Detailed information
Bioinformatically predicted
Overview
| Name | ciaR | Type | Regulator |
| Locus tag | FGL04_RS05120 | Genome accession | NZ_LR594035 |
| Coordinates | 961264..961938 (+) | Length | 224 a.a. |
| NCBI ID | WP_138068433.1 | Uniprot ID | - |
| Organism | Streptococcus pseudoporcinus strain NCTC5385 | ||
| Function | repress competence development (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 917718..965964 | 961264..961938 | within | 0 |
Gene organization within MGE regions
Location: 917718..965964
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FGL04_RS04905 (NCTC5385_01063) | pfkA | 919708..920721 (+) | 1014 | WP_138068410.1 | 6-phosphofructokinase | - |
| FGL04_RS04910 (NCTC5385_01064) | pyk | 920797..922299 (+) | 1503 | WP_007893011.1 | pyruvate kinase | - |
| FGL04_RS04915 (NCTC5385_01065) | lepB | 922543..923100 (+) | 558 | WP_138068411.1 | signal peptidase I | - |
| FGL04_RS04920 (NCTC5385_01066) | glmS | 923404..925218 (+) | 1815 | WP_007893059.1 | glutamine--fructose-6-phosphate transaminase (isomerizing) | - |
| FGL04_RS04925 (NCTC5385_01067) | - | 925344..927101 (+) | 1758 | WP_138068412.1 | PTS mannitol-specific transporter subunit IIBC | - |
| FGL04_RS04930 (NCTC5385_01068) | - | 927127..927525 (+) | 399 | Protein_958 | HTH domain-containing protein | - |
| FGL04_RS04935 (NCTC5385_01069) | - | 927519..927815 (+) | 297 | Protein_959 | mannitol-1-phosphate 5-dehydrogenase | - |
| FGL04_RS04940 (NCTC5385_01070) | - | 927956..928297 (+) | 342 | WP_138068413.1 | zinc ribbon domain-containing protein YjdM | - |
| FGL04_RS04945 (NCTC5385_01071) | - | 928398..929039 (+) | 642 | WP_007893239.1 | amino acid ABC transporter permease | - |
| FGL04_RS04950 (NCTC5385_01072) | - | 929049..929678 (+) | 630 | WP_138068414.1 | amino acid ABC transporter ATP-binding protein | - |
| FGL04_RS04955 (NCTC5385_01073) | - | 929704..930528 (+) | 825 | WP_138068415.1 | amino acid ABC transporter substrate-binding protein | - |
| FGL04_RS04960 (NCTC5385_01074) | - | 930965..931735 (+) | 771 | WP_138068416.1 | CAMP factor family pore-forming toxin | - |
| FGL04_RS04965 (NCTC5385_01075) | - | 931833..933071 (-) | 1239 | WP_138068417.1 | cation diffusion facilitator family transporter | - |
| FGL04_RS04970 (NCTC5385_01076) | pcrA | 933227..935506 (+) | 2280 | WP_138068418.1 | DNA helicase PcrA | - |
| FGL04_RS04975 (NCTC5385_01077) | - | 935841..936083 (+) | 243 | WP_138068419.1 | GlsB/YeaQ/YmgE family stress response membrane protein | - |
| FGL04_RS04980 (NCTC5385_01078) | amaP | 936143..936724 (+) | 582 | WP_007893336.1 | alkaline shock response membrane anchor protein AmaP | - |
| FGL04_RS04985 (NCTC5385_01079) | - | 936734..936922 (+) | 189 | WP_007893304.1 | DUF2273 domain-containing protein | - |
| FGL04_RS04990 (NCTC5385_01080) | - | 936989..937510 (+) | 522 | WP_138068420.1 | Asp23/Gls24 family envelope stress response protein | - |
| FGL04_RS04995 (NCTC5385_01081) | - | 937546..937749 (+) | 204 | WP_007893410.1 | CsbD family protein | - |
| FGL04_RS05000 (NCTC5385_01082) | - | 937760..938248 (+) | 489 | WP_007893126.1 | Asp23/Gls24 family envelope stress response protein | - |
