Detailed information NTG1127500

Bioinformatically predicted

Overview

• Name: comEC/celB
• Type: Machinery gene
• Locus tag: FGL12_RS08160
• Genome accession: NZ_LR594041
• Coordinates: 1686848..1689088 (-)
• Length: 746 a.a.
• NCBI ID: WP_012130665.1
• Uniprot ID: A8AYL9
• Organism: Streptococcus gordonii strain NCTC9124
• Function: ssDNA transport into the cell (predicted from homology) DNA binding and uptake

Genomic Context

Location: 1681848..1694088

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
FGL12_RS08130 (NCTC9124_01637)	-	1682121..1682618 (-)	498	WP_012130659.1	DUF1648 domain-containing protein	-
FGL12_RS08135 (NCTC9124_01638)	-	1682605..1682886 (-)	282	WP_012130660.1	autorepressor SdpR family transcription factor	-
FGL12_RS08140 (NCTC9124_01639)	-	1682864..1683652 (-)	789	WP_012130661.1	YhfC family glutamic-type intramembrane protease	-
FGL12_RS08145 (NCTC9124_01640)	-	1683857..1684930 (-)	1074	WP_012130662.1	serine hydrolase	-
FGL12_RS08150 (NCTC9124_01641)	-	1685042..1685647 (-)	606	WP_012130663.1	Fe-Mn family superoxide dismutase	-
FGL12_RS08155 (NCTC9124_01642)	holA	1685720..1686757 (-)	1038	WP_012130664.1	DNA polymerase III subunit delta	-
FGL12_RS08160 (NCTC9124_01643)	comEC/celB	1686848..1689088 (-)	2241	WP_012130665.1	DNA internalization-related competence protein ComEC/Rec2	Machinery gene
FGL12_RS08165 (NCTC9124_01644)	comEA/celA/cilE	1689072..1689737 (-)	666	WP_012130666.1	helix-hairpin-helix domain-containing protein	Machinery gene
FGL12_RS08170 (NCTC9124_01645)	-	1689834..1690361 (-)	528	WP_138101303.1	HXXEE domain-containing protein	-
FGL12_RS08175 (NCTC9124_01646)	-	1690400..1691140 (-)	741	WP_041789898.1	1-acyl-sn-glycerol-3-phosphate acyltransferase	-
FGL12_RS08180 (NCTC9124_01647)	-	1691270..1693672 (+)	2403	WP_241974397.1	cation-translocating P-type ATPase	-

Sequence

Protein

• Length: 746 a.a.
• Molecular weight: 85524.30 Da
• Isoelectric Point: 9.8278

>NTDB_id=1127500 FGL12_RS08160 WP_012130665.1 1686848..1689088(-) (comEC/celB) [Streptococcus gordonii strain NCTC9124]
MSQWIKKLPLAPIYLCFLLVWLYFAIYSGERLAYLGYSLLIARLIWHYPRKKWLPTLAILIAFSFFFYARRELAERAFQT
QPAPARQVLVLPDTVKVNGDSLSFRGRIDGRLYQLYYKLASPREKKTFQKLTDLVTLEIEAEFNLAEERRNFSGFDYQAY
LKSQGIYRTVKISRIMSSRSSQSTNPFDWLSVWRRKALVFIKSTFPSPMSHYMTGLLFGDLDIDFAEMNGLYSSLGIIHL
FALSGMQVGFFMDVFRKILLRIGLRMETVDWLQFPLSFLYAGLTGFSVSVVRSLVQKLLSQFGVRRLDNFAMTMLVLMLL
MPSFLLTTGGVLSCAYAFIITMLDFEDSSGFRKAVLESLSISLGILPLLIYYFAEFQPWSILLTFLFSIVFDTFMLPLLS
LIFLISPLFAFTQVNVFFQWLEMVIRWVASLSTRPIILGQPNLPLLIILLLVLALLYDFRKQKKIRAGLSLLAILLFFLS
KHPLQNEITVVDIGQGDSIFLRDVRGRTIVIDTGGRVEIGKKEAWQERVRKSNAETTLIPYLKSRGVDHLDQLVLTHTDT
DHMGDMLELAKHFSIREIYVSKGSMTQVDFVDKLKKMKAKVHVVEVGDRLPIFDSALEVLYPLGQGDGGNDDSIVLYGEF
FRTKFLFTGDLEAPGEGQMVTAYPDLRVDVLKAGHHGSKGSSSPEFLEHIKPKLALISAGKNNRYQHPHKETLDRFEKIQ
TKIFRTDEQGAIRFKGWNSWQIETVR

