Detailed information NTG1127256

Bioinformatically predicted

Overview

• Name: pknB
• Type: Regulator
• Locus tag: FGL00_RS08555
• Genome accession: NZ_LR594034
• Coordinates: 1704382..1706277 (-)
• Length: 631 a.a.
• NCBI ID: WP_138098700.1
• Uniprot ID: -
• Organism: Streptococcus dysgalactiae subsp. equisimilis strain NCTC8546
• Function: modulate the activity of ComDE; modulate the activity of VicKR (predicted from homology) Competence regulation

Genomic Context

Location: 1699382..1711277

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
FGL00_RS08530 (NCTC8546_01770)	-	1700132..1700491 (-)	360	WP_003056775.1	S1 RNA-binding domain-containing protein	-
FGL00_RS08535 (NCTC8546_01771)	-	1700491..1701891 (-)	1401	WP_138083991.1	bifunctional Cof-type HAD-IIB family hydrolase/peptidylprolyl isomerase	-
FGL00_RS08540 (NCTC8546_01772)	-	1701928..1702569 (-)	642	WP_014612503.1	response regulator transcription factor	-
FGL00_RS08545 (NCTC8546_01773)	-	1702562..1703566 (-)	1005	WP_138098698.1	sensor histidine kinase	-
FGL00_RS08550 (NCTC8546_01774)	liaF	1703563..1704255 (-)	693	WP_015057977.1	cell wall-active antibiotics response protein LiaF	-
FGL00_RS08555 (NCTC8546_01775)	pknB	1704382..1706277 (-)	1896	WP_138098700.1	Stk1 family PASTA domain-containing Ser/Thr kinase	Regulator
FGL00_RS08560 (NCTC8546_01776)	-	1706274..1707014 (-)	741	WP_014612505.1	Stp1/IreP family PP2C-type Ser/Thr phosphatase	-
FGL00_RS08565 (NCTC8546_01777)	rsmB	1707052..1708374 (-)	1323	WP_138098808.1	16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB	-
FGL00_RS08570 (NCTC8546_01778)	fmt	1708364..1709299 (-)	936	WP_012767424.1	methionyl-tRNA formyltransferase	-

Sequence

Protein

• Length: 631 a.a.
• Molecular weight: 68783.15 Da
• Isoelectric Point: 7.0443

>NTDB_id=1127256 FGL00_RS08555 WP_138098700.1 1704382..1706277(-) (pknB) [Streptococcus dysgalactiae subsp. equisimilis strain NCTC8546]
MIQIGKLFAGRYRILKSIGRGGMADVYLANDLILDNEDVAIKVLRTNYQTDQVAVARFQREARAMAELNHPNIVAIRDIG
EEDGQQFLVMEYVDGADLKKYIQDHAPLSNNEVVRIMEEVLSAMTLAHQKGIVHRDLKPQNILLTKNGVVKVTDFGIAVA
FAETSLTQTNSMLGSVHYLSPEQARGSKATIQSDIYAMGIMLFEMLTGHIPYDGDSAVTIALQHFQKPLPSIIDENHNVP
QALENVVIRATAKKLSDRYGSTFEMSRDLMTALSYNRSRERKVIFDDVESTKPLPKVTPAPVTTPKVAPTPVTSTTESRL
EHTNQMDTLQKPQKKKRNGRFLGTLLKILFSLFIVGVALFTYLVLTKPTSVKVPNVTGVSLKVAKQELQDLGLKVGKVRQ
IESDTVAEGNVVRTDPPTGTAKRKGSAITVYLSIGNKGFEMENYKGIDYQEAMASLMETYGVPKSKIKIERIVTNEYTEN
TVISQSPSAGDKFNPNGKSKITLSVAVSDTVIMPMVTEYTYADAVNTLTALGIEASRIKAYAPSSSSATGFVQVNSPSSK
AIVSGQTPYYGTTLSLSEKGEISLYLYPEETHSSSSSTSSEASSSSSSTNDGTETSSNTELSPSESAGQTP

