Detailed information    

insolico Bioinformatically predicted

Overview

Name   pknB   Type   Regulator
Locus tag   FGL04_RS02755 Genome accession   NZ_LR594035
Coordinates   499940..501868 (+) Length   642 a.a.
NCBI ID   WP_138068160.1    Uniprot ID   A0A4U9XT33
Organism   Streptococcus pseudoporcinus strain NCTC5385     
Function   modulate the activity of ComDE; modulate the activity of VicKR (predicted from homology)   
Competence regulation

Genomic Context

Location: 494940..506868
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  FGL04_RS02740 (NCTC5385_00576) fmt 496917..497849 (+) 933 WP_007892970.1 methionyl-tRNA formyltransferase -
  FGL04_RS02745 (NCTC5385_00577) rsmB 497842..499164 (+) 1323 WP_138068158.1 16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB -
  FGL04_RS02750 (NCTC5385_00578) - 499203..499943 (+) 741 WP_138068159.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -
  FGL04_RS02755 (NCTC5385_00579) pknB 499940..501868 (+) 1929 WP_138068160.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  FGL04_RS02760 (NCTC5385_00580) liaF 501982..502677 (+) 696 WP_007892966.1 cell wall-active antibiotics response protein LiaF -
  FGL04_RS02765 (NCTC5385_00581) - 502674..503678 (+) 1005 WP_138068161.1 sensor histidine kinase -
  FGL04_RS02770 (NCTC5385_00582) - 503671..504312 (+) 642 WP_138068162.1 response regulator transcription factor -
  FGL04_RS02775 (NCTC5385_00583) - 504346..505746 (+) 1401 WP_138068163.1 bifunctional Cof-type HAD-IIB family hydrolase/peptidylprolyl isomerase -
  FGL04_RS02780 (NCTC5385_00584) - 505746..506099 (+) 354 WP_007892969.1 S1 RNA-binding domain-containing protein -

Sequence

Protein


Download         Length: 642 a.a.        Molecular weight: 70076.52 Da        Isoelectric Point: 9.1491

>NTDB_id=1127286 FGL04_RS02755 WP_138068160.1 499940..501868(+) (pknB) [Streptococcus pseudoporcinus strain NCTC5385]
MIQIGKLFAGRYRILKSIGRGGMADVYLANDLILDNEDVAIKVLRTNYQTDQVAVARFQREARAMAELNHPNIVAIRDIG
EEDGQQFLVMEYVDGADLKKFIQDNAPLTNNQVVRIMEEVLSAMTLAHQKGIVHRDLKPQNILLTKEGVVKVTDFGIAVA
FAETSLTQTNSMLGSVHYLSPEQARGSKATIQSDIYAMGIMLYEMLTGHIPYDGDSAVTIALQHFQKPLPSIVDENPSVP
QALENVVIKATAKKLSDRYATTFEMSRDLMTALSYNRSREKKLIFDDGENTRPLPKVTPTPNTNPKTSPKEPIASTKAPQ
ASEQLKKPKKEKKRGRFLGTLFKILFALFVVGVAIFTFLILTKPSNVKVPNLSGRDLQTAKADLQALGLKVGNVEQAPSE
DVSEGKVIETNPIAGTTKREGSKVDILVSKGSSGFKVKDYVGDDYQKAMEDLMTTYGLKRKQISIKRVIKDDYNKQDIVL
SQTPNKGYFNPNGKTKFTLTVATTEIIGMPQLIGMTYKDAKLLLEEKGIDLNRVKVYQMNPNGTTTPVEPNSDTLIAYQK
PLLNGQVSLTDTGEISLYINSDSQHVPSSSSSSSSSTETSSESSTSSSSSSSNSSSESSSGSSSTSTSTSTSTSTTSSNT
VQ

