Detailed information NTG1127213

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: FGL00_RS00345
• Genome accession: NZ_LR594034
• Coordinates: 56138..57049 (+)
• Length: 303 a.a.
• NCBI ID: WP_012766420.1
• Uniprot ID: -
• Organism: Streptococcus dysgalactiae subsp. equisimilis strain NCTC8546
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 51138..62049

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
FGL00_RS00330 (NCTC8546_00067)	purK	51568..52641 (+)	1074	WP_065358524.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
FGL00_RS00335 (NCTC8546_00068)	-	52660..54144 (+)	1485	WP_232043391.1	DUF262 domain-containing protein	-
FGL00_RS00340 (NCTC8546_00069)	purB	54704..55996 (+)	1293	WP_022554088.1	adenylosuccinate lyase	-
FGL00_RS00345 (NCTC8546_00070)	comR	56138..57049 (+)	912	WP_012766420.1	XRE family transcriptional regulator	Regulator
FGL00_RS11090 (NCTC8546_00071)	comS	57136..57231 (+)	96	WP_198455558.1	quorum-sensing system DWW-type pheromone	Regulator
FGL00_RS00350 (NCTC8546_00072)	ruvB	57284..58282 (+)	999	WP_015057190.1	Holliday junction branch migration DNA helicase RuvB	-
FGL00_RS00355 (NCTC8546_00073)	-	58417..58848 (+)	432	WP_048327929.1	low molecular weight protein-tyrosine-phosphatase	-
FGL00_RS00360 (NCTC8546_00074)	-	58877..59278 (+)	402	WP_003049089.1	MORN repeat-containing protein	-
FGL00_RS00365 (NCTC8546_00075)	-	59275..61050 (+)	1776	WP_003059359.1	acyltransferase family protein	-

Sequence

Protein

• Length: 303 a.a.
• Molecular weight: 35726.31 Da
• Isoelectric Point: 4.5798

>NTDB_id=1127213 FGL00_RS00345 WP_012766420.1 56138..57049(+) (comR) [Streptococcus dysgalactiae subsp. equisimilis strain NCTC8546]
MLEHFGEKVRGLRLEKGISREELCGDEAELSVRQLARIELGQSIPSLAKVIFIAKALEVSVGYLTDGANLELPKRYKELK
YLILRTPTYMDDRKLQVRESQFDEIFENYYDQLPEEEQLIIECLQATLDTLLSENINFGVELLQEYFKQTKVKLRFKQND
LILIELYLAYLDIEGMYGEYSDKVFYDSLLDNLLKQFDDFELDELFIVNKIIIDISSLSIKTNKLDNLEKTIAISQKIMA
KIQDWNRMPILKLIEWKYFLIKQKNRKQAEESYTKACLFAQITGDKYLEEQLIKEWEKDICAY

Nucleotide

• Length: 912 bp

>NTDB_id=1127213 FGL00_RS00345 WP_012766420.1 56138..57049(+) (comR) [Streptococcus dysgalactiae subsp. equisimilis strain NCTC8546]
ATGTTAGAGCATTTTGGTGAAAAAGTGAGAGGATTAAGACTTGAGAAAGGGATTAGTCGAGAGGAATTGTGTGGAGATGA
GGCAGAATTGTCTGTTCGCCAGTTGGCGAGGATAGAGCTAGGTCAATCTATACCAAGTTTAGCGAAGGTTATTTTTATTG
CGAAAGCCTTAGAGGTCAGCGTCGGTTATTTGACGGATGGCGCTAACCTAGAACTCCCTAAACGATATAAAGAGTTAAAA
TATCTCATTTTAAGGACTCCGACTTATATGGACGATCGCAAATTACAGGTCCGGGAGTCTCAGTTTGATGAGATATTTGA
AAACTATTATGATCAATTGCCCGAGGAGGAACAATTGATTATAGAATGTTTACAGGCTACGCTAGACACTTTATTAAGTG
AAAACATCAATTTTGGTGTCGAATTATTGCAGGAATATTTTAAACAAACCAAAGTTAAACTACGTTTTAAACAAAACGAC
TTGATACTTATTGAACTCTATCTGGCTTATCTCGATATTGAAGGGATGTATGGAGAATATTCTGATAAGGTTTTTTATGA
TTCTTTGTTAGATAACCTGTTAAAACAATTCGATGACTTTGAATTAGACGAACTGTTCATAGTTAATAAAATTATTATTG
ATATTTCTTCTTTAAGTATTAAAACTAATAAACTAGATAATCTAGAAAAGACGATTGCTATAAGTCAAAAAATCATGGCA
AAAATCCAGGATTGGAATAGAATGCCTATACTAAAATTAATAGAATGGAAGTACTTTTTAATAAAACAAAAGAACAGAAA
ACAAGCAGAGGAATCATATACAAAGGCGTGTCTGTTTGCGCAAATAACAGGAGACAAGTATTTGGAAGAGCAATTAATCA
AAGAATGGGAGAAAGATATTTGTGCTTATTAA

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (12-64)

• ComR tetratricopeptide (ComR_TPR) (73-296)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS8232	82.178	100	0.822
comR	Streptococcus pyogenes MGAS315	54.667	99.01	0.541
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	50.847	97.36	0.495
comR	Streptococcus mutans UA159	49.498	98.68	0.488