| FGL04_RS05005 (NCTC5385_01083) | - | 938395..939039 (+) | 645 | WP_007893328.1 | TrkA C-terminal domain-containing protein | - |
| FGL04_RS05010 (NCTC5385_01084) | tpx | 939143..939622 (+) | 480 | WP_138068421.1 | thiol peroxidase | - |
| FGL04_RS05015 | - | 939668..940206 (-) | 539 | Protein_975 | TetR/AcrR family transcriptional regulator | - |
| FGL04_RS05020 (NCTC5385_01086) | - | 940328..941029 (+) | 702 | WP_138068422.1 | ABC transporter ATP-binding protein | - |
| FGL04_RS05025 (NCTC5385_01087) | - | 941046..943682 (+) | 2637 | WP_138068423.1 | ABC transporter permease | - |
| FGL04_RS05030 (NCTC5385_01088) | - | 943791..944387 (+) | 597 | WP_138068424.1 | restriction endonuclease subunit S | - |
| FGL04_RS05035 (NCTC5385_01089) | - | 944402..945361 (+) | 960 | WP_138068425.1 | aromatic acid exporter family protein | - |
| FGL04_RS05040 (NCTC5385_01090) | - | 945449..945640 (+) | 192 | Protein_980 | MJ0042-type zinc finger domain-containing protein | - |
| FGL04_RS05050 (NCTC5385_01094) | - | 946871..948005 (+) | 1135 | Protein_982 | DUF2130 domain-containing protein | - |
| FGL04_RS05055 (NCTC5385_01095) | truB | 948139..949017 (+) | 879 | WP_138068426.1 | tRNA pseudouridine(55) synthase TruB | - |
| FGL04_RS05060 (NCTC5385_01096) | - | 949048..949962 (+) | 915 | WP_138068427.1 | bifunctional riboflavin kinase/FAD synthetase | - |
| FGL04_RS05065 (NCTC5385_01097) | - | 950067..950471 (+) | 405 | WP_003083419.1 | Spx/MgsR family RNA polymerase-binding regulatory protein | - |
| FGL04_RS05070 (NCTC5385_01098) | - | 950473..950751 (+) | 279 | WP_007893145.1 | UPF0223 family protein | - |
| FGL04_RS05075 (NCTC5385_01099) | - | 950741..951502 (+) | 762 | WP_138068428.1 | inositol monophosphatase family protein | - |
| FGL04_RS05080 (NCTC5385_01100) | - | 951678..952544 (+) | 867 | WP_138068429.1 | phosphate ABC transporter substrate-binding protein PstS family protein | - |
| FGL04_RS05085 (NCTC5385_01101) | pstC | 952555..953490 (+) | 936 | WP_138068430.1 | phosphate ABC transporter permease subunit PstC | - |
| FGL04_RS05090 (NCTC5385_01102) | pstA | 953480..954367 (+) | 888 | WP_003082851.1 | phosphate ABC transporter permease PstA | - |
| FGL04_RS05095 (NCTC5385_01103) | pstB | 954383..955186 (+) | 804 | WP_007893141.1 | phosphate ABC transporter ATP-binding protein PstB | - |
| FGL04_RS05100 (NCTC5385_01104) | pstB | 955198..955956 (+) | 759 | WP_138068431.1 | phosphate ABC transporter ATP-binding protein PstB | - |
| FGL04_RS05105 (NCTC5385_01105) | phoU | 955984..956637 (+) | 654 | WP_007893157.1 | phosphate signaling complex protein PhoU | - |
| FGL04_RS05110 (NCTC5385_01106) | - | 956712..959261 (+) | 2550 | WP_138068432.1 | M1 family metallopeptidase | - |
| FGL04_RS05115 (NCTC5385_01107) | - | 959461..960941 (+) | 1481 | Protein_995 | IS1182 family transposase | - |
| FGL04_RS05120 (NCTC5385_01108) | ciaR | 961264..961938 (+) | 675 | WP_138068433.1 | response regulator transcription factor | Regulator |
| FGL04_RS05125 (NCTC5385_01109) | ciaH | 961931..963253 (+) | 1323 | WP_138068434.1 | sensor histidine kinase | Regulator |