Nucleotide


Download         Length: 1929 bp        

>NTDB_id=1127286 FGL04_RS02755 WP_138068160.1 499940..501868(+) (pknB) [Streptococcus pseudoporcinus strain NCTC5385]
ATGATACAGATTGGCAAATTATTTGCTGGTCGATATCGCATATTAAAATCTATTGGCCGTGGAGGCATGGCAGATGTTTA
TTTAGCTAATGACTTAATTCTAGATAATGAAGACGTGGCAATAAAGGTATTGCGTACTAATTATCAAACGGATCAAGTTG
CTGTCGCACGTTTCCAAAGGGAAGCAAGAGCGATGGCTGAGCTGAATCATCCTAATATCGTAGCTATTAGAGATATAGGC
GAAGAAGACGGGCAGCAATTTTTAGTAATGGAATATGTTGATGGTGCTGATCTTAAGAAGTTCATTCAAGACAATGCACC
TCTGACTAATAATCAAGTCGTTCGGATTATGGAAGAGGTCTTGTCAGCAATGACTTTAGCCCATCAAAAAGGAATTGTCC
ATAGAGATTTAAAGCCGCAGAACATTCTTTTAACTAAAGAAGGTGTTGTCAAAGTCACAGACTTTGGTATTGCTGTTGCT
TTTGCCGAAACCAGCTTAACACAGACTAATTCCATGTTAGGAAGTGTTCATTATTTATCGCCTGAGCAGGCACGTGGCTC
AAAAGCAACCATCCAAAGTGATATCTATGCAATGGGAATCATGCTATATGAAATGTTAACTGGTCACATTCCCTATGATG
GGGATAGTGCGGTAACGATTGCTTTACAACATTTCCAAAAGCCACTCCCTTCCATTGTGGATGAGAATCCCAGTGTGCCA
CAAGCTTTAGAAAATGTTGTTATTAAAGCTACTGCTAAAAAATTGAGTGACCGTTATGCAACGACTTTTGAGATGAGCAG
AGATTTAATGACAGCCTTGAGTTATAACCGTAGTCGTGAAAAGAAGTTGATTTTTGATGACGGTGAGAACACAAGACCTT
TGCCCAAAGTGACGCCTACGCCTAATACCAACCCTAAAACAAGCCCTAAGGAACCAATAGCTTCTACTAAAGCACCGCAA
GCTTCAGAACAGCTTAAAAAGCCGAAAAAAGAGAAAAAACGAGGACGTTTCTTAGGAACTCTTTTCAAAATTTTATTTGC
TTTATTTGTGGTTGGTGTAGCTATCTTTACTTTCTTAATTTTAACCAAACCTTCTAATGTTAAAGTTCCTAACCTAAGTG
GTAGAGATTTACAGACTGCCAAAGCAGATTTACAAGCCCTAGGTTTAAAAGTTGGCAATGTTGAGCAGGCACCAAGCGAG
GACGTTTCAGAAGGGAAAGTTATTGAAACGAATCCGATCGCAGGAACAACAAAGCGTGAAGGGTCTAAAGTAGATATTTT
AGTTTCCAAAGGAAGCAGCGGCTTTAAAGTCAAGGATTATGTAGGTGATGATTACCAAAAAGCTATGGAAGATTTAATGA
CTACCTACGGTTTAAAACGTAAACAAATAAGTATCAAACGCGTCATAAAAGATGACTATAATAAGCAAGACATTGTCTTG
AGCCAGACTCCAAATAAGGGCTACTTTAACCCAAATGGGAAAACAAAGTTCACTTTAACGGTTGCAACTACAGAAATAAT
TGGGATGCCGCAACTTATTGGAATGACTTACAAAGATGCTAAACTCTTGCTTGAAGAGAAAGGGATTGATTTAAATCGTG
TTAAAGTTTATCAGATGAATCCGAATGGTACTACGACCCCGGTTGAACCAAACTCTGATACCTTAATAGCTTATCAAAAA
CCTCTCCTTAATGGACAGGTTTCACTGACGGATACAGGAGAAATTAGTCTCTATATTAATAGTGACAGCCAACATGTTCC
TTCGTCAAGTAGTTCAAGTTCATCAAGTACAGAGACTAGCTCTGAGTCTAGCACTAGTTCAAGTTCTTCCAGTTCAAACT
CCTCTTCGGAGTCAAGTTCTGGATCTAGCTCAACTAGTACTTCAACGAGTACCTCGACATCCACAACGAGTTCAAATACA
GTTCAGTAG

Domains

Predicted by InterproScan.

Protein kinase domain (Pkinase)

(12-233)

PASTA domain (PASTA)

(509-580)

PASTA domain (PASTA)

(367-430)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A4U9XT33

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  pknB Streptococcus mutans UA159

62.607

90.81

0.569
  stkP/pknB Streptococcus salivarius strain HSISS4

61.525

91.9

0.565
  stkP Streptococcus pneumoniae TIGR4

61.556

70.093

0.431
  stkP Streptococcus pneumoniae D39

61.111

70.093

0.428
  stkP Streptococcus pneumoniae R6

61.111

70.093

0.428
  stkP Streptococcus pneumoniae Rx1

60.889

70.093

0.427

Multiple sequence alignment