Nucleotide

• Length: 1896 bp

>NTDB_id=1127256 FGL00_RS08555 WP_138098700.1 1704382..1706277(-) (pknB) [Streptococcus dysgalactiae subsp. equisimilis strain NCTC8546]
ATGATTCAGATTGGCAAGTTATTTGCTGGTCGTTATCGCATTCTAAAATCTATTGGCCGCGGTGGTATGGCGGATGTTTA
TTTAGCAAATGATCTAATCTTGGATAATGAAGACGTTGCAATCAAGGTCTTACGTACCAATTATCAGACAGATCAGGTAG
CGGTTGCCCGTTTCCAACGGGAAGCGCGTGCCATGGCTGAGTTAAACCATCCTAATATTGTTGCCATCCGGGATATAGGT
GAAGAAGACGGACAGCAATTTTTAGTAATGGAATACGTAGATGGCGCTGACTTAAAGAAGTATATTCAAGATCATGCTCC
TCTATCCAATAATGAAGTGGTCAGAATCATGGAAGAGGTGCTTTCTGCCATGACATTAGCTCACCAGAAAGGGATTGTTC
ATAGAGATTTAAAACCTCAAAACATTCTTTTAACTAAAAATGGTGTGGTTAAGGTAACTGACTTTGGGATTGCCGTTGCT
TTTGCGGAAACGAGTTTGACTCAAACCAACTCTATGTTGGGAAGCGTCCATTACCTATCGCCTGAGCAGGCTCGCGGCTC
AAAAGCGACCATTCAAAGTGATATTTATGCGATGGGAATTATGCTCTTTGAAATGTTGACAGGACATATCCCTTATGATG
GCGATAGTGCTGTTACCATTGCTTTGCAACATTTCCAAAAGCCTCTTCCGTCTATTATTGACGAAAACCACAATGTACCG
CAAGCTTTAGAGAATGTGGTTATCCGAGCAACAGCTAAGAAATTAAGCGATCGTTACGGATCAACCTTTGAAATGAGTCG
TGATCTGATGACGGCTCTCAGTTACAACCGGAGTCGTGAACGGAAAGTTATTTTTGATGATGTGGAAAGCACAAAACCTC
TCCCTAAAGTAACACCGGCACCAGTAACGACACCAAAAGTAGCTCCAACTCCTGTTACGTCCACAACTGAAAGTCGTTTA
GAACACACTAATCAGATGGATACGCTCCAGAAACCACAAAAAAAGAAGCGAAATGGTCGTTTCTTGGGTACTTTGTTAAA
AATCCTCTTTTCTCTTTTTATTGTAGGTGTGGCTCTCTTCACTTACTTGGTGCTAACAAAACCTACCTCAGTAAAAGTTC
CTAACGTGACAGGTGTCAGTCTTAAAGTTGCAAAGCAGGAACTGCAAGATTTAGGCTTGAAAGTTGGTAAGGTGAGACAG
ATTGAAAGTGATACTGTTGCGGAAGGGAATGTTGTCCGAACGGATCCACCAACGGGAACAGCCAAGCGCAAGGGTTCAGC
TATCACAGTTTACTTGTCAATTGGTAATAAAGGGTTTGAGATGGAAAACTACAAAGGGATTGATTATCAAGAAGCCATGG
CTAGCTTGATGGAAACTTACGGTGTTCCTAAATCGAAGATTAAGATTGAACGAATCGTGACCAATGAATACACGGAAAAT
ACTGTTATTAGCCAATCTCCGAGTGCAGGGGATAAATTTAATCCTAATGGGAAATCTAAAATTACTCTTAGTGTTGCCGT
GAGTGACACAGTCATTATGCCTATGGTAACAGAATATACCTATGCTGATGCAGTAAATACTTTGACAGCATTAGGTATTG
AAGCTTCAAGGATTAAAGCTTATGCTCCAAGCTCAAGTTCAGCAACAGGTTTTGTTCAGGTTAATTCTCCAAGTTCAAAA
GCTATTGTCAGTGGTCAAACCCCTTATTACGGTACCACATTGAGCCTCTCTGAAAAAGGTGAGATAAGCCTTTACCTTTA
CCCAGAAGAAACGCATTCTTCAAGTAGTTCAACCAGTTCTGAGGCAAGTTCTAGCAGTTCCTCAACAAATGATGGAACGG
AAACAAGTAGTAATACTGAATTAAGCCCATCGGAATCAGCTGGTCAAACCCCTTAA

Domains

Predicted by InterproScan.

• Protein kinase domain (Pkinase) (12-233)

• PASTA domain (PASTA) (511-587)

• PASTA domain (PASTA) (440-505)

• PASTA domain (PASTA) (371-433)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
pknB	Streptococcus mutans UA159	65.358	92.868	0.607
stkP/pknB	Streptococcus salivarius strain HSISS4	62.017	94.295	0.585
stkP	Streptococcus pneumoniae TIGR4	58.221	81.933	0.477
stkP	Streptococcus pneumoniae D39	58.027	81.933	0.475
stkP	Streptococcus pneumoniae R6	58.027	81.933	0.475
stkP	Streptococcus pneumoniae Rx1	57.834	81.933	0.474