FGL18_RS07885 (NCTC6403_01624) - 1635084..1636484 (-) 1401 WP_138126238.1 bifunctional Cof-type HAD-IIB family hydrolase/peptidylprolyl isomerase -
  FGL18_RS07890 (NCTC6403_01625) - 1636521..1637162 (-) 642 WP_014612503.1 response regulator transcription factor -
  FGL18_RS07895 (NCTC6403_01626) - 1637155..1638159 (-) 1005 WP_003061197.1 sensor histidine kinase -
  FGL18_RS07900 (NCTC6403_01627) liaF 1638156..1638848 (-) 693 WP_015057977.1 cell wall-active antibiotics response protein LiaF -
  FGL18_RS07905 (NCTC6403_01628) pknB 1638975..1640870 (-) 1896 WP_138126240.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  FGL18_RS07910 (NCTC6403_01629) - 1640867..1641607 (-) 741 WP_003061786.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -
  FGL18_RS07915 (NCTC6403_01630) rsmB 1641645..1642967 (-) 1323 WP_138126991.1 16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB -
  FGL18_RS07920 (NCTC6403_01631) fmt 1642957..1643892 (-) 936 WP_138126242.1 methionyl-tRNA formyltransferase -

Sequence

Protein


Download         Length: 631 a.a.        Molecular weight: 68785.12 Da        Isoelectric Point: 7.0442

>NTDB_id=1127813 FGL18_RS07905 WP_138126240.1 1638975..1640870(-) (pknB) [Streptococcus dysgalactiae strain NCTC6403]
MIQIGKLFAGRYRILKSIGRGGMADVYLANDLILDNEDVAIKVLRTNYQTDQVAVARFQREARAMAELNHPNIVAIRDIG
EEDGQQFLVMEYVDGADLKKYIQDHAPLSNNEVVRIMEEVLSAMTLAHQKGIVHRDLKPQNILLTKNGVVKVTDFGIAVA
FAETSLTQTNSMLGSVHYLSPEQARGSKATIQSDIYAMGIMLFEMLTGHIPYDGDSAVTIALQHFQKPLPSIIDENHNVP
QALENVVIRATAKKLSDRYGSTFEMSRDLMTALSYNRSRERKVIFDDVESTKPLPKVTPAPVTTPKVAPTPVTSTTESRL
EHTNQMDTLQKPQKKKRNGRFLGTLLKILFSLFIVGVALFTYLVLTKPTSVKVPNVTGVSLKVAKQELQDLGLKVGKVRQ
IESDTVAEGNVVRTDPPTGTAKRKGSAITVYLSIGNKGFEMENYKGIDYQEAMDSLMETYGVPKSKIKIERIVTNEYTEN
TVISQSPSAGDKFNPNGKSKITLSVAVSDTVIMPMVTEYTYADAVNTLTALGIEASRIKAYAPSSSSATGFVQVNSPSSK
AIVSGQTPYYGTTLSLSEKGEISLYLYPEETHSSSSSTSSEASSSSSSTNDGTGTSSNTELSPSESTGQTP