Nucleotide

• Length: 2241 bp

>NTDB_id=1127500 FGL12_RS08160 WP_012130665.1 1686848..1689088(-) (comEC/celB) [Streptococcus gordonii strain NCTC9124]
ATGTCACAGTGGATTAAAAAACTTCCCCTTGCTCCAATCTACTTGTGCTTTCTTTTGGTTTGGCTATACTTTGCTATTTA
TAGTGGTGAAAGACTCGCTTATCTAGGTTATTCCCTTCTTATAGCTCGCCTAATCTGGCATTATCCAAGAAAGAAATGGT
TGCCAACTTTAGCTATTCTAATTGCTTTCTCTTTCTTTTTTTATGCTAGACGTGAGTTGGCGGAACGAGCTTTTCAGACT
CAACCAGCTCCTGCAAGACAAGTTCTTGTTTTACCAGATACTGTTAAAGTGAATGGAGATTCCCTATCTTTCCGTGGTAG
AATAGACGGAAGACTTTATCAGCTCTACTACAAATTAGCAAGTCCAAGAGAGAAAAAAACTTTTCAAAAACTAACTGACT
TGGTCACTTTAGAGATTGAAGCAGAGTTCAATCTAGCAGAAGAACGGCGCAATTTCTCTGGCTTTGACTATCAGGCTTAT
TTAAAAAGTCAGGGAATCTATCGGACTGTTAAGATCAGTAGGATTATGTCTAGTCGTTCTAGTCAGTCTACTAATCCATT
TGATTGGCTGTCTGTTTGGCGTAGGAAGGCCTTGGTTTTCATTAAGTCTACTTTTCCAAGCCCGATGAGTCACTACATGA
CAGGACTCTTGTTTGGTGATTTAGATATTGATTTTGCAGAGATGAATGGCTTGTACTCAAGTTTAGGAATTATCCATCTT
TTTGCTTTATCAGGAATGCAAGTTGGTTTTTTTATGGATGTCTTTCGGAAAATTCTTCTGCGCATAGGCTTAAGGATGGA
AACGGTAGATTGGTTGCAATTCCCGTTGTCCTTTCTTTATGCAGGTTTGACTGGATTTTCTGTGTCAGTAGTGAGGAGTT
TAGTGCAAAAGTTGTTGTCTCAATTTGGAGTGAGGCGCTTGGATAATTTTGCGATGACCATGCTGGTCCTAATGCTTCTT
ATGCCAAGCTTTCTCCTGACAACAGGCGGAGTCCTATCTTGCGCTTATGCCTTTATCATCACTATGTTGGATTTTGAGGA
TTCTAGTGGTTTTCGTAAAGCCGTGCTAGAGAGTTTAAGTATCTCGTTAGGCATTTTACCACTTCTTATCTATTATTTTG
CAGAATTCCAGCCTTGGTCTATCCTCTTGACCTTCCTTTTTTCAATCGTCTTTGATACATTTATGTTACCTCTCTTGAGT
CTAATTTTTCTCATTTCGCCTTTGTTTGCCTTCACTCAAGTTAATGTCTTCTTCCAATGGCTGGAAATGGTGATTCGTTG
GGTAGCTAGTTTGTCAACAAGGCCGATAATTTTAGGACAGCCAAATCTGCCTTTGCTTATTATTCTCCTGCTGGTCTTAG
CCCTGCTCTATGACTTTAGAAAACAAAAAAAGATTAGAGCTGGCCTGAGTCTCTTAGCAATCTTACTATTTTTCCTAAGT
AAACATCCTTTACAAAATGAAATCACAGTGGTAGATATTGGGCAGGGAGACAGTATATTTCTGAGGGATGTCAGAGGTAG
GACTATCGTAATTGATACAGGGGGTCGGGTGGAGATTGGTAAAAAAGAGGCTTGGCAAGAGCGAGTTAGAAAAAGCAATG
CGGAAACGACCTTGATCCCTTATCTAAAAAGCCGAGGAGTGGACCACTTGGATCAATTAGTCCTGACTCACACAGATACA
GACCATATGGGAGATATGTTGGAGTTGGCCAAGCACTTTTCTATCCGAGAAATTTATGTTTCCAAAGGAAGTATGACTCA
AGTTGATTTTGTAGACAAGTTAAAGAAGATGAAAGCTAAAGTTCATGTGGTCGAGGTGGGAGATCGGCTTCCTATCTTTG
ATTCGGCCCTTGAAGTGCTCTATCCACTAGGTCAAGGAGATGGTGGTAATGATGACTCGATTGTCTTGTATGGTGAATTT
TTCCGGACCAAGTTTCTTTTCACAGGAGATTTAGAAGCTCCAGGTGAAGGTCAGATGGTGACAGCCTATCCAGATTTAAG
AGTAGATGTGCTCAAAGCTGGGCATCATGGTTCTAAAGGATCTTCTAGTCCAGAATTTCTAGAGCATATTAAGCCTAAGT
TGGCCTTGATTTCAGCTGGTAAAAACAACCGTTACCAACATCCCCATAAGGAAACTTTAGATAGATTCGAAAAAATCCAG
ACTAAGATTTTTCGGACAGATGAGCAGGGAGCTATTCGATTTAAAGGCTGGAATTCTTGGCAGATAGAAACGGTTCGCTA
G

Domains

Predicted by InterproScan.

• Metallo-beta-lactamase superfamily (Lactamase_B) (494-700)

• Competence protein (Competence) (216-460)

3D structure

• AlphaFold DB: A8AYL9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comEC/celB	Streptococcus mitis SK321	58.233	100	0.583
comEC/celB	Streptococcus mitis NCTC 12261	57.641	100	0.576
comEC/celB	Streptococcus pneumoniae TIGR4	56.894	100	0.57
comEC/celB	Streptococcus pneumoniae Rx1	56.627	100	0.567
comEC/celB	Streptococcus pneumoniae D39	56.627	100	0.567
comEC/celB	Streptococcus pneumoniae R6	56.627	100	0.567
comEC	Lactococcus lactis subsp. cremoris KW2	50.269	99.732	0.501