| FGL04_RS05130 (NCTC5385_01110) | rpsT | 963321..963563 (-) | 243 | WP_171011245.1 | 30S ribosomal protein S20 | - |
| FGL04_RS05135 (NCTC5385_01111) | coaA | 963623..964543 (-) | 921 | WP_138068436.1 | type I pantothenate kinase | - |
| FGL04_RS05140 (NCTC5385_01112) | - | 964808..965398 (+) | 591 | WP_138068437.1 | class I SAM-dependent methyltransferase | - |
Sequence
Protein
Download Length: 224 a.a. Molecular weight: 25532.31 Da Isoelectric Point: 4.3545
>NTDB_id=1127299 FGL04_RS05120 WP_138068433.1 961264..961938(+) (ciaR) [Streptococcus pseudoporcinus strain NCTC5385]
MIKILLVEDDLSLSNSIFDFLDDFADVMQVFDGDEGLYEAESGVYDLILLDLMLPEKNGFQVLKELREKDIKTPVLIMTA
KEGLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRTGKFNENSITFGNLRVDLDRNAVKVNGSAVELLGKEYDLLIY
LLQNQNVILPKSQIFDRIWGFDSDTTISVVEVYVSKIRKKLKDTDFATNLQTLRSVGYILKADD
MIKILLVEDDLSLSNSIFDFLDDFADVMQVFDGDEGLYEAESGVYDLILLDLMLPEKNGFQVLKELREKDIKTPVLIMTA
KEGLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRTGKFNENSITFGNLRVDLDRNAVKVNGSAVELLGKEYDLLIY
LLQNQNVILPKSQIFDRIWGFDSDTTISVVEVYVSKIRKKLKDTDFATNLQTLRSVGYILKADD
Nucleotide
Download Length: 675 bp
>NTDB_id=1127299 FGL04_RS05120 WP_138068433.1 961264..961938(+) (ciaR) [Streptococcus pseudoporcinus strain NCTC5385]
ATGATAAAAATATTACTAGTTGAAGATGATTTAAGTTTATCGAATTCTATTTTTGACTTTCTCGATGATTTTGCTGATGT
TATGCAAGTTTTTGATGGAGATGAAGGTTTATATGAAGCAGAAAGTGGGGTTTATGATTTAATTCTTTTAGATTTAATGC
TCCCAGAAAAAAATGGCTTTCAAGTTCTAAAAGAGCTTAGAGAAAAGGATATTAAGACCCCTGTTTTAATTATGACTGCT
AAAGAAGGGTTAGATGATAAGGGACATGGTTTTGAATTAGGTGCTGATGACTATTTAACCAAGCCTTTTTACTTGGAAGA
ACTTAAAATGCGTATTCAAGCCCTTCTTAAACGAACTGGTAAGTTTAACGAAAACAGTATTACGTTTGGTAATCTCAGAG
TTGACCTTGATCGGAATGCTGTGAAAGTGAATGGTAGTGCTGTTGAACTATTAGGGAAAGAATATGATCTGCTCATCTAT
TTACTTCAAAATCAGAATGTTATTTTACCGAAATCCCAAATTTTTGATCGGATTTGGGGTTTTGATAGTGATACCACTAT
CTCGGTCGTGGAAGTTTATGTTTCTAAAATTCGAAAGAAATTAAAAGATACTGATTTTGCAACAAACTTACAGACCTTAC
GTAGCGTTGGCTACATTTTAAAAGCCGATGACTAA
ATGATAAAAATATTACTAGTTGAAGATGATTTAAGTTTATCGAATTCTATTTTTGACTTTCTCGATGATTTTGCTGATGT
TATGCAAGTTTTTGATGGAGATGAAGGTTTATATGAAGCAGAAAGTGGGGTTTATGATTTAATTCTTTTAGATTTAATGC
TCCCAGAAAAAAATGGCTTTCAAGTTCTAAAAGAGCTTAGAGAAAAGGATATTAAGACCCCTGTTTTAATTATGACTGCT
AAAGAAGGGTTAGATGATAAGGGACATGGTTTTGAATTAGGTGCTGATGACTATTTAACCAAGCCTTTTTACTTGGAAGA
ACTTAAAATGCGTATTCAAGCCCTTCTTAAACGAACTGGTAAGTTTAACGAAAACAGTATTACGTTTGGTAATCTCAGAG
TTGACCTTGATCGGAATGCTGTGAAAGTGAATGGTAGTGCTGTTGAACTATTAGGGAAAGAATATGATCTGCTCATCTAT
TTACTTCAAAATCAGAATGTTATTTTACCGAAATCCCAAATTTTTGATCGGATTTGGGGTTTTGATAGTGATACCACTAT
CTCGGTCGTGGAAGTTTATGTTTCTAAAATTCGAAAGAAATTAAAAGATACTGATTTTGCAACAAACTTACAGACCTTAC
GTAGCGTTGGCTACATTTTAAAAGCCGATGACTAA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| ciaR | Streptococcus mutans UA159 |
89.14 |
98.661 |
0.879 |
| ciaR | Streptococcus pneumoniae Rx1 |
86.425 |
98.661 |
0.853 |
| ciaR | Streptococcus pneumoniae D39 |
86.425 |
98.661 |
0.853 |
| ciaR | Streptococcus pneumoniae TIGR4 |
86.425 |
98.661 |
0.853 |
| ciaR | Streptococcus pneumoniae R6 |
86.425 |
98.661 |
0.853 |
| vicR | Streptococcus mutans UA159 |
36.864 |
100 |
0.388 |
| covR | Lactococcus lactis subsp. lactis strain DGCC12653 |
37.778 |
100 |
0.379 |