Nucleotide


Download         Length: 1896 bp        

>NTDB_id=1127813 FGL18_RS07905 WP_138126240.1 1638975..1640870(-) (pknB) [Streptococcus dysgalactiae strain NCTC6403]
ATGATTCAGATTGGCAAGTTATTTGCTGGTCGTTATCGCATTCTAAAATCTATTGGCCGCGGTGGTATGGCGGATGTTTA
TTTAGCAAATGATCTAATCTTGGATAATGAAGACGTTGCAATCAAGGTCTTACGTACCAATTATCAGACAGATCAGGTAG
CGGTTGCCCGTTTCCAACGGGAAGCGCGTGCCATGGCTGAGTTAAACCATCCTAATATTGTTGCCATCCGGGATATAGGT
GAAGAAGACGGACAGCAATTTTTAGTAATGGAATACGTAGATGGCGCTGACTTAAAGAAGTATATTCAAGATCATGCTCC
TCTATCCAATAATGAAGTGGTCAGAATCATGGAAGAGGTGCTTTCTGCCATGACATTAGCTCACCAGAAAGGGATTGTTC
ATAGAGATTTAAAACCTCAAAACATTCTTTTAACTAAAAATGGTGTGGTTAAGGTAACTGATTTTGGGATTGCCGTTGCT
TTTGCGGAAACGAGTTTGACTCAAACCAACTCTATGTTGGGAAGTGTCCATTACCTATCGCCTGAGCAGGCTCGCGGCTC
AAAAGCGACCATTCAAAGTGATATTTATGCGATGGGAATTATGCTCTTTGAAATGTTGACAGGACATATCCCTTATGATG
GCGATAGTGCTGTTACCATTGCTTTGCAACATTTCCAAAAGCCTCTTCCGTCTATTATTGACGAAAACCACAATGTACCG
CAAGCTTTAGAGAATGTGGTTATCCGAGCAACAGCTAAGAAATTAAGCGATCGTTACGGATCAACCTTTGAAATGAGTCG
TGATCTGATGACGGCTCTCAGTTACAACCGGAGTCGTGAACGGAAAGTTATTTTTGATGATGTGGAAAGCACAAAACCTC
TCCCTAAAGTAACACCGGCACCAGTAACGACGCCAAAAGTAGCTCCAACTCCTGTTACGTCCACAACTGAAAGTCGTTTA
GAACACACTAATCAGATGGATACACTCCAGAAACCACAAAAAAAGAAGCGAAATGGTCGTTTCTTGGGTACTTTGTTAAA
AATCCTCTTTTCTCTCTTTATTGTAGGTGTGGCTCTCTTCACTTACTTGGTGCTAACAAAACCTACCTCAGTAAAAGTTC
CTAATGTGACAGGTGTCAGTCTTAAAGTTGCAAAGCAGGAACTGCAAGATTTAGGCTTGAAAGTTGGTAAGGTGAGACAG
ATTGAAAGTGATACTGTTGCGGAAGGGAATGTTGTCCGAACAGATCCACCAACGGGAACAGCCAAGCGCAAGGGTTCAGC
TATCACAGTTTACTTGTCAATTGGCAATAAAGGGTTTGAGATGGAAAACTACAAAGGGATTGATTATCAAGAAGCCATGG
ATAGCTTGATGGAAACCTACGGTGTTCCTAAATCGAAGATTAAGATTGAACGAATCGTGACCAATGAATACACGGAAAAT
ACTGTTATTAGCCAATCTCCGAGTGCAGGGGATAAATTTAATCCTAATGGGAAATCTAAAATTACTCTTAGTGTTGCCGT
GAGTGACACAGTCATTATGCCTATGGTAACCGAATATACCTATGCTGATGCAGTAAATACTTTGACAGCATTAGGTATTG
AAGCTTCAAGGATTAAAGCTTATGCTCCAAGCTCAAGTTCAGCAACAGGTTTTGTTCAGGTTAATTCTCCAAGTTCAAAA
GCTATTGTCAGTGGTCAAACCCCTTATTACGGTACCACATTGAGCCTCTCTGAAAAAGGTGAGATAAGCCTTTACCTTTA
CCCAGAAGAAACGCATTCTTCAAGTAGTTCAACCAGTTCTGAGGCAAGTTCTAGCAGTTCCTCAACAAATGATGGAACGG
GAACAAGTAGTAATACTGAATTAAGCCCATCGGAATCAACTGGTCAAACCCCTTAA

Domains

Predicted by InterproScan.

Protein kinase domain (Pkinase)

(12-233)

PASTA domain (PASTA)

(440-505)

PASTA domain (PASTA)

(511-587)

PASTA domain (PASTA)

(371-433)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  pknB Streptococcus mutans UA159

65.529

92.868

0.609
  stkP/pknB Streptococcus salivarius strain HSISS4

62.017

94.295

0.585
  stkP Streptococcus pneumoniae TIGR4

58.027

81.933

0.475
  stkP Streptococcus pneumoniae D39

57.834

81.933

0.474
  stkP Streptococcus pneumoniae R6

57.834

81.933

0.474
  stkP Streptococcus pneumoniae Rx1

57.64

81.933

0.472

Multiple sequence alignment